Molecular investigation on measles cases rise and variants co-circulation in the Lazio region, Italy by Cesare Ernesto Maria Gruber, Silvia Gioacchini, Lavinia Fabeni, Martina Rueca, Licia Bordi, Eleonora Lalle, Melissa Baggieri, Paola Bucci, Raoul Fioravanti, Roberto Giuseppetti, Eliana Specchiarello, Pietro Giorgio Spezia, Giulia Berno, Fabrizio Carletti, Gabriella De Carli, Maria Concetta Fusco, Alessandra Barca, Paola Scognamiglio, Antonella Marchi, Emilio D’Ugo, Enrico Girardi, Francesco Vairo, Fabio Magurano, Fabrizio Maggi

“…We analyzed the first cases of measles reported in Lazio (Central Italy) from September 2023 to March 2024, combining molecular characterization and phylogenetic analysis with epidemiological investigation to identify transmission chains and evaluate the sensitivity of PCR tests adopted on circulating viral strains. Methods We tested samples collected through routine measles and rubella surveillance for IgM, IgG and Real-Time PCR. …”
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Sustained Impact of an Intramural Faculty Leadership Training Program at an Academic Medical Center by Nahata L, Gerhardt CA, Way DP, Nikahd M, Mehta LS, Etzkorn LK, Satiani B, Guertin M, Martin DR

“…School of Medicine, Kalamazoo, MI, USA; 7Department of Surgery at The Ohio State University College of Medicine, Columbus, OH, USA; 8Department of Anesthesiology at The Ohio State University College of Medicine, Columbus, OH, USACorrespondence: Daniel R Martin, Department of Emergency Medicine at The Ohio State University College of Medicine, 760 Prior Hall, 376 West 10th Avenue, Columbus, OH, 43210, USA, Tel +1 614 531 1322, Fax +1 614 293 3124, Email Daniel.Martin@osumc.eduPurpose: To examine the sustained impact of a faculty leadership program at an academic health center (AHC) on participants’ perceived effectiveness in leadership skills and leadership attainment compared to faculty controls.Methods: The sample included 95 faculty members who participated in the year-long Faculty Leadership Institute (FLI). …”
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Metabolomics in drugs research on zebrafish-based cardiotoxicity models: endothelial and mitochondrial dysfunction, oxidative stress by N. E. Moskaleva, P. M. Rezvanov, V. M. Samoylov, V. G. Varzieva, S. N. Baskhanova, V. V. Tarasov, E. A. Smolyarchuk, D. A. Kudlay, S. A. Appolonova

“…The analysis is aimed at detecting changes in the level of amino acids (including branched chain BCAAs), products of carnitine metabolism (acylcarnitines) and related metabolic indices reflecting mitochondrial dysfunction, oxidative stress and disorders of the nitric oxide signaling pathway. Materials and methods. Zebrafish embryos were incubated with the test substances in a concentration gradient (0.5–10×NOEC). …”
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Mental disorders and intimate partner violence perpetrated by men towards women: A Swedish population-based longitudinal study. by Rongqin Yu, Alejo J Nevado-Holgado, Yasmina Molero, Brian M D'Onofrio, Henrik Larsson, Louise M Howard, Seena Fazel

“…<h4>Methods and findings</h4>Using Swedish nationwide registries, we identified men from 9 diagnostic groups over 1998-2013, with sample sizes ranging from 9,529 with autism to 88,182 with depressive disorder. …”
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Estimated effect of media use on mothers’ vaccination of their children in Sub-Saharan Africa: a quasi-experimental propensity score matching analysis using DHS data by Melak Jejaw, Kaleb Assegid Demissie, Getachew Teshale, Demiss Mulatu Geberu, Misganaw Guadie Tiruneh, Asebe Hagos, Nigusu Worku, Endalkachew Dellie, Tesfahun Zemene Tafere

“…Thus, this study used the propensity score matching (PSM) analysis to estimate the effect of media exposure on childhood vaccinations. Methods We used nationally representative demography and health survey data collected from 2019 to 2024 among 23,194 children aged 12-23 months in SSA countries. …”
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A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial by Ryan A Mace, Makenna E Law, Joshua E Cohen, Christine S Ritchie, Olivia I Okereke, Bettina B Hoeppner, Judson A Brewer, Stephen J Bartels, Ana-Maria Vranceanu

“…ConclusionsThe RCT will inform the development of a larger efficacy RCT (NIH stage 2) of MHB versus the HEP in a more diverse sample of older adults, testing mechanisms of improvements through theoretically driven mediators and moderators. …”
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METTL14 mediates the m6A methylation of miR-29a-3p, thereby activating the MAP2K6 signaling pathway and exacerbating the inflammatory response associated with spinal tuberculosis by Lijun Feng, Mengqi Zhu, Xu Zhang, Ningkui Niu, Zhiyun Shi

“…Objective This study aimed to validate the expression levels of METTL14 and miR-29a-3p in spinal tuberculosis and explore the regulatory role of METTL14 in mediating miR-29a-3p via the MAP2K6 signaling pathway during spinal tuberculosis-associated inflammation. Methods Twenty cases of peripheral blood samples from patients with spinal tuberculosis and normal individuals were collected respectively. …”
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Classifying the Information Needs of Survivors of Domestic Violence in Online Health Communities Using Large Language Models: Prediction Model Development and Evaluation Study by Shaowei Guan, Vivian Hui, Gregor Stiglic, Rose Eva Constantino, Young Ji Lee, Arkers Kwan Ching Wong

“…When suboptimal results were observed, we generated additional samples of the misclassified ones to give them more attention. …”
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Assessment of the effectiveness and safety of fixed-dose combination of alogliptin and pioglitazone in real clinical practice: results of the PROsperity study by M. V. Shestakova, M. I. Kharakhulakh, Y. A. Belolipetsky

“…To evaluate the therapeutic efficacy and safety of the new fixed-dose combination of alogliptin and pioglitazone, in patients with type 2 diabetes mellitus, in real-world clinical practice.MATERIALS AND METHODS. A multicenter, observational, non-interventional, prospective study of the only fixed-dose combination of alogliptin and pioglitazone, available under the brand name «Incresync», was conducted in the Russian Federation. …”
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Effect of Nickel Content and Cooling Rate on the Microstructure of as Cast 316 Stainless Steels by Lei Chen, Yang Wang, Yafeng Li, Zhengrui Zhang, Zhixuan Xue, Xinyu Ban, Chaohui Hu, Haixiao Li, Jun Tian, Wangzhong Mu, Kun Yang, Chao Chen

“…The austenite-forming element nickel of three different industrial samples is 10%, 12%, and 14%, respectively. The effect of the cooling rate on the ferrite content and precipitation phases of the high Ni content of the 316 stainless steel casting (H-316) is studied by remelting experiments and different methods of quenching of liquid steel. …”
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Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker by Jason-Alexander Hörauf, Amit Singh, Maika Voth, Hamed Moheimani, Cora Rebecca Schindler, Borna Relja, Liudmila Leppik, Ingo Marzi, Dirk Henrich

“…This study investigates whether specific liver-related microRNAs (miRNAs) are released into the circulation in trauma patients with liver injury and whether they can indicate liver damage in the early phase after major trauma. <b>Methods</b>: A retrospective analysis of prospectively collected data and blood samples from 26 trauma patients was conducted. …”
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The role of CPAP as a potential bridge to invasive ventilation and as a ceiling-of-care for patients hospitalized with Covid-19-An observational study. by Jonathan Walker, Shaman Dolly, Liji Ng, Melissa Prior-Ong, Kalpana Sabapathy

“…Patients receiving a ceiling of care more than 24 hours after admission (N = 6) were excluded from the analysis. …”
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Genetic surveillance shows spread of ACT resistance during period of malaria decline in Vietnam (2018-2020) by Johanna Helena Kattenberg, Mathijs Mutsaers, Van Hong Nguyen, Thi Hong Ngoc Nguyen, Arlette Umugwaneza, Maria Lara-Escandell, Xuan Xa Nguyen, Thi Huong Binh Nguyen, Anna Rosanas-Urgell

“…IntroductionVietnam’s goal to eliminate malaria by 2030 is challenged by the further spread of drug-resistant Plasmodium falciparum malaria to key antimalarials, particularly dihydroartemisinin-piperaquine (DHA-PPQ).MethodsThe custom targeted NGS amplicon sequencing assay, AmpliSeq Pf Vietnam v2, targeting drug resistance, population genetic- and other markers, was applied to detect genetic diversity and resistance profiles in samples from 8 provinces in Vietnam (n = 354), in a period of steep decline of incidence (2018–2020). …”
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Impact of prenatal triclosan exposure on ADHD-like symptoms in school-aged children by Jingjing LI, Xiaomeng CHENG, Yan ZHANG, Luanluan LI, Xiaodan YU, Ying TIAN, Yu GAO

“…Nevertheless, relevant research in China remains limited.ObjectiveTo investigate the impact of early pregnancy TCS exposure on ADHD-like symptoms in 7-year-old children.MethodsThis study was based on the Shanghai Birth Cohort (SBC) and included 662 mother-child pairs. …”
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Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors by Juan Chen, Jun-yan Liu, Fan Yang, Ting Zou, Zhan Wang, Jia-Si Liu, Lei She, Xiang-Ping Li, Zhaoqian Liu

“…This study aims to explore the potential metabolic biomarkers to predict risk of irAEs and to investigate the association of plasma metabolites level with survival in patients with lung cancer receiving PD-1/PD-L1 inhibitor treatment.Methods The study collected 170 plasmas of 85 patients with lung cancer who received immune checkpoint inhibitors (ICIs) treatment. 58 plasma samples of 29 patients with irAEs were collected before ICIs treatment and at the onset of irAEs. 112 plasma samples of 56 patients who did not develop irAEs were collected before ICIs treatment and plasma matched by treatment cycles to onset of irAEs patients. …”
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Pornography-Watching Disorder and Its Risk Factors Among Young Adults: Cross-Sectional Survey by Csaba Erdős, Oguz Kelemen, Dávid Pócs, Edit Paulik, András Papp, Edina Horváth, Arbel Golan, Krisztián Széll

“…It also aimed to advance the understanding of PWD as a potential behavioral addiction. MethodsA cross-sectional web-based survey was conducted between September and December 2018, targeting young adults aged 18-35 years in Hungary. …”
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Mortality, ethnicity, and country of birth on a national scale, 2001-2013: A retrospective cohort (Scottish Health and Ethnicity Linkage Study). by Raj S Bhopal, Laurence Gruer, Genevieve Cezard, Anne Douglas, Markus F C Steiner, Andrew Millard, Duncan Buchanan, S Vittal Katikireddi, Aziz Sheikh

“…We hypothesized at least 10% differences in mortality by ethnic group in Scotland that would not be wholly attenuated by adjustment for socio-economic factors or country of birth.<h4>Methods and findings</h4>We linked the Scottish 2001 Census to mortality data (2001-2013) in 4.62 million people (91% of estimated population), calculating age-adjusted mortality rate ratios (RRs; multiplied by 100 as percentages) with 95% confidence intervals (CIs) for 13 ethnic groups, with the White Scottish group as reference (ethnic group classification follows the Scottish 2001 Census). …”
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Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation by Dun Li, Jing Lin, Hongxi Yang, Lihui Zhou, Yujian Li, Zhe Xu, Li Sun, Xinyu Zhang, Weili Xu, Yaogang Wang

“…However, the causal associations of modifiable factors with CMDs and CMM remains to be systematically investigated. Methods In this study, a three-stage design Mendelian randomization (MR) investigation was conducted, using two-sample MR with potential sample overlap correction and multiple testing, multivariable MR analysis, and multi-response MR, with modifiable factors covering domains of socioeconomic factors, behavioral factors, biochemical factors, and physical measures as exposures, and CMM and CMDs as outcomes. …”
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Transcriptomic and histological characteristics of innate immune activation in brain parenchyma in a rat model of neonatal intraventricular hemorrhage by Miriam Zamorano, Sanjna Udtha, Aidan M. Collier, Erica Underwood, Razan El Sayed, Ankit Agarwal, Devin S. Hatchell, Chunfeng Tan, Paul J. Nietert, Scott D. Olson, Brandon A. Miller

“…We previously reported that the innate neuroimmune response in an animal model of IVH was dependent on developmental stage, only occurring in older animals. Methods This study utilized a lysed-blood injection model of IVH in rats. …”
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Community burden of Respiratory Viruses infections during influenza seasons from 2016/2017 to 2023/2024, Apulia region (Southern Italy) by Dr Alfredo Marziani, Dr Valentina Annachiara Orlando, Dr Francesca Centrone, Dr Anna Sallustio, Dr Daniele Casulli, Dr. Daniela Loconsole, Prof. Maria Chironna

“…According to other studies, RVs were more likely to be detected in the under-5 age group. …”
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