Efficacy of Cheiranthus Cheiri in the Treatment of Pericoronitis: A Double-blind, Randomized, Placebo-controlled Trial with Molecular Docking by Shubhamoy Ghosh, Aritra Roy Chowdhury, Sarbendu Paul, Avipsha Sarkar, Abhijit Rana, Mousumi Koley, Indrani Halder, Suman Chandra, Subhranil Saha

“…The intention-to-treat sample was analyzed; Kaplan–Meier analysis and Welch t-tests of unequal variances were run to detect group differences. …”
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Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial by Shaikh Nisar Ahmed Abbas, Arshan Horti, Muhammed Rashid Allapat, Mamadapur Saba Abdul Razzaq, Farooqui Shazia Parveen, Nazim Husain

“…Further studies with larger sample sizes and extended follow-up periods are recommended. …”
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Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study by Wei Du, Biqiu Tang, Senhao Liu, Wenjing Zhang, Su Lui

“…This study aims to examine the relationship between iron levels in specific subcortical brain regions and the risk of psychiatric disorders. Utilizing two-sample Mendelian randomization (MR) analysis, this study investigates the causal associations between iron level changes in 16 subcortical nuclei and eight major psychiatric disorders, including schizophrenia (SCZ), major depressive disorder (MDD), autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, and insomnia. …”
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The Effect of Maternal Vitamin D Intake on the Incidence of Nonspecific Respiratory Distress in Infants: A Randomized Clinical Trial by Nafiseh Pourbadakhshan, Hassan Boskabadi, Mohammad Hosein Ataee Nakhaei, Azadeh Darabi, Morteza Rasti Sani

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Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…<b>Methods:</b> Leveraging multi-omics integration, we conducted bidirectional two-sample Mendelian randomization (MR) using protein quantitative trait loci (pQTLs) from 4998 plasma proteins and genome-wide association data of irAE phenotypes. …”
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Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials by Caroline Goswami, Sherrice Law, Hannah Zhang, Hannah Park, Bhagvat Maheta, Katherine Arnott, Megan Hsu, Kevin Truong, Mark Sheffield, Zahid Iqbal, Chainaronk Limanon, David Pai

“…Future directions can include additional prospective studies with larger sample sizes of healthy adults testing for benefits and adverse effects of prophylactic vitamin D use.…”
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Exploring the Causal Link Between Autoimmune Diseases and Pulmonary Arterial Hypertension: A Bidirectional Mendelian Randomization Study by Chao Ma, Cheng Gong, Bin Wang, Yangmeina Li, Yongxiang Qian, Xiaoying Zhang, Dongmei Di, Min Wang

“…Methods: We conducted a two-sample Mendelian Randomization (MR) analysis to evaluate the causal effect of genetic predisposition to five autoimmune diseases (systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], inflammatory bowel disease [IBD], multiple sclerosis [MS], and type 1 diabetes [T1D]) on the risk of PAH. …”
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Sedentary behaviors, physical activity, and risk of allergic rhinitis and asthma: evidence from cohort and Mendelian randomization studies by Xiaoyu Wang, Yaya Gao, Lin Lou, Wenjie Yang, Wei Xu, Yu Zhao, Jianjun Ren

“…Methods Based on information of questionnaires and registrations provided by UK Biobank, and large-scale GWAS (Genome-Wide Association Study) data, we designed a cohort study with a follow-up period exceeding 11 years and two-sample Mendelian randomization (MR) analysis to explore the causal associations between movement behaviors (SB and PA) and AR and asthma. …”
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Examining the Dose-Response Effects of Mindfulness Meditation Interventions on Well-Being: Protocol for a Randomized Controlled Trial by Nicholas Bowles, Alexander Burger, Jonathan N Davies, Julie A Simpson, Julieta Galante, Simon Dennis, Benjamin Stone, Nicholas T Van Dam

“…Recruitment recommenced in early 2025 and will continue until the end of March 2025 or until the target sample is reached. We estimate that the results will be published by March 2026. …”
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Comparison of the Efficacy of Elastodontic Devices and Aligners in Dentoalveolar Transverse Expansion: A Randomized Open Label Clinical Trial by Eleonora Ortu, Mariano Lacarbonara, Samuele Cova, Elena Gigliozzi, Maria Ausilia D’Angelo, Annalisa Monaco, Davide Pietropaoli

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IL-20RA is Associated with the Risk of Diabetic Microangiopathy: A Bidirectional Mendelian Randomization Analysis and Clinical Validation by Li J, Yang H, Wang T, Ruan N, Lin Y, Fang Z

“…This study aimed to investigate whether altered genetically predicted concentrations of circulating inflammatory cytokines were associated with the development of diabetic microvascular complications using two-sample Mendelian randomization (MR) analysis and clinical validation.Methods: Pooled data on diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and 91 circulating inflammatory cytokines were obtained from publicly available databases. …”
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Motivational interviewing to improve self‐care in heart failure patients (MOTIVATE‐HF): a randomized controlled trial by Ercole Vellone, Paola Rebora, Davide Ausili, Valentina Zeffiro, Gianluca Pucciarelli, Gabriele Caggianelli, Stefano Masci, Rosaria Alvaro, Barbara Riegel

“…Methods and results Parallel randomized controlled trial (1:1:1). A sample of 510 patients (median 74 years, 58% male) and caregivers (median 55 years, 75% female) was randomized to Arm 1 (MI only for patients), Arm 2 (MI for patients and caregivers), or Arm 3 (usual care). …”
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Effects of nitrate supplements on cardiopulmonary fitness at high altitude: A meta-analysis of nine randomized controlled trials. by Chao Kang, Ning Lin, Yanle Xiong, Yi Yang, Jiaojiao Shi, Kaihong Zeng, Xin Ma

“…<h4>Results</h4>A total of 9 studies with a sample size of 161 cases were included in the analysis. …”
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Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization by Suwei Wang, Yuanjing Yang, Zeyu Pang, Yidan Li, Ke Li, Yan Sun, Jurong Yang

“…This study employed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the genetic causal relationship between mtDNA-CN and renal function. …”
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Effectiveness of human albumin for clinical outcome in aneurysmal subarachnoid hemorrhages: a protocol for randomized controlled (HASH) trial by Arshad Ali, Mohsin Khan, Nissar Shaikh, Amr El Mohamad, Mazyona Al-Maadhadi, Noman Shah, Yousef Al-Najjar, Abdul Salam, Ghaya Al-Rumaihi, Ali Ayyad, Sirajeddin Belkhair, Ghanem Al-Sulaiti

“…Methods This single-center open-label, prospective, parallel group randomized control trial will be conducted at Hamad General Hospital, Doha, Qatar, from August 2024 to July 2027. …”
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Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study by Jiang G, Liu R, Xue Y, Ge Q, Nie L, Lv Z, Kong Z, Shi J, Chen H, Li H, Wu X, Xie L, Song Y, Huang H, Gao M

“…Sputum samples were collected daily starting one day before treatment initiation and continuing throughout the treatment period. …”
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The impact of ketogenic diet on the frequency of psychogenic non‐epileptic seizures (PNES): A feasibility randomized pilot study by Reinhard Janssen‐Aguilar, Juan Galindez‐de laPortilla, Iris E. Martínez‐Juárez, Claudia Mimiaga‐Hernandez, Gabriel Alvarado‐Luis, Andrea Aguilar‐Hernandez, Kevin Alan Garcia‐Esparza, Mariel Hernadez‐Palestina, Daniel Crail‐Meléndez

“…The entire sample exhibited a significant decrease in monthly PNES frequency (p = 0.01, Hedges ES = 0.618) without differences between groups. …”
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Evaluation of the effect of Modafinil in the improvement of the level of consciousness in patients with COVID‐19 encephalopathy: A randomized controlled trial by Fatemeh Talebi Kiasari, Mobin Naghshbandi, Maziar Emamikhah, Omid Moradi Moghaddam, Mohammad Niakan Lahiji, Mohammad Rohani, Narges Yazdi, Hamidreza Movahedi, Alireza Amanollahi, Pardis Irandoost, Roya Ghafoury

“…This double‐blinded randomized clinical trial conducted in Tehran, Iran, aimed to assess the potential effectiveness of modafinil in patients with COVID‐19‐related encephalopathy. …”
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Feasibility and effectiveness of cardiac telerehabilitation for older adults with coronary heart disease: A pilot randomized controlled trial by Jing Jing Su, Arkers Kwan Ching Wong, Xi-Fei He, Li-ping Zhang, Jie Cheng, Li-Juan Lu, Lan Lan, Zhaozhao Wang, Rose S.Y. Lin, Ladislav Batalik

“…Methods: The study randomized 43 older adults (84 % males) to the 12-week CTR intervention or standard of care. …”
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Role of metabolic characteristics in the co-occurrence of insomnia, Alzheimer’s disease, and Parkinson’s disease: a Mendelian randomization study by Chengyong Liu, Chi Wang, Jing Jiang, Yuyang Bo, Lixiu Nan, Ying Zhang, Kongxi Zhu, Xiaoqiu Wang, Xinxin Feng, Xiaoyang Lian, Shan Qin

“…ObjectiveThere reportedly exists a significant comorbidity between insomnia and neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), indicative of a potential link to serum metabolic dysregulation.MethodTo elucidate shared pathophysiological mechanisms between insomnia and AD/PD, we performed comprehensive two-sample Mendelian randomization (MR) analyses, investigating 1,400 serum metabolic characteristics for their causal relationships with the risks of insomnia, AD, widely defined AD (WDAD), and PD. …”
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