Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study by Linbin He, Jianhui Wei, Ziye Li, Suyan Guo, Shanyu Lin, Tingting Wang, Lizhang Chen

“…The present Mendelian randomization (MR) study aims to examine the causal relationships between gut microbiome and IBD (including its subtypes), and to explore potential mediating effects of immunocyte. …”
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Feature-based ensemble modeling for addressing diabetes data imbalance using the SMOTE, RUS, and random forest methods: a prediction study by Younseo Jang

“…Methods Using the Scikit-learn diabetes dataset (442 samples, 10 features), we binarized the target variable (diabetes progression) at the 75th percentile and split it 80:20 using stratified sampling. …”
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Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis by Xiaoyun Liu, Sen Yang, Liyun Liu

“…However, the causal relationships of gut microbiome-related metabolic pathways in chondrosarcomas and the specific pathways affected remain largely unknown. Methods We used two-sample bidirectional and multivariate Mendelian randomization (MR) to reveal a causal relationship between the gut microbiota metabolic pathway (GMMP) and chondrosarcoma associated gene 1(CSAG1) via the largest available genome-wide association study (GWAS). …”
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Gut microbiome, dietary habits, and prostate cancer: a two-step Mendelian randomization revealing the causal associations by Junhua Guo, Ting Huang, Heran Zhou

“…Methods We conducted two-sample Mendelian Randomization (MR) analyses utilizing large-scale genome-wide association studies (GWAS) data from the UK Biobank, the MiBioGen consortium, and PCa-related datasets. …”
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Effect of Coffee Consumption on Postoperative Ileus after Colorectal Surgery: A Meta-Analysis of Randomized Controlled Trials by Junjia Zhu, Wenlong Xu, Qi Sun, Jun Geng, Yifeng Yu, Zhenguo Zhao

“…The current literature revealed that postoperative coffee consumption shortened the time to first defecation following elective colorectal surgery. Large sample and tightly controlled multicenter randomized clinical trials are needed to offer a more accurate evaluation of the efficacy of coffee.…”
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Anxiety relief in the post-pandemic era: a randomized trial on the integration of digital technology into dance art healing by Suhui Qiu, Chao Ruan, Ying Wang

“…Trial designThis randomized controlled trial examined the effectiveness of digital technology-integrated dance therapy in alleviating anxiety symptoms associated with post-pandemic isolation.MethodsParticipants, including both professional and amateur dancers, were randomly assigned to either a traditional dance therapy group or a digital dance therapy group utilizing smart fitness mirrors. …”
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Effect of thermo mechanical stimulation during local anesthesia in pediatric dentistry: a pilot randomized clinical trial by Fernanda Vieira Almeida, Bruna Martins da Silva, Edde Caroline Menezes diGesu, Andréia Drawanz Hartwig, Ivam Freire da Silva Júnior, Marília Leão Goettems

“…Materials and methods: Study carried out from May 2018 to July 2019, with children aged 7 to 11 years, without previous experience involving anesthesia in the last 2 years and who needed dental treatment (extraction, restoration or endodontic) under local anesthesia in deciduous molars. The sample was randomized into a control group, which received conventional anesthesia, and an intervention group, which received anesthesia with Buzzy®. …”
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Integration of single-cell sequencing and mendelian randomization reveals novel causal pathways between monocytes and hepatocellular carcinoma by Jiang Yu, Jing Yu, Zhou Kang, Yong Peng

“…Methods This investigation employed single-cell transcriptomic analysis of human hepatic innate lymphoid cells (ILCs) to identify monocyte subpopulations and their cellular markers. Subsequently, two-sample Mendelian randomization (MR) analysis was conducted to examine the causal relationships between these cells, their associated genes, and HCC development. …”
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DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus–Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study by Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu

“…Method: To identify candidate hub genes and develop insights into the pathogenesis of DM-PAD, we employed a comprehensive approach encompassing two-sample Mendelian Randomization (two-sample MR), summary data-based Mendelian randomization (SMR), and Bayesian colocalization (COLOC) methods. …”
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Causal Relationships Between the Gut Microbiota, Inflammatory Cytokines, and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Analysis by Li Changqing, Yu Leying, Ma Caiyun, Wen Hebao, Han Laiguo, Zhao Xiaojiang

“…Initially, we conducted bidirectional two‐sample MR analysis to determine the causal relationships between GM, ICs, and ALS. …”
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Effectiveness Evaluation of a Violence Prevention Parenting Program Implemented at Large Scale: A Randomized Controlled Trial by Elisa Rachel P. Altafim, Maria Beatriz M. Linhares

“…The caregivers were randomly allocated into the intervention (IG, n = 639) or waitlist control (CG, n = 671) groups. …”
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Enhanced Preoperative Pancreatoduodenectomy Patient Education Using Mixed Reality Technology: A Randomized Controlled Pilot Study by Jessica Heard, Paul Murdock, Juan Malo, Joseph Lim, Sourodip Mukharjee, Rohan Jeyarajah

“…However, limitations include the small sample size and single-center design, necessitating larger studies to confirm its broader applicability. …”
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Association between DHA and depression: results from the NHANES 2011–2014 and a bidirectional Mendelian randomization analysis by Yu-hang Chen, Yu Zhang, Wang Zhang

“…This discovery needs to be validated in further prospective studies that require large sample sizes and sufficient follow-up time.…”
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Uncovering leading compounds for alzheimer’s disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation by Xiaohan Sun, Xiaofei Hu, Jianming Wei, Haoyu An

“…A two-sample MR analysis assessed associations between plasma proteins, identified through genome-wide association studies (GWAS), and AD risk. …”
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Influence of immune cells and inflammatory factors on Alzheimer’s disease axis: evidence from mediation Mendelian randomization study by Linzhu, Jianxin Zhang, Wenhui Fan, Chen Su, Zhi Jin

“…Methods This study utilized a two-sample Mendelian randomization (MR) approach to assess the causal relationship between different types of immune cells and AD, while considering inflammatory factors as intermediate variables. …”
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Epigallocatechin-3-gallate prior to composite resin in abfraction lesions: a split-mouth randomized clinical trial by Luísa Valente Gotardo Lara Alves, Lisiane Martins Fracasso, Thiago Vinicius Cortez, Aline Evangelista Souza-Gabriel, Silmara Aparecida Milori Corona

“…The teeth were randomly assigned according to dentin treatment: 0.02% EGCG solution or distilled water (control). …”
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A brief online mindfulness intervention: study protocol for Indonesian undergraduate students, a randomized controlled trial by Ka Yan, Nessa Ikani, Cleoputri Yusainy, Cilia Witteman, Jan Spijker

“…Discussion The findings from this randomized controlled trial will provide evidence for the possible effectiveness of a brief online mindfulness intervention on stress, anxiety, depression, and RNT. …”
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Causal relationships of gut microbiota and blood metabolites with ovarian cancer and endometrial cancer: a Mendelian randomization study by Jinyan Chen, Xuejun Chen, Jiong Ma

“…Abstract Objectives The study aimed to investigate the causal relationships of gut microbiota (GM), ovarian cancer (OC), endometrial cancer (EC), and potential metabolite mediators using Mendelian randomization (MR) analysis. Methods Bidirectional two-sample MR analysis and reverse MR analysis of GM on OC/EC were employed to determine the causal effects of GM on OC/EC and the mediating role of blood metabolites in the relationship between GM and OC/EC, with results validated through sensitivity analysis. …”
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The effects of adjunctive use of a desiccant agent in the treatment of stage III periodontitis (Randomized controlled clinical trial) by Belal Khalil, Ali Abou Sulaiman, Batoul Al Hajjar

“…Materials and Methods: The study sample comprised 25 patients with periodontitis stage Ш (grades A and B). …”
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How to construct analysis of covariance in clinical trials: ANCOVA with one covariate in a completely randomized design structure by WooJin Jung, Kwan Lee, Hyung-Hwan Kim, Chiyeon Lim

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