Levels and determinants of exposure to perfluoroalkyl substances in French pregnant women from the SEPAGES cohort by Nicolas Jovanovic, Anne Lise Brantsæter, Sarah Lyon-Caen, Blandine Duval, Sylvain Carras, Annabelle Bédard, Wassila Ait-Hadad, Blandine de Lauzon-Guillain, Valérie Siroux, Sam Bayat, Inger-Lise Steffensen, Rémy Slama, Line Småstuen Haug, Claire Philippat

“…Results: Seven PFAS were quantified in 83 % or more of the samples, while the remaining PFAS were quantified in less than 20 %. …”
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Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma by Valerie Chew, Tony Kiat Hon Lim, David Tai, Su Pin Choo, Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Sahil Saraf, Han Chong Toh, Benedict Tan, Harry Ho Man Ng, Ren Yuan Lee, Siting Goh, Isabel Shu Ying Tay, Xinru Lim, Sherlly Lim, Bijin Au, Josh Jie Hua Loh, John Edward Connolly, Tracy Loh, Wei Qiang Leow, Joycelyn Jie Xin Lee, Fabio Malavasi, Ser Yee Lee, Pierce Chow, Evan W Newell

“…We then investigated the association between CD38 and ICB treatment outcomes in advanced HCC.Methods Clinically annotated samples from 49 patients with advanced HCC treated with ICB were analyzed for CD38 expression using immunohistochemistry (IHC), multiplex immunohistochemistry/immunofluorescence (mIHC/IF) and multiplex cytokine analysis.Results IHC and mIHC/IF analyses revealed that higher intratumoral CD38+ cell proportion was strongly associated with improved response to ICB. …”
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Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets by Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia, Andrea Marcello Isidori, Antongiulio Faggiano, Rita Mancini, Claudia De Vitis

“…To gain deeper insights into the genomic underpinnings of lung NETs, we conducted a pilot investigation to uncover potential genetic mutations and copy number variations (CNVs) implicated in their pathogenesis. Methods Formalin-fixed, paraffin-embedded intraoperative tumor biopsies and matched peripheral blood mononuclear cell samples were collected from six consecutive patients with lung NETs. …”
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Atezolizumab plus bevacizumab in patients with unresectable or metastatic mucosal melanoma: 3‐year survival update and multi‐omics analysis by Jie Dai, Tianxiao Xu, Lifeng Li, Meiyu Fang, Jing Lin, Jun Cao, Xue Bai, Caili Li, Xiaoting Wei, Junjie Gu, Yaoyao Liu, Xuan Gao, Xuefeng Xia, Jun Guo, Yu Chen, Lili Mao, Lu Si

“…This report updates 3‐year survival outcomes and multi‐omics analysis to identify potential response biomarkers. Methods Forty‐three intention‐to‐treat (ITT) patients received intravenous administration of atezolizumab and bevacizumab every 3 weeks. …”
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Rates of colorectal cancer diagnosis and mortality in people with severe mental illness: results from Australia’s National Bowel Cancer Screening Programme by S. Kisely, K. Spilsbury, C. Bull, S. Jordan, B.J. Kendall, D. Siskind, G. Sara, M. Protani, D. Lawrence

“…These studies mostly predate the introduction of national bowel cancer screening programmes (NBCSPs) and it is unknown if these have reduced disparity in CRC-related mortality for people with SMI. Methods We compared mortality rates following CRC diagnosis at colonoscopy between a nationally representative sample of people with and without SMI who participated in Australia’s NBCSP. …”
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High‐Density Lipoprotein‐Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin‐Deficient Limb–Girdle Muscular Dystrophy Type R2 by Zoe White, Laura Rufibach, Heather Gordish Dressman, Heather Hilsden, Dan Cox, Simone Spuler, John W. Day, Kristi J. Jones, Diana X. Bharucha‐Goebel, Emmanuelle Salort‐Campana, Alan Pestronk, Maggie C. Walter, Carmen Paradas, Tanya Stojkovic, Madoka Mori‐Yoshimura, Elena Bravver, Jordi Diaz‐Manera, Elena Pegoraro, Jerry R. Mendell, the Jain COS Consortium, Volker Straub, Pascal Bernatchez

“…Methods Cross‐sectional circulating total cholesterol (CHOL), high‐density lipoprotein‐associated cholesterol (HDL‐C), non‐HDL‐C, creatine kinase (CK), transaminase levels and bilirubin were collected as part of the Jain Clinical Outcomes Study of Dysferlinopathy, a large multicentre LGMDR2 patient cohort (N = 188), along with ambulatory function values. …”
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Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropat... by George A. Karkashadze, Leyla S. Namazova-Baranova, Leonid M. Yatsik, Olga B. Gordeeva, Elena A. Vishneva, Kamilla E. Efendieva, Elena V. Kaytukova, Natella V. Sukhanova, Natalia S. Sergienko, Julia V. Nesterova, Svetlana E. Kondratova, Madina T. Fatakhova, Alexandr V. Pashkov, Irina V. Naumova, Irina V. Zelenkova, Viktor A. Gankovskiy, Svetlana G. Gubanova, Elizaveta V. Leonova, Alina R. Pankova, Anna A. Alexeeva, Daria A. Bushueva, Tinatin Yu. Gogberashvili, Dmitriy S. Kratko, Safarbegim H. Sadilloeva, Natalia E. Sergeeva, Marina A. Kurakina, Tatiana A. Konstantinidi, Inessa A. Povalyaeva, Margarita A. Soloshenko, Mariya I. Slipka, Viktor V. Altunin, Anastasiya I. Rykunova, Tatiana A. Salimgareeva, Pavel A. Prudnikov, Nadezhda A. Ulkina, Alexey I. Firumyantc, Nikita S. Shilko, Julia E. Kazanceva

“…The aim of the study is to study patterns of neurospecific peptides, neurotransmitters and neuroreceptor markers distribution in the serum of children with various pathogenetic variants of chronic neuropathology. Methods. The study included children from 3 to 16 years old with different pathologies. …”
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Knowledge, attitudes, and practices toward ticks and tick-borne diseases: a cross-sectional study in Rwanda by Abakundana Nsenga Ariston Gabriel, Xiao-Yang Wang, Guo-Yao Zu, Laila Jamil, Blaise Iraguha, Methode Ngabo Gasana, Bing-Bing Gu, Ntakirutimana Theoneste, Lin Zhao, Wu-Chun Cao

“…This study aimed to assess the knowledge, attitudes, and practices toward ticks and tick-borne diseases among adults in Rwanda. Methods The sample size was determined using a single-population proportion formula. …”
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The CatSouth Quasar Candidate Catalog for the Southern Sky and a Unified All-sky Catalog Based on Gaia DR3 by Yuming Fu, Xue-Bing Wu, R. J. Bouwens, Karina I. Caputi, Yuxuan Pang, Rui Zhu, Da-Ming Yang, Jin Qin, Huimei Wang, Christian Wolf, Yifan Li, Ravi Joshi, Yanxia Zhang, Zhi-Ying Huo, Y. L. Ai

“…The Gaia DR3 has provided a large sample of more than 6.6 million quasar candidates with high completeness but low purity. …”
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis by Chun Zhang, Xiuxing Liu, Chenyang Gu, Yuhan Su, Jianjie Lv, Yidan Liu, Yuehan Gao, Hui Chen, Nanwei Xu, Jing Xiao, Zhuping Xu, Wenru Su

“…However, underlying pathogenesis of AU required to develop more efficient therapy remain unclear. Methods: We isolated peripheral blood mononuclear cells (PBMCs) from AU patients and performed single-cell RNA sequencing (scRNA-seq). …”
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Universal, school-based, interventions to improve emotional outcomes in children and young people: a systematic review and meta-analysis by Daniel Hayes, Daniel Hayes, Emre Deniz, Kirsty Nisbet, Abigail Thompson, Anna March, Anna March, Carla Mason, Joao Santos, Rosie Mansfield, Emma Ashworth, Bettina Moltrect, Bettina Moltrect, Shaun Liverpool, Hannah Merrick, Jan Boehnke, Neil Humphrey, Paul Stallard, Praveetha Patalay, Praveetha Patalay, Jessica Deighton, Jessica Deighton

“…Previous reviews have only focused on anxiety and depression symptoms, omitting broader internalising symptoms, nor include the proliferation of newer studies which have focused on mindfulness in schools.MethodsWe conducted a systematic review and meta-analysis, searching MEDLINE, Embase, PsycINFO, and Cochrane Central Register of Controlled trials for studies focusing on universal interventions to improve emotional outcomes for young people aged 8–18 until 15/12/2022. …”
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Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study by Xinran Song, Xinran Song, Weixin Chen, Weixin Chen, Shuang Bai, Shuang Bai, Min Lv, Min Lv, Jian Wang, Jian Wang, Ao Zhang, Ao Zhang, Jiang Wu, Jiang Wu, Wei Zhao, Wei Zhao, Wei Zhao

“…BackgroundInactivated COVID-19 vaccines exhibit more rapid declines in antibody levels than other vaccine platforms, likely owing to transient antigen exposure and limited germinal center persistence. …”
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A national survey of suicidality and non-suicidal self-injury in bipolar disorder: insights from network analysis by Lvchun Cui, Yuncheng Zhu, Yang Li, Jia Zhou, Guiyun Xu, Miao Pan, Zhiyu Chen, Wenfei Li, Zhian Jiao, Mingli Li, Yong Zhang, Jingxu Chen, Xiuzhe Chen, Na Li, Jing Sun, Jian Zhang, Shaohua Hu, Haishan Wu, Zhaoyu Gan, Yan Qin, Yumei Wang, Yantao Ma, Xiaoping Wang, Xiaohong Li, Chuangxin Wu, Yiyun Cai, Jiaye Chen, Baichuan Wu, Zuowei Wang, Daihui Peng, Yiru Fang

“…We used network analysis to explore the associations among suicidality, NSSI, addictive features of NSSI, and symptoms of BD. Methods Participants with BD were recruited from 20 research centers in China. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…Existing primary and secondary prevention strategies for cardiovascular disease have limitations in identifying some high-risk groups, and 1.5-level prevention aims to achieve more precise intervention by early identification of subclinical target organ damage. …”
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Childbearing and Family Instability: The Impact of Children on Women's Divorce Probability in Iran by Davoud Shahpari Sani, Mohammad Jalal Abbasi Shavazi

“…This study integrates these theoretical perspectives to analyze the research problem.     Methods This study employs a descriptive-analytical approach, utilizing secondary data analysis from the 2016 Iranian census (2% sample). …”
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Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation by Jessica Hernandez, Fabian Johannes Pflieger, Julia Schäffer, Leona Bähr, Jenny Schneiders, Thomas Reichel, Marita Meurer, Marita Meurer, Benjamin Lamp, Natali Bettina Bauer, Karsten Krüger, Lois Harden, Maren von Köckritz-Blickwede, Maren von Köckritz-Blickwede, Christoph Rummel, Christoph Rummel, Christoph Rummel

“…LPS-induced hypothermia was more severe in PMN-pretreated mice while other physiological parameters were only altered by LPS alone. …”
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Proteomic profile of plasma-derived extracellular vesicles from Colombian pregnant women with Plasmodium-soil transmitted helminths coinfection by Jahnnyer A. Martínez-Moreno, Alberto Ayllon-Hermida, Alberto Ayllon-Hermida, Alberto Ayllon-Hermida, Berta Barnadas-Carceller, Berta Barnadas-Carceller, Carmen Fernández-Becerra, Carmen Fernández-Becerra, Carmen Fernández-Becerra, Hernando A. del Portillo, Hernando A. del Portillo, Hernando A. del Portillo, Jaime Carmona-Fonseca, Eliana M. Arango-Flórez, Eliana M. Arango-Flórez

“…The size range of EVs was more variable in the three infected groups (100-700 nm) compared to the size range of the uninfected groups (50-300 nm). …”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…Although immune checkpoint inhibitors (ICIs) have shown remarkable clinical efficacy, they can also induce a paradoxical cancer acceleration, known as hyperprogressive disease (HPD), whose causative mechanisms are still unclear. Methods This study investigated the mechanisms of ICI resistance in an HPD-NSCLC model. …”
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Effect of prednisolone on live birth rate in women with unexplained recurrent pregnancy loss: a study protocol for a double-blind, placebo-controlled, multicentre, randomised contr... by Saskia le Cessie, Nan van Geloven, Marie-Louise van der Hoorn, Michael Eikmans, Annemarie Mulders, Eileen Lashley, Jantien Visser, Moniek van der Zanden, Mariette Goddijn, Tess Meuleman, Salwan Al-Nasiry, Harold Verhoeve, Gijs Teklenburg, Jan-Peter de Bruin, Yentl Béquet, Renate Van der Molen, Elske van den Akker-van Marle, Marloes Vermeulen, Merel van den Berg, Astrid Cantineau, Dana Huppelschoten

“…Introduction Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more spontaneous pregnancy losses from the time of conception until 24 weeks of gestation. …”
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Longitudinal transcriptome analysis reveals distinct gene expression patterns in traditional Chinese medicine syndromes of upper respiratory tract infections by Hao Zou, Hao Zou, Changrui Huang, Changrui Huang, Qinqi Feng, Qinqi Feng, Bang Yu, Bang Yu, Jian Liu, Xinyang Shu, Xiaolu Nie, Hongchun Zhang, Xiaohui Zou

“…BackgroundWind-cold (WC) and Wind-heat (WH) are common syndromes of upper respiratory tract infections (URTIs) in traditional Chinese medicine (TCM), presenting different clinical features, but the transcriptomic changes associated with these syndromes remained unclear.Materials and MethodsPatients with WC and WH syndromes were recruited from outpatient unit, pharyngeal swabs were collected for pathogen detection. …”
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