Impact of a massive earthquake on adherence to antiretroviral therapy, mental health, and treatment failure among people living with HIV in Nepal. by Bharat Singh Negi, Sunil Kumar Joshi, Minato Nakazawa, Tomohiro Kotaki, Anup Bastola, Masanori Kameoka

“…Therefore, the objectives of this study were i) to assess the association of antiretroviral therapy (ART) adherence with mental health problems, and social behaviors, ii) to examine factors affecting treatment failure, and iii) to investigate changes in ART adherence and post-traumatic stress disorder (PTSD) among people living with HIV 6 and 12 months after the disaster.<h4>Methods</h4>Study was conducted 6 months after the earthquake in 2015 with a sample size of 305 earthquake victims with HIV and followed after 12 months of the earthquake. …”
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Ertapenem+meropenem including double carbapenem therapy (EMDCT) versus meropenem+imipenem including double carbapenem therapy (MIDCT) in the therapy of carbapenem-resistant Klebsie... by Merve Mert Vahabi, Deniz Akyol, Deniz Dağ, Gamze Şanlıdağ, Şevket Yeniyol, Arda Kaya, Dilşah Başkol, Seichan Ketentzi, Buğra Özkara, Şükrü Dirik, Gökhan Vatansever, Derya Kaya, Meltem Tüğdür, Hüseyin Aytaç Erdem, Feriha Çilli, Hilal Sipahi, Hüsnü Pullukçu, Meltem Taşbakan, Bilgin Arda, Oğuz Reşat Sipahi

“…BACKGROUND-AIM: In this retrospective matched cohort study, we aimed to compare the clinical outcomes of EMDCT including therapy receiving cases with MIDCT receiving CRKPI cases. MATERIALS/METHODS: This study was performed at a 1800+ bedded tertiary-care hospital.Adult patients with culture proven CRKPI(bacteremia,pneumonia,UTI,other)treated with EMDCT or MIDCT including regimens between August 2016 and October 2023 were included in the study.Matching was performed as one MIDCT matched to minimum 1 or 2 EMDCT when n is possible i)according to the sample infecting strain was yielded (bacteremia vs.bacteremia etc.)ii)being in the clinic or intensive care unit at the time of the first Infectious Diseases consultation. …”
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Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target by Sara Patrizi, Silvia Vallese, Sabina Barresi, Matteo Cassandri, Isabella Giovannoni, Lucia Pedace, Luana Abballe, Flavia Vinciarelli, Celeste Antonacci, Alessandra Stracuzzi, Barbara Mancini, Ida Russo, Angela Di Giannatale, Rossella Rota, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele

“…Methods: We conducted whole-genome DNAm and transcriptome analyses on 10 parameningeal head and neck ARMS patients, including 4 patients under 1 year old and 6 over 10 years old. …”
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Updates from a single-center phase 2 study of PD-1 inhibitor combined with hypomethylating agent plus CAG regimen in patients with relapsed/refractory acute myeloid leukemia by Hui-Sheng Zhou, Hui-Sheng Zhou, Yong-Feng Su, Jun Wang, Ya-Lei Hu, Ya-Lei Hu, An Wang, Lei Xu, Yi-Zhi Wang, Xuan Zheng, Yu-Qing Li, Yu-Qing Li, Kai-Li Min, Kai-Li Min, Chun-Ji Gao, Dai-Hong Liu, Dai-Hong Liu, Xiao-Ning Gao, Xiao-Ning Gao

“…Our study aimed to analyze the effectiveness and safety of combining tislelizumab with a hypomethylating agent (HMA) plus CAG regimen in treating patients with r/r AML, with an increased sample size and in comparison, with a historical control group for more reliable data support (ClinicalTrials.gov identifier NCT04541277).MethodsThe study included a total of 37 patients with r/r AML who received the tislelizumab + HMA + CAG regimen.ResultsThe overall response rate was 69.4%, with a median overall survival of 12.1 months and event-free survival of 6.2 months. …”
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High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1 by Roberta Lucianò, Maurizio Colecchia, Maurizio Colecchia, Francesca Sanvito, Irene Locatelli, Chiara Venegoni, Alessia Di Coste, Davide Danilo Zani, Angelica Stranieri, Chiara Giudice, Antonella Rigillo, Matteo Gambini, Francesco Montorsi, Francesco Montorsi, Andrea Salonia, Andrea Salonia, Marco Moschini, Massimo Alfano

“…The aim of this study was to investigate the expression of the α5β1 integrin and its specificity in high-grade UC in humans and dogs, a marker recently reported in the human bladder in situ carcinoma and murine model of orthotopic bladder cancer.MethodsExpression of integrin α5β1 was established by immunohistochemistry in 67 human bladder samples [four non-tumor tissues, 10 low-grade, 10 intermediate-grade, and 43 high-grade non-muscle invasive bladder cancer (NMIBC)] and 12 canine bladder tumor specimens.ResultsThe α5β1 integrin was not expressed by urothelial cells in the conditions of inflammatory cystitis, actinic cystitis, benign hyperplasia, and low/intermediate grade NMIBC; it was identified as a specific marker expressed only by the malignant cells in the urothelium in 81% of human and all canine high-grade NMIBC.ConclusionsThe expression of α5β1 integrin is a specific marker of high-grade UC located in the urothelium of humans and dogs and might be tested for targeted delivery of contrast agents or drugs. …”
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High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array by Hannah Viola, Liang-Hsin Chen, Seongbin Jo, Kendra Washington, Cauviya Selva, Andrea Li, Daniel Feng, Vincent Giacalone, Susan T. Stephenson, Kirsten Cottrill, Ahmad Mohammad, Evelyn Williams, Xianggui Qu, Wilbur Lam, Nga L. Ng, Anne Fitzpatrick, Jocelyn Grunwell, Rabindra Tirouvanziam, Shuichi Takayama

“…Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress toward therapeutics. …”
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Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal B... by Nigel Curtis, Susan Donath, Dan Casalaz, Petra Zimmermann, Anne-Louise Ponsonby, Nicole L Messina, Kaya Gardiner, Katie Flanagan, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Katie J Allen, Peter Vuillermin, Mike South

“…Introduction BCG vaccination reduces all-cause infant mortality in high-mortality settings by more than can be attributed to protection against tuberculosis. …”
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Epidemiology and genetic diversity of common human coronaviruses in Beijing, 2015-2023: A prospective multicenter study by Qi Huang, Lu Kang, Xiaofeng Wei, Cheng Gong, Hui Xie, Maozhong Li, Yiting Wang, Mei Dong, Fang Huang

“…ABSTRACT: Objectives: To investigate the epidemiological and genetic features of common human coronaviruses (HCoVs) in Beijing in the context of the COVID-19 pandemic. Methods: We collected clinical samples from patients with acute respiratory tract infections (ARTIs) in 35 sentinel hospitals from 2015 to 2023. …”
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Non-Immersive Virtual Reality Exercise Can Increase Exercise in Older Adults Living in the Community and in Long-Term Care: A Randomized Controlled Trial by Sheehy L, Bharadwaj L, Nissen KA, Estey JL

“…Lisa Sheehy,1 Lalita Bharadwaj,2 Kelsey Annie Nissen,2 Justine L Estey2 1Bruyère Health Research Institute, Ottawa, Ontario, Canada; 2Centre for Innovation and Research in Aging, Fredericton, New Brunswick, CanadaCorrespondence: Lisa Sheehy, Bruyère Health Research Institute, 43 Bruyère St, Ottawa, ON, K1N 5C8, Canada, Tel +01 613 562 6262 ext. 1593, Email lsheehy@bruyere.orgPurpose: To assess the impact of an 8-week non-immersive virtual reality exercise program for older adults on 1) balance, physical function, community integration and quality of life; 2) falls, emergency room visits, hospital and long-term care admissions; 3) quantity of exercise performed; and 4) acceptance of non-immersive virtual reality.Patients and Methods: This prospective, assessor-blinded, randomized controlled trial was carried out on two separate samples of older adults: those living in their own homes (“home-based”) and those living in long-term care (“facility-based”). …”
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Geographic variation in secondary metabolites contents and their relationship with soil mineral elements in Pleuropterus multiflorum Thunb. from different regions by Yaling Yang, Siman Wang, Ruibin Bai, Feng Xiong, Yan Jin, Hanwei Liu, Ziyi Wang, Chengyuan Yang, Yi Yu, Apu Chowdhury, Chuanzhi Kang, Jian Yang, Lanping Guo

“…The levels of metabolites in HSW samples are influenced by soil mineral elements, with stilbene glycosides being more susceptible to such influences compared to anthraquinones. …”
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The NGC 3109 Satellite System: The First Systematic Resolved Search for Dwarf Galaxies Around an SMC-mass Host by Amandine Doliva-Dolinsky, Burçin Mutlu-Pakdil, Denija Crnojević, Dhayaa Anbajagane, Jeffrey L. Carlin, Jonah Medoff, David J. Sand, Erik Tollerud, Sungsoon Lim, Paul Bennet, Alex Drlica-Wagner, Catherine E. Fielder, Jonathan R. Hargis, Kai Herron, Laura Congreve Hunter, Michael G. Jones, Ananthan Karunakaran, Annika H. G. Peter, Aaron J. Romanowsky, Kristine Spekkens, Jay Strader, Beth Willman, Julio A. Carballo-Bello, William Cerny, Astha Chaturvedi, Nitya Kallivayalil, Clara E. Martínez-Vázquez, Gustavo E. Medina, Noelia E. D. Noël, Andrew B. Pace, Alex H. Riley, Joanna D. Sakowska, Adam Smercina, Kathy Vivas, Monika Adamów, Clecio R. Bom, Yumi Choi, Peter S. Ferguson, Mahdieh Navabi, Alfredo Zenteno, (DELVE Collaboration)

“…We introduce a newly developed semiresolved search method, used alongside a resolved search, to identify crowded dwarf galaxies around NGC 3109. …”
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Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities by Qing-shan Chen, Rui-zhao Cai, Yan Wang, Ge-hao Liang, Kai-ming Zhang, Xiao-Yu Yang, Dong Yang, De-Chang Zhao, Xiao-Feng Zhu, Rong Deng, Jun Tang

“…This study aims to investigate SE heterogeneity in TNBC and its influence on BETi effectiveness, with the goal of advancing BETi precision treatment strategies and enhancing therapeutic efficacy. Methods We conducted a comprehensive analysis of H3K27ac ChIP-Seq data from TNBC cell lines and clinical samples, integrating multiple bulk RNA-Seq, scRNA-Seq, and stRNA-Seq datasets to characterize the SE landscape and heterogeneity in TNBC. …”
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How firearm legislation impacts firearm mortality internationally: A scoping review by Brianna Greenberg, Alexandria Bennett, Asad Naveed, Raluca Petrut, Sabrina M. Wang, Niyati Vyas, Amir Bachari, Shawn Khan, Tea Christine Sue, Nicole Dryburgh, Faris Almoli, Becky Skidmore, Nicole Shaver, Evan Chung Bui, Melissa Brouwers, David Moher, Julian Little, Julie Maggi, Najma Ahmed

“…Our objective was to document the extent and nature of evidence on the impact of firearm legislation on mortality from firearm violence. Methods: A scoping review was conducted under PRISMA-ScR guidance. …”
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Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Enterobacterales isolated from wild animals in captivity by Lei Lei, Panfeng Xiong, Zelin Yan, Yanyan Zhang, Yuchen Wu, Gongxiang Chen, Houhui Song, Rong Zhang

“…However, the presence and molecular characteristics of tet(X)-carrying bacteria in these animals remain unknown. Methods: Eighty-four samples were collected from captive wild animals. tet(X) variants were detected using polymerase chain reaction and the isolates were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. …”
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Proteomic Profiling of Human Peripheral Blood Cell Targets of IgG Induced by SARS-CoV-2: Insights into Vaccine Safety by Nicolle Rakanidis Machado, Lais Alves do Nascimento, Beatriz Oliveira Fagundes, João Vitor da Silva Borges, Fabio da Ressureição Sgnotto, Isabella Siuffi Bergamasco, Juliana Ruiz Fernandes, Thalyta Nery Carvalho Pinto, Anna Julia Pietrobon, Gil Benard, Maria Notomi Sato, Jefferson Russo Victor

“…This study investigates the IgG autoantibody responses in patients with varying severities of COVID-19 infection and compares these responses with vaccinated individuals. Methods: We utilized proteomic profiling to analyze autoantibody reactivity against a broad spectrum of proteins expressed in lymphoid and myeloid cell subsets in serum samples from severe and moderate COVID-19 patients, as well as vaccinated individuals who received the inactivated CoronaVac (Sinovac) vaccine. …”
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Clinical and fertility outcomes in lynch syndrome patients with endometrial carcinoma or endometrial Intraepthelial neoplasia treated with fertility sparing management by Hadley W. Reid, Alexandria N. Young, Sophia H. Yin, Isabela Covelli Velez, Mary Kathryn Abel, David L. Kolin, Elizabeth S. Ginsburg, Matthew B. Yurgelun, Colleen Feltmate, Jessica D. St Laurent

“…Progesterone response rates appear to be lower than those in sporadic cases, though similar clinical and histologic factors (age, BMI, and p53 expression pattern) may predict disease regression and fertility outcomes. A larger sample and standardized treatment paradigm are needed to provide more evidence on fertility sparing management for LS patients.…”
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Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma by Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Miao Dang, Huanqin Zhang, Weizheng Zhou, Xu Guo, Jinliang Xing

“…Methods Capture-based mtDNA sequencing was carried out in plasma cell-free DNA samples from 1168 participants, including 571 patients with HCC, 301 patients with chronic hepatitis B or liver cirrhosis (CHB/LC) and 296 healthy controls (HC). …”
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Molecular signatures of invasive and non-invasive pituitary adenomas: a comprehensive analysis of DNA methylation and gene expression by Yike Chen, Ningning Zhao, Jiahao Zhang, Xinyi Wu, Jian Huang, Xiaohui Xu, Feng Cai, Sheng Chen, Liyin Xu, Wei Yan, Yuan Hong, Yunfei Wang, Hui Ling, Jianxiong Ji, Gao Chen, Hongcang Gu, Jianmin Zhang, Qun Wu

“…Methods Reduced representation bisulfite sequencing (RRBS) and RNA sequencing (RNA-seq) were performed on 129 samples from the Second Affiliated Hospital of Zhejiang University, including 69 tissue samples from invasive and non-invasive pituitary adenomas (NPA) and 60 blood samples from IPA, NPA and healthy individuals. …”
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Calcium and silicon nanofertilizers improved morphological attributes and fatty acid composition in olive; an insight to synergistic interaction between these elements by Javad Erfani-Moghadam, Abdolkarim Zarei

“…The utilization of nano-fertilizers for targeted and controlled nutrient release represents a promising strategy to advance sustainable agricultural practices while minimizing environmental impact. Method The effects of foliar application of Ca and Si nanoparticles were investigated on the morphological attributes and fatty acid composition of olive tree cultivar ‘Zard’. …”
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A habilidade motora de chute: relações entre experiência, sexo e estágio motor (La habilidad motora de pateo: relaciones entre experiencia, sexo y etapa motriz) (The motor skill of... by Manoella Michel Kucharski, Ednaldo da Silva Pereira Filho, Jesus Molina Saorin

“…Both instruments applied in this study were previously validated by the Delphy Method. The chi square test (association of variables p≤ .05) was used for the analysis on the categories: motor experience, sex and motor stages. …”
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