Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases by Feixiang Yang, Xiangyu Zhang, Wei Dai, Ke Xu, Yunyun Mei, Tianrui Liu, Kun Wang, Qianjun Liang, Peng Guo, Chaozhao Liang, Jialin Meng

“…A multivariate GWAS framework using genomic structural equation modeling (genomic SEM) was constructed, with an effective sample size of 651,820 individuals. Bidirectional Mendelian randomization (MR) was employed to assess causal relationships between sarcopenia and 30 urological diseases. …”
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Effect of different light qualities on photosynthetic characteristics and fruit quality of Shine Muscat grapevines grown under rain-sheltered cultivation by GONG Xiaomin, YU Guanghui, LI Xiujie, WANG Rong, CHEN Guangxia, WU Yusen, WU Xinying, ZHANG Zhichang, LI Bo, MA Yujiao

“…For phenological assessment, the flowering rate was quantified as the ratio of inflorescence-bearing buds to total observed buds during the subsequent spring phenological phase. Bud sampling followed a randomized complete block design, with three biological replicates per treatment. …”
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Efficacy of danhong injection adjuvant therapy in patients with acute ischemic stroke: a real-world, multicenter, retrospective study by Danping Pan, Haitong Wan, Haitong Wan, Yu He, Jiehong Yang, Yilei Guo, Li Yu, Feihu Zhang, Guoqing Zheng, Bin Xu, Yaohong Song, Mingjun Zhao, Xiangzhe Liu, Jianhe Liu, Gang Sun, Yaming Lin

“…However, due to limited sample sizes, large-scale clinical studies are still needed to confirm its efficacy.MethodsThis real-world, multicenter retrospective study used inpatient data from eight centers across Mainland China. …”
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Late-gestation heat stress alters placental structure and function in multiparous dairy cows by L.T. Casarotto, H.N. Jones, P. Chavatte-Palmer, J. Laporta, F. Peñagaricano, V. Ouellet, J. Bromfield, G.E. Dahl

“…A representative cotyledon sample was isolated for histological analysis. Tissues were also processed for RNA sequencing and DNA methylation analysis. …”
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Adherence characteristics and reasons for abandonment of physical exercise-based interventions in older adults in Latin America: A scoping review (Características de la adherencia... by Igor Cigarroa, Rafael Zapata-Lamana, Gonzalo Leiva-Gajardo, Eduardo Vasquez, Eva Parrado-Romero, Jaime Vásquez-Gomez, Cristian Alvarez, Fanny Petermann-Rocha, Daniel Reyes-Molina

“…We searched for articles in Spanish, English, and Portuguese carried out in people aged 65 years and over.101 out of 4,642 randomized controlled trials (RCT) were included. A total sample of 5,013 older adults (79% women), with an average age of 68.2 years started their studies and 4,312 finished it, presenting an adherence to the interventions of 86%. …”
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Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…Materials and Methods: This prospective, double-blinded and randomised clinical study was conducted in the Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (a tertiary care institute), Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India, from September 2023 to July 2024, with a sample size of 40 patients. Patients with American Society of Anaesthesiologists (ASA) I/II status were randomly allocated into two equal groups of 20 each. …”
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Characteristics of malaria vector populations and transmission before a randomised controlled trial assessing the efficacy of next-generation insecticide-treated nets in Côte d’Ivo... by Ludovic Phamien Ahoua Alou, Alphonsine Amanan Koffi, Edouard Dangbenon, Soromane Camara, Joseph Biggs, Marius Gonse Zoh, Serge Brice Assi, Colette Sih, Benoit Talbot, Manisha Ann Kulkarni, Louisa Alexandra Messenger, Natacha Protopopoff, Jackie Cook, Raphael N’Guessan

“…To assess biting rate and biting behaviour, human landing catches were conducted hourly indoors and outdoors in six randomly selected houses in each cluster, starting at 18:00 and continuing until 08:00 the next morning. …”
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THROMBOLYTIC AND ANTICOAGULANT THERAPY FOR PULMONARY EMBOLISM WITH HIGH AND INTERMENDIATE RISK OF EARLY DEATH. PART 1. MORTALITY ANDCOMPLICATIONS by O. V. Nikitina, I. P. Mikhailov, D. A. Kosolapov, V. I. Avfukov, E. A. Ostrogina, S. N. Kuznetsov, T. N. Cherkashina, N. I. Mirda

“…Characteristics of a sample 503 patients with a high and intermediate risk of early death at the age of 16 to 93 years (mean age 61±16, Ме 63 (51; 74) admitted to the resuscitation department in 2011–2016. …”
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Effects of pork protein ingestion prior to and following performing the army combat fitness test: markers of performance by Kelly Hines, Hudson Lee, Sarah E. Johnson, Adriana Gil, Nicolas D. Barringer, Christopher J. Rasmussen, Ryan Sowinski, Drew E. Gonzalez, Richard B. Kreider

“…On testing days, participants donated a blood sample and consumed a pre-exercise meal on testing days. …”
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Effect of Traditional Chinese Medicine in prevention and treatment of anti-tumor drug induced hand-foot syndrome (中医药防治抗肿瘤药物所致手足综合征效果的Meta分析)... by ZHOU Qiaoli (周巧丽), ZHOU Fanhua (周樊华)

“…Conclusion The TCM treatment can improve the total effective rate in the treatment of anti-tumor drug-induced HFS, and the effect was better than the western medicine treatment and placebo. However, the sample size of the included study was small, and the quality of included literature was poor, which may affect the validity of evidence. …”
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Efficacy of Jinshui Liujun decoction on chronic obstructive pulmonary disease patients: a systematic review and meta-analysis by Wanqiu Huang, Hui Wang, Di Wu, Lu Zhang, Jiabing Tong, Jiabing Tong, Minghui Yu, Zegeng Li, Zegeng Li, Qinjun Yang, Qinjun Yang

“…Sources of heterogeneity were partially identified through meta-regression, but further rigorous randomized controlled trials are still required.Systematic Review Registrationhttps://osf.io/msw7b.…”
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Resistance and Impact Training During Weight Loss Improves Physical Function and Body Composition in Older Adults With Obesity by Jakub Mesinovic, Anoohya Gandham, Mavil May Cervo, Paul Jansons, Costas Glavas, Michael Braude, Juan Pena Rodriguez, Barbora De Courten, Ayse Zengin, Belinda R. Beck, Peter R. Ebeling, David Scott

“…Additional trials with larger sample sizes and longer durations are warranted to explore whether HiRIT can attenuate weight loss–related muscle and bone mass declines. …”
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Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational stu... by QiPing Feng, Wei-Qi Wei, Cecilia P Chung, Rebecca T Levinson, Alexandra C Sundermann, Jonathan D Mosley, Lisa Bastarache, Jane F Ferguson, Nancy J Cox, Dan M Roden, Joshua C Denny, MacRae F Linton, Digna R Velez Edwards, C Michael Stein

“…<h4>Background</h4>Observations from statin clinical trials and from Mendelian randomization studies suggest that low low-density lipoprotein cholesterol (LDL-C) concentrations may be associated with increased risk of type 2 diabetes mellitus (T2DM). …”
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The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study by Simin Sajadi, Mohammad Amin Khadembashiri, Gholamreza Raissi, Mohamad Mehdi Khadembashiri, Korosh Mansouri, Homayoun Hadizadeh-Kharazi, Mohammad Taghi Joghataei, Seyed Pezhman Madani, Bijan Forogh, Sina Parsipour

“…Further research with larger sample sizes and longer follow-up periods is needed to confirm these findings and determine optimal dosing strategies. …”
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Efecto y satisfacción de un programa de actividad física controlada por pulsómetro en el índice de masa corporal de escolares con sobrepeso-obesidad (Effect of and satisfaction wi... by Emilio J Martinez-López, Jesús Moreno-Cerceda, Sara Suarez-Manzano, Alberto Ruiz-Ariza

“…The main aim of this research was to analyze the effect of a program based on extracurricular PA, using heart rate monitor to quantify the volume and intensity of PA, on the body mass index (BMI). 69 young students with overweight-obesity aged nine to 12 years participated in this study. The sample was randomly split in two groups: PA program and heart rate monitor (EG1, n=23), PA program without heart rate monitor (EG2, n=23), and control group, whose members did not carry out any program nor used any heart rate monitor (CG, n=23). …”
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Analysis of Interdisciplinary Differences in the Structure of the Scientific Genre in the Introduction Section of Humanities Research Articles by Roya Peyravi, Hossein Ghorbanpoor Arani, Abbas Zaree

“…A total of 45 papers were randomly selected from indexed journals approved by the Ministry of Science over the past decade to serve as the sample. …”
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Efectos de una intervención de 12 semanas de ejercicio en los niveles de hemoglobina glicada (HbA1c) en pacientes con cáncer (Effects of a 12-week exercise intervention on glycated... by Naiara Virto, Paula Etayo-Urtasun, José Ramón Sánchez Isla, María Soledad Arietanizbeaskoa, Nere Mendizabal Gallastegui, Gonzalo Grandes, Borja Gutierrez, Aitor Coca, Xabier Río

“…Baseline and 3-month assessments were performed to evaluate changes in HbA1c, fat and musculoskeletal mass for the 22 participants who completed the study. Analyzing the sample there were significant improvements in HbA1c (p=0.033), when excluding those over 65 years of age, the differences were greater (p=0.017). …”
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Role and Therapeutic Potential of miR-301b-3p in Regulating the PI3K-AKT Pathway via PIK3CB in Eosinophilic Chronic Rhinosinusitis by Shu F, Wang Y, Jiang Y, Li L, Mu Z, Shi L, Gong X, Zhang B, Zhang F, Mao D

“…This study aimed to explore the regulatory role of miR-301b-3p in these mechanisms and evaluate its therapeutic potential.Methods: High-throughput miRNA sequencing of human and mouse nasal mucosa tissues identified miR-301b-3p as a key candidate molecule. Mendelian randomization (MR) analysis confirmed its causal relationship with chronic rhinosinusitis (CRS). …”
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Design and rationale of MYOFLAME-19 randomised controlled trial: MYOcardial protection to reduce post-COVID inFLAMmatory heart disease using cardiovascular magnetic resonance Endpo... by Valentina O. Puntmann, Dietrich Beitzke, Andreas Kammerlander, Inga Voges, Dominik D. Gabbert, Marcus Doerr, Bishwas Chamling, Biykem Bozkurt, Juan Carlos Kaski, Erica Spatz, Eva Herrmann, Gernot Rohde, Philipp DeLeuw, Lenka Taylor, Christine Windemuth-Kieselbach, Cornelia Harz, Marta Santiuste, Laura Schoeckel, Juliana Hirayama, Peter C. Taylor, Colin Berry, Eike Nagel

“…The proportion of AEs related to the contrast agent gadobutrol will also be analyzed. A calculated sample size is a total of 280 participants (accounting for 22 subjects (8%) drop out), randomized in 1:1 fashion to 140 in the verum and 140 placebo groups. …”
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Randomised phase II trial of CAPTEM or FOLFIRI as SEcond-line therapy in NEuroendocrine CArcinomas and exploratory analysis of predictive role of PET/CT imaging and biological mark... by Ivan Lolli, Daniele Santini, Rossana Berardi, Giuseppe Badalamenti, Toni Ibrahim, Alfredo Berruti, Alberto Bongiovanni, Chiara Liverani, Sara Pusceddu, Silvana Leo, Giovanni Di Meglio, Stefano Tamberi, Fabio Gelsomino, Francesca Pucci, Francesca Bergamo, Sergio Ricci, Flavia Foca, Stefano Severi, Mauro Cives, Davide Campana, Nicola Silvestris, Angela Buonadonna, Maria Pia Brizzi, Francesca Spada, Sara Cingarlini, Lorenzo Antonuzzo, Davide Pastorelli

“…A Bryant and Day design taking into account treatment activity and toxicity was used to estimate the sample size. All analyses will be performed separately for each treatment group in the intention-to-treat population. …”
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