Campylobacter colonization and undernutrition in infants in rural eastern Ethiopia — a longitudinal community-based birth cohort study by Dehao Chen, Dehao Chen, Sarah Lindley McKune, Sarah Lindley McKune, Yang Yang, Ibsa Aliyi Usmane, Ibsa Abdusemed Ahmed, Jafer Kedir Amin, Abdulmuen Mohammed Ibrahim, Abadir Jemal Seran, Nurmohammad Shaik, Amanda Ojeda, Bahar Mummed Hassen, Loic Deblais, Belisa Usmael Ahmedo, Kedir Abdi Hassen, Mussie Bhrane, Xiaolong Li, Nitya Singh, Kedir Teji Roba, Nigel P. French, Gireesh Rajashekara, Mark J. Manary, Jemal Yusuf Hassen, Arie Hendrik Havelaar, on behalf of the CAGED Research Team

“…Campylobacter infection could be a linchpin between livestock fecal exposure and health outcomes in low-resource smallholder settings.MethodsWe followed a birth cohort of 106 infants in rural smallholder households in eastern Ethiopia up to 13 months of age. …”
Get full text

Assessment of <i>ERBB2</i> and HER2 expression in metastatic breast cancer using the nCounter® system and a 100-gene scale by R.  M.  Paltuev, O.  A.  Volynshchikova, Sh.  R.  Abdullaeva, S.  N.  Aleksakhina, A.  S.  Artemyeva, E.  A.  Baychorov, S.  Yu.  Bakharev, Yu.  A.  Belaya, A.  A.  Bozhok, V.  A.  Vasin, V.  I.  Vladimirov, A.  Yu.  Vorontsov, E.  A.  Gaysina, A.  A.  Gofman, V.  N.  Dmitriev, E.  N.  Imyanitov, V.  V.  Klimenko, A.  V.  Komyakhov, M.  M.  Konstantinova, M. V.  Kopp, A.  G.  Kudaybergenova, I.  A.  Lalak, D.  L.  Matevosyan, N.  M.  Mudzhiri, O.  V.  Poltareva, O.  I.  Sevryukova, V.  F.  Semiglazov, T.  Yu.  Semiglazova, M.  M.  Urezkova, A.  S.  Chichkanova, L.  A.  Churilova, M.  V.  Shomova

“…To increase the efficacy of systemic therapy for breast cancer, reduce inappropriate prescribing, and ensure a tailored approach to systemic breast cancer therapy using the information on individual molecular characteristics of the tumor.Materials and methods. We explored the expression of 100 genes involved in breast cancer development in 106 tumor samples from patients with metastatic breast cancer. …”
Get full text

Cocaine Cues Used in Experimental Research: A Systematic Review by Eileen Brobbin, Natalie Lowry, Matteo Cella, Alex Copello, Simon Coulton, Jerome Di Pietro, Colin Drummond, Steven Glautier, Ceyda Kiyak, Thomas Phillips, Daniel Stahl, Shelley Starr, Lucia Valmaggia, Colin Williams, Paolo Deluca

“…To advance understanding of CET for cocaine treatment, this systematic review aims to categorise the range of cocaine cues used in research. <b>Methods</b>: A systematic review of the existing literature with searches conducted on PubMed and Web of Science bibliographic databases with no time constraints in August 2024 (PROSPERO: CRD42024554361). …”
Get full text

Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort by Tahmeed Ahmed, Molline Timbwa, Moses Ngari, Mohammod Jobayer Chisti, Kirkby D Tickell, Hama Diallo, Robert Bandsma, Judd L Walson, Syed Asad Ali, James Berkley, Ezekiel Mupere, Ali Faisal Saleem, Lei Xia, Wieger Voskuijl, Hang Wu, Benson Singa, Shalton Mwaringa, Christina Lancioni, Isabel Potani, Abu Sadat Mohammad Sayeem bin Shahid, Caroline Tigoi, James Njunge, Yunyun Gong, Michael N Routledge

“…We examined the role of aflatoxin exposure in inpatient and post-discharge mortality.Methods In a nested case-cohort from the CHAIN cohort, we compared aflatoxin exposure at admission and discharge with death or survival in hospital (n=755) or up to 180-days post-discharge (n=585) and with community participants (CP, n=222). …”
Get full text

Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China by Li Chen, Yi‐Chen Kong, Jia‐Wei Tian, Pei‐Yu Han, Song Wu, Chen‐Jie He, Ti‐Lian Ren, Bo Wang, Lian Qin, Yun‐Zhi Zhang

“…Yunnan Province, located on China's border, reports the highest annual incidence of scrub typhus, highlighting the need to better understand OT infection in both human patients and small mammals in this region. Methods In this study, clinical data on scrub typhus cases in Xiangyun County People's Hospital were retrospectively collected. …”
Get full text

Outcomes of Active Treatment for Localised Prostate Cancer After Holmium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis by Alberto Artiles Medina, Ana Tagalos Muñoz, Ana Domínguez Gutiérrez, Alfonso Muriel García, José Daniel Subiela, Noelia Álvarez Díaz, Guillermo Fernández Conejo, Victoria Gómez Dos Santos, Almudena Coloma del Peso, Francisco Javier Burgos Revilla

“…Limitations were scarcity of relevant studies (especially for treatments other than RP), their predominantly observational and retrospective nature, and their small sample sizes. Conclusions and clinical implications: The findings from this meta-analysis should be considered for patient counselling and management decisions, bearing in mind that patients with prior HoLEP who undergo RP have more intraoperative complications and urethrovesical anastomotic leaks and an increased postoperative incontinence rate. …”
Get full text

Fully Automated Assessment of Cardiac Chamber Volumes and Myocardial Mass on Non-Contrast Chest CT with a Deep Learning Model: Validation Against Cardiac MR by Ramona Schmitt, Christopher L. Schlett, Jonathan I. Sperl, Saikiran Rapaka, Athira J. Jacob, Manuel Hein, Muhammad Taha Hagar, Philipp Ruile, Dirk Westermann, Martin Soschynski, Fabian Bamberg, Christopher Schuppert

“…<b>Conclusions</b>: Automated cardiac chamber volume and myocardial mass quantification on non-contrast chest CT produced viable measurements in this retrospective sample. <b>Relevance Statement</b>: An automated cardiac assessment on non-contrast chest CT provides quantitative morphological data on the heart, enabling a preliminary organ evaluation that aids in incidentally identifying at-risk patients who may benefit from a more targeted diagnostic workup.…”
Get full text

Smoking cessation for people accessing homeless support centres (SCeTCH): comparing the provision of an e-cigarette versus usual care in a cluster randomised controlled trial in Gr... by Lynne Dawkins, Kirstie Soar, Francesca Pesola, Allison Ford, Caitlin Notley, Rachel Brown, Emma Ward, Lauren McMillan, Debbie Robson, Anna Varley, Charlotte Mair, Jessica Lennon, Janine Brierley, Amy Edwards, Peter Hajek, Allan Tyler, Steve Parrott, Jinshuo Li, Linda Bauld, Bethany Gardner, Sharon Cox

“…We aimed to test the effectiveness of an e-cigarette (EC) intervention designed to help people accessing homeless support services to stop smoking. Methods A two-arm cluster randomised controlled trial. …”
Get full text

Dyslipidemia in the Russian Federation: population data, associations with risk factors by O. M. Drapkina, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, Yu. A. Balanova, S. A. Maksimov, G. A. Muromtseva, M. B. Kotova, N. S. Karamnova, S. E. Evstifeeva, O. A. Litinskaya, M. S. Pokrovskaya, N. A. Imaeva, E. M. Filichkina, O. E. Ivlev, G. E. Svinin, L. I. Gomanova, Yu. V. Doludin, I. A. Efimova, A. L. Borisova, B. M. Nazarov, E. B. Yarovaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, E. N. Chernysheva, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, V. S. Shramko, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovyova, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, I. V. Tantsyreva, I. N. Baryshnikova, M. G. Ataev, M. O. Radjabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, I. A. Khakuasheva, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, A. A. Keskinov, V. S. Yudin, S. M. Yudin, A. V. Kontsevaya, S. A. Shalnova

“…To study the prevalence of dyslipidemias and their association with various risk factors in the Russian population of men and women aged 35-74 years in 2020-2022.Material and methods. This work was carried out as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study. …”
Get full text

α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback by Ying-Hao Hu, Ying-Hao Hu, Jun Han, Jun Han, Lin Wang, Chao Shi, Chao Shi, Yan Li, Yan Li, Opeyemi Joshua Olatunji, Xiu Wang, Xiu Wang, Jian Zuo, Jian Zuo, Jian Zuo

“…Metabolic indicators and basic clinical parameters were evaluated using samples collected on day 20 and 38 since immunization. …”
Get full text

Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital by Rashid Nadeem, Ishma Aijazi, Ashraf Elhoufi, Crystal Danthi, Nouha Azaza, Mohd Kafeel Khan, Mohannad Alheraki, Muhammed Jamshaid, Asadullah Nawazani, Sadia Tariq, Sobia Siddiq, Muzammil Hafeez, Mukesh Kumar, Islam Bon, Ahmed Elsousi, Lamiaa Salama, Sahish Kamat, Rami Abdalla

“…Background: Most COVID-19 studies conclude old age and coexisting illnesses as mortality determinants owing to different populations or methodologies, or omitting factors affecting outcomes. Methods: We analyzed COVID-19 patients’ data (N = 391) of Dubai Hospital between January 1, 2020 and June 30, 2020. …”
Get full text

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer by Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu

“…However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear. Methods The correlation between m6A and APA was analyzed by using RNA methylation sequencing of OC cells and single‐cell sequencing of clinical samples from public databases. …”
Get full text

Long-term outcomes in leucine-rich glioma inactivated-1 autoimmune encephalitis and associated biomarkers of inflammation and neuronal and glial injury by Tyler L. Borko, Tyler L. Borko, Phillip Winters, Kelli M. Money, Stefan Sillau, Sadie Eggmann, Sean Selva, Alanna Ritchie, Ryan Kammeyer, Ryan Kammeyer, Gregory P. Owens, Jeffrey L. Bennett, Jeffrey L. Bennett, Amanda L. Piquet

“…Blood-based biomarkers for inflammation and neuronal and glial injury have been evaluated as potential markers of disease severity and prognosis in AE.MethodsPatients diagnosed with LGI1 AE, confirmed by cell-based assay, were enrolled and followed prospectively to gather plasma samples for biomarker testing. …”
Get full text

Comprehensive regional study of ESBL Escherichia coli: genomic insights into antimicrobial resistance and inter-source dissemination of ESBL genes by Lisa Di Marcantonio, Sofia Chiatamone Ranieri, Michela Toro, Alice Marchegiano, Francesca Cito, Nadia Sulli, Ilaria Del Matto, Valeria Di Lollo, Alessandra Alessiani, Giovanni Foschi, Ilenia Platone, Massimiliano Paoletti, Nicola D’Alterio, Giuliano Garofolo, Anna Janowicz

“…This study investigated the occurrence, genomic characteristics, and dissemination dynamics of ESBL-producing E. coli in Abruzzo, Italy, by analyzing 956 isolates from humans, livestock, wildlife, and food products.MethodsPhenotypic and genomic analyses were performed on the isolates to assess ESBL-E. coli occurrence and characteristics. …”
Get full text

Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo by Jean Claude Djontu, Marcel Tapsou Baina, Jacque Dollon Mbama Ntabi, Abel Lissom, Dieu Merci Umuhoza, Naura veil Assioro Doulamo, Christevy Jeanney Vouvoungui, Reauchelvy Kamal Boumpoutou, Alain Maxime Mouanga, Etienne Nguimbi, Francine Ntoumi

“…The objective of this study was to determine the prevalence of molecular markers of P.falciparum resistance to SP in individuals with microscopic malaria infection in the south of Brazzaville. Methods: Two parallel surveys (health facilities and community-based cross sectional studies) were carried out in urban and rural areas in southern Brazzaville. …”
Get full text

BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults by Claire J. Cadwallader, Anna M. VandeBunte, D. Luke Fischer, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario‐Lago, Julio C. Rojas, Eliana Marisa Ramos, Jessica E. Rexach, Jennifer S. Yokoyama, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto

“…One hundred twenty‐three of the sample completed comprehensive neuropsychological evaluation. …”
Get full text

An automated blood test for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) to predict the absence of intracranial lesions on head CT in... by Alfonso Lagares, Javier de la Cruz, Hugo Terrisse, Odile Mejan, Vladislav Pavlov, Celine Vermorel, Jean-François Payen, Maxime Maignan, Damien Viglino, Laurent Jacquin, Marion Douplat, Said Laribi, Philippe Pes, Patrick Ray, Jérémy Guenezan, Mustapha Sebbane, Frédéric Belen, Guillaume Durand, Cordelia Abric, Cédric Gil-Jardiné, Pudaru Mihai, Julián Morales, Ana Castuera, Ana María Castano-Leon, Juan Delgado, Jose F. Alen

“…We sought to validate the performance of this combination of biomarkers at predetermined cutoff values with an automated immunoassay to predict which patients did not have intracranial lesions. Methods: This prospective, observational study was conducted in France and Spain at 16 emergency departments. …”
Get full text

Hospitalized patients and stimulant use-associated heart failure: importance of ejection fraction and related risk factors by Akshat Agrawal, Brooke Scardino, Diensn G. Xing, Md. Shenuarin Bhuiyan, Md. Shenuarin Bhuiyan, Rick A. Bevins, Kalgi Modi, Tarek Helmy, Steven A. Conrad, Steven A. Conrad, Nicholas E. Goeders, Md Mostafizur Rahman Bhuiyan, John A. Vanchiere, John A. Vanchiere, A. Wayne Orr, A. Wayne Orr, Christopher G. Kevil, Christopher G. Kevil, Mohammad Alfrad Nobel Bhuiyan, Mohammad Alfrad Nobel Bhuiyan, Mohammad Alfrad Nobel Bhuiyan

“…Our study also compares demographic and comorbidities between the HF subtypes.MethodsNational Inpatient Sample data from 2008 to 2020 were used to identify hospital admissions among stimulant users with HF. …”
Get full text

The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical tr... by Gianna F. Mastrofini, Bridget A. McFadden, Alexa J. Chandler, Blaine S. Lints, Harry P. Cintineo, Nathaniel D. Rhoades, Caroline S. Vincenty, Sten O. Stray-Gundersen, Abbi D. Lane, Shawn M. Arent

“…This study aimed to investigate the physiological, biochemical, and psychometric effects of a brand-specific, hemp-derived CBD product in healthy adults over a 12-week observation period.Methods 54 healthy males and females (age = 25 ± 7y; BMI = 24.82 ± 3.25 kg/m2) recruited from a large Southeastern University completed the study. …”
Get full text

Dynamic Simulation of Soil Moisture Under Typical Land Preparation in Semi-arid Loess Area Using HYDRUS-1D Model by Dong Hongxia, Zhang Qindi, Wei Qiang

“…[Objective] The dynamic characteristics of soil moisture under different land preparation measures were analyzed in order to provide a scientific basis for assessing the eco-hydrological benefits of slope land preparations and for promoting vegetation restoration in arid areas. [Methods] We used an in-situ controlled study of natural slopes, fish-scale pits, and reverse slopes of a Pinus tabulaeformis forest in a semi-arid loess area along with dynamic monitoring of soil moisture and rainfall events and HYDRUS-1D software simulations to quantify the effects of different land preparation measures on the vertical migration characteristics of soil moisture. …”
Get full text