Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study. by Daniel B Rosoff, George Davey Smith, Nehal Mehta, Toni-Kim Clarke, Falk W Lohoff

“…The objective of this study is to use a wide range of CVD risk factors and outcomes to evaluate potential total and direct causal roles of alcohol and tobacco use on CVD risk factors and events.<h4>Methods and findings</h4>Using large publicly available genome-wide association studies (GWASs) (results from more than 1.2 million combined study participants) of predominantly European ancestry, we conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of alcohol consumption and smoking on a wide range of CVD risk factors and outcomes. …”
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Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial by Jia-Chen Wang, Li Zhao, Xiang-Yang Yu, Ting-Ping Wu, Chang-Fa Xia, Ju-Fang Shi, Hui He, Zhi-Qi Chen, Dan Shi, Han Xue, Qi Ao, Shu-Ping Liao, Zhang-Qiang Zheng, Qiong-Fang Huang, Lin Li, Sui-Ling Lin, Ying-Xue Li, Wen-Long Hu, Ji Peng, Lin Lei, Mao-Mao Cao, Fan Yang, Xin-Xin Yan, Si-Yi He, Meng-Di Cao, Shao-Li Zhang, Yi Teng, Qian-Ru Li, Nuo-Pei Tan, Hao-Yang Yu, Hong-Hui Cheng, Xi-Mo Wang, Wei-Qing Wu, Wan-Qing Chen

“…Abstract Background More efficacious, noninvasive screening methods are needed for advanced colorectal neoplasia. miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples. …”
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Molecular and genomic investigation of an urban outbreak of dengue virus serotype 2 in Angola, 2017-2019. by Zoraima Neto, Pedro A Martinez, Sarah C Hill, Domingos Jandondo, Julien Thézé, Marinela Mirandela, Renato Santana Aguiar, Joilson Xavier, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Filipa Vaz, Gisel Reyes Castro, Joana Paula Paixão, Nicholas J Loman, Philippe Lemey, Oliver G Pybus, Jocelyne Vasconcelos, Nuno Rodrigues Faria, Joana de Morais

“…Here, we report results from molecular and genomic investigations conducted at the Ministry of Health national reference laboratory (INIS) in Angola on suspected dengue cases detected between January 2017 and February 2019.<h4>Methods</h4>A total of 401 serum samples from dengue suspected cases were collected in 13 of the 18 provinces in Angola. …”
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Performance of quantitative point-of-care tests to measure G6PD activity: An individual participant data meta-analysis. by Arkasha Sadhewa, Ari Winasti Satyagraha, Mohammad Shafiul Alam, Wondimagegn Adissu, Anup Anvikar, Germana Bancone, Praveen K Bharti, Vinod K Bhutani, Santasabuj Das, Muzamil Mahdi Abdel Hamid, Mohammad Sharif Hossain, Nitika Nitika, Bernard A Okech, Lydia Visita Panggalo, Arunansu Talukdar, Michael E von Fricken, Ronald J Wong, Daniel Yilma, Ric N Price, Kamala Thriemer, Benedikt Ley

“…The World Health Organization recommends G6PD testing prior to 8AQ-based hypnozoitocidal treatment.<h4>Methods</h4>We undertook an individual level meta-analysis of the performance of commercially available quantitative point-of-care diagnostics (PoCs) compared with reference spectrophotometry. …”
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Ordovician conodonts of the Katkoyeh formation in the Kuh-e-Bonorg section, Kalmard Horst (west of Tabas) by Mohammad Nezhadabbas, Abbas Ghaderi, Hadi Jahangir, Ali Reza Ashouri

“…In the current research we have looked for the succession Katkoyeh formation in a section at the south of Kuh-e-Bonorg, eastern flank of the Kalmard anticline, from the age dating view, based on the conodont contents.   Material & Methods In the Kuh-e-Bonorg section, 80 rock samples were collected bed by bed for conodont content while only seven of them were productive. …”
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The study of the elemental composition of peppermint (Mentha piperita) by K. V. Andrianov, Yu. A. Fedchenkova, O. P. Khvorost

“…Materials and methods of research The peppermint leaves of 3 samples were the object of our research. …”
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Patient Reported Outcome Measures in cancer care: a hybrid effectiveness-Implementation trial to optimise Symptom control and health service Experience (PROMISE)–protocol for a ran... by David Wyld, Afaf Girgis, Elizabeth Miller, Penelope M Webb, Gunter Hartel, Karen Martin, Rahul Ladwa, Melissa Eastgate, Suzanne O’Brien, Sabe Sabesan, Raymond J Chan, Amy Brown, Robert Mason, Mark B Pinkham, Bena Brown, Louisa G Collins, Fiona Crawford Williams, Kerrie Doupain, Vicki Fennelly, Peter McGuire, Rebecca Packer, Jasotha Sanmugarajah, Georgia Slapp, Doreen Tapsall, Jeanie White, Laurelie R Wishart

“…PROM scores can be tracked over time allowing more timely identification of problems and more appropriate intervention. …”
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Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory dis... by Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Annina Lyly, Annina Lyly, Viljami Salmi, Viljami Salmi, Mikko Nuutinen, Mikko Nuutinen, Michael Kilpiö, Michael Kilpiö, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Mikko Niemi, Mikko Niemi, Mikko Niemi, Anu Laulajainen-Hongisto, Lena Hafrén, Mika Mäkelä, Paula Kauppi, Paula Virkkula, Alma Helevä, Alma Helevä

“…The study explores various outcomes, including reduction in polyp burden, improvement in QoL, treatment-related side effects, and biomarker analyses derived from nasal swabs, blood, and urine samples.MethodsAirGOs Medical is an investigator-initiated RDBCT conducted at Helsinki University Hospital. …”
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EARice10: a 10&thinsp;m resolution annual rice distribution map of East Asia for 2023 by M. Song, M. Song, M. Song, L. Xu, L. Xu, J. Ge, J. Ge, J. Ge, H. Zhang, H. Zhang, H. Zhang, L. Zuo, L. Zuo, J. Jiang, J. Jiang, J. Jiang, Y. Ding, Y. Ding, Y. Ding, Y. Xie, Y. Xie, Y. Xie, F. Wu, F. Wu

“…The accuracy of EARice10 was evaluated using more than 90 000 validation samples and achieved an overall accuracy of 90.48 %, with both the user accuracy and the producer accuracy exceeding 90 %. …”
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Is there a difference in the phthalate exposure between adults with metabolic disorders and healthy ones? by Stepanović Kristina, Vuković Bojan, Milanović Maja, Milošević Nataša, Bosić-Živanović Dragana, Stojadinović Aleksandra, Tomić-Naglić Dragana, Lepić Sanja, Milić Nataša, Medić-Stojanoska Milica

“…Methods. For the study purpose, the first morning urine sample of 308 participants was screened for the presence of 10 phthalate metabolites: mono-ethyl phthalate (MEP), mono-(2-ethylhexyl) phthalate (MEHP), mono-n-butyl phthalate (MBP), mono-iso-allyl phthalate (MiAP), mono-n-allyl phthalate (MnAP), mono-cyclohexyl phthalate (MCHP), mono-benzyl phthalate (MBzP), mono-n-octyl phthalate (MOP), mono-n-propyl phthalate (MPP) and mono-methyl phthalate (MMP). …”
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Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns by Petra Janovska, Kristina Bardova, Zuzana Prouzova, Zuzana Prouzova, Ilaria Irodenko, Tatyana Kobets, Eliska Haasova, Eliska Haasova, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Viktor Stranecky, Stanislav Kmoch, Martin Rossmeisl, Petr Zouhar, Jan Kopecky

“…In humans, this postnatal decline is not well characterized due to the scarcity of appropriate samples.ObjectiveTo characterize the effect of (i) gestational age at birth and (ii) length of survival after birth on hepatic haematopoiesis across various cell lineages involved.MethodsLiver autopsy samples from 25 born-alive infants, predominantly extremely preterm newborns who died mainly between 1 day and 3 weeks after birth, were analysed. …”
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Immigrants' and refugees' unmet reproductive health demands in Botswana: Perceptions of public healthcare providers by John O. Oucho, Njoku O. Ama

“…Using NCS Pearson statistical software, the sample size for the study was determined to be 851. …”
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Comprehensive genomic study of Plasmodium falciparum in Sierra leone: genetic variation and resistance patterns by Xin-jie Zhan, Shen-Bo Chen, Tian-yu Wang, Yi-wen Duan, Hai-Mo Shen, Jun-Hu Chen, Jing-jing Xie

“…Methods We collected P. falciparum samples from Freetown, Sierra Leone, between December 2022 and March 2023. …”
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Effect of human papillomavirus infection on semen quality and assisted reproductive technology outcomes: a prospective observational cohort study by Sara Stigliani, Erika Coppo, Maria Bonaffini, Elena Maccarini, Francesca Bovis, Ida Casciano, Claudia Massarotti, Fausta Sozzi, Anna Marchese, Paola Scaruffi, Paola Anserini

“…We aimed to evaluate the prevalence of HPV infection in men and its correlation with semen parameters and reproductive outcomes. Methods In this prospective observational cohort study, 384 semen samples were collected from 237 male partners of infertile couples. …”
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Influence of storage conditions on the toxicity of whole-cell pertussis vaccine in outbred mice by I. A. Alekseeva, D. N. Lepikhova, O. Yu. Borisova, A. S. Pimenova, I. Yu. Andrievskaya, I. V. Ibragimkhalilova

“…The results suggest a more complete detoxification of pertussis toxin in the samples of WCPV kept with the inactivating agent under recommended storage conditions for at least 10–12 months compared with that after a shorter period. …”
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Implementation of health warnings on alcoholic beverages in Spain by Luis Sordo, Jarileen Padilla-Cruz, Marina Bosque-Prous, Ainara Díaz-Geada, Gregorio Barrio, Aina Lafon-Guasch, Judit Rogés, Iñaki Galán

“…Study design: Cross-sectional study conducted in Madrid, Spain, between March and April 2023. Methods: A convenience sample was designed by selecting four supermarket chains with a 40 % share of food distribution and two specialized alcohol stores. …”
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Comprehensive clinical and metabolomics profiling of COVID-19 Mexican patients across three epidemiological waves by David Alejandro García-López, Joel Monárrez-Espino, Juan Carlos Borrego-Moreno, Jiamin Zheng, Rupasri Mandal, Claudia Torres-Calzada, Juan José Oropeza-Valdez, Alanne Tenório Nunes, Sergio Hugo Sánchez Rodríguez, Jesús Adrián López, Blanca Estela Calzada Rodríguez, David S. Wishart, Yamilé López-Hernández, Yamilé López-Hernández

“…IntroductionAs of mid-2024, COVID-19 has affected over 676 million people worldwide, leading to more than 6.8 million deaths. Numerous studies have documented metabolic changes occurring during both the acute phase of the disease and the recovery phase, which, in some cases, contribute to the development of long COVID syndrome.Aims and methodsIn this study, we aimed to evaluate clinical, laboratory, and comprehensive metabolomic data from hospitalized COVID-19 patients during the second, third and fourth waves (Alpha, Delta, and Omicron). …”
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Clinicopathological and genetic analysis of orbital solitary fibrous tumors by Qing Wang, Zonghan Nan, Xun Liu, Limin Zhu, Emmanuel Eric Pazo, Tianming Jian, Liang Zhao, Jinzhi Zhao, Tingting Lin

“…Abstract Purpose To investigate the clinicopathological and genetic characteristics of patients with orbital solitary fibrous tumor (SFT) for clinical reference. Methods This single-center retrospective case-series study assessed clinical manifestations, imaging features, treatment, and prognosis of patients with orbital SFT. …”
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SARS-CoV-2 and Streptococcus pneumoniae colonization and disease: an observational study in adults by Sara Calvo-Silveria, Sara Calvo-Silveria, Lucía Fernández-Delgado, Lucía Fernández-Delgado, Aida González-Díaz, Aida González-Díaz, Rocío España-Bonilla, Laura Calatayud, Laura Calatayud, Jordi Niubó, Sara Martí, Sara Martí, Sara Martí, Ma Ángeles Domínguez, Ma Ángeles Domínguez, Ma Ángeles Domínguez, Jordi Càmara, Jordi Càmara, Carmen Ardanuy, Carmen Ardanuy, Carmen Ardanuy

“…This study aims to analyze their co-occurrence, focusing on disease progression, colonization rates and clinical outcomes.MethodsTo this end, three approaches were used. First, a laboratory-based analysis of invasive pneumococcal disease (IPD) in adults (2019-2023). …”
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The Field Assessment of Quiescent Egg Populations of <i>Aedes aegypti</i> and <i>Aedes albopictus</i> during the Dry Season in Tapachula, Chiapas, Mexico, and Its Potential Impact... by José Ignacio Navarro-Kraul, Luis Alberto Cisneros Vázquez, Keila Elizabeth Paiz-Moscoso, Rogelio Danis-Lozano, Jesús A Dávila-Barboza, Beatriz Lopez-Monroy, Rosa María Sánchez-Casas, Marco Antonio Domínguez-Galera, Pedro Christian Mis-Avila, Ildefonso Fernandez-Salas

“…Evolutionary characteristics for the two species including partial egg hatching, ambient-regulated quiescence, the ability of the embryo to survive for a more extended period intra-seasonally, the egg sticking to inner container walls, demands urgent operational research to achieve successful egg-proof larval container methods.…”
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