Preclinical Pharmacokinetic Evaluation of Mithramycin and Mithramycin SA Tryptophan-Conjugated Analog by Kumar Kulldeep Niloy, Jamie Horn, Nazmul H. Bhuiyan, Khaled A. Shaaban, Suhas S. Bhosale, Thomas E. Prisinzano, Jon S. Thorson, Jurgen Rohr, Markos Leggas

“…To explore their pharmacokinetic (PK) differences, this study examined the plasma PKs and plasma protein binding (PPB) of MTM and MTMSA-Trp in mice, rats, and monkeys. <b>Methods</b>: Protein binding was investigated by rapid equilibrium dialysis in plasma from mice, rats, monkeys, and humans. …”
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Factors associated with disability among the adult population in Nepal by Ram Prasad Dhakal, Vijay Aryal, Pitambar Acharya, Yadav Acharya, Devaraj Acharya

“…In this study, we aimed to determine the factors associated with disability among the population aged 15 years and over in Nepal. Methods This study employs a quantitative approach using secondary data from the Nepal Demographic and Health Survey (NDHS) 2022. …”
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Level of overweight and obesity surpassed underweight among women in 40 low and middle-income countries: Findings from a multilevel multinomial analysis of population survey data. by Kusse Urmale Mare, Kebede Gemeda Sabo, Beriso Furo Wengoro, Begetayinoral Kussia Lahole

“…Thus, this study intended to provide insights into the current level of malnutrition among women of reproductive age in low- and middle-income countries.<h4>Methods</h4>A secondary analysis of Demographic and Health Survey data from 40 low- and middle-income countries was performed using a weighted sample of 1,044,340 women of reproductive age. …”
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Study on the role of FGF13 in the repair of inferior alveolar nerve injury by regulating mitochondrial function by JIAO Yi, SUN Xinrong, LIU Weicai

“…[Objective:] To explore the role and mechanism of fibroblast growth factor 13 (FGF13) in the repair of inferior alveolar nerve injury. [Methods:] To establish the model of inferior alveolar nerve injury in SD (Sprague-Dawley) rats. …”
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Integrating network pharmacology and multi-omics in a systems approach: a mechanism study of Jinhong tablets against chronic superficial gastritis by Lihao Xiao, Tingyu Zhang, Yun Liu, Chayanis Sutcharitchan, Qingyuan Liu, Xiaoxue Fan, Jian Feng, Huifang Gao, Shao Li, Tong Zhang

“…Purpose This study aimed to elucidate the mechanism by which JHT alleviates CSG, integrating network pharmacology, untargeted metabolomics, and gut microbiota analyses. Methods The CSG rat model was established, and treatment effects were assessed via Hematoxylin and eosin (H&E) staining. …”
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Prevalence and associated factors of emotional and behavioral problems in Indonesian early adolescents: A cross-sectional study by Ririn Isma Sundari, Mei Neni Sitaresmi, Lely Lusmilasari

“…Objective: This study aimed to assess the prevalence of emotional and behavioral problems among early adolescents in Central Java, Indonesia, and to identify internal and external factors associated with these problems during the post-pandemic transition from hybrid to offline learning. Methods: A cross-sectional study was conducted from May to June 2023 involving 256 adolescents aged 10–14 years in Central Java. …”
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Differential effects of left DLPFC anodal and cathodal tDCS interventions on the brain in children with autism: A randomized controlled trial by Jiannan Kang, Juanmei Wu, Xinping Huang, Wenqin Mao, Xiaoli Li

“…Anodal tDCS intervention appeared to have a more positive impact compared to cathodal intervention. …”
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The effect of computer prompt in breaks of sedentary behaviour among office workers: a systematic review and meta-analysis by Jaime Leppe-Zamora, Sara Ramos-Fuster, Barbara Muñoz-Monari, Sonia Roa-Alcaino, Olga Lucía Sarmiento

“…Conclusions Computer prompt software interventions show effectiveness in reducing sitting time among office workers. However, more long-term prospective studies with larger sample sizes are needed to accurately determine the effectiveness of computer prompts on various work- and health-related outcomes. …”
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Determinant factors influencing stunting prevention behaviors among working mothers in West Java Province, Indonesia: a cross-sectional study by Neti Juniarti, Ethar Alsharaydeh, Citra Windani Mambang Sari, Desy Indra Yani, Alison Hutton

“…This study aimed to identify the determinants of working mothers’ stunting prevention behavior, including individual factors, work-related stress, well-being, knowledge, and attitudes toward the behavior of working mothers in supporting the prevention of stunting in West Java Province, Indonesia. Methods This study used a cross-sectional design with a total sample of 225 working mothers in 78 offices mapped in Bandung city, Bekasi city, Bekasi Regency, Karawang Regency, West Bandung Regency, and Sumedang Regency in West Java Province, Indonesia. …”
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Gender differences in the prevalence, correlated factors and comorbidity of depression in adolescents: a cross-sectional study in Shanghai, China by Yi Wang, Xiyan Zhang, Yan Li, Hongyun Qin, Xin Li

“…Besides, the evidence from Chinese adolescent samples is limited. This study aimed to explore gender differences in the depression-related factors, the potential interactions of the associated factors and clinical features of comorbid depression and anxiety among Chinese adolescents.MethodsA cross-sectional study involving 3,510 participants aged 11 to 16 years from schools (private and public) in Shanghai was conducted with an anonymous paper-and-pencil questionnaire. …”
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Robust prognostic biomarkers and a risk prediction model specific to EGFR-mutated lung adenocarcinoma patients via multicohort meta-analysis by Haangik Park, Yejin Kim, Hwiin Jo, Myeong-Ha Hwang, Hyojin Son, Sechan Lee, Gwan-Su Yi

“…We aimed to develop reliable prognostic markers and a risk prediction model specific to EGFR-mutated patients through integrative analysis of multicohort data. Methods: We analyzed transcriptome profiles from 1495 patients across six public datasets, dividing them into EGFR-mutated and non-EGFR-mutated groups. …”
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Clonidine and dexmedetomidine for controlled hypotension during functional endoscopic sinus surgery: a comparative study by Erick Namegabe Mugabo, Yvette Masime Kulimushi, Gregor Pollach, Rania Abdelazim Sabra, Ragab Saad Beltagy, Furaha Nzanzu Blaise Pascal

“…This study was conducted to evaluate the efficacy of clonidine compared to dexmedetomidine for controlled hypotension during FESS. Methods After ethical approval, 80 patients undergoing elective FESS were included in the study and randomly allocated to Group C or Group D. …”
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Resilience of student youth in Russia under uncertainty by A. V. Makhnach, A. I. Laktionova, Yu. V. Postylyakova

“…Students with high resilience are more optimistic about the opportunities for professional growth and a decent life in Russia, in contrast to students with low resilience. 3. …”
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Respiratory chronic health conditions and racial disparities associated with e-cigarette use: a cross-sectional analysis using behavioral risk factor surveillance data by Ashley Comiford, Steven Pan, Sixia Chen

“…The overall objective was to assess the associations between e-cigarette use and COPD and asthma and how race/ethnicity and cigarette smoking modifies these associations.MethodsData were retrieved from the 2016–2018 and 2020–2021 Behavioral Risk Factor Surveillance System datasets, a national annual health survey representing the US general adult population. …”
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Can patient self-evaluation of functional status be used for evaluation of impairment of motor function in Guillain-Barré syndrome? Mapping clinician- and patient-reported outcomes... by Antoine Regnault, Angély Loubert, Stéphane Quéré, Qun Lin, Glen Frick, Hirokazu Ishida, Yuko Abeta, Helene Chevrou-Severac

“…Given that the R-ODS reflects the patient perspective, it may be used to capture a more complete picture of GBS severity.…”
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The Haplotype TGGAG in the ABCA3 Gene Increases the Risk of Respiratory Distress Syndrome in Preterm Infants in Southern China by Wenjun Tian, Xiuqi Chen, Huijuan Qin, Qiufen Wei, Shuying Zhang, Shangying Tang, Liangrong Liao, Yanming Zhang, Yujun Chen

“…The haplotype TGGAG was significantly more frequent in RDS infants than in non-RDS infants (p = 0.026; odds ratio 3.41; 95% confidence interval 1.088–10.685). …”
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An Evaluation of Italian Midwives' Knowledge of Stillbirth Clinical Management, Bereavement Care and Prevention of Recurrences: A Post-Hoc Analysis of the BLOSSoM Study by Claudia Ravaldi, Laura Mosconi, Elisa Carelli, Aurora Frontini, Sara Tagliavini, Eleonora Cossu, Francesca Monari, Fabio Facchinetti, Alfredo Vannacci

“…Aim of this study is to analyse the knowledge of Italian midwives about the main aspects of clinical management included in international stillbirth guidelines. Methods: The subject of this paper is a post-hoc analysis of the BLOSSoM study. …”
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Does Area Deprivation Index Predict Worse Initial Preoperative Patient-Reported Outcomes in Patients Who Underwent Microfracture for Osteochondral Lesions of the Talus? by Warren Austin, Kenzo M. Cotton BS, Garcia Findlay BS, Marfred Munoz Umanes MS, Richard Michael Smith MD, Cortes Brown MD, Warren Austin, Lauren Lewis MD MPH, Jarrett D. Cain DPM MSc, Macalus V. Hogan MD, MBA

“…This study aimed to investigate the association between social deprivation and preoperative patient-reported outcomes. Methods: Institutional review board approval was obtained (IRB 20020136). …”
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Current research progress of tranexamic acid in the management of patients with traumatic injuries in emergency settings by Gengwei Zhang, Juan Liu, Zhang Wen, Zhang Wen, Jia He, Haifeng Chang

“…This review aims to synthesize current evidence on TXA's efficacy, mechanisms, and clinical applications in the trauma management, identify research gaps, and propose future directions to optimize its use.MethodsA comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library up to April 2025. …”
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Anxiety and burnout in infectious disease nurses: the role of perceived stress and resilience by Yalan Huang, Zonghua Wang, Yongguang Li, Zhihan Zhao, Weiyi Wang, Changxia Cai, Xiushuang Wu, Li Liu, Mengting Chen

“…This study aimed to explore investigate the association between anxiety and burnout among nurses working in such environments and scrutinized the mediating role of perceived stress and the moderating influence of resilience on the principal relationship. Methods Employing a cross-sectional study using a web-based design, data were collected from 1,579 clinical nurses working in infectious disease ward across 50 hospitals in China. …”
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