Body composition changes in resistance-trained adults Following 8-Weeks of supplementation with a combination of plant protein and creatine monohydrate by Joesi M. Krieger, Kevin F. Holley, Alex C. Schrautemeier, James L. Tice, Joshua Iannotti, Anthony M. Hagele, Connor J. Gaige, Wyatt B. McLaughlin, Ralf Jäger, Chad M. Kerksick

“…PPCr may influence ICW shifts, warranting further investigation using a longer intervention and larger sample sizes.…”
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A psychometric study of the Flourishing Scale for people living with dementia by Chris Clarke, Kalpita Baird, Esme Moniz‐Cook, Gail Mountain, Emma Wolverson, Ellen Lee, Catherine Hewitt

“…FS total scores were not associated with cognitive ability or time since diagnosis in this sample but were associated with living alone / with others. …”
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Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis by Yi Yu, Yi Yu, Xinju Li, Zheng Zhu, Zheng Zhu, Yingdong Wang, Yingdong Wang, Qiang Xi, Jiwen Qiu, Yidan Xu, Ruonan Liang, Yi Guo, Mingxing Zhang

“…However, the sequential analysis indicated limitations due to small sample size which hindered drawing definitive conclusions.ConclusionCompared with sham acupuncture, acupuncture is effective in improving subjective sleep quality in patients with CID. …”
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The effect of an exam-indicated cerclage before 24 weeks of gestation to prevent preterm birth: A systematic review and meta-analysis by Bouchra Koullali, Charlotte E. van Dijk, Charlotte E. Kleinrouweler, Jacqueline C.E.J.M.P. Limpens, Ben W. Mol, Martijn A. Oudijk, Eva Pajkrt

“…The main weaknesses were retrospective designs, small sample sizes and the poor comparability of the intervention and control groups. …”
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Effects of 8-weeks of supplementation with a plant protein blend + creatine monohydrate on changes in maximal strength in resistance-trained males and females by Anthony M. Hagele, Kevin F. Holley, Alex C. Schrautemeier, James L. Tice, Joshua Iannotti, Joesi M. Krieger, Connor J. Gaige, Wyatt B. McLaughlin, Ralf Jäger, Chad M. Kerksick

“…Further investigations involving longer protocol duration with larger sample sizes may be warranted to further determine the potential efficacy of PPCr supplementation.…”
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Regulatory effects of the bidirectional crosstalk between hepatic gene expressions and gut microbiota on the productive performances and egg quality of induced molting treated laye... by Fuguang Xue, Pengyun Ma, Yunlei Li, Xiaoke Zhang, Xinying Xu, Zhong Ma, Yanyan Sun, Jingwei Yuan, Hui Ma, Jinsong Pi, Huadong Wu, Ling Li, Yuanqi Qu, Jilan Chen

“…Productive performances and egg quality were meticulously recorded for each replicate, followed by the sampling of one bird from each replicate for the intestinal morphological analysis. …”
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Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease by Angelika Hettenbach, Tanja Elger, Muriel Huss, Gerhard Liebisch, Marcus Höring, Johanna Loibl, Arne Kandulski, Martina Müller, Hauke Christian Tews, Christa Buechler

“…This association also existed in male UC patients and could not be evaluated in women due to the small sample size. Conclusions: In active IBD, a reduction in FC and almost all CE species was observed only in males, while serum PCSK9 levels remained within normal ranges in both sexes. …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…This was done because the limited sample size of the primary exposure variable (home vs. hospital) did not have enough power to answer the non-inferiority question as proposed. …”
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Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning by Li-Wei Zhang, Ji Yang, Hua-Wei Jiang, Hua-Wei Jiang, Xiu-Qiang Yang, Ya-Nan Chen, Wei-Dang Ying, Ying-Liang Deng, Min-hui Zhang, Hai Liu, Hong-Lei Zhang

“…Additionally, we utilized weighted correlation network analysis (WGCNA) to select module genes and applied Random Forest (RF) and Support Vector Machine (SVM) algorithms to identify pivotal feature genes influencing pterygium progression. …”
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Development of a nomogram for predicting pancreatic portal hypertension in patients with acute pancreatitis: a retrospective study by Yong Lv, Hui Luo, Yingjie Zhang, Xiangping Wang, Yanglin Pan, Yunling Li, Qiaoyu Su, Xianchen Zhan, Linhui Zhang, Xiaoyu Kang, Shuhui Liang, Gui Ren

“…Future studies with larger sample sizes are necessary to confirm our findings and conduct external validation.…”
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SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementi... by Yu Liu, Olaf Gefeller, Jian Su, Ming Zhong, Elmar Graessel, André Kratzer, Petra Scheerbaum, Julia-Sophia Scheuermann, Yaping Ding, Jianwen Lu

“…Participants will be randomly allocated to the intervention or control group. …”
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Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…The proposed model should be tested on an alternative sample, using longitudinal data, and extended to include additional explanatory factors (e.g. activity avoidance). …”
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Virtual body image exercises for people with obesity – results on eating behavior and body perception of the ViTraS pilot study by Kathrin Gemesi, Nina Döllinger, Natascha-Alexandra Weinberger, Erik Wolf, David Mal, Sebastian Keppler, Stephan Wenninger, Emily Bader, Carolin Wienrich, Claudia Luck-Sikorski, Marc Erich Latoschik, Johann Habakuk Israel, Mario Botsch, Christina Holzapfel

“…Long-term human intervention studies with larger sample sizes are necessary to examine the efficacy of integrating this kind of VR system into standard obesity therapy. …”
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Indirect comparison of the efficacy and safety of alirocumab and evolocumab on major cardiovascular events: a systematic review and network meta-analysis by Leyu Xu, Leyu Xu, Ming Lei, Ming Lei, Liren Li, Liren Li, Yilei Li, Yilei Li, Chunping Gu, Chunping Gu, Ping Zheng, Ping Zheng

“…The all-cause mortality rates were lower in patients treated with alirocumab compared to those treated with evolocumab but the differences were not statistically significant, probably due to heterogeneity in the sample size and follow-up duration between different studies. …”
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Impacts of omega-3 fatty acids intervention on immune functions and clinical outcomes in surgical gastric cancer patients: a systematic review and trial sequential meta-analysis by Han Yang Yue, Xue Ting Yang, Jian Cheng Zhang, Ping Zhou, Jue Xia He, Jun Zeng, Jun Ying Li, Hua Jiang

“…Trial sequential analysis demonstrated that the conclusion on the primary outcome improvement is robust because it reached the required sample size and excluded the presence of false positive results. …”
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Consistent improvements in liver histology across subgroups in a post hoc analysis of the SYNERGY-NASH trial with tirzepatide by Mark L. Hartman, Rohit Loomba, Eric J. Lawitz, Raj Vuppalanchi, Jérôme Boursier, Elisabetta Bugianesi, Masato Yoneda, Yuanyuan Tang, Bram Brouwers, Mathijs C. Bunck, Axel Haupt, Arun J. Sanyal

“…Methods: Participants (n = 190) were randomly assigned 1:1:1:1 to receive once-weekly subcutaneous tirzepatide (5, 10, or 15 mg) or placebo for 52 weeks. …”
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The Effectiveness of Computerized Cognitive Training in Patients With Poststroke Cognitive Impairment: Systematic Review and Meta-Analysis by Min Gao, Lu Huang, Jiang Yi, Tianqi Zhang, Guangyao Zhu, Qi Zhang, Jiaxiao Tian, Rongxuan Zhao, Xiaoqin Duan, Zhongliang Liu

“…Future research should increase sample sizes based on CCT system types and offer intensive, tailored training multiple times weekly. …”
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Advancing human-use experience for real-world evidence for the registration of traditional Chinese medicine products in China by Mingge Xia, Yan Xue, Luwei Zhu, Xianwen Chen, Carolina Oi Lam Ung, Sheng Han, Yunfeng Lai, Hao Hu

“…Among the five cases of direct registration, three relied solely on retrospective observational studies, while two conducted small-sample prospective studies in conjunction with retrospective observational studies. …”
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Efficacy of sacubitril/valsartan on improving clinical symptoms in patients with acute myocardial infarction complicated with heart failure: a retrospective study by Guiping Wang, Ruolin Zhang, Xuyang Li, Shuping Zuo, Boheng Zhang, Yanan Zhao, Suya Sun, Juanjuan Zhang, Xiaokun Liu

“…Given the study’s limitations, including its single-center design, small sample size, and baseline differences. Further multi-center, randomized controlled trials are warranted to validate these findings and explore tailored treatment strategies for AMI patients with concurrent HF.…”
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Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series by Giacomo Savini, Alice Galzignato, Catarina P. Coutinho, Jinhai Huang, Yue Wu, Piero Barboni, João Mendanha Dias, Filomena J. Ribeiro, Domenico Schiano-Lomoriello

“…Assuming a minimum Pearson r correlation coefficient between variables of 0.5 with a power of 80% and a P value less than 0.05, a minimum sample size of 29 (58 eyes) cases was required. Results Forty-three patients were enrolled. …”
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