Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis by Xudong Xin, Xudong Xin, Xudong Xin, Xudong Xin, Haidong Zhou, Song Huang, Wenzhao Zhang, Jiahou Xu, Wei Wang, Jihua Wei, Jihua Wei, Jihua Wei, Jihua Wei, Liqing Li

“…A rat model of diabetic foot ulcer (DFU) was established and randomly divided into three groups: control, model, and treatment groups. …”
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Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule by Fanfan Wang, Fanfan Wang, Jianting Wen, Jianting Wen, Jian Liu, Jian Liu, Ling Xin, Yanyan Fang, Yanyan Fang, Yue Sun, Mingyu He, Mingyu He

“…Additionally, FISH, luciferase reporter assays, and rescue experiments were performed to validate the regulatory role of ENST00000619282 and its sponge-like function in RA-FLS. Clinical samples were analyzed to determine the correlation between FTO/YTHDF1/ENST00000619282/Bax/Bcl-2 and immune-inflammatory markers. …”
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Intelligent recognition algorithm and application of coal mine overhead passenger device based on multiscale feature fusion by Beijing XIE, Heng LI, Hang DONG, Zheng LUAN, Ben ZHANG, Xiaoxu LI

“…However, there are several challenges that need to be addressed, such as the limited number of samples in the cmopd dataset, poor lighting conditions in underground images, overlapping and occlusion between operating cmopd, varying sitting postures of miners, difficulty in detecting small cmopd targets, complex model deployment, and low efficiency of traditional recognition methods for cmopd with different passenger-carrying statuses.To overcome these challenges, a cmopd dataset was created from various coal mines in Guizhou province. …”
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UJI TOLERANSI TANAMAN TEMBAKAU (Nicotiana tabacum L.) TERHADAP CEKAMAN KADMIUM (Cd), TIMBAL (Pb), DAN TEMBAGA (Cu) PADA KULTUR CAIR by S Rosidah, YU Anggraito, KK Pukan

“…</p><p> </p><p class="BasicParagraph"><em>This research investigated the physiological, anatomical, and morphological responses of tobacco (</em><em>Nicotiana tabacum L.) on stresses of heavy metals Cu, Cd, and Pb. </em><em>The samples were 3- to 4-week tobacco plants germinated in vitro and then were exposed to heavy metals for 14 days.…”
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IMRC-exo alleviates limb injury by inhibiting ferroptosis in a rabbit model of deinagkistrodon acutus snakebite envenomation by Linjie Lai, Wang Du, Haohao Wu, Wanjuan Liu, Ke lv, Peixin Shangguan, Lutao Xie, Jiefeng Xu, Pin Lan

“…At the end of the experiment, muscle tissue samples of the injured limb were obtained to detect gross pathological damage and cell apoptosis. …”
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Overview of Effects of Motor Learning Strategies in Neurologic and Geriatric Populations: A Systematic Mapping Review by Li-Juan Jie, PhD, Melanie Kleynen, PhD, Guus Rothuizen, MSc, Elmar Kal, PhD, Andreas Rothgangel, PhD, Susy Braun, PhD

“…The risk of bias 2 tool was used to assess bias; additionally, papers underwent screening for sample size justification. Data Synthesis: Identified articles regarding the effects of the targeted motor learning strategies started around the year 2000 and mainly emerged in 2010. …”
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Adapting the alcohol and alcohol problems perception questionnaire and the drug and drug problems perception questionnaire: A psychometric analysis of a person-centred approach by Andrea RAYNAK, Michel Bédard, Brianne Wood, Christopher Mushquash

“…Conclusions: Although limited by a small sample size and data from a single setting, the findings of this study provide preliminary support that slightly modified versions of the PC- AAPPQ and PC-DDPPQ may hold promise for use with practising clinical nurses in similar contexts.…”
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Understanding health care workers’ mental health needs: insights from a qualitative study on digital interventions by Anish K. Agarwal, Rachel E. Gonzales, Lauren Southwick, Devon Schroeder, Meghana Sharma, Lisa Bellini, David A. Asch, Nandita Mitra, Mohan Balachandran, Courtney Benjamin Wolk, Emily M. Becker-Haimes, Rachel E. Kishton, Sarah Beck, Raina M. Merchant

“…Participants A purposive sample of 64 HCWs, including physicians, nurses, technicians, administrative staff, and social workers, was recruited. …”
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Public Disclosure of Results From Artificial Intelligence/Machine Learning Research in Health Care: Comprehensive Analysis of ClinicalTrials.gov, PubMed, and Scopus Data (2010-2023... by Shoko Maru, Ryohei Kuwatsuru, Michael D Matthias, Ross J Simpson Jr

“…Most trials (85%; 305/357) had sample sizes of ≤1000, yet larger trials (n>1000) had higher publication rates (30.8%; 16/52) than smaller trials (n≤1000) (17.4%; 53/305). …”
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Resource-Oriented Case Management to Implement Recommendations for Patients With Chronic Pain and Frequent Use of Analgesics in General Practices (Project RELIEF): Protocol for a S... by Regina Poß-Doering, Sabrina Brinkmöller, Alexandra Balzer, Viktoria Sophie Wurmbach, Cinara Paul, Regina Stolz, Marco Richard Zugaj, Jonas Tesarz, Michel Wensing, Cornelia Straßner

“…ResultsRecruitment occurred between October and December 2024. Targeted sample size was 6 practices and 50 patients. The intervention period will be February-June 2025. …”
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Protocol for a multicentre, prospective, open-label, randomised controlled trial to compare PROs and safety outcomes between preoperative and postmastectomy radiotherapy in locally... by Li Zhang, Jiong Wu, Guangyu Liu, Shuang Hao, Jianjing Hou, Changming Zhou, Yifeng Hou, Keda Yu, Zhen Hu, Genhong Di, Zhi Min Shao, Xiaoli Yu

“…Data will be analysed using SPSS and Stata software. The target sample size will be 80 participants.Ethics and dissemination This study will be performed according to the Helsinki Declaration. …”
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The prevalence of erectile dysfunction and its associated factors among diabetic patients in the Southwestern Region of Saudi Arabia analytical cross-sectional study by Safar Saad Battar, Faisal Saeed Al-Qahtani, Mohammed Mansour M. Alqahtani, Rayyan Mohammed A. Alassiri, Abdulrhman Saeid Z. Alshahrani, Mohammed Ahmed M. Alhanash, Nawaf Faris A. Alnahdi, Saad Ali S. Alasiri, Abdulaziz Saud S. Alotaibi, Ali Mohammed AlAmri

“…The sample included 398 married male Saudi nationals aged 18 years and older, diagnosed with diabetes and attending PHCCs. …”
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Cardiopulmonary exercise testing following acute pulmonary embolism: Systematic review and pooled analysis of global studies by Gabriella VanAken, Daniel Wieczorek, Drew Rubick, Ahmad Jabri, Domingo Franco‐ Palacios, Gillian Grafton, Bryan Kelly, Olusegun Osinbowale, Syed T. Ahsan, Rana Awdish, Herbert D. Aronow, Supriya Shore, Vikas Aggarwal

“…In conclusion, this study, which was limited by small sample sizes and few multicenter studies, found no significant difference in exercise capacity between individuals tested <6 months versus ≥6 months after acute PE. …”
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Fungistatic and Bactericidal Activity of Hydroalcoholic Extracts of Root of <i>Jatropha dioica</i> Sessé by Lizeth Aguilar-Galaviz, Jorge Cadena-Iñiguez, Dalia Abigail García-Flores, Gerardo Loera-Alvarado, Diego Rivera-Escareño, María Azucena Ortega-Amaro

“…The phenol content ranged from 8.92 ± 0.25 to 12.10 ± 0.34 mg EAG g⁻¹ and flavonoid content ranged from 20.49 ± 0.33 to 28.21 ± 0.73 mg QE g⁻¹ of sample dry weight. The results highlight the biological activity of <i>J. dioica</i> as an alternative to biopesticides that minimize agrochemical applications and generate pathogen resistance. …”
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Effects of mindfulness meditation combined with progressive muscle relaxation on sleep disorders, anxiety, and depression in patients with sarcopenia undergoing hemodialysis by Yongyao Wu, Haojie Zhang, Lei Jiang, Zhiping Liu, Xinfei Li, Bei Guo, Junyuan Li, Pengjie Xu, Jiang Liu, Rizhen Yu

“…This approach is simple, unrestricted, and widely applicable, making it worthy of clinical promotion.LimitationsThe study had a small sample size and a short follow-up period.Clinical trial registrationhttps://register.clinicaltrials.gov/, identifier NCT06261372.…”
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Integrating clinical data and genetic susceptibility to elucidate the relationship between systemic lupus erythematosus and human cytomegalovirus infection by Xin Luo, Liuliu Quan, Qingting Lin, Huiteng Rong, Yue Liu, Jiaqi Meng, Xin You

“…Moreover, Mendelian randomization (MR) was used to investigate the causal relationship between SLE and HCMV infection. …”
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Psychiatric Outcomes of Subthalamic Nucleus Deep Brain Stimulation: A Systematic Review of Short- and Long-Term Effects by Mattia Vittorio Pomes, Giordano D’Urso, Ilaria Bove, Luigi Maria Cavallo, Lorenzo Della Ragione, Carmela Palmiero, Francesco Perrotta, Felice Esposito, Teresa Somma

“…Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) for observational studies and the Cochrane Risk of Bias Tool for randomized controlled trials (RCTs). <b>Results</b>: A total of 16 studies met the inclusion criteria, with sample sizes from 10 to 149 patients and short- to long-term follow-ups (up to 17 years). …”
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Dementia Moves: protocol for a feasibility study testing a physical rehabilitation program for long-term care residents with moderate to severe dementia by Caitlin McArthur, Niousha Alizadehsaravi, Rebecca Affoo, Karen Cooke, Natalie F. Douglas, Marie Earl, Melanie K. Farlie, Trudy Flynn, Parisa Ghanouni, Susan W. Hunter, Shannan M. Grant, Laura E. Middleton, Elaine Moody, Cheryl Smith, Linda Verlinden, Lori E. Weeks

“…We hypothesize the intervention will be feasible without modification if 16 individuals are recruited over 6 months, 65% of our sample is retained at 6 months and 75% of the completed exercises are performed at a moderate to high intensity. …”
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Prevalence and risk factors for long COVID among cancer patients: a systematic review and meta-analysis by Hongkun Xu, Hongkun Xu, Tingting Lu, Yajie Liu, Jingqi Yang, Simeng Ren, Baojin Han, Honghao Lai, Long Ge, Jie Liu

“…Patients with comorbidities are at a high risk of developing long COVID. Further randomized controlled trials with rigorous methodological designs and large sample sizes are needed for future validation.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023456665.…”
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Effect of 8 weeks Aerobic Training and Artichoke Distillate on Lipid Profile and Liver Enzymes in Women with Non-Alcoholic Fatty Liver by Atefeh Jamshidpour, Vahid Tadibi, Nayebali Rezvani

“…The control group performed no intervention during the study period. Blood sample and ultrasound sonography of the liver were performed 48 hours before and after the intervention to measure serum levels of Alanine Aminotransferase, Aspartate Aminotransferase, lipid profile (total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein), and liver fat.Results: Results showed that liver fat levels were significantly decreased within the aerobic (P = 0.034) and the artichoke (P = 0.011) groups. …”
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