A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Survival rate, body weight, and quality of life were positive outcomes by the end of the trial despite a high sample reduction, especially in the placebo group. …”
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Impact of Baseline Kidney Function on the Rate of Progressive Kidney Disease After Pregnancy: A Population-Based Cohort Study Research Protocol by Lavanya Bathini, Nivethika Jeyakumar, Jessica Sontrop, Eric McArthur, Yuguang Kang, Bin Luo, Aminu Bello, David Collister, Sofia Ahmed, Padma Kaul, Erik Youngson, Branko Braam, Nir Melamed, Michelle Hladunewich, Amit X. Garg

“…Design: Population-based cohort study using provincial administrative health care databases in Ontario and Alberta, Canada. Setting: The sample will be accrued from April 1, 2007, to March 31, 2023, in Ontario and from April 1, 2012, to March 31, 2023, in Alberta. …”
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Resistance exercise snacks as a workplace health intervention by Tom Brandt, Christian Thomas Lothar Schwandner, Annette Schmidt

“…Pumping iron in Australia: Prevalence, trends and sociodemographic correlates of muscle strengthening activity participation from a national sample of 195,926 adults. PLoS ONE, 11(4), Article e0153225. https://doi.org/10.1371/journal.pone.0153225 Doherty, T. …”
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Community-Based Intervention for Type 2 Diabetes Management in Developing Countries: A Systematic Review by Lutfian Lutfian, Izdihar Javier Wardika, Aufa Azizah, Fahmi Wildana, Yusti Muzdalifa Taplo, Riki Wartakusumah

“…A review of twelve articles, with sample sizes ranging from 54 to 12,140 participants, explored interventions such as exercise, empowerment, peer support, and web-based programs. …”
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Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind c... by Una Martin, Timothy Barrett, Susan Mollan, Karen E Morrison, Ruth Evans, Isabelle Meunier, Rajat Gupta, Andrew Peet, Martin Wilson, Sulev Koks, Wojciech Młynarski, Patrick Yu-Wai-Man, Agathe Roubertie, Darren Barton, Dewi Astuti, Renuka P Dias, Lucinda Billingham, Kun Hu, Malgorzata Zatyka, Archana Kulkarni, Benjamin Wright, Kristian Brock, Victoria Homer, Rebecca Malpass, Heather Rose, Christophe Orssaud, Zsuzsanna Nagy, Tracy Lynch, Sabrina Cronier, Amandip Malhi, Pooja Takhar, Amy Lamb, Gema Esteban-Bueno

“…Patients who satisfied the eligibility criteria were randomly assigned (2:1) to receive two times per day oral gastro-resistant sodium valproate tablets up to a maximum dose of 800 mg 12 hourly or sodium valproate-matched placebo. …”
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Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid‐Lowering Therapy by Zhendong Mei, Lili Xu, Qingxia Huang, Chenhao Lin, Mengyao Yu, Shalaimaiti Shali, Hongyi Wu, Yijing Lu, Runda Wu, Zhen Wang, Lingfeng Luo, Zhonghan Sun, Liang Sun, Juying Qian, Guochong Chen, Huiru Tang, Kang Yao, Yan Zheng, Yuxiang Dai, Junbo Ge

“…The association of metabolites with CAD severity was examined using multivariate linear regression, and the underlying potential causality was explored using a 2‐sample Mendelian randomization approach. Two composite metabolomic indices were constructed to reflect CAD severity using least absolute shrinkage and selection operator linear regression, and their associations with risk of major adverse cardiac events during a median follow‐up of 3.8 years were evaluated using Cox models. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Schools were allocated to PAU or ZF-SEND arm using minimisation with 80% random component and balanced by size of school. Analyses Primary (feasibility) outcomes were estimated with their associated 95% confidence intervals (CIs). …”
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Additional Treatments to the Local tumour for metastatic prostate cancer-Assessment of Novel Treatment Algorithms (IP2-ATLANTA): protocol for a multicentre, phase II randomised con... by Francesca Fiorentino, Iqbal Shergill, John McGrath, Manal Kumar, Martin John Connor, Taimur Tariq Shah, Katarzyna Smigielska, Emily Day, Johanna Sukumar, Naveed Sarwar, Michael Gonzalez, Alison Falconer, Natalia Klimowska-Nassar, Martin Evans, Olivia Frances Naismith, Kamalram Thippu Jayaprakash, Derek Price, Shiva Gayadeen, Dolan Basak, Gail Horan, Denise Sheehan, Azman Ibrahim, Cathryn Brock, Rachel A. Pearson, Nicola Anyamene, Catherine Heath, Bhavan Rai, Giles Hellawell, Stuart McCracken, Bijan Khoubehi, Stephen Mangar, Vincent Khoo, Tim Dudderidge, John Nicholas Staffurth, Mathias Winkler, Hashim Uddin Ahmed

“…Embedded feasibility sample size is 80, with 918 patients required in the main phase II component. …”
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Assessment of Microsatellite Genetic Diversity of Cultured Eriocheir sinensis Populations from Jiangsu and Anhui by Yuting HU, Jun LING, He JIANG, Huan WANG, Tingshuang PAN, Guoqing DUAN, Huaxing ZHOU, Min YANG, Tong LI

“…The leg muscle of the sampled crabs was extracted, and genomic DNA was extracted according to the instructions of the genome extraction kit (TianGen DP304). …”
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Fluid balance dynamics and early postoperative outcomes in orthotopic liver transplantation: a prospective cohort study by Suzana Margareth Lobo, Pedro Saggioro Paulucci, Lucas Martins Tavares, Graziela Benardin Luckemeyer, Luana Fernandes Machado, Neymar Elias de Oliveira, Silvia Prado Minhoto, Rita Cassia Alves Silva, Renato Ferreira da Silva, Marlon Souza Freitas, Francisco Ricardo Marques Lobo, Joana Berger-Estilita

“…However, the single-centre design and convenience sample limit the generalizability of our findings, necessitating validation through multicenter studies. …”
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Comparative analysis of physicochemical properties, bioequivalence, safety and tolerability of the first domestic semaglutide by A. S. Ametov, I. E. Shokhin, E. A. Rogozhina, T. G. Bodrova, M. E. Nevretdinova, P. A. Bely, K. Ya. Zaslavskaya, V. S. Scherbakova, D. V. Kurkin, K. N. Koryanova, E. S. Mishchenko, E. Yu. Kesova, E. D. Kozlov, E. S. Samoshkina, D. N. Andreev, Yu. G. Kazaishvili, S. M. Noskov, L. A. Balykova

“…A semaglutide concentration was determined in serum samples using a previously validated enzyme-linked immunosorbent assay (ELISA) method. …”
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The role of individual ambidexterity on organizational performance by Zahra Rajaei, Fereydon Ramazani, Seyed Hossein Behdani

“…The statistical population consists of the employees of the Veterinary Organization in South Khorasan Province (190 individuals), with a research sample of 125 selected randomly based on Morgan's table. …”
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Palynofacies and Sporomorph EcoGroups-based paleoecology implications for the Dalichai Formation, Andariyeh, central Alborz by Firoozeh Hashemi Yazdi, Neda Bashiri, fereshteh sajjadi

“…The particles were counted for each sample to determine palynodebries and palynofacies. …”
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THROMBOLYTIC AND ANTICOAGULANT THERAPY FOR PULMONARY EMBOLISM: AN EFFECT ON PULMONARY PERFUSION (PART 2) by O. V. Nikitina, I. P. Mikhailov, N. Y. Kudryashova, E. V. Migunova, O. A. Alekseyechkina, E. V. Kungurtsev, N. M. Udalova, S. Z. Khusainov, I. B. Kostyuchenko

“…Characteristics of the sample. The perfusion scintigraphy was performed in 381 cases out of 503 patients with a diagnosis of pulmonary embolism of high/intermediate risk of early death, treated in the Intensive Care Unit for Surgical Patients from 2011 to 2016. …”
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Impact of sleep hygiene education on sleep and nutrition in children aged 10–18 years by Çiğdem Müge Haylı, Seockhoon Chung, Dilek Demir Kösem

“…Results: In the study sample, the proportions of male and female participants (training group) were 60.0% and 40.0%, respectively. …”
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Creatine monohydrate ingested daily compared to only on training days on body composition, muscle thickness, and strength after 12 weeks of resistance training: preliminary results by Ignacio Quiroz, Scott C. Forbes, Thomas Hayes, Felipe Bermúdez, Alan Szinavel, Cristian Campos, Paula Méndez, Francisco Pino de la Fuente, Claudio Pérez de Tudela, Álvaro Reyes, Bruno Ticozzi, Mauricio Jorquera, José Gómez-López, Darren G. Candow, Matías Monsalves-Álvarez

“…However, caution is warranted based on the small sample size and low statistical power.…”
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Muscular strength and endurance adaptations to functional resistance training in young elite field hockey players by Alper Cenk Gürkan, Meriç Eraslan, Serhat Aydın, Tolga Altuğ, Mustafa Türkmen, Mehmet Söyler, Mustafa Alper Mülhim, Musa Şahin, Baykal Karataş, İbrahim Orkun Akcan, Hamza Küçük

“…The mean height of participants was 180.28 ± 4.54 cm, and their mean weight was 75.59 ± 3.08 kg. Participants were randomly divided into two groups: the experimental group (n = 14) and the control group (n = 14). …”
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Circulating linoleic acid and its interplay with gut microbiota during pregnancy for gestational diabetes mellitus by Jiahui Qiu, Ping Hu, Fan Li, Yichao Huang, Yunhaonan Yang, Fengjiang Sun, Ping Wu, Yuwei Lai, Yi Wang, Xiangwang He, Yidan Dong, Peiqi Zhang, Shanshan Zhang, Nianwei Wu, Tianlei Wang, Shizhuo Yang, Shuo Li, Jiaying Yuan, Xiaojuan Liu, Gang Liu, Yayi Hu, Jason H. Y. Wu, Da Chen, An Pan, Xiong-Fei Pan

“…Plasma LA levels were measured using gas chromatography-mass spectrometry, and gut microbiota was analyzed through 16S rRNA gene sequencing and shotgun metagenomic sequencing. A two-sample Mendelian randomization study was conducted using data from the IEU OpenGWAS database and the FinnGen consortium. …”
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Examining the feasibility of a crisis-focused Cognitive Behaviour Therapy (CBT)–informed psychological intervention for inpatients experiencing psychosis (the CRISIS study): result... by Lisa Wood, Anthony P. Morrison, Mary Birken, Ceri Dare, Ella Guerin, Patrick Nyikavaranda, Nira Malde-Shah, Karen Persaud, Panarai Ford, Cyntheia Nebo, Caroline S. Clarke, Brynmor Lloyd-Evans, Kathryn Greenwood, Glyn Lewis, Barbara Lay, Graeme MacLennan, Nicola Morant, Fiona Nolan, Vanessa Pinfold, Colette Christiansen, Claire Williams, Sonia Johnson

“…Findings: Between 1st February 2021 and 28th February 2022, 145 participants were referred to the study and 52 participants were randomised (during the COVID-19 pandemic). 26 were randomly allocated to cCBTp and 26 to TAU. We were able to recruit 87% of our target sample size. …”
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USING A NOVEL PSYCHOSOCIAL GROUP INTERVENTION TO IMPROVE ADAPTION, COPING AND MENTAL HEALTH OUTCOMES FOLLOWING DYSVASCULAR LIMB AMPUTATIONS: A FEASIBILITY STUDY by Rosalie J. Steinberg, Lawrence R. Robinson, Oksana Kachmarchuk, Sharon Jankey, Stephanie Posa, Amanda L. Mayo, Mindy Simon, Alex Kiss, Crystal Mackay, Robert Simpson, Marina B. Wasilewski, Steven Dilkas, Sander L. Hitzig

“…OBJECTIVE: To determine the feasibility of a psychosocial group therapy intervention for individuals with dysvascular LEA undergoing inpatient rehabilitation. METHODOLOGY: This randomized controlled trial randomly assigned dysvascular LEA rehabilitation inpatients into a supportive-expressive group therapy (SEGT) or a treatment as usual (TAU) group. …”
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