Non-Adrenergic Vasopressors in Patients with or at Risk for Vasodilatory Shock. A Systematic Review and Meta-Analysis of Randomized Trials. by Alessandro Belletti, Mario Musu, Simona Silvetti, Omar Saleh, Laura Pasin, Fabrizio Monaco, Ludhmila A Hajjar, Evgeny Fominskiy, Gabriele Finco, Alberto Zangrillo, Giovanni Landoni

“…Thus, in recent years, interest in catecholamine-sparing agents such as vasopressin, terlipressin and methylene blue has increased; however, few randomized trials, mostly with small sample sizes, have been performed. …”
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Association of modifiable risk factors and telomere length with five neuroendocrine neoplasms: a bidirectional Mendelian randomization study by Xujia Li, Lingli Huang, Yue Yan, Yuming Rong, Xuxian Chen, Mengge Gao, Jinsheng Huang

“…Methods A bidirectional two-sample Mendelian randomization (MR) analysis was employed to elucidate the causal relationships between 41 potential risk factors and five neuroendocrine neoplasms. …”
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Causal relationship between oral microbiota and epilepsy risk: Evidence from Mendelian randomization analysis in East Asians by Chenyang Zhao, Fei Chen, Qiong Li, Wei Zhang, Lixiu Peng, Chaoyan Yue

“…We aim to estimate the potential links between oral microbiota and epilepsy and elucidate which specific oral microbes may directly influence the pathogenesis of epilepsy. Methods A two‐sample MR analysis was conducted using genome‐wide association study (GWAS) data specific to OM and epilepsy in East Asian individuals. …”
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Patient compliance with braces vs. Invisalign®: a secondary data analysis from a randomized clinical trial by Graziela Hernandes VOLPATO, Paula Vanessa Pedron OLTRAMARI, Renata Rodrigues de ALMEIDA-PEDRIN, Thais Maria Freire FERNANDES, Marcio Rodrigues de ALMEIDA, Gabriela UTRAGO, João POIANI, Ana Cláudia de Castro Ferreira CONTI

“…Objective: This study compared patient compliance during the first year of orthodontic treatment using aligners and conventional fixed appliances. Methodology: The sample included 39 participants (22.1±4.62 years, 25 males, 14 females) randomized into two groups: orthodontic aligners (OA, 20 patients, 23.7±5.6 years, 12 males, 8 females) and fixed appliances (FA, 19 patients, 20.5±4.5 years, 12 males, 7 females). …”
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Bidirectional Relationship Between Atopic Dermatitis and Psychiatric Comorbidities in Individuals of European Ancestry: A Mendelian Randomization Study by Zhe Wu, Chenglong Wu, Xuanyi Chen, Qiufang Qian, Zhirong Yao

“…This study employed bidirectional 2-sample Mendelian randomization to investigate the potential causal relationships between atopic dermatitis and 8 psychiatric conditions: depression, anxiety, autism spectrum disorder, attention deficit hyperactivity disorder, suicidality, bipolar disorder, obsessive-compulsive disorder, and schizophrenia. …”
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A preliminary randomized trial of the safety, tolerability, and clinical effects of hemp-derived cannabidiol in alcohol use disorder by Raeghan L. Mueller, Jake F. Hooper, Jarrod M. Ellingson, Aviva K. Olsavsky, Aviva K. Olsavsky, Rachael Rzasa-Lynn, Angela D. Bryan, L. Cinnamon Bidwell, Kent E. Hutchison

“…Future studies with larger sample sizes will be necessary to replicate and extend these findings by addressing the question of whether a small amount of THC may work synergistically with CBD.…”
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Effectiveness of Shacklock's Neural Mobilization for Acute and Sub‐Acute Lumbar Disc Prolapsed: A Randomized Controlled Trial by Zahid Bin Sultan Nahid, Faruq Ahmed, Md Faruqul Islam, Zakia Rahman, Md Furatul Haque, Asma Arju, Md Rafiqul Islam, Golam Moula, Bibekanonda Sarker

“…Methods The study was a double‐blinded, randomized controlled trial. A total of 42 individuals with LDP were allocated randomly by computer‐generated numbers to an experimental and a control group. …”
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Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus by Jianye Cao, Tiantao Du, Jian Li, Baiyu Chen, Xianting Xie, Guoshu Zhang, Jia Feng, Tao Xu

“…This study aims to elucidate causal relationships among immune cell populations, plasma metabolites, and lichen planus using Mendelian randomization (MR) techniques.MethodsEmploying a two-sample, two-step MR approach, with single nucleotide polymorphisms (SNP) serving as genetic instruments for both exposures and mediators, this study minimizes biases from confounding and reverse causality. …”
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Efficacy of repetitive transcranial magnetic stimulation for subjective chronic tinnitus: a randomized controlled trial meta-analysis by Ziyan He, Defu Liao, Qipei Ji, Shichang Yan, Shuangchun Ai

“…Meta-analysis was conducted using RevMan 5.4 software.ResultsSixteen randomized controlled trials (RCTs) involving 1,105 chronic tinnitus patients were included. …”
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Effects of anesthetic nasal masks on hypoxemia in overweight/obese patients undergoing gastroscopy: a randomized controlled trial by Huan Liu, Peipei Guo, Lijian Chen, Xuesheng Liu, Huisheng Wu

“…Patients were randomly assigned (1:1) to receive oxygen via nasal masks or nasal cannulas using a computer-generated randomization sequence. …”
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Systemic inflammatory factors in non-alcoholic steatohepatitis-induced hepatocellular carcinoma: A bidirectional Mendelian randomization analysis by Kang Fu, Yiming Zhou, Zhongyi Guo, Xiaotong Chen, Lin Sun, Xiao Hu

“…Methods: This study employed a two-sample Mendelian randomization (MR) approach to systematically investigate the causal relationships among inflammatory proteins, non-alcoholic steatohepatitis (NASH), and HCC. …”
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Appraising the causal effects of circulating micronutrients on liver cirrhosis: Evidence from large‐scale Mendelian randomization analysis by Junlong Lin, Jialin Chen, Zhichao Li, Baifeng Qian, Yunpeng Hua

“…This Mendelian randomization (MR) analysis aimed to examine the causal impact of micronutrients on liver cirrhosis. …”
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Causal relationship between glycemic traits and inflammatory eye diseases and their complications, and myopia: a Mendelian randomization analysis by Yingying Nie, Xunlang Zhang, Xiaoxiao Wu, Qiulin Mi, Zhihuang Yang, Junguo Duan

“…This study evaluates specific indicators to address these knowledge gaps. A two-sample Mendelian randomization framework from a genome-wide association study was used. …”
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Comparison of the efficacy among different interventions for radiodermatitis: A Bayesian network meta‑analysis of randomized controlled trials. by Ying Guan, Shuai Liu, Anchuan Li, Wanqin Cheng

“…However, studies with larger sample size on different interventions are warranted in the future.…”
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Causal relationships between gut microbiota and IgA nephropathy: evidence from Mendelian randomization and microbiome validation by Xin Wang, Jiong Liu, Wuda Huoshen, Jing Liu, Xue Qiao, Hong Zhang, Xu-Jie Zhou

“…This study used a two-sample Mendelian randomization (MR) approach, validated with 16S rRNA datasets, to identify these causal relationships.Methods We performed MR analysis using genetic instruments for 412 gut microbiota taxa from genome-wide association studies (GWAS) as exposures and IgAN GWAS data as outcomes. …”
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A study protocol for a randomized controlled feasibility trial of behavioural therapy for interepisode bipolar symptoms (STABILISE) by Kim Wright, Fiona Warren, Sandra Bucci, Barnaby D. Dunn, Steven Jones, Heather O’Mahen, Rod S. Taylor, Antonieta Medina-Lara

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Efficacy and safety of acupuncture as an adjuvant therapy for osteoporosis: a systematic review and meta-analysis of randomized controlled trials by Zixin Teng, Jingwei Zhu, Kuiwu Li, Tingting Tong, Wei Li, Haoran Chu, Peiyang Sun

“…Current evidence is limited by regional bias and methodological heterogeneity. Multicenter, large-sample RCTs are needed to standardize protocols and validate long-term therapeutic efficacy.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024499354.…”
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The impact of high-intensity exercise on patients with depression: a systematic review and meta-analysis of randomized controlled trials by Junru Zeng, Hong Wang

“…However, due to limitations such as small sample sizes, potential heterogeneity, and result instability, further validation through large-scale, multi-centre, randomized, double-blind clinical trials is warranted.…”
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A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health by Sneha Singh, Anootpal Gogoi, Ashish Kumar, Eesha, Dr., Rinku Jagnade, Gaurav Jain, Sanjay Rastogi, Sanjay Dutta

“…More research with a broad sample size and multicentre trials is required. Clinical relevance: The article reveals the positive relationship between Lycopene and gingivitis. …”
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Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma by Fu ZD, Wang Y, Yan HL, Wu JH

“…According to the results of reverse MR analysis, there is no significant causal relationship between BCC and the above-mentioned inflammatory proteins.Conclusion: This two-sample MR study revealed a strong association between circulating inflammatory proteins and the development of BCC. …”
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