Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals by Chisom Soremekun, Chisom Soremekun, Chisom Soremekun, Chisom Soremekun, Daudi Jjingo, Daudi Jjingo, Daudi Jjingo, David Kateete, Oyekanmi Nash, Dorothea Nitsch, Moffat Nyirenda, Moffat Nyirenda, Dipender Gill, Eleftheria Zeggini, Eleftheria Zeggini, Harald Grallert, Harald Grallert, Annette Peters, Annette Peters, Annette Peters, Tinashe Chikowore, Tinashe Chikowore, Chiara Batini, Chiara Batini, Opeyemi Soremekun, Opeyemi Soremekun, Segun Fatumo, Segun Fatumo

“…Using GWAS summary statistics, we applied a univariable and multivariable Two-sample MR to estimate the causal relationship between hematological traits and T2D.ResultsIn the main IVW MR estimates, genetically predicted levels of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV) were associated with decreased risk of T2D. …”
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The open-closed mod-minimizer algorithm by Ragnar Groot Koerkamp, Daniel Liu, Giulio Ermanno Pibiri

“…This method can be elegantly described as sampling the smallest closed sycnmer (Edgar, PeerJ 2021) in the window according to some random order. …”
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Genetically Predicted Serum 25‐Hydroxyvitamin D Concentrations in Related to Type 2 Diabetes Mellitus: A Mendelian Randomization Study by Jin Yang

“…The second study, identified by PMID: 29892013, includes a sample size of 468,298 Europeans. Results Both univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) analyses demonstrate that genetically predicted elevated levels of serum 25(OH)D are consistently associated with a reduced risk of T2DM. …”
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Application of Goal Setting to Increase Self Efficacy in Vocational Students: A Non Randomized Control Trial Approach by Wulan Dyah Lokahitta, Ghozali Rusyid Affandi

“…The collected data was analyzed using the Independent Samples T-Test and Paired Samples T-Test. The results of this study inform that the application of goal setting has an impact on students' self-efficacy. …”
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The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta‐Analysis of Randomized Clinical Trials by Atefeh Zandifar, Rahim Badrfam, Mahdi Mohammaditabar, Bita Kargar, Saba Goodarzi, Amirhossein Hajialigol, Shera Ketabforoush, Afshin Heidari, Hanie Fathi, Arman Shafiee, Hadi Pourjafar

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Efficacy of different remineralizing agents on primary teeth exposed to therapeutic gamma radiation: An in vitro randomized control study by Yomna O. Morad, Shaymaa A. El Shishiny, Rania I. Hindi, Asmaa A. El Sheshiny, Amira M. Samy

“…Results were investigated concerning pre- and post-irradiation values difference. The paired-samples t-test was performed to compare the atomic and weight percentages of the selected elements obtained from the samples in the control groups before and after therapeutic radiation. …”
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Effects of community-wide vaccination with PCV-7 on pneumococcal nasopharyngeal carriage in the Gambia: a cluster-randomized trial. by Anna Roca, Philip C Hill, John Townend, Uzo Egere, Martin Antonio, Abdoulie Bojang, Abiodun Akisanya, Teresa Litchfield, David E Nsekpong, Claire Oluwalana, Stephen R C Howie, Brian Greenwood, Richard A Adegbola

“…Cross-sectional surveys (CSSs) to collect nasopharyngeal swabs were conducted before vaccination (2,094 samples in the baseline CSS), and 4-6, 12, and 22 mo after vaccination (1,168, 1,210, and 446 samples in CSS-1, -2, and -3, respectively). …”
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Oxycodone does not affect placental circulatory physiology during the early first stage of labor—A randomized trial by Leena Alanne, Hannu Kokki, Anu Mykkänen, Maija‐Riitta Ordén, Valtteri Rinne, Juha Räsänen, Merja Kokki

“…The second dose of oxycodone 0.05 mg/kg was allowed at 60 min to all parturients with contraction pain ≥5/10. Maternal plasma samples were collected at each study phase and after delivery with umbilical cord plasma samples, to measure oxycodone concentrations. …”
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Transcriptome analysis in human breast milk and blood in a randomized trial after inactivated or attenuated influenza immunization by Elizabeth P. Schlaudecker, Travis L. Jensen, Casey E. Gelber, Phillip J. Dexheimer, Mark C. Steinhoff, David I. Bernstein, Johannes B. Goll

“…We performed an RNA-Seq analysis on blood and breast milk samples from a subset of subjects enrolled in a randomized, double-blind controlled study in breastfeeding women who received either intranasal LAIV and intramuscular placebo, or intramuscular TIV and intranasal placebo (LAIV, n = 10 and TIV, n = 6). …”
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Investigating the Effectiveness of an Exercise Protocol for Dynamic Balance in Amateur Female Soccer Players: A Randomized Clinical Trial by Shirley Mireya Ortiz Pérez, David Marcelo Guevara Hernández, Vanessa de los Ángeles Belloso de Norieg, Fernando Daniel Álvarez Maigualema

“…Materials and Methods: A total of 24 females participated in this study and were randomly assigned to a control (n=12) and an experimental group (n=12). …”
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The Effect of Listening to Holy Quran Recital on Pain and Length of Stay Post-CABG: A Randomized Control Trial by Mohannad Eid Aburuz, Ghadeer Al-Dweik, Fatma Refaat Ahmed

“…Methods. This was a randomized control trial on 132 patients recruited from four hospitals in Amman, Jordan. …”
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Effect of drama-education for alcohol/substance user on attitudes toward violence against women: randomized controlled design by Hümeyra Hançer Tok, Makbule Tokur Kesgin

“…Further studies with larger and more diverse samples are recommended to confirm the generalizability and long-term impact of this approach. …”
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Experimental Investigation on the Variation in Shear Strength of Clayey Soil Reinforced with Randomly Distributed Alkali-Resistant Glass Fiber by Aşkın Özocak, Ertan Bol, Eylem Arslan, Ercüment Kekeç, Sedat Sert

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Baseline gut microbiome and metabolites are correlated with changes in alcohol consumption in participants in a randomized Zonisamide clinical trial by Liv R. Dedon, Hanshu Yuan, Jinhua Chi, Haiwei Gu, Albert J. Arias, Jonathan M. Covault, Yanjiao Zhou

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Effect of exercise rehabilitation, neuromuscular muscle stimulation, and massage on ischemic stroke recovery and hypertension: a randomized trial by Ammar Hadi, Shimal H. Hamad, Nabaz Ali Ahmed

“…Caution is warranted when interpreting these findings, and further studies are needed with improved methodology and larger samples. …”
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Novel active-feedback device improves sleep quality in insomnia disorder: a randomized placebo-controlled trial by Antonia Ypsilanti, Maan van de Werken, Anna Robson, Petra Examilioti, Lambros Lazuras, Lambros Lazuras

“…Finally, an independent samples t-test and content analysis indicated a more positive user experience in the experimental group.ConclusionThe SleepCogni device appears to be a useful tool for improving sleep outcomes in individuals with insomnia disorder, showing effects on both insomnia severity and subjectively evaluated sleep. …”
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Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation by Wenyong Liao, Yang Jiang, Jiwen Zhang, Yinghao Wu, Xue Yu, Shaohong Chen, Haiyan Liu, Linlin Xiu, Gansheng Zhong

“…We aimed to investigate whether specific gut microbial taxa causally influence goiter risk through the short-chain fatty acid (SCFA)-iodine-thyroid axis.MethodsWe performed Mendelian randomization (MR) analysis using gut microbiota genome-wide association study (GWAS) data (MiBioGen consortium, n = 18,340) and goiter GWAS data (FinnGen R10, 10,312 cases/401,869 controls). …”
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Relationship between retinol metabolism and hepatocellular carcinoma: a comprehensive analysis of Mendelian randomization, prognostic characteristic and experiment by Fuqing Chen, Yifan Cai, Jianyin Zhou

“…The aim of this study was to elucidate the characteristics of retinol metabolism in HCC through Mendelian randomization, prognostic model and experimental validation. …”
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Role of PD-L1 in mediating the effect of lipid on ulcerative colitis: a mediation Mendelian randomization study by Peihong Li, Yiwen Wang, Hongyi Hu, Boyun Sun

“…This study employed Mendelian randomization (MR) to investigate the relationships among lipids, inflammatory factors, and UC.MethodsWe analyzed data on 179 lipids from the GeneRISK cohort (7,174 individuals), 91 inflammation-related proteins from the EBI GWAS Catalog (14,824 participants), and UC GWAS summary statistics from the FinnGen Biobank (411,317 samples). …”
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Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis by Jingzhi Wang, Simin Peng

“…Using summary data from genome-wide association studies (GWAS), we conducted a Mendelian randomization (MR) analysis with two samples, treating 91 circulating inflammatory proteins as exposure factors and CS as the outcome. …”
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