Melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia: the MAGIC non-inferiority RCT by Christopher Deery, Robert Bolt, Diana Papaioannou, Matthew Wilson, Marie Hyslop, Esther Herbert, Nikki Totton, Zoe Marshman, Tracey Young, Jennifer Kettle, Sondos Albadri, Simon Atkins, Katie Biggs, Janet Clarkson, Chris Evans, Laura Flight, Jacqui Gath, Fiona Gilchrist, Kate Hutchence, Nicholas Ireland, Amanda Loban, Amy Norrington, Hamish Paton, Jaydip Ray, Helen Rodd, Elena Sheldon, Richard Simmonds, Christopher Vernazza

“…Future work There remains a need to develop or repurpose another drug with a more favourable side effects profile to midazolam. …”
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Effect of microbubble as local drug delivery system in endodontic management - An In-Vitro study by V. Shyam Ganesh, K. Vijay Venkatesh, D. Sihivahanan, Pradeep Kumar Yadalam, Deepti Shrivastava, Kumar Chandan Srivastava

“…Furthermore, they are more suitable for focusing on particular body regions and are safer and non-invasive. …”
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In-depth assessment of BRAF, NRAS, KRAS, EGFR, and PIK3CA mutations on cell-free DNA in the blood of melanoma patients receiving immune checkpoint inhibition by Isabel Heidrich, Charlotte Rautmann, Cedric Ly, Robin Khatri, Julian Kött, Glenn Geidel, Alessandra Rünger, Antje Andreas, Inga Hansen-Abeck, Finn Abeck, Anne Menz, Stefan Bonn, Stefan W. Schneider, Daniel J. Smit, Christoffer Gebhardt, Klaus Pantel

“…Methods We conducted a prospective analysis of 241 longitudinal samples from 39 patients with unresectable stage III/IV melanoma using a SYSMEX targeted NGS panel covering 1,114 COSMIC mutations. …”
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Evaluating the Integration of Technology by Teachers in E-Education in Elementary Schools Based on the International Standards for Technology in Education (ISTE) by Maryam Pourjamshidi

“…This research was applied in terms of purpose and employed a survey method. The statistical population consisted of all male elementary school teachers in one district one of Hamedan city during the 2022-2023 academic year, with a sample of 140 participants. …”
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Rationale and design of the preserved versus reduced ejection fraction biomarker registry and precision medicine database for ambulatory patients with heart failure (PREFER-HF) stu... by James L Januzzi, Hanna K Gaggin, Megan Welch, Daniel A Zlotoff, Kevin Wei, Andrew Abboud, Austin Nguonly, Asher Bean, Kemar J Brown, Roy F Chen, David Dudzinski, Neyat Fiseha, Melvin Joice, Davis Kimaiyo, Mackenzie Martin, Christy Taylor

“…A multidimensional characterisation of ambulatory patients with and without HF across LVEF groups is needed to better understand and manage patients with HF in a more precise manner.Methods and analysis To date, the first cohort of 1313 out of total planned 3000 patients with and without HF has been enroled in this single-centre, longitudinal observational cohort study. …”
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MLAR-Net: A Multilevel Attention-Based ResNet Module for the Automated Recognition of Emotions Using Single-Channel EEG Signals by M. Maithri, U. Raghavendra, Anjan Gudigar, Samir Kumar Praharaj, Karthikeyan Sriram, Massimo Salvi, Chai Hong Yeong, Filippo Molinari, U. Rajendra Acharya

“…This performance surpasses existing state-of-the-art methods for single-channel EEG-based emotion recognition. …”
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Correlation between T cell immunity and the duration of EGFR-TKI resistance acquisition in patients harboring EGFR mutations by Atsuto Mouri, Kyoichi Kaira, Ou Yamaguchi, Ayako Shiono, Yu Miura, Kosuke Hashimoto, Satoshi Yamasaki, Fuyumi Nishihara, Hisao Imai, Kunihiko Kobayashi, Hiroshi Kagamu

“…To determine the relationship between the duration of EGFR-TKI resistance acquisition and antitumor T cell immunity, and the effect of EGFR-TKIs on T cell immunity. Methods This prospective observational study enrolled 43 patients who received osimertinib. …”
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Auto Machine Learning and Convolutional Neural Network in Diabetes Mellitus Research—The Role of Histopathological Images in Designing and Exploring Experimental Models by Iulian Tătaru, Simona Moldovanu, Oana-Maria Dragostin, Carmen Lidia Chiţescu, Alexandra-Simona Zamfir, Ionut Dragostin, Liliana Strat, Carmen Lăcrămioara Zamfir

“…The development of sophisticated computational models for histopathological images has received significant attention in recent years, but most of them rely on free datasets. <b>Materials and Methods:</b> Motivated by this drawback, the authors created an original histopathological image dataset that resulted from an animal experimental model, acquiring images from normal female rats/rats with experimentally induced diabetes mellitus (DM)/rats who received an antidiabetic therapy with a synthetic compound (AD_SC). …”
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Occurrence of Alleles of the <i>HLA-A/B/C/DPB1/DQB1/DRB1</i> Genes in Autoimmune Hepatitis (Results of a Single-Center Study) by M. D. Chanyshev, Yu. G. Sandler, N. V. Vlasenko, N. A. Bodunova, A. G. Glushchenko, A. S. Chegodar, A. V. Vykhodtseva, E. V. Vinnitskaya, K. F. Khafizov, V. G. Akimkin

“…Aim: determination of alleles of HLA genes associated with autoimmune hepatitis (AIH) and overlap syndrome (OS) in the Russian population.Materials and methods. The study included 160 adult patients with a verified diagnosis of AIH or OS. …”
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Incidence, outcomes, and mortality risk factors of acute kidney injury in critically ill children: a tertiary care center study in Saudi Arabia by Tareq Alayed, Abdulaziz Alansary, Mohammed Al-Nahdi, Abdullah Alotaibi, Raghad Alhuthil, Moath Al Abdulsalam, Fahad Aljofan, Abdullah Alturki, Tariq Alofisan

“…DESIGN: Retrospective cohort SETTING: A PICU PATIENTS AND METHODS: The study included children (aged 4 weeks to 14 years) who were admitted to the PICU from (2016 to 2019) and developed AKI at King Faisal Specialist Hopsital and Research Centre. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…This study examines how SIRT1 protein levels correlate with clinicopathological characteristics and survival outcomes in patients with breast cancer. Methods: A total of 407 BC formalin-fixed paraffin-embedded (FFPE) samples were collected from King Abdulaziz University Hospital, Saudi Arabia. …”
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Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in non-small cell lung cancer patients undergoing anti-PD1 therapy by Kriti Jain, Anika Goel, Deepa Mehra, Deepak Kumar Rathore, Akshay Binayke, Shyam Aggarwal, Surajit Ganguly, Amit Awasthi, Evanka Madan, Nirmal Kumar Ganguly

“…BackgroundThis study investigates the predictive potential of circulating cytokines for response and survival outcomes in patients with advanced non-small cell lung cancer (NSCLC) undergoing immune checkpoint inhibitor (ICI) therapy.Materials and methodsA cohort of 64 patients with advanced NSCLC receiving ICI therapy were included. …”
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Computer adaptive testing to assess impairing behavioral health problems in emergency department patients with somatic complaints by Lauren M. O'Reilly, Azhar I. Dalal BS, Serena Maag MS, Matthew T. Perry BS, Alex Card DO, Max B. Bohrer BS, Jackson Hamersly BS, Setarah Mohammad Nader MD, Kelli Peterson RN, David G. Beiser, Robert D. Gibbons, Brian M. D'Onofrio, Paul I. Musey

“…Abstract Objectives To assess: (1) the prevalence of mental health and substance use in patients presenting to the emergency department (ED) through use of a computer adaptive test (CAT‐MH), (2) the correlation among CAT‐MH scores and self‐ and clinician‐reported assessments, and (3) the association between CAT‐MH scores and ED utilization in the year prior and 30 days after enrollment. Methods This was a single‐center observational study of adult patients presenting to the ED for somatic complaints (97%) from May 2019 to March 2020. …”
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Characterising developmental dynamics of adult epigenetic clock sitesResearch in context by Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil

“…This knowledge could be used to optimise healthy ageing well before the onset of age-related conditions. Methods: We leveraged results from two longitudinal population-based cohorts (N = 5019 samples from 2348 individuals) to characterise trajectories of adult clock sites from birth to early adulthood. …”
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Serum trihalomethanes and cognitive decline: investigating environmental risk factors for neurodegenerative diseases by Jianping Liu, Sufang Wang, Yuanying Song, Rong Luo, Lijian Han, Lijian Han

“…A final analytic sample of 743 participants aged 60 years or older was analyzed. …”
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Lipids, Apolipoproteins, Lipid‐Lowering Drugs, and the Risk of Cerebral Small Vessel Disease: A Mendelian Randomization Study by Yi Xie, Shuai Liu, Xinyue Wang, Hao Huang, Minghuan Wang, Wensheng Qu, Zhiyuan Yu, Wei Wang, Xiang Luo

“…Specifically, the genetically determined expressions of lipid fractions in various size‐defined lipoprotein particles were more closely related to the risk of SVS than WMH. …”
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Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study... by Anna Lena Platzbecker, Janine Gronewold, Sara Schramm, Susanne Moebus, Andreas Stang, Börge Schmidt, Christian Weimar, Martha Jokisch, the Heinz Nixdorf Recall Study Investigative Group

“…Abstract Introduction As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non‐amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex‐ and age‐specific effects of T2DM on incident MCI after five years in a population‐based sample. Methods A total of 145 participants with T2DM and 1322 without T2DM were included. …”
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Anopheles mosquitoes in Mondulkiri forest, Cambodia: abundance, distribution, seasonal patterns and Plasmodium prevalence by Sebastien Boyer, Bros Doeurk, Antsa Rakotonirina, Sophy Chy, Chantrea Vong, Eakpor Piv, Baura Tat, Malen Ea, Chansophea Chhin, Sreyvouch Phen, Nimol Kloeung, Sopheakvatey Ke, Jean Popovici, Patrice Piola, Benoit Witkowski, Pierre-Olivier Maquart, Amélie Vantaux

“…Anopheles species were more prevalent during the late rainy season (August to November), with year-round activity observed. …”
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Characteristics of upper and lower respiratory tract microbiota after lung transplantation by Yuhang Cai, Yuchen Fan, Ao Chen, Xiaohua Wang, Lulin Wang, Jiaqi Chen, Zhang Wang, Jia Li, Xinzhu Yi, Chunrong Ju

“…Most amplicon sequence variants (ASVs) belonged to the families Enterobacteriaceae, Pseudomonadaceae, and Stenotrophomonas in BALF, while most ASVs belonged to the genera Streptococcus, Pseudomonadaceae, and Stenotrophomonas in sputum samples. Regarding dynamic changes, Corynebacterium and Staphylococcus were more prevalent in the early post-operative period but gradually decreased by 7 days post-operatively, while the common microbiota found in healthy populations based on literature became the most abundant ASVs at 6 months post-operatively in our study participants. …”
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Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMR... by Henry W. Chase, Danella M. Hafeman, Merage Ghane, Alexander Skeba, Tyler Brady, Haris A. Aslam, Richelle Stiffler, Lisa Bonar, Simona Graur, Genna Bebko, Michele Bertocci, Satish Iyengar, Mary L. Phillips

“…Methods Here, we evaluated measures of FC, regional variance, and global signal (GS) across six functional MRI (fMRI) sequences of different tasks and resting states and their relationship with individual differences in self‐reported measures of symptoms of depression, anxiety, impulsivity, reward sensitivity, and sensation seeking, as well as demographic variables and acquisition order, within groups of distressed and healthy young adults (18–25 years old). …”
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