Hypothalamic atrophy and structural covariance in amnestic mild cognitive impairment and Alzheimer’s dementia by Hannah Pecher, Melanie Storch, Frauke Beyer, Veronica Witte, Christian-Frank Baasner, Peter Schönknecht, Christopher M. Weise

“…A number of studies have discussed hypothalamic involvement in AD with consecutive metabolic and/or autonomic disturbances yet only few studies have investigated hypothalamic atrophy in AD and its early stages in particular. Methods: We applied semi-automated volumetry of the hypothalamus (HTH) in 3 T MRI in a sample N = 175 participants [age 74.9 ± 7.22; gender 85 m/90f; cognitively normal controls (CN; N = 56); amnestic mild cognitive impairment (MCI; N = 78); AD (N = 41)] from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). …”
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Low Saturation Confidence Distribution-based Test-Time Adaptation for cross-domain remote sensing image classification by Yu Liang, Shilei Cao, Juepeng Zheng, Xiucheng Zhang, Jianxi Huang, Haohuan Fu

“…We evaluate LSCD-TTA on six domain adaptation tasks across three RS datasets, where LSCD-TTA outperforms existing DA and TTA methods with average accuracy gains of 4.99% on Resnet-50, 5.22% on Resnet-101, and 2.37% on ViT-B/16.…”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…IntroductionCoeliac disease (CD) manifests more frequently in individuals with Down syndrome (DS) and its prevalence varies across different studies. …”
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Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis by Noppachai Siranart, Pannathorn Nakaphan, Thanathip Suenghataiphorn, Panisara Fangsaard, Tanattida Phanthong, Patavee Pajareya, Somkiat Phutinart, Pawaris Tirakunwichcha, Suwit Paksin, Pornnicha Sowalertrat, Sakkarin Chirapongsathorn, Kittithat Tantitanawat

“…ABSTRACT Introduction While gastrointestinal involvement is a common manifestation of systemic lupus erythematosus (SLE), the association between gastroparesis and SLE remains unclear. Methods We analyzed data from the National Inpatient Sample (NIS) database from 2016 to 2021. …”
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Disparities in objective sleep measures among individuals who have undergone polysomnographic studies by Min-Woong Sohn, Nathan A. Farr, Hyeeun K. Shin, Soojung Ahn, Myla D. Goldman, Sara N. Pasha, Hyojung Kang, Chae Won Kim, Jennifer M. Lobo

“…Our objective is to assess disparities in objectively measured sleep parameters between races/ethnicities using data from an academic medical center in the US.Materials and methodsWe used data extracted through text mining from sleep reports of in-lab polysomnography (PSG) studies conducted for adults aged 18 years or older at the University of Virginia Health System between 2010 and 2021. …”
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Transcriptomic analysis of laser-capture microdissected tumors reveals RAD51AP1 as a tumor-specific marker associated progression from pancreatic intraepithelial neoplasia to invas... by Fereshteh Rezagholizadeh, Adel Salimi, Ali Sharifi-Zarchi, Farid Azmoudeh-Ardalan, Kazem Mousavizadeh, Fatemeh Tajik, Mahshid Panahi, Hossein Khorramdelazad, Masoud Baghai Wadji, Atefeh Kashanizadeh, Alireza Lotfalizadeh, Seyed Javad Mowla, Mohammad Taghi Joghataei

“…Conclusions RAD51AP1 is a tumor-specific molecule that associated with more aggressive behavior, advanced disease, and a worse survival rate. …”
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Association of Metformin Use with Asthma Exacerbation in Patients with Concurrent Asthma and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies by Li Wen, Wang Zhong, Yihui Chai, Qin Zhong, Jie Gao, Liancheng Guan, Zhang mengzhi, Liu Huaiquan, Yu Haiyang, Wang Qingxue, Yang Changfu, Chen Yunzhi

“…Metformin reduced the risk of asthma-related hospitalization and exacerbation but was not statistically significant. More randomized trials involving larger samples should be considered, and the mechanisms of these effects need to be fully elucidated.…”
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Uptake, Accuracy, Safety, and Linkage into Care over Two Years of Promoting Annual Self-Testing for HIV in Blantyre, Malawi: A Community-Based Prospective Study. by Augustine T Choko, Peter MacPherson, Emily L Webb, Barbara A Willey, Helena Feasy, Rodrick Sambakunsi, Aaron Mdolo, Simon D Makombe, Nicola Desmond, Richard Hayes, Hendramoorthy Maheswaran, Elizabeth L Corbett

“…HIVST uptake in months 13-24 was more rapid (70.9% uptake by 6 mo), with fewer (7.3%, 95% CI 6.8%-7.8%) positive participants. …”
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Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration by Annika Breuer, Delara Kamalizade, Tobias Baumgartner, Juliane L. Berns, Thoralf Opitz, Franziska S. Thaler, Susanne Schoch, Lars Komorowski, Christoph Helmstaedter, Rainer Surges, Albert J. Becker, Julika Pitsch

“…Subsequent screening of 118 anti-GAD65-positive patients revealed that 32 of them had additional autoantibodies targeting CN1A, which were also present in all available corresponding CSF samples. Limbic encephalitis was more often diagnosed in anti-CN1A/anti-GAD65-positive compared to the anti-GAD65-positive patients. …”
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Clinical Study on Prevention of Irinotecan-Induced Delayed-Onset Diarrhea by Hot Ironing with Moxa Salt Packet on Tianshu and Shangjuxu by Xianghong Lai, Anmei Wang

“…To study the clinical efficacy of hot ironing of the Tianshu and Shangjuxu with moxa salt packet to prevent irinotecan (CPT-11)-induced delayed-onset diarrhea (IIDD). Methods. A randomized controlled study was conducted on a sample of 120 patients with advanced colorectal cancer who were hospitalized in our oncology department and treated with FOLFIRI chemotherapy regimen from February 2018 to July 2021. …”
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Prevalence of Musculoskeletal Disorders in Patients with Coronary Artery Disease by E. D. Bazdyrev, N. A. Terentyeva, K. E. Krivoshapova, V. L. Masenko, E. A. Wegner, А. N. Kokov, S. A. Pomeshkina, O. L. Barbarash

“…To study the prevalence of musculoskeletal disorders in patients with stable coronary artery disease (CAD).Material and methods. Patients with stable CAD (n=387) were included in the study. …”
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Understanding Gender-Specific Daily Care Preferences: Topic Modeling Study by Kyungmi Woo, Se Hee Min, Aeri Kim, Subin Choi, Gregory L Alexander, Terrence O’Malley, Maria D Moen, Maxim Topaz

“…ObjectiveThis study aims to identify and analyze the key themes and daily care preferences from unstructured adult text narratives with a focus on uncovering gender-specific variations. MethodsThis study used 4350 deidentified, unstructured textual data from MyDirectives (MyDirectives, Inc), an interactive online platform. …”
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Social health insurance, family support, and chronic diseases as determinants of health service utilization among senior citizens in rural Nepal by Sujan Poudel, Anusha Parajuli, Nirmal Duwadi, Bal Krishna Bhatta, Shishir Paudel, Dhurba Khatri, Damaru Prasad Paneru, Yam Prasad Sharma

“…This study aims to assess the status of health service utilization and its influencing factors among senior citizens in rural municipalities of the Kaski district, Nepal. Methods A cross-sectional study was carried out in selected wards of all rural municipalities of Kaski District (Annapurna, Machhapuchre, Madi and Rupa). …”
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Impact on Patient Outcomes of Continuous Vital Sign Monitoring on Medical Wards: Propensity-Matched Analysis by Bradley Rowland, Amit Saha, Vida Motamedi, Richa Bundy, Scott Winsor, Daniel McNavish, William Lippert, Ashish K Khanna

“…ObjectiveThis study aims to evaluate the clinical outcomes of primary medical patients who received either continuous or, as a contemporaneous control, intermittent vital monitoring as the standard of care using propensity matching. MethodsPropensity-matched analysis of a population-based sample of 7971 patients admitted to the medical wards between January 2018 and December 2019 at a single, tertiary United States medical center. …”
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Social Listening for Patient Experiences With Stopping Extended-Release Buprenorphine: Content Analysis of Reddit Messages by Michael K Gilbert, Ashlynn R Daughton, Howard D Chilcoat, Celine M Laffont, Stephanie Strafford, Angela M DeVeaugh-Geiss

“…ObjectiveThis study sought to understand experiences with stopping BUP-XR as described on social media. MethodsReddit records (March 2018 to August 2022) were evaluated for the presence of referents to BUP-XR using parallel criteria based on predefined keywords and subreddit context. …”
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Association of physical activity, sedentary behaviour, sleep and myopia in children and adolescents: a systematic review and dose-response meta-analysis by Huimin Ding, Liqun Jiang, Xuanqiao Lin, Chaoying Ye, Buongo Chun

“…Although longer SD was associated with a reduced risk of myopia, this effect did not reach statistical significance at any exposure level.Subgroup analyses revealed that protective effects of PA were more evident in low- and middle-income countries, smaller sample sizes, and cross-sectional studies, while increased risks related to ST and NW were stronger in low-income settings. …”
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Adolescent Youth Survey on HIV Prevention and Sexual Health Education in Alabama: Protocol for a Web-Based Survey With Fraud Protection Study by Henna Budhwani, Ibrahim Yigit, Josh Bruce, Christyenne Lily Bond, Andrea Johnson

“…A total of 30% self-reported their race as African American or Black; 12% were Hispanic or Latinx. More than half reported being sexually active in the past 6 months. …”
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Pneumococcal Infection and Vaccination-Related Knowledge, Attitudes and Practices Among Saudi Residents by Wed S. Althobaiti, Abeer D. Alnefaie, Kaifah M. Althaali, Ola M. Alsufyani, Yassmin M. Shebany, Ayman A. Atalla, Ibtihal M. Alotaibi, Eman Y. Santali, Sayed F. Abdelwahab

“…This study determined the knowledge, attitudes, and practices (KAP) of Saudi residents regarding pneumococcal infection and vaccination. <b>Study design and Methods</b>: This observational cross-sectional study was conducted across Saudi Arabia from November 2024 to March 2025. …”
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ZBTB10 as a potential prognosis biomarker and correlates with the tumor immune microenvironment in stomach adenocarcinoma by Yingdi Jiang, Fuhua Han, Lu Dai, Shali Qiu, Yanjie Zhou, Ke Wang, Jiang Lin

“…However, its specific roles in oncogenesis, prognosis, and immune infiltration in stomach adenocarcinoma (STAD) remain to be elucidated. Methods We analyzed ZBTB10 mRNA and protein expression profiling in STAD tissues using various bioinformatics tools, including TIMER2, GEO, Human Protein Atlas (HPA) databases, and R software. …”
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Implication of Exclusive Breastfeeding in Early Childhood Dental Disorders: Large Cohort Evidence, US National Survey of Children Health by Laurens Holmes, Janille Williams, Neyha Thompson, Valescia John, Kerti Depeika, Benjamin Ogundele, Michael Enwere

“…We aimed to assess the nexus between exclusive breastfeeding during the first 6 months and oral health disorders, namely toothache, decayed teeth, or unfilled cavities in early childhood. <b>Materials and Methods: Design:</b> Cross-sectional epidemiologic design of nationally representative data collected via telephone surveys in the United States was utilized. …”
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