Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis. by Elaine W Butterly, Peter Hanlon, Anoop S V Shah, Laurie J Hannigan, Emma McIntosh, Jim Lewsey, Sarah H Wild, Bruce Guthrie, Frances S Mair, David M Kent, Sofia Dias, Nicky J Welton, David A McAllister

“…Multimorbidity, where individuals have 2 or more conditions, is negatively associated with quality of life. …”
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Evaluation of the Digital Support Tool Gro Health W8Buddy as Part of Tier 3 Weight Management Service: Observational Study by Petra Hanson, Farah Abdelhameed, Mohammed Sahir, Nick Parsons, Arjun Panesar, Michaela de la Fosse, Charlotte Summers, Amit Kaura, Harpal Randeva, Vinod Menon, Thomas M Barber

“…ObjectiveThis service evaluation study assessed the use, effectiveness, and clinical impact of the W8Buddy digital support tool as part of the National Health Service WMS. MethodsW8Buddy, a personalized digital platform, provides a tailored weight management plan to empower individuals and was collaboratively developed with input from patients, the clinical team, and DDM Health. …”
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Impact of neoadjuvant chemotherapy on perioperative nutritional status in breast cancer patients: a prospective cohort study by Dandan Zhang, Congyi Ma, Hexiao Ding, Ting Liu, Huan Li

“…This study aims to provide insight by longitudinally tracking the nutritional status of BC patients undergoing NAC compared to those who do not. Methods: We conducted a prospective study at a tertiary hospital in China, enrolling BC patients who met the inclusion criteria of a confirmed diagnosis of invasive BC without significant comorbidities. …”
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Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma by Liu S, Lin Z, Zhou J, Yang X, You L, Yang Q, Li T, Hu Z, Zhan X, Jiang Y, Sun B

“…While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations remains poorly understood.Methods: We recruited 64 participants (24 EA, 20 NEA, 20 healthy controls [HC]) for the discovery cohort, with validation in an external cohort (10 EA, 8 NEA, 8 HC). …”
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Abstract 071: Oral Contraceptive Use and Development of Acute Ischemic Stroke: A Population‐Based Retrospective Cohort Study by Alis J. Dicpinigaitis, Giana Dawod, Bridget A. Nolan, Catherine A. Morse, Jon Rosenberg, Gurmeen Kaur, Ji Y. Chong, Stephan A. Mayer, Chirag D. Gandhi, Fawaz Al‐Mufti

“…Modern OCP formulations contain lower doses of estrogen, the putative causative agent for AIS in this population, and underscores the need to re‐evaluate the risk initially demonstrated in older formulations containing higher levels of estrogen. Methods Hospitalizations for female patients aged 15‐50 were identified in the National Inpatient Sample (NIS) registry from 2015‐2020, excluding admissions associated with pregnancy or the postpartum period. …”
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Incidence and Severity of Acute Myocardial Injury after Thoracic Surgery: Effects of Nicorandil by K. V. Protasov, O. A. Barahtenko, E. V. Batunova, E. A. Rasputina

“…To study the perioperative dynamics of myocardial injury biomarkers high-sensitivity cardiac troponin I (hs-cTnI), ischemia-modified albumin (IMA) and soluble ST2 (sST2) when taking nicorandil in lung cancer patients with concomitant coronary heart disease (CHD) undergoing surgical lung resection.Material and methods. The study included 54 patients (11 women and 43 men) with non-small cell lung cancer and concomitant stable CHD who underwent lung resection in the volume of lobectomy or pneumonectomy. …”
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Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study. by Shanquan Chen, Benjamin R Underwood, Peter B Jones, Jonathan R Lewis, Rudolf N Cardinal

“…We assessed the association between lithium use and the incidence of dementia and its subtypes.<h4>Methods and findings</h4>We conducted a retrospective cohort study comparing patients treated between January 1, 2005 and December 31, 2019, using data from electronic clinical records of secondary care mental health (MH) services in Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), United Kingdom (catchment area population approximately 0.86 million). …”
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Schema-Informed Digital Mental Health Intervention for Maladaptive Cognitive-Emotional Patterns: Randomized Controlled Trial by Seohyun Jeong, Hyeonseong Kim, Silvia Kyungjin Lho, Inae Hwang, Seongjun Mun, Soohyun Kim, Hyejin Lim, Hyeonhee Kim, Min-Sup Shin, Woori Moon

“…The intervention group was also more likely than the waitlist to seek external mental health services (t216=2.59; P=.01; mean difference=0.45; 95% CI 0.12-0.80). …”
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The prognostic significance and Immunomodulatory role of SCGB3A1 expression in stage I lung adenocarcinoma by Xin Zhang, ShiNing Li, Yujin Lv, XinYu Liu, Yong Ao, LeQi Zhong, Yi Hu

“…We propose that SCGB3A1 may offer a novel treatment approach for lung adenocarcinoma patients who do not respond well to targeted therapies. Methods We obtained RNA sequencing data from 539 lung adenocarcinoma samples, 59 normal tissues, and 2 metastatic cancer tissues from The Cancer Genome Atlas database. …”
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Intimate partner violence during pregnancy against 601,534 women aged 15 to 49 years in 57 LMICs: prevalence, disparities, trends and associated factors using Demographic and Healt... by David Jean Simon, Vénunyé Claude Kondo Tokpovi, Adama Ouedraogo, Kassoum Dianou, Ann Kiragu, Comfort Z. Olorunsaiye, Bénédique Paul

“…We also examined changes in IPVDP in LMICs and associated factors. Methods: Data for this study were extracted from Demographic and Health Surveys conducted in 57 LMICs from 2000 to 2024. …”
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Vertical bacterial variability in oxidation ponds in the tropical zone by C. Tudsanaton, T. Pattamapitoon, O. Phewnil, W. Wararam, K. Chunkao, P. Maskulrath, M. Srichomphu

“…The purpose of this study is to examine the vertical variability of bacteria in natural treatment oxidation ponds in tropical zones.METHODS: Wastewater samples were collected from an oxidation pond at 3 different depths (0–0.6, 0.6–1.5 and more than 1.5 meter), and their chemical, physical and biological qualities were analysed. …”
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Análisis del tiempo de clase en EF y propuestas para su optimización (Analysis of class time in physical education and proposals for optimization) by Celia María Ruiz Heredia, Amador Jesús Lara Sánchez, Francisco José López Gallego, Javier Cachón Zagalaz, Pedro Valdivia Moral

“…The sample constituted of two groups of fifth-graders from a primary school, out of which 3 students were extracted. …”
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Results of various somatic mutations detection in patients with chronic myeloid leukemia by E. A. Kuzmina, E. Yu. Chelysheva, B. V. Biderman, O. A. Shukhov, E. A. Stepanova, E. P. Gadzhieva, A. N. Petrova, I. S. Nemchenko, A. V. Bykova, M. A. Guryanova, A. V. Kokhno, A. G. Turkina, A. B. Sudarikov

“…To evaluate the genetic profile of blood cells in CML patients using nextgeneration sequencing.Materials and methods. Retrospective study was conducted in two groups of patients: group 1 with TKI therapy failure (n = 29) and group 2 with optimal response to TKI therapy (n = 29). …”
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A Data-Driven Approach to Assessing Hepatitis B Mother-to-Child Transmission Risk Prediction Model: Machine Learning Perspective by Dung Nguyen Tien, Huong Thi Thu Bui, Tram Hoang Thi Ngoc, Thuy Thi Pham, Dac Trung Nguyen, Huyen Nguyen Thi Thu, Thi Thu Hang Vu, Thi Lan Anh Luong, Lan Thu Hoang, Ho Cam Tu, Nina Körber, Tanja Bauer, Lam Khanh Ho

“…These findings offer actionable insights to support the development of more targeted and effective HBV MTCT prevention strategies.…”
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Usefulness of Interventions Using a Smartphone Cognitive Behavior Therapy Application for Children With Mental Health Disorders: Prospective, Single-Arm, Uncontrolled Clinical Tria... by Shinichiro Nagamitsu, Ayumi Okada, Ryoichi Sakuta, Ryuta Ishii, Kenshi Koyanagi, Chizu Habukawa, Takashi Katayama, Masaya Ito, Ayako Kanie, Ryoko Otani, Takeshi Inoue, Tasuku Kitajima, Naoki Matsubara, Chie Tanaka, Chikako Fujii, Yoshie Shigeyasu, Michiko Matsuoka, Tatsuyuki Kakuma, Masaru Horikoshi

“…However, a higher-intensity CBT program is necessary for more severely depressed children.…”
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Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China by ZHENG Xin, XUE Yuanye, WANG Haobiao, WU Litiao, LI Ran, DANG Yingnan, CHEN Tingting, XU Xiaoxuan, ZENG Xuezhen, ZENG Jinfeng

“…[Objective] To conduct a retrospective statistical comparison of alanine aminotransferase (ALT) test values in blood donors prior to blood collection, aiming to analyze the objective characteristics of the population with elevated ALT levels (ALT>50 U/L) and provide reference data for adjusting the screening eligibility threshold for ALT. [Methods] The preliminary ALT screening data of 30 341 blood donor samples collected prior to blood donation from three smart blood donation sites at the Shenzhen Blood Center between 2022 and 2023 were extracted and compared with data from a health examination department of a tertiary hospital in Shenzhen (representing the general population, n=24 906). …”
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The application of antibiotic-loaded bone cement in preventing periprosthetic joint infection: an umbrella review by Yangbin Cao, Peiyuan Tang, Hua Chai, Wenbo Ma, Bin Lin, Ying Zhu, Ahmed Abdirahman, Wenfeng Xiao, Jun Zhang, Yusheng Li, Shuguang Liu, Ting Wen

“…Abstract Objectives The purpose of this study was to provide thorough, understandable and precise evidence for the clinical use of antibiotic-loaded bone cement (ALBC) in preventing periprosthetic joint infection (PJI). Methods We evaluated the effectiveness of ALBC in preventing PJI by conducting an umbrella review of existing meta-analysis. …”
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Compliance of extended infusion of piperacillin/tazobactam with the desired pharmacokinetic/pharmacodynamic index in septic patients by Tomić Nataša, Vukmirović Saša, Sabo Stanislav, Uvelin Arsen, Popović Radmila, Vicković Sanja, Tomić Ljiljana, Tomić Zdenko

“…The aim of this study was to analyze the efficacy of prolonged intermittent infusion of PIP/TAZ in patients with sepsis in the ICU to achieve the desired PK/PD index. Methods. A prospective, controlled, non-interventional study included patients with abdominal post-operative sepsis. …”
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Study of novel 1,4-dihydropyridine derivatives as prospective anti-inflammatory remedies: a randomised controlled trial by E. Yu. Bibik, D. S. Krivokolysko, G. A. Batishcheva, A. A. Samokish, Yu. S. Venidiktova, A. V. Myazina, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko

“…A study of the anti-inflammatory action of novel compounds, 1,4-dihydropyridine derivatives, in a classical formalin-induced paw oedema test in white rats.Methods. Originally synthesised 1,4-dihydropyridine derivatives were preliminarily subjected to virtual screening using the SwissTargetPrediction toolkit. …”
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Favorable pattern of arterial stiffness and vascular aging in a unique cohort of offspring of early life famine survivors by K. M. Tolkunova, D. A. Usoltsev, E. V. Moguchaia, M. A. Boyarinova, A. M. Erina, E. P. Kolesova, S. V. Kibkalo, E. Yu. Vasileva, N. N. Artemov, O. P. Rotar, A. O. Konradi, E. V. Shlyakhto

“…To study the characteristics of arterial stiffness and vascular aging phenotypes in two generations of descendants (children and grandchildren) of the siege of Leningrad survivors, compared to a control group.Material and methods. Residents of the siege of Leningrad who experienced famine during early childhood in the Great Patriotic War (19411944) underwent examination between 2009 and 2014. …”
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