Participatory approaches for developing a practical handbook integrating health information for supporting individuals with mild cognitive impairment and their families by Yujiro Kuroda, Aya Goto, Taiki Sugimoto, Kosuke Fujita, Kazuaki Uchida, Nanae Matsumoto, Hiroyuki Shimada, Rei Ohtsuka, Minoru Yamada, Yoshinori Fujiwara, Aya Seike, Madoka Hattori, Gabin Ito, Hidenori Arai, Takashi Sakurai

“…This article provides a comprehensive record of the development process. Methods We adopted a participatory research model for the methodology, which comprised five phases and involved an interdisciplinary team specializing in dementia and health literacy. …”
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Aberrant overexpression of m6A writer and reader genes in pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL) by Sumedha Saluja, Shuvadeep Ganguly, Jay Singh, Ayushi Jain, Gunjan Sharma, Shilpi Chaudhary, Karthikeyan Pethusamy, Parthaprasad Chattopadhyay, Anita Chopra, Archna Singh, Subhradip Karmakar, Sameer Bakhshi, Jayanth Kumar Palanichamy

“…Background: m6A modification, regulated by writers (METTL3, METTL14), erasers (ALKBH5, FTO), and readers (IGF2BPs), is implicated in various cancers, including leukemias. Methods: In our study, we examined a cohort of 227 pediatric B-ALL patients (152 primary and 75 relapsed) and assessed the expression profiles of m6A machinery genes, including both writers and erasers, as well as the IGF2BP RNA-binding proteins, which are known as m6A readers. …”
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Porphyromonas gingivalis association with inflammatory markers and exosomal miRNA-155 in saliva of periodontitis patients with and without diabetes diagnosed with COVID-19 by Boy M. Bachtiar, Endang W. Bachtiar, Ardiana Kusumaningrum, Hari Sunarto, Yuniarti Soeroso, Benso Sulijaya, Efa Apriyanti, Citra Fragrantia Theodorea, Irandi Putra Pratomo, Yudhistira, Defi Efendi

“…The study aimed to address whether the abundance of Porphyromonas gingivalis which causes periodontitis, differed compared with that of Aggregatibacter actinomycetemcomitans (used as control) and to analyze the correlation of periodontitis with the expression levels of severe acute respiratory syndrome coronavirus 2 receptor (ACE2) and periodontitis inflammatory markers (TLR-2/TLR-4, TNFα, and miR-155). Materials and Methods: A saliva sample (5 mL) was obtained from 23 hospitalized patients with COVID-19, categorized into two groups: diabetic (G1, n = 10) and non-diabetic (G2, n = 13). …”
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Association of plasma metabolites with treatment response after intravitreal anti-vascular endothelial growth factor injections in treatment-naïve neovascular age-related macular d... by Inês Laíns, Deeba Husain, Joan W Miller, Ivana K Kim, John B Miller, Demetrios G Vavvas, Raviv Katz, Liming Liang, Jessica Lasky-Su, Archana Nigalye, Kevin M Mendez, David Wu, Hanna Choi, Augustine Bannerman, Hae Min Kang, Krupa Sourirajan, Roshni Bhat, Georgiy Kozak, Rodrigo A Alvarez

“…Background/aims To investigate the association between plasma metabolomic profiles and treatment response after intravitreal anti-vascular endothelial growth factor (VEGF) injections in treatment-naïve neovascular age-related macular degeneration (nAMD).Methods This is part of a prospective longitudinal study that included patients with treatment-naïve nAMD who have undergone three loading intravitreal anti-VEGF injections. …”
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Adaptive cohort design and LAT1 expression scale: study protocol for a Phase 2a trial of QBS72S in breast cancer brain metastases by Rukayat Taiwo, Paul M. Harary, Thy T. H. Trinh, Monica Granucci, Sophie Bertrand, Brandon Carlson-Clarke, Sophia B. Chernikova, Kate Therkelsen, Mili Arora, Michelle E. Melisko, Michael Iv, Hannes Vogel, Summer Han, Christine Xie, Susie Brain, Vivian Lee, Krishna L. Bharani, Seema Nagpal, Melanie Hayden Gephart

“…Our exploratory endpoints may facilitate identification of more rapid and reliable biomarkers of LMD treatment response and resistance. …”
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The impact of a school-based physical activity program on children's movement behaviors, aerobic fitness and motor competence: a follow up study by Moreno Bloch, Rita Cordovil, Rita Cordovil, Luís P. Rodrigues, Luís P. Rodrigues, Clarice Martins, Maria L. Braga, Susana Vale, Susana Vale, Rui Proença, João Brito, João Brito, José Guilherme, José Guilherme, Carlos Neto, André Seabra, André Seabra, Júlio A. Costa

“…Due to school changes and parental noncompliance, the sample decreased from 38 to 23 participants (EG; n = 13; CG; n = 10), a 39% dropout rate.ResultsOne year post-intervention, the EG spent more time in moderate-to-vigorous PA (MVPA; + 41 min/day), less time in SED (−234 min/day), slept longer (+103 min/night), covered greater distances in the YYIR1C (+174 m), and achieved higher MC scores (+19% on the MCA battery test) compared to the CG. …”
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Spatial distribution of Culex mosquitoes across England and Wales, July 2023 by Emma Widlake, Roksana Wilson, Jack Pilgrim, Alexander G. C. Vaux, Jolanta Tanianis-Hughes, Amirah Haziqah-Rashid, Ken Sherlock, Agata Delnicka, Amelia Simpson, Anthony J. Abbott, Colin J. Johnston, Jude Martin, Kendall Barlow, Eloise Aliski, Saffron Shiels, Sara Gandy, Sarah M. Biddlecombe, Joanna de Klerk, Luigi Sedda, Jolyon M. Medlock, Matthew Baylis, Marcus S. C. Blagrove

“…Here, we describe a comprehensive nationwide field surveillance study conducted during July 2023 to map the distribution of the WNV and USUV competent vectors: Culex pipiens biotype pipiens, Culex pipiens biotype molestus and Culex torrentium, across England and Wales. Methods Mosquitoes were sampled for 3 trap nights (3TN) at 200 sites in rural, urban and suburban settings, selected using a lattice plus close pairs surveillance design. …”
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Microbial community structure and resistome dynamics on elevator buttons in response to surface disinfection practices by Shanshan Ye, Shanshan Ye, Shifu Peng, Xiaolei Wang, Xiaolei Wang, Jingjing Fan, Jingjing Fan, Chenxue Zhu, Liye Huang, Ying Huang, Keping Cheng, Tingting Ni, Yuqing Qian, Xiaosong Wu, Xiaosong Wu, Xiaosong Wu, Xiaosong Wu, Yan Xu, Yan Xu, Yan Xu, Yan Xu

“…Both α-diversity (within-sample diversity) and β-diversity (between-sample diversity) were lower and more distinct in quarantine hotels compared to the other environments. …”
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Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona by Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, José Pumarega, José Pumarega, José Pumarega, Ruth Aguilar, Ruth Aguilar, David Prieto-Merino, Laura Campi, Laura Campi, Cristina Rius, Cristina Rius, Cristina Rius, Judit Villar-García, Marta Vidal, Marta Vidal, Marta Vidal, Alfons Jimenez, Alfons Jimenez, Alfons Jimenez, Antonio Peña, Miguel-Ángel Muñoz, Miguel-Ángel Muñoz, Leonardo Trasande, Leonardo Trasande, Leonardo Trasande, Francisco Bolúmar, Francisco Bolúmar, Gemma Moncunill, Gemma Moncunill, Gemma Moncunill, Magda Gasull, Magda Gasull, Magda Gasull, Carlota Dobaño, Carlota Dobaño, Carlota Dobaño

“…BackgroundFrom a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-2 infection and COVID-19.ObjectiveTo investigate the specific and combined effects of personal levels of cytokines and immunoglobulins—measured in individuals’ blood 4 years before the pandemic—on the risk of SARS-CoV-2 infection and COVID-19 in a general population.MethodsWe conducted a prospective cohort study in 240 individuals from the general population of Barcelona. …”
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5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target by Nuo Xu, Zhaoya Gao, Deyan Wu, Hangyu Chen, Zijian Zhang, Lei Zhang, Yuchen Wang, Xuyang Lu, Xu Yao, Xuelan Liu, Yi‐You Huang, Meiying Qiu, Sen Wang, Jinqiang Liang, Can Mao, Feng Zhang, Huimin Xu, Yujiao Wang, Xian Li, Zhexin Chen, Dandan Huang, Jingyi Shi, Wensheng Huang, Fuming Lei, Zeruo Yang, Long Chen, Chuan He, Haichuan Zhu, Hai‐Bin Luo, Jin Gu, Jian Lin

“…Based on 5hmC‐Seal analysis of blood and tissue samples, this study found that portal venous blood was more relevant to tumour gDNA than peripheral blood. …”
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Proteolytic Activity Inhibition in Gingival Fluid by Cysteine Protease Inhibitors Obtained from Egg White and <i>Fallopia japonica</i> Extract: An In Vitro Study by Maciej Siewiński, Maciej Dobrzyński, Krzysztof Gołąb, Maciej Janeczek, Łukasz Nieradko, Barbara Bażanów, Andrzej Rapak, Marius Boariu, Stefan-Ioan Stratul, Alla Belova, Sorina Mihaela Solomon, Renata Samulak, Monika Machoy

“…This research has the following aims: 1. to analyze in vitro the inhibition of cysteine protease activity in the gingival crevicular fluid (GCF) and 2. to compare the toxicity of natural raw inhibitors (obtained from <i>Fallopia japonica</i> plant and egg white) with chlorhexidine (CHX) using an MTS viability test. <b>Methods</b>: Samples of GCF were collected from healthy (N = 17) individuals and (N = 65) periodontal patients. …”
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Molecular analysis of influenza A(H3N2) in a remote tropical island during 2014-2019 to identify the frequency of introduction and local circulation by Sikandar Azam, Takeaki Imamura, Michiko Okamoto, Yusuke Sayama, Mayuko Saito, Mariko Saito-Obata, Clyde Dapat, Raita Tamaki, Christina Dahlia Joboco, Joanna Ina Manalo, Samantha Louise Bado, Joanne De Jesus Cornejo, Socorro Lupisan, Marianette Inobaya, Veronica Tallo, Beatriz P Quiambao, Hitoshi Oshitani

“…By conducting molecular analysis, this study aimed to identify A(H3N2) introduction events and the duration of local circulation in a geographically remote tropical island. Methods: Nasopharyngeal/nasal samples were collected from symptomatic children under 5 years old in a remote tropical island of the Philippines between 2014 and 2019. …”
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Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital by Minh Ngoc Nguyen, Beryl Primrose Gladstone, Giulia De Angelis, Michael Biggel, Basil Britto Xavier, Christine Lammens, Qiang Lin, Sandra Van Puyvelde, Herman Goossens, Samir Kumar-Singh, Youri Glupczynski, Yehuda Carmeli, Evelina Tacconelli, Surbhi Malhotra-Kumar, the SATURN WP1, 4, 5 study groups

“…PA- and HA-ESBL patients developed significantly more ESBL-E infections than ESBL-free patients (P < 0.001). …”
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A comparative study of blood pressure submission between mobilec app users and non-users in Romania: a pilot cohort study by Liviu Ionut Serbanoiu, Liviu Ionut Serbanoiu, Stefan Sebastian Busnatu, Stefan Sebastian Busnatu, Andreea Elena Lacraru, Andreea Elena Lacraru, Maria Alexandra Pana, Maria Alexandra Pana, Suzana Guberna, Suzana Guberna, Dragos Trache, Dragos Trache, Plesu Elena, Plesu Elena, Catalina Liliana Andrei, Catalina Liliana Andrei, Crina Sinescu, Crina Sinescu

“…With the growing availability of eHealth solutions, this study aimed to evaluate the user experience and engagement of individuals with and without CVD in using telemonitoring technology.MethodsA prospective cohort study was conducted involving 24 participants who used a smartwatch application for telemonitoring. …”
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Evaluating the Efficacy of Gelatin-Chitosan-Tetraethyl Orthosilicate Calcium Hydroxide Composite as a Dental Pulp Medicament on  COX-2, PGP 9.5, TNF-α Expression and Neutrophil num... by Yulita Kristanti, Mh Busra Fauzi, Bidhari Pidhatika, Iwa Sutardjo Rus Sudarso, Retno Ardhani, Al-qatta Ghadah Abdulrahman, Endytiastuti Endytiastuti, Heni Susilowati, Juni Handajani

“…Alternative materials have been developed to provide more biocompatible materials with better dentin formation ability. …”
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Usability testing of EatsUp®: mobile application for monitoring balanced dietary practices and active lifestyle among adolescents—a study in Jakarta, Indonesia by Erfi Prafiantini, Erfi Prafiantini, Erfi Prafiantini, Rina Agustina, Rina Agustina, Betty Purwandari, Dian Novita Chandra, Dian Novita Chandra, Dini Rahma Bintari, Fellatinnisa Zafira Rajwadini, Jihan Farhanah, Aryono Hendarto

“…Usability testing is essential to ensure mobile app features align with adolescent preferences and promote sustained behavior change.MethodsWe conducted an experimental usability study from June to August 2024 in Jakarta, Indonesia targeting adolescents aged 15–18 who used the EatsUp® mobile application. …”
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Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet by Jian Ma, Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian, Xuemei Lian

“…In CYP27A1(−/−) mice, hepatic lipid accumulation was more severe with further suppression of ABCA1, whereas ABCA1 expression in the lung remained elevated. …”
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Meditation for subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials by Jiaxin Shi, Hao Tian, Jingwen Wei, Wenhan Xu, Qin Luo, Jin Peng, Jun Xia, Wenying Huai, Ying Xiong, Yunhui Chen

“…This meta-analysis aimed to systematically evaluate its effectiveness on this population.MethodsA comprehensive search across nine databases was performed from inception to April 1, 2024, to identify eligible randomized controlled trials (RCTs). …”
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Changes in Alcohol Consumption During and After the Covid-19 Pandemic From 2020 to 2023 in a Prospective Cohort of Italian Adults by Sonia Cerrai, Giulia Carreras, Filippo Monti, Chiara Stival, Alessandra Lugo, Cristina Bosetti, Silvia Biagioni, Tiziana Fanucchi, Giuseppe Gorini, Andrea Amerio, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Sabrina Molinaro, Luc Smits, Silvano Gallus, the “Lost in Italy” and “Lost in Toscana” Study Investigators

“…Background: The lockdowns imposed by the government during coronavirus disease 2019 (COVID-19) pandemic have had a significant impact on the Italian population habits. Methods: LOckdown and lifeSTyles in Italy and in Tuscany studies collected data on a representative sample of the Italian adult population in 2020 (n = 6,003) followed up through 2023 via four additional surveys (3,000 ≤ n ≤ 6,600) through an online self-administered questionnaire. …”
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First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers by Aurélien Marabelle, Aung Naing, Funda Meric-Bernstam, Xingfeng Bao, Andrea Varga, David S Hong, Aparna Parikh, Geoffrey I Shapiro, Özlem Ataman, Larisa Reyderman, Terri A Binder, Min Ren, Mingjie Liu, Satish Dayal, Amy Y Siu, Pallavi Sachdev, Lucy Xu, Vijay Bhagawati-Prasad, Ilian Tchakov, Chean Eng Ooi

“…This first-in-human phase 1 study assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD) and recommended phase 2 dose of E7046.Methods This first-in-human study enrolled 30 patients with advanced tumors of cancer types associated with high levels of myeloid infiltrates. …”
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