Increased <i>MAGE-C</i> Family Gene Expression Levels as a Biomarker of Colon Cancer Through the Demethylation Mechanism by Mikhlid H. Almutairi, Waad A. Alsoraie, Turki M. Alrubie, Ahmad S. Alkhaldi, Nada S. Alhajri, Monira A. Alaujan, Manar H. Almutairi, Bader O. Almutairi

“…The goal was to assess their potential use as cancer biomarkers for the early detection and improvement of CC treatment. Methods: <i>MAGE-C1</i>, <i>MAGE-C2</i>, and <i>MAGE-C3</i> family gene expression levels were examined using RT-PCR and qRT-PCR assays in 26 adjacent normal colon (NC) and CC tissue samples from male and female Saudi patients. …”
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CD66b⁺ Tumor-Infiltrating Neutrophil-like Monocytes as Potential Biomarkers for Clinical Decision-Making in Thyroid Cancer by Hamdullah Yanik, Ilgin Demir, Ertugrul Celik, Ece Tavukcuoglu, Ibrahim Burak Bahcecioglu, Adile Begum Bahcecioglu, Mehmet Mert Hidiroglu, Sumeyra Guler, Nese Ersoz Gulcelik, Mehmet Ali Gulcelik, Kerim Bora Yilmaz, Gunes Esendagli

“…CD66b⁺ neutrophil-like monocytes constitute a novel subset of myeloid cells that are implicated in the modulation of anti-tumor immune responses, but their role in thyroid cancer remains unclear. <i>Materials and Methods:</i> Peripheral blood and thyroid nodule tissue samples were obtained from 24 patients with papillary thyroid carcinoma, and from 10 patients who underwent surgery for symptoms of tracheal compression due to benign thyroid nodules. …”
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Changes in tree-ring wood density of European beech (Fagus sylvatica L.), silver fir (Abies alba Mill.), and Norway spruce (Picea abies (L.) H. Karst.) in European mountain forests... by Chiara Torresan, Torben Hilmers, Admir Avdagić, Edmondo Di Giuseppe, Matija Klopčič, Mathieu Lévesque, Florian Motte, Enno Uhl, Tzvetan Zlatanov, Hans Pretzsch

“…., tree-ring width, current tree diameter, and latewood to earlywood ratio) and drought events on wood density. Methods In total, 150 tree cores were sampled from mountain forests in Bulgaria, Bosnia and Herzegovina, Slovenia, Switzerland, and Germany. …”
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Effects of YouTube Health Videos on Mental Health Literacy in Adolescents and Teachers: Randomized Controlled Trial by Rebekka Schröder, Tim Hamer, Victoria Kruzewitz, Ellen Busch, Ralf Suhr, Lars König

“…ObjectiveThe study evaluates the effectiveness of a short educational YouTube Health video for promoting mental health literacy in adolescents and teachers. MethodsTwo independent samples of 352 adolescents and 502 teachers from Germany were recruited from a large panel, representative of the German population with internet access. …”
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Experiences Receiving and Delivering Virtual Health Care For Women: Qualitative Evidence Synthesis by Karen M Goldstein, Sharron Rushton, Allison A Lewinski, Abigail Shapiro, Tiera Lanford-Davey, Jessica N Coleman, Neetu Chawla, Dhara B Patel, Katherine Van Loon, Megan Shepherd-Banigan, Catherine Sims, Sarah Cantrell, Susan Alton Dailey, Jennifer M Gierisch

“…ConclusionsThe benefits of virtual care for health care access may be more acutely felt by women, especially those with preexisting challenges. …”
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Proposing a two-stage screening approach to distinguish between transient and enduring postnatal depressive symptoms: A prospective cohort study by Johanne Smith-Nielsen, Ida Egmose, Stephen Matthey, Maria Stougård, Sophie Reijman, Mette Skovgaard Væver

“…What are the implications of adopting a two-stage screening approach? Methods: In a prospective cohort study, 427 postnatal women in Copenhagen who scored above the cut-off on their initial EPDS screening (EPDS-1) underwent a second screening (EPDS-2) 1–4 weeks later, without intervention in between. …”
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Effects of Tanreqing injection against ventilator-associated pneumonia: a meta-analysis and systematic review of clinical studies by Pochen Li, Yang Wu, Danxia Ge, Ruyi Xu, Qianping Zhang, Yujiao Li, Lingyao Zhang, HsuanChieh Peng, Fangyu Yu

“…However, some of the included clinical studies had limitations such as small sample sizes, lack of sample size calculations. Therefore, future study designs should be more rigorous to enhance the reliability of findings.Systematic Review Registration:https://inplasy.com/inplasy-2025-2-0008/.…”
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STRUCTURAL AND FUNCTIONAL STATE OF THE MYOCARDIUM AND SYSTEMIC INFLAMMATION ACTIVITY IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE PRESENCE OF ARTERIAL H... by Rostyslav Kovalchuk, Uliana Bahan

“…The research aims to identify the features of the structural and functional state of the myocardium and manifestations of systemic inflammation in patients with acute ST-elevation myocardial infarction in the presence of such risk factors as arterial hypertension and COVID-19. Material and Methods. The study included 68 patients with STEMI aged 45 to 83 years (mean age 63,80±9,30 years) who underwent primary percutaneous coronary intervention with stenting of the infarcted coronary artery within 24 hours of the onset of clinical manifestations. …”
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Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping by Xiaoxi Zhu, Huiling Zheng, Xue Wan, Hang Duan, Ying Qi, Weijia Tang, Fan Yang, Fan Yang, Limei Yu, Limei Yu

“…Furthermore, it seeks to conduct an in-depth analysis of the genetic information within the breakpoint regions, thereby providing a more comprehensive scientific foundation for genetic counseling of RSA couples at both the cellular and genetic levels.Material and MethodsThis study involved the selection of nine subjects from two families who underwent genetic counseling at our hospital. …”
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Shear Strength Characteristics of Soft Soil in Nansha District of Guangzhou by WANG Wei-qi, LIAN Chang-jiang, LI Jian-ping, CHEN Zhi-yong, CHENG Dong-hai, CAI Wei-long, TANG Kai, LI Chao

“…Future research should focus on collecting additional soft soil test samples to obtain more definitive conclusions.…”
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Boosting Coercivity of 3D Printed Hard Magnets through Nano‐Modification of the Powder Feedstock by Philipp Gabriel, Varatharaja Nallathambi, Jianing Liu, Franziska Staab, Timileyin David Oyedeji, Yangyiwei Yang, Nick Hantke, Esmaeil Adabifiroozjaei, Oscar Recalde‐Benitez, Leopoldo Molina‐Luna, Ziyuan Rao, Baptiste Gault, Jan T. Sehrt, Franziska Scheibel, Konstantin Skokov, Bai‐Xiang Xu, Karsten Durst, Oliver Gutfleisch, Stephan Barcikowski, Anna Rosa Ziefuss

“…Additive manufacturing, particularly Powder Bed Fusion of metals using a laser beam (PBF‐LB/M), offers potential for near‐net‐shaped Nd‐Fe‐B permanent magnets but often falls short compared to conventional methods. A less explored strategy to enhance these magnets is feedstock modification with nanoparticles. …”
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Fast photostable expansion microscopy using QDots and deconvolution. by Loku Gunawardhana, Wilna Moree, Jiaming Guo, Camille Artur, Tasha Womack, Jason L Eriksen, David Mayerich

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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Methods Study design A three-arm randomised controlled trial (RCT) comparing two parenting interventions, ETPB and MB, with CAU only. …”
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Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results by Akansha Singh, Jessica Fernanda Affonso de Oliveira, Jessica Fernanda Affonso de Oliveira, Jessica Fernanda Affonso de Oliveira, Jessica Schrader, Deepan Kishore, Sri Vidhya Chandrasekar, Steven Fiering, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Ashish Ranjan

“…The study focused on their potential to induce local and systemic antitumor immune responses and achieve tumor control.MethodCPMV was obtained through the mechanical inoculation of Vigna unguiculata, while CRT-NP was generated using cationic liposomes loaded with a CRT-expressing plasmid. …”
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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas by Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding

“…In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.Methods We assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&amp;E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses. …”
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Downregulation of the p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation by Ester Ciociola, Tanmoy Dutta, Kavitha Sasidharan, Lohitesh Kovooru, Francesca R. Noto, Grazia Pennisi, Salvatore Petta, Angela Mirarchi, Samantha Maurotti, Bernardette Scopacasa, Luca Tirinato, Patrizio Candeloro, Marcus Henricsson, Daniel Lindén, Oveis Jamialahmadi, Arturo Pujia, Rosellina M. Mancina, Stefano Romeo

“…However, there are contrasting results regarding the mechanisms that promote this protection. Methods We downregulated MARC1 in primary human hepatocytes (PHHs) using short interfering RNA (siRNA). …”
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Assessing germline TP53 mutations in cancer patients: insights into Li-Fraumeni syndrome and genetic testing guidelines by Anastasiia Danishevich, Daria Fedorova, Natalia Bodunova, Maria Makarova, Maria Byakhova, Anna Semenova, Vsevolod Galkin, Maria Litvinova, Sergey Nikolaev, Irina Efimova, Pavel Osinin, Tatyana Lisitsa, Anastasiya Khakhina, German Shipulin, Tatiana Nasedkina, Syuykum Shumilova, Oleg Gusev, Airat Bilyalov, Elena Shagimardanova, Leyla Shigapova, Marina Nemtsova, Olesya Sagaydak, Mary Woroncow, Saida Gadzhieva, Igor Khatkov

“…This study investigated the frequency and spectrum of TP53 pathogenic variants associated with Li-Fraumeni syndrome in a large cohort of mainly breast cancer patients from Russia. Methods The study analyzed 3,455 genomic DNA samples from cancer patients using next-generation sequencing panels and whole-genome sequencing. …”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…SLC27A3 expression level also increased in pazopanib-resistant 786-O cells (786-O-PR) with more LD accumulation compared to parental cells. …”
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Foraminiferal morphogroups of the Early–Middle Cretaceous succession in northeastern Rafsanjan and their significance as palaeoenvironmental bioindicators by Tayebeh Ahmadi

“…In this study, foraminifera fossils in the Earlt to Middle Cretaceous marine carbonate succession of northeastern Rafsanjan were analyzed to interpreting palaeoenvironmental conditions. Material & MethodsA total of 65 benthic and planktonic foraminiferal genera were extracted from the 100 limestone samples in the Gezeresh section, 40 km northeastern Rafsanjan city, Kerman Province, Iran. …”
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Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia by Bingxin Zhang, Shuxia Zhu, Dong Zheng, Xinyi Zhang, Wenxia Xie, Shujuan Zhou, Sisi Zheng, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Zixing Chen, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma

“…However, the relationship between cuproptosis and acute lymphoblastic leukemia (ALL) remains to be further elaborated. Methods In ALL, 12 cuproptosis-related genes (CRGs) were analyzed at genetic and single-cell levels. …”
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