Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus by Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li

“…However, the effects of SY-009 on human plasma metabolomics are still unknown.ObjectiveThis study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism involved.Study designIn the phase Ib study, a total of 50 participants with T2DM were enrolled and randomly assigned to the 0.5 mg BID, 1 mg BID, 2 mg BID, 1 mg QD, and 2 mg QD dose groups, with a 4:1 random allocation within each group to receive either the SY-009 capsule or placebo. …”
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Study on the vibration prediction model of step group hole blasting considering non-stationarity by LI Hongchao, ZHANG Qipeng, HUANG Guoquan, SHI Yulian, HUANG Yonghui, HAN Haoxuan, YI Jiaxin, QU Chenliang

“…In order to eliminate the effect of model randomness, the 95% confidence interval is used to determine the optimal number of cycles (500 times), and the measured waveforms in the field as a sample, through the residual similarity to quantify the match between the simulated waveforms and the measured waveforms. …”
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A comparative study of blood pressure submission between mobilec app users and non-users in Romania: a pilot cohort study by Liviu Ionut Serbanoiu, Liviu Ionut Serbanoiu, Stefan Sebastian Busnatu, Stefan Sebastian Busnatu, Andreea Elena Lacraru, Andreea Elena Lacraru, Maria Alexandra Pana, Maria Alexandra Pana, Suzana Guberna, Suzana Guberna, Dragos Trache, Dragos Trache, Plesu Elena, Plesu Elena, Catalina Liliana Andrei, Catalina Liliana Andrei, Crina Sinescu, Crina Sinescu

“…However, limitations such as small sample size, potential self-selection bias, and lack of randomization must be considered. …”
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Intranasal insulin for improving cognitive function in multiple sclerosis by Scott D. Newsome, Kathryn C. Fitzgerald, Abbey Hughes, Meghan Beier, Jacqueline Koshorek, Yujie Wang, Daniela Pimentel Maldonado, Thomas Shoemaker, Taimur Malik, Tarik Bayu, Pablo E. Ravenna, Ama Avornu, Elias S. Sotirchos, Meghan Romba, John Muschelli, Todd T. Brown, Peter A. Calabresi, Ellen M. Mowry

“…We completed a phase Ib/II, randomized, double-blind, placebo-controlled trial; participants were randomized in a 1:1:1 fashion, stratified by relapsing versus progressive MS, to intranasal insulin 10 ​international units (IU) twice a day, 20 IU twice a day, or placebo for 24 weeks. …”
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Potential effects of Asian-adapted Mediterranean diet in depression and anxiety among women with metabolic dysfunction-associated steatotic liver disease: a secondary analysis by Alicia Salamanca-Sanabria, Yu Chung Chooi, Evelyn Xiu Ling Loo, Evelyn Xiu Ling Loo, Xianning Lai, Vera Sergeyevna Brok Volchanskaya, Yap Seng Chong, Yap Seng Chong, Johan Gunnar Eriksson, Johan Gunnar Eriksson, Johan Gunnar Eriksson, Johan Gunnar Eriksson, Johan Gunnar Eriksson

“…Future research with larger sample sizes is needed to confirm these effects and explore underlying mechanisms.Clinical trial registrationhttp://clinicaltrials.gov, NCT05259475.…”
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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy by Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Joanne Weidhaas, Mark Scholz, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Donatello Telesca

“…Trained classifiers included classification trees, LASSO-regularized logistic regression, boosted trees, and random forests. Final performance measures were reported on the training set using leave-one-out cross validation and validated on held-out samples. …”
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Development of a host-signature-based machine learning model to diagnose bacterial and viral infections in febrile children by Fang Bai, Zelong Gong, Dong Cui, Xiaomei Zhang, Wenteng Hong, Yi Gao, Kai Lin, Weijie Chen, Lu Li, Juan Huang, Biying Zheng, Junfa Xu, Na Xiao

“…In this study, through integrative bioinformatics analysis, we aimed to construct artificial neural network (ANN, multilayer perceptron) and random forest (RF) models based on host gene signatures to diagnose bacterial or viral (B/V) infection in febrile children.ResultsTranscriptome data from the whole blood of children were collected from a public database. …”
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Diagnosis of Peripheral Pulmonary Lesions with Transbronchial Lung Cryobiopsy by Guide Sheath and Radial Endobronchial Ultrasonography: A Prospective Control Study by Ling Jiang, Jian Xu, Chunfang Liu, Na Gao, Jing Zhao, Xue Han, Xiaolin Zhang, Xiaohui Zhao, Yuan Liu, Weixue Wang, Junjun Zhao

“…EBUS-GS-TBCB might be useful if only the first sample was taken into account.…”
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Efficacy of holmium laser versus pneumatic lithotripsy for mid and distal ureteric stones above 10 mm size by Arvind Arvind, Sudipta Kumar Singh, Partha Protim Mondal, Shashi Kant Tewary, Ankit Agarwal, Apurv Shukla, Ranjan Kumar Dey, Shiva Manohar Dutta

“…Data were analyzed using Microsoft Excel, SPSS (v27.0), and GraphPad Prism (v5), employing two-sample and paired t-tests (significance at P≤0.05). …”
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Treatment of cattle with ivermectin and its effect on dung degradation and larval abundance in a tropical savanna setting by Miriam Ruhinda, Kang Xia, Cassidy Rist, Gerald Shija, Issa N. Lyimo, Felician Meza, Carlyle Brewster, Carlos Chaccour, N. Regina Rabinovich, Roger Schürch

“…As water was lost, sub-sample dry weight increased, and organic matter decreased similarly over time for the treatment and control. …”
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Use of chlorhexidine chip after scaling and root planning on periodontal disease: A systematic review and meta-analysis by Cleber Davi Del Rei Daltro Rosa, Jéssica Marcela de Luna Gomes, Sandra Lúcia Dantas de Moraes, Cleidiel Aparecido Araujo Lemos, Tatiana Prosini da Fonte, João Pedro Justino de Oliveira Limirio, Eduardo Piza Pellizzer

“…Inclusion criteria involved: randomized controlled clinical trials, with a minimum of 15 patients included on the sample and each patient has two sites of probing depth of ≥5 mm; The minimum follow up was at least 1 months of follow-up and the outcomes present in the studies probing depth (PD), plaque index (PI) and clinical attachment level (CAL) after scaling and root planning (SRP). …”
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Implications of adverse and benevolent childhood experiences on the physical and mental health of Mexican adults: a population-based studyResearch in context by Daniela León Rojas, Fabiola Castorena Torres, Nissa Yaing Torres-Soto, Irene Martín-Estal, Veronica Mundo Rosas, Brenda Martinez Tapia, Julieta Rodríguez-de-Ita

“…Methods: From September to November 2023, this cross-sectional study recruited a nationally representative sample of adults aged 18–65, randomly selected from urban and rural areas. …”
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Healthcare workers' knowledge and attitudes regarding artificial intelligence adoption in healthcare: A cross-sectional study by Moustaq Karim Khan Rony, Khadiza Akter, Latifun Nesa, Md Tawhidul Islam, Fateha Tuj Johra, Fazila Akter, Muhammad Join Uddin, Jeni Begum, Md. Abdun Noor, Sumon Ahmad, Sabren Mukta Tanha, Most. Tahmina Khatun, Shuvashish Das Bala, Mst. Rina Parvin

“…Methods: A cross-sectional research design was employed, incorporating a dual-method approach to select participants using randomness and convenience sampling techniques. Validity was ensured through a literature review, content validity, and reliability assessment (Cronbach's alpha = 0.85), and exploratory factor analysis identified robust underlying factors. …”
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How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-hea... by Robert J. Holtackers, Augustin C. Ogier, Ludovica Romanin, Estelle Tenisch, Isabel Montón Quesada, Ruud B. van Heeswijk, Christopher W. Roy, Jérôme Yerly, Milan Prsa, Matthias Stuber

“…Finally, acquisition efficiency was reported for both imaging techniques, which was defined as the time required for data sampling divided by the total scan time. Results: No significant differences in left-ventricular EDV and ESV were found between free-running imaging for 1, 2, 3, 5, and 6 min and standard 2D breath-held cine imaging. …”
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Effect of Brassinosteroid and Melatonin Foliar Application on Biochemical Characteristics and Growth Indices of Quinoa (Chenopodium quinoa Willd) under Drought Stress Condition by N Pakgohar, A. A Maghsoudi Mood, H Farahbakhsh, A Pasandi pour

“…For morphological trait assessment, including plant height, leaf area, dry weight of aerial parts, and yield components, five plants were randomly sampled from each plot. Biological yield, harvest index, and grain yield were calculated by harvesting plants from the middle four rows, each 2 meters long. …”
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Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy by Jing Xu, Li Shen, Yongjie Shui, Wei Yu, Qingqu Guo, Risheng Yu, Yulian Wu, Qichun Wei

“…Abstract Background High‐quality randomized controlled trials have demonstrated the benefit of radiotherapy (RT) in patients with radical resected gastric cancer (GC), however, utilization rates of postoperative RT remain remarkably low. …”
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Effect of sowing depth and mulching types on soil water storage at different growth stages of chickpea under rainfed farming by moslem fetri, Mohammad Eghbal Ghobadi, Mokhtar Ghobadi, Gholamreza Mohammadi

“…In order to estimate soil moisture content, sampling was conducted by auger. Data were analyzed using the SAS and MSTATC softwares and the means were compared using the Duncan test at the 5% level. …”
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24-Epibrasinolid and Cauliflower (Brassica oleracea var. botrytis) Extract Effect on Grain Yield and Some Morphophysiologycal Characteristics of the Sensitive and Tolerant Quinoa (... by R Sohrabi, A Pirzad, M Niazkhani, T MirMahmoodi

“…The investigated factors included the tolerant (Titikaka) and semi-sensitive (Sajma) Quinoa cultivars to salinity, the use of stress-modulating substances (at three levels, without application, application of 24-epibrasinolide and application of cauliflower extract), and the salinity levels (2 levels, without salinity and 15 dS m-1) of irrigation water. After sampling, morphological, biochemical and fodder quality characteristics were measured. …”
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Latent class analysis and influencing factor study of work-related musculoskeletal disorders among operating room nurses in tertiary hospitals by Xiaogui TANG, Li LI, Yue ZHAO, Ningning HU, Feng FU, Boya LI, Mengru YANG, Yinglan LI

“…ObjectiveTo estimate the prevalence of WMSDs among operating room nurses in tertiary hospitals, explore the characteristics and latent categories of WMSDs, and analyze the influencing factors associated with the occurrence of WMSDs. MethodUsing a randomized cluster sampling method, operating room nurses from nine tertiary hospitals in Urumqi were selected as study participants between December 2023 and January 2024. …”
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Comparison of the Performance Between the Montbiliard × Holstein Crossbred and Holstein Calves in Hot and Humid Areas by Pirouz Shakeri, Hassan Khamisabadi, Mehdi Bahrami Yekdangi, Mahdi Abasy Firouzjaei, Amir Ali Shakeri

“…All variables were statistically analyzed using the mixed-model procedure of the statistical analysis systems in a completely randomized design. Animals were expected as the random effect in the experimental model. …”
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