The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway by Xuemei Li, Siyi Wang, Hanwen Cao, Simin Xu, Chao Xiong, Jinhai Yu, Yunxiu Chen, Zhangjun Ren, Min Li, Ying Hu, Puying Gan, Qihua Xu, Yaohua Wang, Hongfei Liao

“…The intersection of DEGs and FRGs yielded ferroptosis-related genes associated with TAO.The transcriptional expression of FRGs was validated using real-time quantitative polymerase chain reaction (RT-qPCR) on orbital adipose tissue samples from TAO patients and healthy controls. Single-cell sequencing of six human tissue samples further analyzed changes in cellular subpopulations within the TAO microenvironment.Additionally, a co-culture model of CD163 + macrophages and TAO orbital fibroblasts, along with an in vitro TGF-β1-induced orbital fibroblast (OF) model, was constructed to validate the role of the TGF-β1/SMAD2/3 axis in ferroptosis regulation. …”
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The Safety of Telerehabilitation: Systematic Review by Hila Shnitzer, Josh Chan, Thomas Yau, McKyla McIntyre, Angie Andreoli, Ailene Kua, Mark Bayley, Carl Froilan Leochico, Meiqi Guo, Sarah Munce

“…ResultsSearch results identified 9022 references, of which 37 randomized controlled trials met the criteria for inclusion. …”
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Nutritional Status of Children and Its Associated Factors in Selected Earthquake-Affected VDCs of Gorkha District, Nepal by Asmita Shrestha, Chet Kant Bhusal, Binjwala Shrestha, Kiran Dev Bhattarai

“…As the sample was 420, 42 children were selected randomly from every ward. …”
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Combining methylated RNF180 and SFRP2 plasma biomarkers for noninvasive diagnosis of gastric cancer by Zhihao Dai, Jin Jiang, Qianping Chen, Minghua Bai, Quanquan Sun, Yanru Feng, Dong Liu, Dong Wang, Tong Zhang, Liang Han, Litheng Ng, Jun Zheng, Hao Zou, Wei Mao, Ji Zhu

“…Materials & Methods: A total of 165 healthy individuals, 34 patients with precancerous gastric lesions, and 104 patients with confirmed GC were divided into training and validation sets; methylated RNF180 and SFRP2 were detected in circulating DNA from blood samples. Six models, including those based on logistic regression, Naive Bayes, K-nearest neighbor algorithm, glmnet, neural network, and random forest (RF) were built and validated. …”
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Machine learning-assisted assessment of extracellular vesicles can monitor cellular rejection after heart transplant by Jacopo Burrello, Stefano Panella, Ilaria Barison, Chiara Castellani, Alessio Burrello, Lorenzo Airale, Jessica Goi, Veronica Dusi, Roberto Frigerio, Gino Gerosa, Chiara Tessari, Nicola Pradegan, Giuseppe Toscano, Giovanni Pedrazzini, Mattia Corianò, Francesco Tona, Sara Bolis, Alessandro Gori, Marina Cretich, Marny Fedrigo, Annalisa Angelini, Lucio Barile

“…A total of 285 blood samples were analyzed for EV surface antigens exploiting two flow cytometry-based protocols. …”
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Assessing disparities in access, use, and potential benefits of weather and climate information services among farmers in Guatemala’s Dry Corridor by Maya Moore, Geneva List, Max Mauerman, Dante Salazar Ballesteros, Walter Baethgen

“…Noteable, only 50 % of the sampled farmers report access to any weather or climate information. …”
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ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis by Anquan Ma, Chuanyao Zhai, Qixuan He, Wenhao Wang, Huiping Ren, Kai Mao, Weipeng Lan, Jing Lan

“…Methods In this study, we analyzed ENTR1 expression levels in normal and tumor tissues using clinical sample data from multiple databases. We also employed Mendelian randomization (MR) analysis of ENTR1. …”
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The tissue and circulating cell‐free DNA‐derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer by Qingjian Chen, Yu‐Hong Xu, Shiyang Kang, WuHao Lin, Linna Luo, Luping Yang, Qi‐Hua Zhang, Pan Yang, Jia‐Qian Huang, Xiaoni Zhang, Jing Zhang, Qi Zhao, Rui‐Hua Xu, Hui‐Yan Luo

“…By comparing with the mutational profiles of metastatic CRC plasma samples, we found that ZNF717 was exclusively mutated in CRAs, while KMT2C and KMT2D mutations were detected in both CRA and CRC. …”
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Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma by Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Miao Dang, Huanqin Zhang, Weizheng Zhou, Xu Guo, Jinliang Xing

“…Moreover, we constructed a random forest algorithm-based HCC detection model by utilizing ccf-mtDNA fragmentomic features. …”
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EFFECT OF DIETARY SUPPLEMENTATION OF VITAMIN E AND SELENIUM ON TOTAL ANTIOXIDANT STATUS AND IN VITRO IMMUNE COMPETENCE IN GROWER GHUNGROO PIGS by Rubayat Hussain, T. Samui, Joycy Seiba Khukhodziinai, P. K. Das, P. R.Ghosh, D. Banerjee, K Das, S. Naskar, S. Bag, J.Mukherjee

“…Blood samples were collected from all the experimental animals on days 15, 30, 45, and 60 of supplementation for analysis. …”
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A Data-Driven Approach to Link GC-MS and LC-MS with Sensory Attributes of Chicken Bouillon with Added Yeast-Derived Flavor Products in a Combined Prediction Model by Simon Leygeber, Carmen Diez-Simon, Justus L. Großmann, Anne-Charlotte Dubbelman, Amy C. Harms, Johan A. Westerhuis, Doris M. Jacobs, Peter W. Lindenburg, Margriet M. W. B. Hendriks, Brenda C. H. Ammerlaan, Marco A. van den Berg, Rudi van Doorn, Roland Mumm, Age K. Smilde, Robert D. Hall, Thomas Hankemeier

“…Methods: Chicken bouillon samples containing diverse YPs were chemically and sensorially characterized using statistical multivariate analyses. …”
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Response efficacy of PD-1 and PD-L1 inhibitors in salivary gland cancers: a systematic review and meta-analysis by Zahra Babamohamadi, Amirreza Taherkhani, Ali Yousefzadeh, Ali Moradi, Marziyeh Heidari, Zahra Sadat Hoseini Nasab, Seyedeh Mona Haghi, Ayda Afkhami, Mohaddeseh Belbasi, Masoud Noroozi, Niloofar Deravi

“…Due to the high heterogeneity of the studies, more RCTs with a larger sample size are required to prove the association.…”
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Supervised Physical Activity Interventions in Children and Adolescents with Cancer Undergoing Treatment—A Systematic Review by Nadja Battanta, Krystyna Lange, Sabine V. Kesting, Daniela Marx-Berger, Philip Heesen, Hannah Ober, Aron Onerup, Saskia M. F. Pluijm, Eva Scheler, Emma J. Verwaaijen, Katrin Scheinemann, Maria Otth

“…Variability in interventions and outcomes, along with small sample sizes and heterogeneous patient populations, made it difficult to draw clear conclusions. …”
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Concordance of shoulder symptoms and imaging findings: a protocol for the Finnish Imaging of Shoulder (FIMAGE) study by Rachelle Buchbinder, Eira Viikari-Juntura, Harri Rissanen, Tommi Härkänen, Seppo Koskinen, Kari Kanto, Simo Taimela, Markku Heliövaara, Pirjo Toivonen, Teppo Jarvinen, Niko Sillanpää, Mika Paavola, Roope Kalske, Lasse Rämö, Thomas Ibounig, Saara Raatikainen, Tomasz Czuba, Robert Björkenheim, Danielle van der Windt

“…Overall, there is a paucity of high-quality evidence on the prevalence, clinical relevance and prognosis of ‘abnormal’ imaging findings of the shoulder.The aim of the Finnish Imaging of Shoulder (FIMAGE) study is fourfold: to assess (1) the prevalence of shoulder symptoms and the most common anatomical variants and imaging abnormalities of the shoulder; (2) the concordance between shoulder symptoms, function and imaging abnormalities; (3) the most important determinants of symptoms, function and imaging abnormalities; and (4) the course of shoulder complaints over 5 years.Methods The FIMAGE target population of 600 participants, aged 40–75 years, will be randomly selected from a nationally representative general population sample of 9922 individuals originally recruited for the Finnish Health 2000 Survey. …”
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Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints by Xianyong Yin, Jack Li, Debraj Bose, Jeffrey Okamoto, Annie Kwon, Anne U. Jackson, Lilian Fernandes Silva, Anniina Oravilahti, Xiaomeng Chu, Heather M. Stringham, Lei Liu, Ruyi Peng, Zhijie Xia, Samuli Ripatti, Mark Daly, Aarno Palotie, Laura J. Scott, Charles F. Burant, Eric B. Fauman, Xiaoquan Wen, Michael Boehnke, Markku Laakso, Jean Morrison

“…Here, we perform two-sample Mendelian randomization to systematically infer the potential causal effects of 1099 plasma metabolites measured in 6136 Finnish men from the METSIM study on risk of 2099 binary disease endpoints measured in 309,154 Finnish individuals from FinnGen. …”
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Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy by Qingsong Chen, Tao Li, Tao Zhang, Yue Zhou, Weifeng Huang, Hui Li, Li Shi, Jianxiao Li, Qi Zhang, Man Ma, Pan Wang, Hui Hu, Gongbin Wei, Jiangxia Xiang, Yuan Cheng, Jun Yang, Guangbin Huang, Yongming Li, Dingyuan Du

“…Gene expression data from 20 samples, comprising 10 controls and 10 severe trauma patients with TIC, were analyzed. …”
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Patterns of Opportunistic Infections and Antiretroviral Therapy Efficacy in Newly Diagnosed Human Immunodeficiency Virus-1 Patients: A Descriptive Study in India by N Kisenjang, Sumit Arora, Pooja Sangwan, Imam D Khan, Charu Mohan, Anmol Sharma, Vikram Sharma, Ankit Rao, Aditya Puniyani, Shivani Sangwan, Alisha Sharma, Swati Jain, Anuradha Makkar, Preeti Badhan, H Vanalahruaii

“…Materials and methods: This ambispective descriptive study was conducted over 6 months at a 1,000-bed tertiary-care teaching hospital in New Delhi, including 100 patients with confirmed HIV-1 infection. Randomized sampling was used, adhering to National AIDS Control Organization (NACO) guidelines for inclusion. …”
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Aquatic system assessment of potentially toxic elements in El Manzala Lake, Egypt: A statistical and machine learning approach by Asmaa Nour Aly Al-Falal, Salah Elsayed, Ezzat A. El Fadaly, Aissam Gaagai, Hani Amir Aouissi, Mohamed S. Abd El-baki, Mohamed Hamdy Eid, Abdallah Elshawadfy Elwakeel, Zaher Mundher Yaseen, Osama Elsherbiny, E.I. Eltahir, Mohamed Gad

“…Water samples, collected over the 2020/2021 and 2021/2022 periods, included sixteen physicochemical parameters for index calculation. …”
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Nutraceutical eicosapentaenoic acid in treatment-resistant depression: The psychoneuroimmunity and clinical implications by Jane Pei-Chen Chang, Ayesha Zafar Iqbal, Quang Le Do, Muhammad Yaseen, Suet-Kei Wu, Ikbal Andrian Malau, Halliru Zailani, Kuan-Pin Su

“…A total of twelve studies, including randomized controlled trials and open label studies, with a combined sample size of 498 participants have reported encouraging outcomes with eicosapentaenoic acid -predominant omega-3 polyunsaturated fatty acids in Treatment Resistant depression. …”
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Determining the Relationship Between Oxidative Stress and Subclinical Ketosis in Dairy Cows by Seyyed Mohammad Hosein Ghaheri, Seyedeh Ommolbanin Ghasemian, Behnam Pedram

“…Methods: This clinical study was conducted on 50 Holstein dairy cows in the industrial dairy farm of Shams Abad Dairy Complex, Qom province, Iran, over three months in the summer of 2022. The samples were selected randomly from apparently healthy cows in the last lactation period, present in the dry period. …”
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