Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context by Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-Qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Hui-Miao Song, Hui-Wu Gao, Ke An, Dong-Li Zhu, Zhi Yang, Yan Guo, Tie-Lin Yang

“…This study aims to address this issue by generating a cartilage expression quantitative trait loci (eQTLs) and a functional fine-mapping resource. Methods: We performed cis-eQTL analysis using genomics and cartilage transcriptomics data from 204 patients with OA (largest sample size to date). …”
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Effect of Telitacicept on Circulating Gd-IgA1 and IgA-Containing Immune Complexes in IgA Nephropathy by Jincan Zan, Lijun Liu, Guisen Li, Hongguang Zheng, Nan Chen, Caili Wang, Deqiong Xie, Li Zuo, Rongshan Li, Pengfei Zhang, Yue Wang, Wenxiang Wang, Lin Li, Jianmin Fang, Jicheng Lv, Hong Zhang

“…However, serum biomarkers that could predict the clinical response during the treatment remain unclear. Methods: Plasma samples from 24 participants in the phase 2 clinical trial were collected at baseline and after 4, 12, and 24 weeks; with 8 participants in the placebo group, 9 in the 160 mg group, and 7 in the 240 mg group. …”
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Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia by Temur K. Muminov, Vladimir A. Gushchin, Vladimir A. Gushchin, Vladimir A. Gushchin, Denis A. Kleymenov, Artem P. Tkachuk, Artem P. Tkachuk, Viktor A. Manuylov, Viktor A. Manuylov, Andrei E. Siniavin, Andrei E. Siniavin, Daria A. Ogarkova, Nadezhda A. Kuznetsova, Vladimir I. Zlobin, Alexander L. Gintsburg, Alexander L. Gintsburg

“…Blood serum samples were tested for anti-TBE virus IgG antibodies. …”
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Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and cruci... by Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere, Simone Lucchesi, Chiara Coppola, Simone Costagli, Gabiria Pastore, Anna Sicuranza, Monica Tozzi, Arianna Lippi, Francesca Panza, Monica Bocchia, Alessandro Bucalossi, Guido Garosi, David Bennett, Sonia Bernazzali, Massimiliano Fabbiani, Francesca Montagnani, Donata Medaglini

“…Summary: Background: Individuals with primary and secondary immunodeficiencies, being more susceptible to infections, are a priority for vaccination. …”
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Clinical and epidemiological characteristics of influenza and SARS-CoV-2 virus among patients with acute febrile illness in selected sites of Ethiopia 2021–2022 by Musse Tadesse Chekol, Musse Tadesse Chekol, David Sugerman, Adamu Tayachew, Adamu Tayachew, Zelalem Mekuria, Neamin Tesfay, Aynalem Alemu, Aynalem Alemu, Andargachew Gashu, Andargachew Gashu, Wolde Shura, Melaku Gonta, Admikew Agune, Aster Hailemariam, Yonas Assefa, Mesfin Wossen, Abdulhafiz Hassen, Parsons Michele, Rachel Silver, Hulemenaw Delelegn, Lozano Briana, Tesfu Kasa, Nigatu Kebede

“…We determined the fraction of AFI attributable to influenza and SARS-CoV-2 in Ethiopia, along with an understanding of their epidemiological characteristics.MethodsFrom February 2021 to June 2022, we enrolled patients meeting an AFI case definition (age >5 years with fever ≥38°C) who presented at one of four selected sentinel hospital sites in Jimma, Harari, Addis Ababa, and Gonder. …”
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Allometric equations model for estimating an above and below ground biomass of dipterocarp forest in the tropics by I. Heriansyah, Luthfy Abdullah , J.S. Rahajoe, R. Susanti, Y. Lisnawati, Subarudi , R. Dewi, Darwo , Mawazin , Abdurachman , Karmilasanti , N. Wakhid, D. Wicaksono, R. Effendi, A.S. Yunianto, M.A. Qirom, N. Mindawati

“…Based on forest type, planted forests show more uniform relationships between tree diameter, height and biomass components, indicative of managed growing conditions. …”
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β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease by Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong

“…Abstract Background β-synuclein (β-syn), mainly expressed in central nerve system, is one of the biomarkers in cerebrospinal fluid (CSF) and blood for synaptic damage, which has been reported to be elevated in CSF and blood of the patients of prion diseases (PrDs). Methods We analyzed 314 CSF samples from patients in China National Surveillance for CJD. …”
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Impact of acupuncture treatment on the lumbar surgery rate for low back pain in Korea: A nationwide matched retrospective cohort study. by Wonil Koh, Kyungwon Kang, Yoon Jae Lee, Me-Riong Kim, Joon-Shik Shin, Jinho Lee, Jun-Hwan Lee, Kyung-Min Shin, In-Hyuk Ha

“…This nationwide retrospective cohort study investigated the association between acupuncture treatment and lumbar surgery rate in patients with LBP.<h4>Methods</h4>Using the National Health Insurance Service Sample Cohort Database for 2002-2013, we identified newly diagnosed LBP patients in Korea between 2004 and 2010 and divided them into an acupuncture group and control group according to whether or not they received acupuncture. …”
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Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes by Cecilia Catellani, Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Ilaria Ferrigno, Veronica Buia, Chiara Marvisi, Chiara Marvisi, Giulia Cassone, Mariagrazia Catanoso, Gabriella Di Tommaso, Luigi Boiardi, Rexhep Durmo, Annibale Versari, Massimiliano Casali, Giulia Besutti, Giulia Besutti, Lucia Spaggiari, Alessandro Zerbini, Francesco Muratore, Francesco Muratore, Carlo Salvarani, Carlo Salvarani, Stefania Croci

“…The aim of this study was to deepen the understanding of the immunological mechanisms behind this treatment regimen in patients with LV-GCA.Methods15 patients with active LV-GCA were included in this study. …”
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Differential neutrophil responses in murine following intraperitoneal injections of Escherichia coli and Staphylococcus aureus by Yanyan Zhu, Jingya Luo, Xianzhu Xia, Hao Feng, Pingsen Zhao

“…Objective: This study aimed to investigate the proportion of neutrophils among leukocytes, in various tissues following intraperitoneal injection of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in mice. Methods: Twelve specific-pathogen free (SPF) male mice, aged eight weeks, were segregated into three groups, each containing four mice. …”
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Etiologic Characteristics of Influenza Epidemics on the Territory of Russia in the Period of Pandemic COVID-­19 in 2020–2023 by P. A. Petrova, N. I. Konovalova, A. Y. Boyarintseva, D. M. Danilenko, A. D. Vasilieva, T. N. Shelepanova, A. V. Prokopets, M. Y. Eropkin

“…Establish the etiological nature of influenza epidemics in 2020–2023 in Russia and the antigenic properties of influenza viruses of the types A and B which circulated on its territory in 2020–2023. Methods. Isolation of influenza viruses from PCR+-clinical materials (nazo-pharingeal swabs and post-mortem tissue samples) in the cell lines MDCK and MDCK-Siat1; antigenic analysis by means of the reaction of hemagglutination-inhibition (HI) and micro-neutralization (MN) with the cell-ELISA detection using the post-infectious ferret antisera and rat polyclonal antisera; antigenic cartography. …”
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Correlation of excess salt intake identified by the survey with urine sodium level and blood pressure: data of ESSE-RF study by Yu. A. Balanova, V. A. Kutsenko, S. A. Shalnova, A. E. Imaev, A. V. Kapustina, G. A. Muromtseva, S. E. Evstifeeva, N. S. Karamnova, S. A. Maksimov, E. B. Yarovaya, O. M. Drapkina, A. N. Redko, S. N. Alekseenko, S. V. Gubarev, I. A. Viktorova, M. A. Livzan, I. A. Grishechkina, M. Yu. Rozhkova, N. N. Prishchepa, N. N. Vezikova, I. S. Skopets, S. S. Yakushin, E. V. Filippov, N. V. Dobrynina, N. N. Nikulina, K. G. Pereverzeva, K. A. Moseichuk

“…To study the association of blood pressure (BP) and hypertension (HTN) with salt intake estimated by the survey and the urinary Na+ concentration among men and women 25-64 years old, examined within the ESSE-RF and ESSE-RF-2 studies.Material and methods. Representative samples of the Russian population aged 25-64 years were examined. …”
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Vaping leads tobacco consumption among university students in Arab countries: a study of behavioral and psychosocial factors associated with smoking by Malik Sallam, Malik Sallam, Eman Khamis Alnazly, Eman Khamis Alnazly, Adil Sajwani, Adil Sajwani, Kholoud Al-Mahzoum, Yousef Alkhalaf, Aisha Aldaihani, Abdulrahman Aldousari, Mohammad Alhajeri, Meshari Almutairi, Shekha Alnajdi, Mohammad Alkhozam, Abdulaziz Muneer Alsubaiei, Naser Eisa, Sulaiman Altheyab, Doaa H. Abdelaziz, Doaa H. Abdelaziz, Noha O. Mansour, Mohammed Sallam, Mohammed Sallam, Mohammed Sallam, Mohammed Sallam

“…Multivariate analyses revealed that male students were more likely to engage in all three tobacco use forms. …”
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Prognostic significance of serum MUC5AC in resected pancreatic ductal adenocarcinoma: initial insights by Ashish Manne, Yonghua Bao, Ankur Sheel, Amir Sara, Upender Manne, Kannan Thanikachalam, Ashwini Esnakula, Timothy M. Pawlik, Jordan M. Cloyd, Susan Tsai, Anup Kasi, Ravi Kumar Paluri, Deepak Sherpally, Sravan Jeepalyam, Lianbo Yu, Wancai Yang

“…BackgroundWe investigated the association between serum MUC5AC (sMUC5AC) levels and patient outcomes in individuals who underwent resection for pancreatic ductal adenocarcinoma (PDA), including those treated with neoadjuvant therapy (NAT) and those who had upfront surgery (UpS) followed by adjuvant therapy.MethodsSerum samples from the Ohio State University biorepository collected from January 2010 to June 2021 were utilized. …”
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Sport participation as an educational tool and a means of promoting physical, mental, and social well-being by Francesco Sgrò

“…Finally, Coppola et al. (2024) reviewed the training methods used in youth volleyball, identifying strengths and weaknesses that emerged in the studies they analyzed…”
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Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population by Alexander Owusu Boakye, Alexander Owusu Boakye, Christian Obirikorang, Christian Obirikorang, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, Evans Asamoah Adu, Evans Asamoah Adu, Doris Winter, Eric Ebenezer Boham, Eric Ebenezer Boham, Hakim Alani, Sylvester Kofi Newton, Nana Safi Toure Almoustapha, James Deke, James Deke, Welbeck Odame Dzadey, Louis Adu-Amoah, Louis Adu-Amoah, Sally-Ann Kroduah, Sally-Ann Kroduah, Mary Ama Grant, Gracelyn Asare, Amos Amoako-Adusei, Wibke Loag, Jenny Kettenbeil, Yaw Adu Sarkodie, Ebenezer Oduro-Mensah, Alfred Edwin Yawson, Stephen Apanga, Rose Odotei Adjei, Rose Odotei Adjei, Austin Gideon Adobasom-Anane, Austin Gideon Adobasom-Anane, Eva Lorenz, Eva Lorenz, Aurélia Souares, Aurélia Souares, Oumou Maiga-Ascofaré, Oumou Maiga-Ascofaré, Oumou Maiga-Ascofaré, Jürgen May, Jürgen May, Jürgen May, Nicole S. Struck, Nicole S. Struck, John Humphery Amuasi, John Humphery Amuasi, John Humphery Amuasi, John Humphery Amuasi

“…This study investigated the association between ACE2 SNPs, rs2285666 and rs2106809, and the SARS-CoV-2 infection susceptibility in a Ghanaian population.MethodsGenomic DNA was extracted, using a magnetic bead-based method, from blood samples of a random-subset of 1,334 participants drawn from a two-stage cluster, population-based household cross-sectional SARS-CoV-2 IgG seroprevalence survey. …”
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Remote, smart telemonitoring of COVID-19 survivors for early detection of deterioration in cardiac health (the PARTMO study) by Josephine Sau Fan Chow, Josephine Sau Fan Chow, Josephine Sau Fan Chow, Josephine Sau Fan Chow, Josephine Sau Fan Chow, Nutan Maurya, Nutan Maurya, Susan San Miguel, Rumbidzai Teramayi, Ahilan Parameswaran, Annamarie D’Souza, Gregory Melbourne, Joseph Descallar, Young Juhn, Enoch Chan, Jerome Pong

“…IntroductionThis study aims to implement a virtual model of care in the primary healthcare setting, utilising biosensor technologies (S-Patch EX) to remotely monitor and identify clinical signs and symptoms of cardiovascular conditions (mainly arrhythmias) in patients post-COVID-19 infection.MethodsThis open-label, non-randomised, observational study was conducted in patients aged 18 years and above, clinically diagnosed with COVID-19 after June 2021, and those residing within Greater Western Sydney. …”
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Prevalence and clinical implications of major and minor ANCAs in Tunisian (North African) patients with systemic lupus erythematosus by Zeineb Meddeb, Zeineb Meddeb, Zeineb Meddeb, Houssem Abida, Houssem Abida, Dhouha Krir, Dhouha Krir, Ahlem Ben Hmid, Ahlem Ben Hmid, Ahlem Ben Hmid, Raja Aouaidia, Raja Aouaidia, Cherifa Abdelkéfi, Cherifa Abdelkéfi, Yosra Nasri, Ines Ben Sghaier, Hayet Kebaier, Samar Samoud, Samar Samoud, Rim Goucha, Rim Goucha, Saloua B’Chir Hamzaoui, Saloua B’Chir Hamzaoui, Mélika Ben Ahmed, Mélika Ben Ahmed, Mélika Ben Ahmed, Thara Larbi, Thara Larbi, Imen Zamali, Imen Zamali, Imen Zamali, Yousr Galai, Yousr Galai

“…This study aimed to assess the prevalence, antigenic targets, and clinical correlations of ANCAs in SLE patients in a Tunisian (North African) cohort. MethodsWe conducted a cross-sectional case-control study involving 30 patients with systemic lupus erythematosus (SLE) and 30 healthy controls. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Our findings emphasise the importance of LUTS being managed in primary care where possible, as in addition to cost savings and reduced waiting times, this is a more accessible option for patients, who tend to be more comfortable and confident being treated by familiar clinicians or in more familiar environments. …”
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Meta Analysis of the effect of acupoint sticking application for rheumatoid arthritis (穴位贴敷疗法治疗类风湿性关节炎疗效的Meta分析) by GUO Yali (郭亚丽), LI Haiting (李海婷), JIA Sansan (贾伞伞), WEN Caoli (文曹丽), ZHANG Yun (张云)

“…Objective To systematically evaluate the effect of acupoint sticking application for rheumatoid arthritis, and to provide clinical evidence-based. Methods Literatures were available by searching the database including CNKI, Wanfang Data, VIP, CBM, PubMed, Embase and Cochrane library, and then two independent researchers respectively screened and determined the final inclusion literatures in the study. …”
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