Minimally invasive differential diagnosis of melanocytic intraocular neoplasms by A. Yu. Tsygankov, S. V. Saakyan, E. B. Myakoshina, A. M. Burdennyi, V. I. Loginov

“…Purpose: to analyze the mutation frequency of the GNAQ/GNA11 gene in circulating tumor DNA and genotypes of the polymorphic marker C3435T of the ABCB1 gene in a large sample of patients with intraocular melanocytic neoplasms (IMN).Material and methods. …”
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Potential liquid biopsy markers of exosomal microRNAs in renal interstitial fibrosis blood and urine by Chunyan Lv, Yuan Zhong, Yao Hu, Yan Tang

“…Materials and Methods: High-throughput miRNA sequencing was performed on blood and urine exo-miRNAs from three RIF patients and three healthy volunteers, and differential expression analysis and bioinformatic processing were performed. …”
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Dry needling as an adjunct treatment to multimodal rehabilitation protocol following rotator cuff repair surgery: a preliminary, randomized sham-controlled trial by Faeze Naseri, Mehdi Dadgoo, Mohammadreza Pourahmadi, Morteza Nakhaei Amroodi, Shirin Azizi, Amirhossein Shamsi

“…Future studies should consider different control groups, long-term follow ups, larger sample sizes, and more MTrP-DN sessions to better understand their potential impact. …”
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PO86 | Emicizumab in patients with moderate hemophilia A and severe bleeding phenotype: single-center real-world experience

“…In the subgroup of patients with moderate HA and severe bleeding phenotype, a significant reduction of the bleeding rate was observed, leading to the approval of emicizumab prophylaxis in this setting. Methods: Herein, we report the cases of 3 patients with moderate HA and severe hemorrhagic phenotype, treated with emicizumab prophylaxis and followed at our institution. …”
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Analysis of Palatal Rugae Pattern in Angle’s Classification of Malocclusion using Dental Casts in Chengalpattu District, Southern India: A Cross-sectional Study by Kashish Kariya, KT Magesh, Ramya Mahalingam, M Sathya Kumar, R Aravindhan, A Sivachandran, R Swaathi

“…Aim: To investigate potential correlations between Angle’s classification of malocclusion and the palatal rugae pattern. Materials and Methods: A cross-sectional observational study was conducted in the Department of Oral and Maxillofacial Pathology at SRM Kattankulathur Dental College and Hospital, Chengalpattu, Tamil Nadu, India. …”
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CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model by Shih-Hsuan Chan, Chin-Yu Lin, Hsuan-Jung Tseng, Lu-Hai Wang

“…Here, we investigated the role of CD24a, the murine CD24 gene, in tumor progression and TME immune dynamics in a murine triple-negative breast cancer (TNBC) model. Methods Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 knockout technology was employed to generate CD24a knockout in the murine TNBC cell line 4T1. …”
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Assessment of specific T-cell immunity in patients who have been ill and vaccinated against COVID-19 by T. A. Platonova, M. S. Sklyar, A. A. Golubkova, T. A. Semenenko, E. A. Karbovnichaya, M. A. Chernyshev, A. V. Vorobyov, S. S. Smirnova

“…However, most studies are currently devoted to evaluating only the humoral link of immunity, and its cellular component remains insufficiently studied.The aim of the study was to evaluate the features of the formation and changes of the T-cell link of immunity in patients with a new coronavirus infection and vaccinated against this disease.Materials and methods. The study was performed on the basis of the clinical and diagnostic laboratory of the European Medical Center “UMMC-Health “LLC. …”
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The mediating role of daily living ability and sleep in depression and cognitive function based on a structural equation model by Liu Huijun, Zhang Xiange, Yang Ming, Sun Jiayi, Peng Juanjuan, Xu Wangquan, Song Yueli, Fang Guixia

“…It extends upon existing research and provides evidence for new areas of intervention that may ameliorate and delay cognitive decline in the elderly. Methods Data were collected from a representative sample of 5,470 (aged 60 years and above) in Anhui Province from the 2019 Anhui Health and Life Expectancy Survey(AHLS). …”
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Integrated analysis of single-cell, spatial and bulk RNA-sequencing identifies a cell-death signature for predicting the outcomes of head and neck cancer by Yue Pan, Lei Fei, Shihua Wang, Hua Chen, Changqing Jiang, Hong Li, Changsong Wang, Yao Yang, Qinggao Zhang, Yongwen Chen

“…BackgroundCell death plays an essential role in carcinogenesis, but its function in the recurrence and postoperative prognosis of head and neck cancer (HNC), which ranks as the 7th most common malignancy globally, remains unclear.MethodsData from five main subtypes of HNC related single-cell RNA sequencing (scRNA-seq) were recruited to establish a single-cell atlas, and the distribution of cell death models (CDMs) across different tissues as well as cell subtypes were analyzed. …”
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Dementia Moves: protocol for a feasibility study testing a physical rehabilitation program for long-term care residents with moderate to severe dementia by Caitlin McArthur, Niousha Alizadehsaravi, Rebecca Affoo, Karen Cooke, Natalie F. Douglas, Marie Earl, Melanie K. Farlie, Trudy Flynn, Parisa Ghanouni, Susan W. Hunter, Shannan M. Grant, Laura E. Middleton, Elaine Moody, Cheryl Smith, Linda Verlinden, Lori E. Weeks

“…Abstract Background Most long-term care (LTC) residents live with dementia and the proportion with more advanced cognitive impairment is increasing. …”
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Prevalence and risk factors for long COVID among cancer patients: a systematic review and meta-analysis by Hongkun Xu, Hongkun Xu, Tingting Lu, Yajie Liu, Jingqi Yang, Simeng Ren, Baojin Han, Honghao Lai, Long Ge, Jie Liu

“…This study aimed to determine the prevalence of long COVID and explore potential risk factors among cancer patients.MethodsA systematic search was performed on PubMed, Web of Science, and Embase from database inception until 21 March 2024, to identify studies that reported long COVID in cancer patients. …”
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What Matters Most to Veterans When Deciding to Use Technology for Health: Cross-Sectional Analysis of a National Survey by Bella Etingen, Bridget M Smith, Stephanie L Shimada, Stephanie A Robinson, Robin T Higashi, Ndindam Ndiwane, Kathleen L Frisbee, Jessica M Lipschitz, Eric Richardson, Dawn Irvin, Timothy P Hogan

“…ObjectiveThis study aimed to understand what matters most to US military veterans when deciding whether to use digital health technologies (DHTs) such as mobile health apps or devices to manage their health and compare these factors between veterans with and without prevalent chronic physical and mental health conditions. MethodsWe conducted a cross-sectional analysis of survey data collected from a national sample of veterans who receive care from the Veterans Health Administration (VHA), which was predominantly gathered as part of the last wave of a larger longitudinal data collection effort. …”
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Studying the pathogenic role of catecholamines in the development of retinopathy of prematurity on an experimental model of the disease by L. A. Katargina, N. A. Osipova, A. J. Panova, N. S. Bondarenko, Yu. O. Nikishina, A. R. Murtazina, M. V. Ugryumov

“…The isolated retinal samples were homogenized in 10 volumes of 0.1 n HClO4 containing 50 pmol/ml (or more) of 3,4-dihydroxybenzylamine (DBA), using an ultrasonic homogenizer (Labsonic M, Sartorius), centrifuged at 2000g for 20 minutes, and the norepinephrine, dopamine and precursor of dopamine — L-3,4 dihydroxyphenylalanine (L-DOPA) were determined in the resulting supernatant. …”
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Maintaining Resilience and Well-Being in the Era of Climate Change: Protocol of an Acceptability and Feasibility Pilot of the Bee Well Program for Treating Eco-Anxiety in Rural Chi... by Suzanne M Cosh, Warren Bartik, Rosie Ryan, Amanda Jefferys, Kaii Fallander, Phillip J Tully, Amy D Lykins

“…Those in rural areas are also more likely to be impacted by natural hazards, further underscoring the need to support this population. …”
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Seroprevalence of dengue virus infection among febrile patients visiting healthcare facilities in the selected districts of Afar region, Northeast Ethiopia by Biruk Zerfu, Tesfu Kassa, Gezahegne Mamo, James W. Larrick, Mengistu Legesse

“…This study assessed the seroprevalence of DENV infection among febrile patients in healthcare facilities in the Afar region. Methods A cross-sectional study was conducted from September 2022 to March 2023 in Amibara, Harunka and Awash Sebat city administration districts, involving febrile patients suspected of having malaria. …”
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Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes by Heli Segersvärd, Niina Sandholm, Valma Harjutsalo, Heidi Tikkanen, Riikka Kosonen, Mika Laine, Ilkka Tikkanen, Per-Henrik Groop, Päivi Lakkisto, the FinnDiane Study Group

“…We studied the association of HMOX1 polymorphisms and HO-1 serum concentrations with vascular complications and all-cause mortality in individuals with type 1 diabetes (T1D). Methods The study population consists of individuals with T1D participating in the Finnish Diabetic Nephropathy Study (FinnDiane). …”
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Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy by Nairong Ruan, Nairong Ruan, Ming Liang, Ming Liang, Yuehong Liu, Xi Mei, Chengying Zheng

“…We aimed to define amounts of cortical activation and to identify indicators of brain function to better distinguish between these types of dementia and aid diagnosis using functional near-infrared spectroscopy (fNIRS).MethodsOxygenated hemoglobin (HbO) concentrations in the brains of patients with AD and LBD were detected using fNIRS. …”
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Risk factors, management, and outcomes of amniotic fluid embolism: A multicountry, population-based cohort and nested case-control study. by Kathryn E Fitzpatrick, Thomas van den Akker, Kitty W M Bloemenkamp, Catherine Deneux-Tharaux, Alexandra Kristufkova, Zhuoyang Li, Timme P Schaap, Elizabeth A Sullivan, Derek Tuffnell, Marian Knight

“…This study aimed to pool data from multiple countries in order to describe risk factors, management, and outcomes of AFE and to explore the impact on the findings of considering United Kingdom, international, and United States AFE case definitions.<h4>Methods and findings</h4>A population-based cohort and nested case-control study was conducted using the International Network of Obstetric Survey Systems (INOSS). …”
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Predictors for regression and progression of actively surveilled cervical intraepithelial neoplasia grade 2: A prospective cohort study by Laura Bergqvist, Anni Virtanen, Ilkka Kalliala, Ralf Bützow, Maija Jakobsson, Annu Heinonen, Karolina Louvanto, Joakim Dillner, Pekka Nieminen, Karoliina Aro

“…Abstract Introduction To evaluate predicting clinical factors for regression and progression of cervical intraepithelial neoplasia (CIN) grade 2 (CIN2) in young women during two years of active surveillance. Material and Methods This was a single‐center prospective observational cohort study. …”
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Effect of Robot-Assisted Gait Training on Lower Limb Motor Function of Children with Cerebral Palsy： A Meta-Analysis by JIANG Xiaoyu, BI Hongyan, SUN Wenyu, LIU Huifen, SU Hang, JIANG Jiahui

“…Due to the limitations of the included studies, high-quality, multicenter and large sample size clinical RCTs are still needed in the further research to provide more reliable evidence.…”
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