Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study by Natalia Ortega, Nick J. Mueller, Abbas Dehghan, Tosca O. E. de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O. Chocano-Bedoya

“…We performed a one-sample Mendelian randomization using two-stage least-squares regression. …”
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Construction of a nomogram prediction model for the pathological complete response after neoadjuvant chemotherapy in breast cancer: a study based on ultrasound and clinicopathologi... by Pingjuan Ni, Yuan Li, Yu Wang, Xiuliang Wei, Wenhui Liu, Mei Wu, Lulu Zhang, Feixue Zhang

“…ObjectiveTo explore the application value of ultrasound in evaluating the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer and construct a nomogram prediction model for pathological complete response (pCR) following different cycles of NAC based on ultrasound and clinicopathological features, and further investigate the optimal prediction cycle.MethodsA total of 249 breast cancer patients who received NAC were recruited. …”
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Integrated peripheral blood multi-omics profiling identifies immune signatures predictive of neoadjuvant PD-1 blockade efficacy in head and neck squamous cell carcinoma by Hao Zhang, Wenjie Wu, Meng Wang, Jie Zhang, Chuanbin Guo, Guojun Han, Lin Wang

“…The aim of this study is to develop a predictive model for neoadjuvant PD-1 therapy response in HNSCC patients using exclusively liquid biopsy approaches-namely, peripheral blood immune profiling (CyTOF) and plasma cytokine panels (Olink). Methods In a prospective trial involving 50 HNSCC patients treated with neoadjuvant tislelizumab plus chemotherapy, peripheral blood samples were collected pre- and post-treatment. …”
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HIIT versus MICT in MASLD: mechanisms mediated by gut-liver axis crosstalk, mitochondrial dynamics remodeling, and adipokine signaling attenuation by Dongkun Deng, Lin Xu, Yufei Liu, Chang Li, Qingfeng Jiang, Jiaming Shi, Shuo Feng, Yunhua Lin

“…It is noteworthy that HIIT was more effective in improving mitochondrial function in MASLD than MICT (P < 0.001). …”
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Determinants of tetanus immunization among pregnant women where tetanus has not been eliminated: a multilevel analysis of 6 countries by Werkneh Melkie Tilahun, Habtamu Geremew, Lamrot Yohannes Abay, Adugnaw Bantie Kebie, Mulat Belay Simegn

“…BackgroundTwo or more doses of the tetanus toxoid (TT) vaccine in pregnancy afford the fetus passive immunity and reduce neonatal mortality by 96%. …”
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The mediating role of self-compassion in the relationship between childhood trauma and the symptoms of body dysmorphic disorder by Motahhareh Kargar Shooroki, Azadeh Choobforoushzadeh, Azra Mohammadpanah Ardakan

“…Specifically, cognitive distortions stemming from cognitive-behavioral patterns, coupled with diminished self-esteem and self-worth as conceptualized by attachment theory, are believed to contribute to lower self-compassion, subsequently leading to a higher incidence of BDD symptoms. Methods A cross-sectional design employing structural equation modeling (SEM) was utilized to construct an optimal model for BDD symptoms, where the mediating role of self-compassion was tested in the relationship between childhood trauma and BDD symptoms. …”
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Evaluating hepatitis B screening, prevalence, vaccination coverage, and linkage to care in Abuja, Nigeria: insights from a cross-sectional study by Ogechukwu MaryAnn Akabuike, Mabel Kamweli Aworh, Nkiruka Lynda Uzoebo, John Erwat, Onyinyechi Agukwe, Kingsley Ngong, Amos Dangana, Kenneth Enwerem, Idris Nasir Abdullahi

“…The study aimed to raise awareness of HBV, enroll participants for HBV screening, determine HBV prevalence across various communities, vaccinate negative cases and link positive cases to care. Methods A cross-sectional study was conducted in 16 districts of Abuja from April 2022 to March 2023. …”
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Faktor Risiko Asma Pada Murid Sekolah Dasar Usia 6-7 Tahun di Kota Padang by Afdal ., Finny Fitry Yani, Darfioes Basir, Rizanda Machmoed

“…If seeing the increased incidence of asthma, genetic factors might not play a role solely, but the environmental factors might play moreObjective The aim of this study was to determine the prevalence and the risk factors of asthma in elementary school children aged 6-7 years in Padang.Methods This research is cross sectional study in 20 elementary schools in Padang during June until November 2009, total sample of 879 students. …”
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The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study by Gustė Klimaitė, Arūnas Vasiliauskas, Pranas Grinkevičius, Dominyka Grinkevičienė, Deivydas Šapalas

“…The objectives of this study were to evaluate the effectiveness of nano-HA varnish and peptide P11-4 in restoring enamel surface hardness after artificial lesions in vitro and to compare them to a control group and fluoride varnish. <i>Materials and Methods:</i> Artificial enamel lesions were created on the buccal surfaces of 36 extracted human molars, which were randomly divided into four groups (<i>n</i> = 9): control, peptide P11-4, fluoride varnish, and nano-hydroxyapatite varnish. …”
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The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control study by Amjad Ahmadi, Leili Shokoohizadeh, Farshad Sheikhesmaili, Bahram Nikkhoo, Asadollah Mohammadi, Mohammadali Khan Mirzaei, Mohammad Yousef Alikhani, Rasoul Yousefimashouf

“…Therefore, the study aims to investigate the role of vitamin D in the pathogenesis and treatment of ulcerative colitis. Methods This case-control study included 94 participants who were divided into four groups. …”
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Molecular Detection and Clinical Impact of <i>Helicobacter pylori</i> Virulence Genes in Gastric Diseases: A Study in Arequipa, Peru by Yuma Ita-Balta, Alice Zegarra-Adanaque, Johany Sanchez-Guillen, Miguel Farfán-Delgado, Carlos Ortiz-Castro, Alexis Germán Murillo Carrasco, Alejandro Miranda Pinto, Cecilia Manrique-Sam

“…This study investigates the prevalence, distribution, and clinical relevance of its key virulence genes, <i>vacA</i> and <i>cagA</i>, in a Peruvian patient cohort. <b>Materials and Methods</b>: Fifty-one gastric biopsies were collected from patients with a presumptive diagnosis of <i>H. pylori</i>-induced gastritis at Hospital Carlos Alberto Seguín Escobedo in Arequipa, Peru, in March 2024. …”
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The influence of dietary choices: investigation of the relationship dietary inflammatory index and fetal growth restriction by Ayşe Gülçin Baştemur, İclal Sena Gezer, Burcu Kesikli, Atakan Tanaçan, Özgür Kara, Nuray Yazıhan, Dilek Şahin

“…The study aimed to investigate the correlation between maternal DII, total oxidant status (TOS), total antioxidant status (TAS), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) levels in FGR-diagnosed pregnant women. Methods This prospective-observational study included FGR-diagnosed pregnant women and healthy pregnant women with gestational ages of 32–38 weeks (n = 23 per group). …”
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Healthcare under fire: quantifying the impact of violence on medical services in facilities supported by International Medical Corps in three prefectures of Central African Republi... by Natalya Kostandova, Jennifer OKeeffe, Audrey Mahieu, Blaise Bienvenu Ali, Christian Mulamba, Pierre Somsé, Odilon Guesset Bingou IV, Sebastien Dackpa, Gerard Mbonimpa, Thierry Fikiri, Larissa Fast, Leonard Rubenstein

“…This study examined the impact of attacks on healthcare in three conflict-affected prefectures—Ouaka, Haute-Kotto, and Vakaga—between 2016 and 2020, assessing both immediate and longer-term disruptions. Methods Disruptions at primary and referral facilities were evaluated using program data from International Medical Corps (IMC) and attack data from IMC, key informants, secondary datasets, and local media. …”
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The Clinical Value of the Combined Detection of Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Prognostic Nutritional Index (PNI) in Ear... by Zheng J, Zheng L, Wang X, Mao X, Wang Q, Yang Y, Mo D

“…The study delves into novel hematological inflammatory markers, such as systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and prognostic nutritional index (PNI), to explore their potential applications in early diagnosis of GC.Methods: From October 2020 and August 2024, 1339 GC patients admitted to our hospital were enrolled in this study. …”
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Association of Adenotonsillectomy with Vaso-occlusive Crisis Frequency in Sickle Cell Patients of Eastern Saudi Arabia: A Retrospective Study by Moath Alfaleh, Omar Alanzi, Ali Alaskari, Mohammed Alzamil, Hussain Al-Baharna

“…Aim: To evaluate the relationship between adenotonsillectomy and VOC frequency in SCD patients who underwent adenotonsillectomy. Materials and Methods: A retrospective cohort study was conducted in the Otorhinolaryngology Department in Qatif Central Hospital, Qatif, Saudi Arabia, in June 2023. …”
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Preoperative Talocalcaneal Distance and Subtalar Fusion are Not Associated with Worse Patient-Reported Outcomes in Progressive Collapsing Foot Deformity by Grace DiGiovanni BS, Agnes Jones MS, Seif El Masry, Jonathan T. Deland MD, Scott J. Ellis MD, Matthew S. Conti MD

“…Category: Hindfoot; Other Introduction/Purpose: As progressive collapsing foot deformity (PCFD) advances, narrowing between the lateral talar process and calcaneus at the angle of Gissane often occurs. This signifies more advanced peri-talar subluxation and may result in sinus tarsi impingement. …”
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Study of TRAF3IP3 for prognosis and immune infiltration in hepatocellular carcinoma by Xing Wang, Xin Gao, Airu Liu, Yan Qin, Zhi-Yu Ni, Xiao Lan Zhang

“…We aimed to demonstrate the relationship between TRAF3IP3 and HCC and explore the potential role of TRAF3IP3 in HCC. Methods The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Genotype-Tissue Expression (GTEx), KM-Plotter, University of Alabama at Birmingham Cancer data analysis Portal (UALCAN), and Xiantao Academic Online Website were utilized for the systematic analysis of TRAF3IP3. …”
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Effect of Soft Rehabilitation Robot Gloves on Upper Limb and Hand Function of Stroke Patients：A Meta-Analysis by YU Tingting, SHEN Yuwei, WAN Guomeng, LI Jianan

“…Meta-analysis results showed that, compared with the control group, FMA-UE score [<italic>MD</italic>=8.05, 95% <italic>CI </italic>(7.01,9.09), <italic>Z</italic>=15.20, <italic>P</italic>&lt;0.000 01], MBI score [<italic>MD</italic>=9.91, 95% <italic>CI</italic> (2.65,17.17), <italic>Z</italic>=2.68, <italic>P</italic>=0.007], WMFT score [<italic>MD</italic>=8.39, 95% <italic>CI</italic> (6.99,9.78), <italic>Z</italic>=11.81，<italic>P</italic>&lt;0.000 01], grip strength [<italic>SMD</italic>=0.39, 95% <italic>CI</italic> (0.11,0.67), <italic>Z</italic>=2.75, <italic>P</italic>=0.006], and ARAT score [<italic>MD</italic>=11.18, 95% <italic>CI</italic> (9.10, 13.26), <italic>Z</italic>=10.53, <italic>P</italic>&lt;0.000 01] were significantly higher in the experimental group, but there was no significant difference in BBT score between two groups [<italic>MD</italic>=0.53, 95% <italic>CI</italic> (-1.47, 2.53), <italic>Z</italic>=0.52, <italic>P</italic>=0.60].ConclusionSRG can improve the upper limb and hand motor function and activities of daily living of stroke patients, but more large-sample and high-quality RCTs would be needed to further verify its efficacy.…”
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Exploring the Relationship Between Public Social Media Accounts, Adolescent Mental Health, and Parental Guidance in England: Large Cross-Sectional School Survey Study by Wakithi Siza Mabaso, Sascha Hein, Gabriela Pavarini, Mina Fazel

“…ObjectiveThis study aims to investigate the association between having a public social media account and anxiety and depression in school-going adolescents. MethodsOverall, 80 secondary schools and further education colleges in England were sampled using a cross-sectional web-based survey as part of the 2023 OxWell Student Survey. …”
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A Novel Oncogenic and Drug-Sensitive KIF5B-NTRK1 Fusion in Lung Adenocarcinoma by Hui Li, Huicong Liu, Lisha Xiao, Huabin Gao, Huiting Wei, Anjia Han, Gengpeng Lin

“…Moreover, <i>KIF5B</i>-<i>NTRK1</i> gene chimera has been shown to be an oncogene, activating both the MAPK and PI3K/AKT signaling pathways. The biopsy sample was analyzed using various methods such as hematoxylin–eosin staining (HE), immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS) based on a 1267-gene panel. …”
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