A pilot randomized controlled trial evaluating the impact of a skills and attitudes based program on marital quality by Alphonse Nkurunziza, Japhet Niyonsenga, Claudine Munganyinka, Jeanne Marie Ntete, Jean Mutabaruka

“…Future studies should examine the long-term effects of such interventions and consider larger samples for sub-Group analyses. Trial registration The Pan African Clinical Trials Registry PACTR202408536250978. …”
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The impact of the timing of pasta intake on sleep quality and health outcomes: a protocol for a randomized controlled trial by S. Lotti, M. Dinu, A. Napoletano, G. Pagliai, M. Tristan Asensi, I. Giangrandi, F. Cesari, M. Becatti, A. Amedei, C. Fiorillo, R. Marcucci, B. Colombini, F. Sofi

“…At the beginning and end of each phase, participants will wear an actigraph for 7 days and provide saliva, blood, and stool samples. Additional assessments include body composition analysis, indirect calorimetry, and food and lifestyle diaries. …”
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Efficacy and safety of DL‐3‐N‐butylphthalide in the treatment of ischemic poststroke aphasia: A randomized clinical trial by Jing Tian, Peng Yang, Jianing Yang, Rui Wang, Biyi Zhou, Kun Zhang, Yanying Zhao, Binbin Wang, Lijuan Liu, Ruomeng Chen, Haoran Wu, Ruihan Miao, Li Guo, Xiaoyun Liu

“…Language skills were assessed using the Western Aphasia Battery‐Aphasia Quotient (WAB‐AQ). We collected plasma samples and detected neurotransmitters by liquid chromatography‐mass spectrometry. …”
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The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin—A Randomized, Controlled, Crossover Study by Liva K. Stuhr, Joshua B. Feinberg, Thea Christoffersen, Konstantinos Dimopoulos, Mikkel B. Christensen, David P. Sonne, Troels Riis, Peter S. Plomgaard, Jens P. Goetze, Emil L. Larsen, Kristian Karstoft

“…Blood was sampled during and after the interventions and analyzed for activated partial thromboplastin time (aPTT) and plasma heparin via an anti‐factor Xa assay. …”
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Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial by Queralt Asla, Maite Garrido, Eulàlia Urgell, Sílvia Terzan, Alicia Santos, Mercè Fernández, Nimmy Varghese, Cihan Atila, Anna Calabrese, Betina Biagetti, Franziska Plessow, Ignasi Gich, Mirjam Christ-Crain, Anne Eckert, Susan M. Webb, Elizabeth A. Lawson, Anna Aulinas

“…Samples were collected over 120 min to assess oxytocin. …”
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Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial by Ahmed Shoukry, Yasser ElKassar, Michaella K. Hezagirwa, Rehab El-Said

“…Results A total of 874 urine samples were collected from women in both groups (438 from the Lf group and 436 from the control group), and their results were analyzed. …”
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The Impact of Replacing Sugar in Sweets by Isomalt on Blood Glucose Management: Evidence from Recent Randomized, Controlled Trials by Lisa Schweitzer, Stephan Theis

“…Capillary blood samples were taken at baseline up to 180 min to determine blood glucose and insulin levels. …”
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Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization by Wei Chen, Mingjuan Luo, Jingyi Guo, Suna Wang, Dandan Yan, Xiaohui Feng, Yunting Huang, Tao Zeng, Li Shen, Rong Zhang, Jing Yan, Cheng Hu, Weituo Zhang, Xiangtian Yu

“…Clinical characteristics and serum samples were collected during the GDM screening stage, and the genome and metabolome were tested. …”
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Effects of gut microbiota on cognitive impairment in Parkinson’s disease: a comprehensive Mendelian randomization and case–control study by Yukun Feng, Yukun Feng, Qi Chang, Hao Zhou, Wei Zhang, Wei Zhang, Ling Xie, Xueyang Deng, Xueyang Deng, Tao Chen, Tao Chen, Weiguo Liu

“…Notably, the maltose to sucrose ratio was identified as a mediator of the positive causal effect of Subdoligranulum on PDD, with a mediation value of 13.2%. The clinical samples confirmed the efficacy of Subdoligranulum sp. in distinguishing patients with PDD from normal controls (area under the curve (AUC) = 0.80, 95% CI: 0.674–0.924). …”
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Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study by Neil A. Schwarz, Matthew T. Stratton, Ryan J. Colquhoun, Alexia M. Manganti, Margaux Sherbourne, Florian Mourey, Caitlyn C. White, Heather Day, Micaela C. Dusseault, Geoffrey M. Hudson, Christopher R. Vickery, Holly C. Schachner, Philip G. Kasprzyk, Jing-Ke Weng

“…Blood samples were analyzed for erythropoietin, myoglobin, creatine kinase-MM, and C-reactive protein.Results Salidroside supplementation enhanced overall percent predicted oxygen uptake during high-intensity intermittent exercise (p < 0.01). …”
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Probiotics mitigate stress and inflammation in malnourished adults via gut microbiota modulation: a randomized controlled trial by Maryam Ahmadi-Khorram, Maryam Ahmadi-Khorram, Alireza Hatami, Alireza Hatami, Parastoo Asghari, Parastoo Asghari, Ali Jafarzadeh Esfehani, Asma Afshari, Fateme Javdan, Fateme Javdan, Mohsen Nematy, Mohsen Nematy

“…The current study examined the effects of multi-strain probiotic supplementation on stress levels in underweight individuals using the Perceived Stress Scale (PSS).MethodsA double-blind, randomized, placebo-controlled trial involved 100 underweight participants were randomized to receive either a probiotic supplement (Lactobacillus acidophilus, L. casei, L. rhamnosus; 3 × 109 CFU) or placebo for 8 weeks. …”
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Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial by Eman M. Nada, Nashwa M. El-Gharbawy, Haidy Abbas, Rehab H. Werida

“…Method In a double-blind, randomized control trial, 60 patients with type 2 diabetes mellitus were randomly assigned into three groups: Group I was given placebo; Group II curcumin 1100 mg; Group III fenofibrate 160 mg (each administered orally once daily) to ongoing glimepiride 4 mg therapy administered orally once daily for three months. …”
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Treatment outcomes for acute T-lymphoblastic leukemias/lymphomas: data from the ALL-2016 multicenter prospective randomized trial by O. A. Aleshina, I. V. Galtseva, E. S. Kotova, G. I. Isinova, T. N. Obukhova, V. N. Dvirnik, A. B. Sudarikov, M. E. Grishunina, O. S. Samoilova, K. D. Kaplanov, V. A. Lapin, S. N. Bondarenko, E. S. Fokina, N. V. Minaeva, T. S. Konstantinova, Yu. V. Sveshnikova, E. E. Zinina, A. S. Antipova, O. Yu. Baranova, E. A. Borisenkova, Yu. O. Davydova, N. M. Kapranov, S. M. Kulikov, Yu. A. Chabaeva, V. V. Troitskaya, E. N. Parovichnikova

“…However, the study was non-randomized and the need for auto-HSCT in clinical practice requires careful study.Aim. …”
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Unification of various type expressions for probability distribution of arbitrary random noise and vibration waves based on their actual fluctuation ranges (theory and experiment) by M. OHTA, N. NAKASAKO, Y. XIAO

“…In the measurement of actual random phenomena, the observed data often result in a loss or a distortion of information due to the existence of a definite dynamic range of measurement equipments. …”
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Corrosion behavior and random corrosion morphology reconstruction of welded joints of Q420qFNH weathering steel in a marine environment by Yan Ma, Qing hua Zhang, Chuang Cui, Kun Tang

“…Accelerated corrosion tests were conducted on 54 coupon samples and 14 cruciform-welded joints. Characteristic parameters were extracted and analyzed using computer vision and image processing techniques. …”
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Enhanced random vector functional link based on artificial protozoa optimizer to predict wear characteristics of Cu-ZrO2 nanocomposites by Mamdouh I. Elamy, Mohamed Abd Elaziz, Mohammed Azmi Al-Betar, A. Fathy, M. Elmahdy

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Resource Characteristics of Common Reed (<i>Phragmites australis</i>) in the Syr Darya Delta, Kazakhstan, by Means of Remote Sensing and Random Forest by Azim Baibagyssov, Anja Magiera, Niels Thevs, Rainer Waldhardt

“…To address this gap in knowledge, in this study, the biomass resource characteristics of common reed were estimated for one of the significant reed bed areas of Kazakhstan, the Syr Darya Delta, using ground-truth field-sampled data as the dependent variable and high-resolution Sentinel-2 spectral bands and computed spectral indices as independent variables in multiple Random Forest (RF) regression models. …”
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Mapping the Brain&amp;rsquo;s Role in Osteoarthritis: New Evidence for Prevention by Di J, Xi Y, Liu Y, Qi L, Chen S, Qin Y, Xiang C

“…Jingkai Di,1,2,&amp;ast; Yujia Xi,3,&amp;ast; Yaru Liu,4 Likun Qi,3 Shuai Chen,1,2 Yingda Qin,3 Chuan Xiang1,2 1Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Shanxi Provincial Key Laboratory of Bone and Soft Tissue Injury Repair, Taiyuan, People’s Republic of China; 3The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 4The Third Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Chuan Xiang, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China, Tel +86 15903410351, Email chuanxiang@sxmu.edu.cnPurpose: This study explores the causal link between brain structural parameters and Osteoarthritis (OA), aiming to prevent OA progression.Patients and Methods: We used two-sample Mendelian randomization. In addition to European OA data with a sample size of 484,598, Firth correction OA data from the same source, and SPA correction OA data were included as outcome data. 3913 brain imaging-derived phenotypes (IDPs) from the UK Biobank were used as exposure data. …”
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Causal associations between blood metabolites and breast cancer by Guanying Liang, Dazhuang Miao, Chun Du

“…We conducted a systematic two-sample Mendelian randomization (MR) analysis to identify key human blood metabolites and potential biomarkers for breast cancer development. …”
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Identifying key palmitoylation-associated genes in endometriosis through genomic data analysis by Jinyan Kai, Jiaqi Su, Yinping You, Xiaoliang Liang, Haitao Huang, Jie Fang, Qiong Chen

“…Methods This study integrated transcriptomic analysis and Mendelian randomization (MR) to identify a causal gene set implicated in endometriosis. …”
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