Influence of age and scholing on the performance in a modified Mini-Mental State Examination version: a study in Brazil Northeast Influência da idade e escolaridade sobre a perform... by Paulo Roberto de Brito-Marques, José Eulálio Cabral-Filho

“…OBJECTIVE: To assess the cognitive performance of low and middle educated old people in a modified version of the adapted to portuguese language MMSE. METHOD: A study was carried out enrolling 253 individuals, aged 60 to 90 years included in different schooling levels. …”
Get full text

Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…They are more likely to be admitted to hospital and need health care. …”
Get full text

Socio-economic inequalities in minimum dietary diversity among Ethiopian children aged 6–23 months: a decomposition analysis by Nigusu Worku, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Mihret Getnet, Wubshet Debebe Negash, Wubshet Debebe Negash, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Asebe Hagos

“…BackgroundGlobally, inappropriate feeding practices account for more than two-thirds of all cases of child mortality during the first 2 years of a child’s life. …”
Get full text

Genetic Alterations in Chromatin Regulatory Genes in Upper Tract Urothelial Carcinoma and Urothelial Bladder Cancer by Shuo Wang, Xuzhi Yan, Weihua Lan, Yapeng Wang, Ze Wang, Dali Tong, Yao Zhang, Qiang Ran, Haoyang Li, Junhao Jin, Haiyang Xiao, Jing Xu, Qian Yan, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Jun Qin, Luofu Wang, Jun Jiang, Qiuli Liu

“…We examined alterations of chromatin regulatory genes in molecular subtypes, clonal relatedness, and T‐cell receptor (TCR) diversity in UTUC and UCB. Materials and Methods Targeted next‐generation sequencing or whole‐exome DNA sequencing and TCR sequencing were conducted with 34 UTUC and 49 UCB specimens from 63 patients. …”
Get full text

Randomized clinical trial of peer integrated collaborative care intervention after physical injury by Eileen M Bulger, Peter Thomas, Jin Wang, Lauren K Whiteside, Ronald Maier, Allison Engstrom, Douglas F Zatzick, Joan Russo, Patrick Heagerty, Khadija Abu, Tanya Knutzen, Jake Shoyer, Navneet Birk, Cristina Conde, Paige Ryan, Matt Iles-Shih, Lawrence Palinkas

“…Objectives The goal of the current study was to assess the effectiveness of a peer integrated collaborative care intervention for postinjury outcomes.Methods Injury survivors ≥18 years of age were screened for post-traumatic stress disorder (PTSD) symptoms and severe postinjury concerns; screen-positive patients were randomized to the intervention versus enhanced usual care control conditions. …”
Get full text

Multidrug-resistant Organisms Among Patients in COVID-19 Wards Compared to Non-COVID-19 Wards in Indonesian Hospitals by Shod A. Zulkarnain, Radhitya Abdullah, Ardellia G. Pradnyadevati, Muhammad FR Roesianto, Oktavia K. Putri, Raden BR Padmosudiro, Ryan M. Ramadhan, Susanthy Djajalaksana, Dewi Indiastari, Wiwi Jaya, Arie Z. Fathoni, Irene Ratridewi, Sofiana A. Sahara, Etty F. Ruliatna, Anne Voor in ’t holt, Juliette A. Severin, Nurima DP Hastuti, Sanarto Santoso, Dewi Santosaningsih

“…BACKGROUND: The effect of the COVID-19 pandemic on the emergence and spread of MDROs is largely unknown, especially in limited-resource settings. METHODS: A prospective, observational cohort study was conducted in both COVID-19 and non-COVID-19 wards of Ngudi Waluyo Hospital, Wlingi, Blitar (NWH, secondary care) and Dr. …”
Get full text

Changes in retail cigarette price after tax increase: Findings from the 2018–2020 ITC Vietnam surveys by Thi Phuong Thao Tran, Thi Ngoc Phuong Nguyen, Thu Trang Vu, Thai Uyen Tran, Don Nguyen, Thi Hai Phan, Son Dao The, Min Kyung Lim, Anne C. K. Quah, Jin-Kyoung Oh, Hoang Van Minh

“…This study aims to describe changes in the purchase price of cigarettes following an excise tax increase from 70% to 75% in January 2019. Material and Methods Data were collected from people who currently smoke cigarettes in the longitudinal ITC Vietnam surveys: 1870 participants in Wave 1 (pre-increase), 1564 in Wave 2 (post-increase), and 1308 in Wave 3 (post-increase). …”
Get full text

Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023) by Xiaolei Wu, Haiyin Hu, Yuetong Wang, Alice Josephine Fauci, Yazi Zhang, Wenting Song, Fengwen Yang, Boli Zhang, Junhua Zhang, Zhaochen Ji

“…However, quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.…”
Get full text

Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, an... by Emma Naomi James, Muy-Teck Teh, Yufeng Li, Christine Wagner-Bock, Zahra Falah Al-Khateeb, Lee Peng Karen-Ng, Terry Roberts, Linnea Synchyshyn, Amy Lewis, Ana O’Loghlen, Andrew Silver, Adina Teodora Michael-Titus, Mark Bennett, Jacob Guy Bundy, Maria Elzbieta Mycielska, Eric Kenneth Parkinson

“…However, the detailed mechanism of senescent cell extracellular citrate (EC) accumulation is not clear.MethodsEC following various drug and cytokine treatments was measured in human fibroblast and keratinocyte conditioned medium by gas chromatography/mass spectroscopy and liquid chromatography/mass spectroscopy. …”
Get full text

Loneliness among dementia caregivers: evaluation of the psychometric properties and cutoff score of the Three-item UCLA Loneliness Scale by Amira Mohammed Ali, Saeed A. Al-Dossary, Carlos Laranjeira, Carlos Laranjeira, Carlos Laranjeira, Abeer Selim, Abeer Selim, Abeer Selim, Souheil Hallit, Souheil Hallit, Souheil Hallit, Abdulmajeed A. Alkhamees, Aljawharah Fahad Aljubilah, Musheer A. Aljaberi, Ebtesam Abdullah Alzeiby, Annamaria Pakai, Haitham Khatatbeh

“…This instrumental study aimed to examine the factor structure, reliability, convergent validity, criterion validity, and cutoff scores of a short loneliness measure: the Three-Item version of the University of California, Los Angeles, Loneliness Scale (UCLALS3) in a convenience sample of dementia family caregivers (N = 571, mean age = 53 ±12 years, 81.6% females).MethodsExploratory and confirmatory factor analyses were used to examine the structure of the UCLALS3 while receiver-operating characteristic (ROC) curve, including caregiving burden and emotional distress as outcomes, was used to examine its cutoff.ResultsOne factor accounted for 79.0% of the variance in the UCLALS3; it was perfectly invariant across genders but variant at the metric level across countries. …”
Get full text

Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors by Haojiong Zhang, Haojiong Zhang, Haojiong Zhang, Jing Gao, Jing Gao, Jing Gao, Jiyi Hu, Jiyi Hu, Jiyi Hu, Weixu Hu, Weixu Hu, Weixu Hu, Qingting Huang, Qingting Huang, Qingting Huang, Lin Kong, Lin Kong, Lin Kong

“…Investigating peripheral immune cell changes could offer valuable insights for integrating immunotherapies and optimizing treatment outcomes.MethodsIn this observational study, we enrolled 12 patients with head and neck bone and soft tissue tumors treated at our center between November 1, 2022, and November 1, 2024. …”
Get full text

Home blood pressure during night-time sleep – a feasible treatment target for patients with hypertension: a proof-of-concept randomised controlled trial by Eric Kam-Pui Lee, Shuqi Wang, Benjamin Hon-Kei Yip, Esther Yee-Tak Yu, Shuk-Yun Leung, Jinghao Han, Yue-Kwan Choi, Kam-Fai Chow, Wai-Ho Chung, Byran P. Yan, Anastasia S. Mihailidou, Richard J. McManus, Samuel Yeung-Shan Wong

“…Background: This trial assessed the feasibility of titrating evening dosing of anti-hypertensive medications based on nighttime home blood pressure measurement (HBPM) readings in primary care for hypertensive (HT) patients.Methods: 78 patients with nocturnal HT and stage I daytime HT were randomly assigned in a 1:1 ratio to either nighttime HBPM measurements (intervention group) or daytime HBPM measurements (control group). …”
Get full text

Randomised controlled trial of perinatal vitamin D supplementation to prevent early-onset acute respiratory infections among Australian First Nations children: the ‘D-Kids’ study p... by Anne B Chang, Peter S Morris, Tom Snelling, Paul V Licciardi, Michael J Binks, David Simon, E Kim Mulholland, Adrienne Kirby, Heather D'Antoine, Amy S Bleakley, Susan J Pizzutto, Michelle Lamberth, Verity Powell, Jane Nelson, Geetha Rathnayake, Amanda J Leach

“…While ARI-related mortality is low in Australia, First Nations infants are hospitalised with ARIs up to nine times more often than their non-First Nations counterparts. …”
Get full text

Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol by Andreas Obermair, Monika Janda, Sandra C Hayes, Elizabeth Eakin, Marcelo Nascimento, Dimitrios Vagenas, Jermaine Coward, Louisa G Gordon, Catherine Shannon, James Nicklin, Jeffrey Goh, Vanessa L Beesley, Penny Webb, Merran Williams, Sheree Rye, Rosalind R Spence, Helene O’Neill, Melissa J Newton, Sara Baniahmadi, Andrea Garret

“…However, these recommendations are derived from research typically involving cohorts with more common cancers and relatively good prognosis, such as breast and prostate. …”
Get full text

Effect of a Pleuran-Based Supplement on Salivary IgA Secretion in Children With Recurrent Respiratory Infections by Peter Kunc, MD, PhD, Jaroslav Fabry, MD, PhD, Michaela Matiscakova, MD, Katarina Istvankova, DVM, Zuzana Diamant, MD, PhD, Juraj Majtan, PhD, DSc, Milos Jesenak, MD, PhD

“…This study aimed to evaluate the effects of a pleuran-based supplement (ß-glucan isolated from Pleurotus ostreatus in combination with vitamin D and zinc) on mucosal immunity –through modulating salivary secretory immunoglobulin A (sIgA) levels –in children with RRIs. Methods: This monocentric, prospective, open-label pilot study investigated the effect of an orally administered pleuran/vitamin D/zinc supplement (1–2 chewable tablets daily depending on body weight) on the dynamics of sIgA secretion measured in saliva samples collected at three timepoints: at baseline and after 4–6 and 8–10 days. …”
Get full text

Evaluation of statistical models of carriage to predict the impact of the 10-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in Nigeria by Aishatu L. Adamu, John. Ojal, Caroline Mburu, Katherine E. Gallagher, Stefan Flasche, Kofo Odeyemi, Christy A.N. Okoromah, Isa S. Abubakar, Musa M. Bello, Victor Inem, Angela Karani, Boniface Karia, Donald Akech, Ifedayo M.O. Adetifa, J. Anthony G. Scott

“…We sought to determine the applicability of three published statistical carriage-based models for the evaluation of PCV10 impact in Nigeria, where carriage prevalence data are available from urban and rural sites. Methods: We applied external data, with assumptions, to empirical carriage prevalence data to predict IPD incidence rate ratios (IRRs). …”
Get full text

Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis by Alessio Gerussi, Oliver Lester Saldanha, Giorgio Cazzaniga, Damiano Verda, Zunamys I. Carrero, Bastian Engel, Richard Taubert, Francesca Bolis, Laura Cristoferi, Federica Malinverno, Francesca Colapietro, Reha Akpinar, Luca Di Tommaso, Luigi Terracciano, Ana Lleo, Mauro Viganó, Cristina Rigamonti, Daniela Cabibi, Vincenza Calvaruso, Fabio Gibilisco, Nicoló Caldonazzi, Alessandro Valentino, Stefano Ceola, Valentina Canini, Eugenia Nofit, Marco Muselli, Julien Calderaro, Dina Tiniakos, Vincenzo L’Imperio, Fabio Pagni, Nicola Zucchini, Pietro Invernizzi, Marco Carbone, Jakob Nikolas Kather

“…This study investigates the use of a deep learning (DL)-based pipeline for the diagnosis of AIH and PBC to aid differential diagnosis. Methods: We conducted a multicenter study across six European referral centers, and built a library of digitized liver biopsy slides dating from 1997 to 2023. …”
Get full text

Improved tumor-type informed compared to tumor-informed mutation tracking for ctDNA detection and microscopic residual disease assessment in epithelial ovarian cancer by Mehdi Ben Sassi, Henri Azais, Charles Marcaillou, Sylvain Guibert, Emmanuel Martin, Jérôme Alexandre, Louise Benoit, Aurélien de Reynies, Emilie Laude, Cam Duong, Jacques Medioni, Bruno Borghese, Anne-Sophie Bats, Valerie Taly, Pierre Laurent-Puig

“…Plasma samples from 47 advanced-stage EOC patients receiving chemotherapy and 54 healthy subjects were analyzed. …”
Get full text

High prevalence of resistance to macrolides and fluoroquinolones in Mycoplasma genitalium isolated from patients in two Russian megalopolises – Moscow and St. Petersburg in 2021– 2... by Edelstein I.A., Gushchin A.E., Gladin D.P., Romanov A.V., Negasheva E.S., Frigo N.V., Kozlov R.S., Potekaev N.N., Kozlova N.S., Borukhovich D.G.

“…Petersburg in 2021–2024. Materials and Methods. A total of 530 M. genitalium DNA-positive specimens (urethral and cervical swabs) obtained from men and women from the STD clinic in St. …”
Get full text

Levels and types of physical activity in Russia according to the ESSE-RF study: is there a trace of the COVID-19 pandemic? by M. B. Kotova, S. A. Maksimov, S. A. Shalnova, A. V. Kontsevaya, Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, G. A. Muromtseva, N. S. Karamnova, S. E. Evstifeeva, A. V. Kapustina, O. A. Litinskaya, M. S. Pokrovskaya, E. B. Yarovaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, E. N. Chernysheva, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. D. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovyova, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, I. V. Tantsyreva, I. N. Baryshnikova, M. G. Ataev, M. O. Radjabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, I. A. Khakuasheva, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, A. A. Keskinov, V. S. Yudin, S. M. Yudin, O. M. Drapkina

“…The study showed that 27,4% of the sample have insufficient physical activity. Among the low physical activity category, there are more women than men (28,12 vs 26,7%, p<0,001); among men, high physical activity was more often identified (24,1 vs 18,3%, p<0,001). …”
Get full text