Multicentre open-label randomised controlled trial comparing the efficacy and safety of colistin-based combination therapy with the best available therapy for treating hospital-acq... by Tao Chen, Chen Zhang, Jianfeng Xie, Yingzi Huang, Xiangquan Li, Jiaqiong Li

“…Participants will be randomly assigned to a colistin-based combination therapy group or the best available therapy group. …”
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Inflammatory bowel disease in sub-Saharan Africa: a protocol of a prospective registry with a nested case–control study by Gerhard Rogler, Benjamin Misselwitz, Leolin Katsidzira, Wisdom F Mudombi, Rudo Makunike-Mutasa, Bahtiyar Yilmaz, Annika Blank, Andrew Macpherson, Stephan Vavricka, Innocent Gangaidzo

“…Two age and sex-matched non-IBD controls per case are recruited—a sibling or second-degree relative, and a randomly selected individual from the same neighbourhood. …”
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Transforming Retinal Photographs to Entropy Images in Deep Learning to Improve Automated Detection for Diabetic Retinopathy by Gen-Min Lin, Mei-Juan Chen, Chia-Hung Yeh, Yu-Yang Lin, Heng-Yu Kuo, Min-Hui Lin, Ming-Chin Chen, Shinfeng D. Lin, Ying Gao, Anran Ran, Carol Y. Cheung

“…The aim of this study is to compare the detection performance for severe DR between original fundus photographs and entropy images by deep learning. A sample of 21,123 interpretable fundus photographs obtained from a publicly available data set was expanded to 33,000 images by rotating and flipping. …”
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Mental health dynamics between mothers and siblings of children with disabilities by Erica Zahl, Hugo Cogo-Moreira, Trude Fredriksen, Solveig Kirchhofer, Solveig Kirchhofer, Stian Orm, Stian Orm, Torun Vatne, Torun Vatne, Matteo Botta, Krister Fjermestad, Krister Fjermestad

“…The sample comprised 214 siblings aged 8–16 years and their parents (N = 203 mothers, N = 124 fathers). …”
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Safety and efficacy of ketamine use in patients with vaso‐occlusive crisis: A systematic review and meta‐analysis by Ernesto Calderon Martinez, Stephin Zachariah Saji, Thomas Campos Carmona, Vaidarshi Abbagoni, Mohammad Salman, Mishell Estefanía Llerena Vargas, Suchita Mylavarapu, Druvini Fernando, Lakshmi Sheethal Arvapalli, Nathalia Schettino Samad, Nithin Karnan, Camila Sanchez Cruz

“…Further research is needed to increase the sample size and power of the analysis to clarify optimal dosing and administration protocols for ketamine in this context.…”
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A scoping review of suicide prevention interventions for Latinx adults: strategies, gaps, and future directions by Airín D. Martínez, Samantha Kloft, Pablo Fernandez, Parastoo Dezyani, Alandra Ricci, Delvis J. Hernández, Kelley Cunningham

“…During full-text review, 34 articles were included for the final sample. We randomly selected 10 articles and coded them to check for inter-rater reliability (r = 0.90). …”
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Acupuncture-assisted anaesthesia for catheter ablation of atrial fibrillation to reduce the consumption of morphine hydrochloride and postoperative nausea and vomiting (PONV): stud... by Qi Wang, Yuqi Jia, Xuecheng Zhang, Yujiang Dong, Zhihui Hou, Wenqi Deng, Menghe Zhang, Qiurun Mu, Hongling Jia

“…Although several studies have been conducted on AAA, its safety and efficacy in AF catheter ablation remain unclear due to small sample sizes and a paucity of methodologically rigorous designs. …”
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Development of a multi-laboratory integrated predictive model for silicosis utilizing machine learning: a retrospective case-control study by Guo-kang Sun, Yun-hui Xiang, Lu Wang, Pin-pin Xiang, Zi-xin Wang, Jing Zhang, Ling Wu

“…ObjectiveDue to the high global prevalence of silicosis and the ongoing challenges in its diagnosis, this pilot study aims to screen biomarkers from routine blood parameters and develop a multi-biomarker model for its early detection.MethodsA case-control study was conducted to screen biomarkers for the diagnosis of silicosis using LASSO regression, SVM and RF. A sample of 612 subjects (half cases and half controls) were randomly divided into training and test groups in a 2:1 ratio. …”
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Prevalence of thyroid autoantibody positivity in women with infertility: a systematic review and meta-analysis by Yingqin Huang, Baoli Xie, Jiaxu Li, Fu Hang, Qianwen Hu, Yufu Jin, Rongyan Qin, Jiaxin Yu, Jianxin Luo, Ming Liao, Aiping Qin

“…However, the prevalence of thyroid autoantibodies in women with infertility remains unclear due to variability in study designs, sample sizes, and populations. In this meta-analysis, we aimed to assess the prevalence of thyroid autoantibodies in women with infertility compared with that in healthy controls. …”
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Oncologic outcomes with and without amniotic membranes in robotic-assisted radical prostatectomy: A propensity score matched analysis by Jonathan Noël, Daniel Stirt, Marcio Covas Moschovas, Sunil Reddy, Abdel Rahman Jaber, Marco Sandri, Seetharam Bhat, Travis Rogers, Subuhee Ahmed, Anya Mascarenhas, Ela Patel, Vipul Patel

“…Continuous and categorical variables in matched groups was tested by two-sample Kolmogorov-Smirnov test and Fisher's exact test respectively. …”
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Mixed Reality in Undergraduate Nursing Education: A Systematic Review and Meta-Analysis of Benefits and Challenges by Laura Guillen-Aguinaga, Esperanza Rayón-Valpuesta, Sara Guillen-Aguinaga, Blanca Rodriguez-Diaz, Rocio Montejo, Rosa Alas-Brun, Enrique Aguinaga-Ontoso, Luc Onambele, Miriam Guillen-Aguinaga, Francisco Guillen-Grima, Ines Aguinaga-Ontoso

“…Despite positive qualitative findings, methodological variability, small sample sizes, and publication bias contributed to mixed quantitative results. …”
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Prevalence of Carbapenem-resistant and Carbapenemase-Producing Enterobacterales in Healthcare and Community Settings in the United Kingdom: A Systematic Review and Meta-Analysis by Dr Hossam Almadhoon, Dr Winnie WY Lee, Miss Emma R Carter, Mr Ibrahim Ahmad, Dr Colin S Brown, Dr Nina J Zhu, Prof Alison H Holmes

“…For CPE, a high pooled proportion was observed in healthcare carriage samples at 1.23% (95%CI: 0.68%–1.91%; I2= 98.10%; n= 262,524) compared to infection samples at 0.03% (95%CI: 0.00%–0.37%; I2= 0.00%; n= 888). …”
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Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants by Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Thomas H. Mosley, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N. Ahmad Aziz, Monique M. B. Breteler, Kerstin Wirkner, Markus Scholz, Christian Fuchsberger

“…Two loci were female-specific while one was sex-differential with respective candidate genes containing androgen response elements. Two-sample Mendelian randomization was applied to search for causal relationships between sex hormones, odour identification and neurodegenerative diseases. …”
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Evidence Graph Analysis of Postoperative Pain Sensitization Induced by Perioperative Sleep Deprivation by XUE Jianjun, WANG Caihong, GUO Lingling, LI Xiuxia, ZHANG Jie, XU Ziqing, HOU Huaijing, YANG Kehu

“…More high-quality, large-sample and standardized clinical studies should be carried out in the future to provide better scientific basis for clinical work.…”
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Principles of effective out-patient diagnostics of diffuse liver diseases by Komova A. G., M. V. Mayevskaya, V. T. Ivashkin

“…Overall 5000 Moscow inhabitants age 18 to 75 years, chosen randomly within the «the liver check up» project, have been included in prospective population study. …”
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Muay Thai exercises improve quality of life, love of life and self-control by Oktay Şahin, Coşkun Yılmaz, Süreyya Yonca Sezer, Fatma Neşe Şahin, Levent Ceylan, Baha Engin Çelikel, Çetin Tan, Mine Akkuş Uçar, Nagihan Kirikoğlu

“…The sample sizes for the MTT and CON groups were both 25. …”
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The effect of differential and traditional training methods on electromyographic changes of lower body muscles in performing and learning crawl swimming by Raha Nikravesh, Seyed Kazem Mousavi Sadati, Jaleh Bagherli, Mohammad Ali Aslankhani

“…The aim of the present study was to investigate the effect of differential and traditional training methods on electromyographic changes of lower body muscles in performing and learning crawl swimming.Methods: In this study, 36 swimmers aged 20 to 25 years who had no experience in swimming training were selected as a sample and randomly divided into three groups of control, traditional exercises and differential exercises. …”
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Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study by Francesco Fisicaro, Francesco Fisicaro, Klizia Cortese, Rita Bella, Manuela Pennisi, Giuseppe Lanza, Giuseppe Lanza, Kaoru Yuasa, Yoshikazu Ugawa, Yasuo Terao

“…With this single-blind, sham-controlled, crossover design trial, we aimed to assess whether taVNS was able to improve the digit span score, as well as to modulate the pupillary response to cognitive load in a sample of 18 elderly Japanese volunteers with no self-reported cognitive impairments.ResultsSubjects were randomized to receive either real or sham taVNS during a digit span task while recording the pupil size, and then switched over to the other treatment group. …”
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Clinical efficacy of meridian differentiation acupuncture in the treatment of intractable insomnia based on objective data: a protocol for a multicentre, single-blind, randomised c... by Yun Li, Nan Lin, Bo Li, Ling Gao, Li Dong, Wenming Chu, Xi-Yan Gao, Xueyang Guo, Bo-Yu Zhang

“…Previous clinical research has indicated that meridian differentiation acupuncture (MA), based on objective data, can notably enhance sleep quality in patients with intractable insomnia. However, small sample sizes and a lack of objective measures necessitate further investigation. …”
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Comparison of the effects of different teaching methods on the effectiveness of teaching neurology in China: a bayesian network meta-analysis and systematic review by Xiangyu Li, Longsheng Zhang, Wenjun Sun, Min Lei, Ying Li, Jiacheng Zhang, Xing Huang

“…However, these studies often suffer from limited sample sizes, single-center studies and low quality, compounded by the lack of direct comparative analyses between teaching methods, thereby leaving the identification of the most effective method unresolved. …”
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