Changing trends in oral mucosal diseases in China (2016–2024): a cross-sectional study of 316,166 patients with focus on COVID-19 impact and use of chinese patent medicines by Peiru Zhou, Xu Zhang, Yifan Chen, Jiakun Fang, Yanhong Meng, Furong Yang, Pan Wei, Hong Hua

“…It also explores trends in the use of Chinese patent medicines (CPMs) for treatment. Methods This retrospective, cross-sectional study included 316,166 patients from the Department of Oral Medicine at Peking University School and Hospital of Stomatology between 2016 and 2024. …”
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Prevalence and transmission of HIV-1 drug resistance mutations among patients with treatment failure and newly diagnosed people in Liangshan Prefecture, China, in 2021–2023 by Rong Pei, Rong Pei, Yulian Zhang, Chunnong Jike, Gang Yu, Ling Su, Ju Wang, Lin Xiao, Yubing Wang, Maogang Shen, Jiayi Liao, Yifei Zheng, Joris Hemelaar

“…A deeper understanding of HIV-1 drug resistance can lead to improvements in current treatment policies.MethodsWe conducted an analysis of HIV drug resistance mutations (DRMs) among patients with treatment failure and people newly diagnosed with HIV in Liangshan Prefecture. 8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 15 counties and two cities in Liangshan Prefecture between 2021 and 2023.Results43.0% of patients with treatment failure acquired HIV through the heterosexual route, followed by injecting drug use (38.7%), while newly diagnosed individuals mainly acquired HIV through the heterosexual route (86.7%). 95.6% of patients with treatment failure were infected with HIV-1 variant CRF07_BC and 2.7% with CRF08_BC, and newly diagnosed individuals were also main infected with HIV-1 variant CRF07_BC (90.9), followed by CRF08_BC (4.0%) and CRF01_AE (2.5%). …”
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A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population by Arno R. Bourgonje, Martin F. Bourgonje, Sacha la Bastide-van Gemert, Tom Nilsen, Clara Hidden, Ron T. Gansevoort, Douwe J. Mulder, Jan-Luuk Hillebrands, Stephan J.L. Bakker, Robin P.F. Dullaart, Harry van Goor, Amaal E. Abdulle

“…In this study, we aimed to investigate a potential association between the plasma biomarker of inflammation calprotectin and new-onset CKD in a population-based cohort study. Methods: Individuals without CKD at baseline (n = 4662) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) prospective population-based cohort study in the Netherlands were included. …”
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Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review by Jessica Hier, Galit Avior, Marc Pusztaszeri, Joshua R. Krasner, Noura Alyouha, Veronique-Isabelle Forest, Michael P. Hier, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Tamilia, Richard J. Payne

“…Methods A retrospective chart review of 122 cases was performed: 101 patients from the McGill University teaching hospitals and 21 patients from the Hillel Yaffe Medical center, Technion University. …”
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Hip fractures in Chinese TikTok (Douyin) short videos: an analysis of information quality, content and user comment attitudes by Zhuoxin Li, Zhuoxin Li, Yashi Lin, Yashi Lin, Kairou Zhang, Kairou Zhang, Ran Li, Ran Li, Mei Ju, Yanhua Chen, Jing Fu, Ruiyu Huang, Ling Zhu, Junjun Sun, Yanxia Guo, Min Gao, Yue Hu, Gang Liu, Baolu Zhang

“…While numerous Douyin videos address hip fracture, their information quality and factors affecting user comment attitudes remain uncertain.ObjectiveThis study aims to analyze the content, information quality, and user comment attitudes of videos depicting hip fractures on Chinese TikTok (Douyin).MethodsThe search term “hip fracture” was used on Douyin, which resulted in 170 samples being included. …”
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Characterization of intrahepatic B cells in acute-on-chronic liver failure by Yudong Zhao, Wei He, Chenchen Wang, Nana Cui, Changjie Yang, Zhengrui You, Bisheng Shi, Lei Xia, Xiaosong Chen

“…Previous reports were only based on immunophenotyping of peripheral blood samples. Here, we aim to dissect liver-infiltrating B-cell subpopulation in ACLF.MethodsPaired liver perfusate and peripheral blood were freshly collected from healthy living donors and recipients during liver transplantation. …”
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BRCA1 promoter hypermethylation is not associated with germline variants in Polish breast cancer patients by Karolina Prajzendanc, Paweł Domagała, Jolanta Hybiak, Wojciech Kluźniak, Cezary Cybulski, Katarzyna Białkowska, Alicja Ogrodniczak, Janusz Ryś, Aleksandra Sejda, Marek Szwiec, Joanna Tomiczek-Szwiec, Tomasz Kluz, Roksana Dwornik, Dagmara Cylwik, Jacek Gronwald, Jan Lubiński, Anna Jakubowska

“…Additionally, the correlation between the detected variants and breast cancer incidence, as well as clinical characteristics, was assessed. Materials and methods One hundred breast cancer patients with BRCA1 methylation were analyzed using pyrosequencing to quantify methylation levels. …”
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Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics by Alexander Tristancho-Baró, Ana Isabel López-Calleja, Ana Milagro, Mónica Ariza, Víctor Viñeta, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, David Badenas-Alzugaray, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…This study aims to investigate the genomic determinants associated with cefiderocol resistance in CPE isolates of human origin. <b>Methods</b>: Comparative genomic analyses were conducted between cefiderocol-susceptible and -resistant CPE isolates recovered from human clinical and epidemiological samples at a tertiary care hospital. …”
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Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism by Mai Han, Gang Cui, Yan Zhao, Xianbo Zuo, Xiaoxue Wang, Xin Zhang, Na Mi, Jiangli Jin, Chunyan Xiao, Jing Wang, Wei Wu, Yajuan Li, Jintong Li

“…Additionally, it evaluates the impact of CYP1A2, CYP2C19, and CYP3A4 gene polymorphisms on GP1707D07 metabolism.MethodsThe study enrolled twelve healthy adult subjects to receive the treatments consisting of GP681 monotherapy and GP681-itraconazole co-administration in a fixed-sequence. …”
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Comparative Analysis of Long-Term Measles Immune Response After Natural Infection and Routine Vaccination in China by Sihong Zhao, Qianli Wang, Juan Yang, Qiaohong Liao, Juanjuan Zhang, Xiaoyu Zhou, Jiaxin Zhou, Zeyao Zhao, Yuxia Liang, Junteng Luo, Jingting Cai, Yanpeng Wu, Wei Wang, Hongjie Yu

“…In this study, we aimed to determine the distinct dynamics of vaccine-induced and naturally acquired antibodies, with specific focus on difference in vaccine-induced antibody responses across different birth cohorts. <b>Methods:</b> Based on two cohorts and one cross-sectional study conducted in Anhua County, Hunan Province, China, serum samples from children who followed China’s routine measles vaccination schedule (i.e., two-dose schedule at 8/18 months) and adults who acquired immunity through natural infection were tested for measles IgG antibodies using an enzyme-linked immunosorbent assay. …”
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Comparison of two combined drug therapy regimens for renal damage in patients with metastatic kidney cancer after previously performed unilateral nephrectomy by K. S. Titov, M. V. Epifanova, A. A. Alimov, O. Yu. Nesterova, E. V. Shutov, S. S. Lebedev, G. M. Zapirov

“…Combined immunotherapy with ipilimumab + nivolumab in patients with metastatic RCC in patients with a single kidney has a more pronounced deterioration in renal function compared with combined immunotherapy with pembrolizumab + axitinib.…”
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Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes by Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng

“…While these subtypes share clinical, genetic, and pathological features, their transcriptomic similarities and differences remain poorly understood. Methods We applied single-nucleus RNA-sequencing (snRNA-seq) to prefrontal cortex samples from individuals with non-cognitive impairment control (NCI), and dementia subtypes (AD, DLB, and PDD) to investigate cell type-specific gene expression patterns and pathways underlying pathological similarities and differences across dementia subtypes. …”
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HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study by Irma Wati Ngadimon, Devi Mohan, Mohd Farooq Shaikh, Ching Soong Khoo, Hui Jan Tan, Yu Mey Lee, Nor Syazwani Chamhuri, Farizal Fadzil, Nursyazwana Zolkafli, Alina Arulsamy, Jegan Thanabalan, Angel Aledo‐Serrano, Wing Loong Cheong

“…This prospective longitudinal study investigated whether serum HMGB1 levels are associated with PTE development and cognitive decline over 12 months post‐TBI. Methods Serum samples were collected from 41 TBI patients, including mild and moderate to severe, at baseline, 6, and 12 months following TBI. …”
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Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk by Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma

“…This study aimed to employ plasma metabolomics to identify metabolic subtypes linked to CKM severity and explore early biomarkers for high-risk individuals. Methods A cross-sectional study was conducted involving 163 adults, which included 86 individuals clinically staged as CKM 0–3 according to the criteria proposed by the American Heart Association (AHA). …”
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Conception and development of a neurological registry of patients with persistent health impairments following work-related COVID-19 disease in Germany by Schwenkreis, Peter, Kozak, Agnessa, Gonschorek, Andreas, Schmehl, Ingo, Seddigh, Susann, Fürst, Andrea, Wohlfahrt, Kai, Rademacher, Corinna, Engel, Lynn, Wefers, Jacob, Kobes, Kerrin, Kleinmüller, Olaf, Wischnat, Jana, Nienhaus, Albert, Tegenthoff, Martin

“…The design of the post-COVID registry, along with a description of the study population, is detailed in this paper.Methods: The registry includes patients with an occupational disease or accident. …”
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Potentials of cytokinesis blocked micronucleus assay in radiation triage and biological dosimetry by G. Tamizh Selvan, P. Venkatachalam

“…PubMed search tool was used with keywords of MN, biodosimetry, radiotherapy and restricted to human samples. Since Fenech and Morely developed the assay, it has undergone many technical and technological reforms as a biomarker of various applications. …”
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Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study by Yaqin Peng, Ruijie Xie, Yifeng Luo, Yifeng Luo, Yifeng Luo, Penghao Guo, Zhongwen Wu, Yili Chen, Pingjuan Liu, Jiankai Deng, Bin Huang, Kang Liao

“…Additionally, there is still a lack of clinical data to reveal the association between pathogen loads detected by ddPCR and corresponding BSIs.MethodsIn this prospective study, 173 patients with suspected BSIs were enrolled. …”
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Efficacy and safety of Chinese classical prescriptions for dilated cardiomyopathy: a systematic review and Bayesian network meta-analysis by Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Xiao Xia, Yonghao Li, Deshuang Yang, Wenjie Zhang

“…Furthermore, additional larger RCTs with longer follow-up periods and standardized outcome reporting are required to give more solid evidence to support our findings due to the small sample size of the current studies and the presence of risk of bias.…”
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EVALUASI ELEMEN TEKNIS RUANG BERSAMA RUSUNAWA MAHASISWA SEBAGAI HUNIAN SEHAT DI MASA PANDEMI COVID-19 by Citra Amalia Amal, Andi Annisa Amalia, Siti Fuadillah A. Amin, Rifaldi Rifaldi

“…The results of the study found that the two samples of student flats, in general, had met the Healthy Home Principles. …”
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An examination of the associations between nutritional peaking strategies in physique sport and competitor characteristics by Kai A. Homer, Matt R. Cross, Eric R. Helms

“…The aim of this research was to examine the effect of competitor characteristics on the specific nutritional peaking strategies implemented, the length of these strategies, and the range of daily carbohydrate (CHO) intakes during these strategies.Methods A 58-item survey was developed to gather information on peak week nutrition and training practices of physique athletes. …”
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