Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization by Yifang He, Yanli Wang, Xiali Wang, Xiali Wang, Shuangping Deng, Dandan Wang, Qingqing Huang, Guorong Lyu

“…This study aimed to identify hub genes and investigate potential molecular mechanisms associated with PCOS through a combination of bioinformatics analysis and Mendelian randomization (MR).MethodsThis study employed bioinformatics analysis in conjunction with MR methods using publicly available databases to identify hub genes. …”
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Effects of sensory room intervention on autonomic function in healthy adults: A pilot randomized controlled trial. by Hikari Otsuka, Keisuke Irie, Tomohiro Kogata, Azumi Onitsuka, Hiroyuki Inadomi

“…Thirty-nine healthy young adults were randomly divided into the sensory room intervention (SRI) and sedentary activity (SA) groups, and given a 30-minute intervention. …”
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The efficacy of acupuncture for diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trails by Ruisi Ge, Rihe Liu, Mengru He, Jiawei Wu, Feng Zhang, Chang Huang

“…However, the above conclusions need to be verified by larger samples and higher quality randomized controlled trials.Systematic review registration[https://www.crd.york.ac.uk/], identifier [CRD42023451575].…”
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An Indole-Rich Postbiotic Reduces Itching in Dogs: A Randomized, Double-Blinded Placebo-Controlled Study by Aylesse Sordillo, Jonna Heldrich, Raphaël Turcotte, Ravi U. Sheth

“…Skin and coat health was assessed on Days 0, 14, and 28, and the gut microbiome was sequenced from fecal samples on Days 0 and 28. CIHP reduced scratching by 20% relative to the baseline (<i>p</i> = 0.032) and PVAS score by 27% compared to the placebo (<i>p</i> = 0.02). …”
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Effect of Squat Exercises on Fatigue and Quality of Life of Pregnant Women: A Randomized Controlled Trial Study by Maryam Malmir, Seyedeh Zahra Masoumi, Farideh Kazemi, Mansoureh Refaei

“…The pregnant women were randomly using blocks of four divided into two groups according to the inclusion criteria. …”
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Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study by Hattan Mohamed Arab, Hassan Abed, Arkadiusz Dziedzic, Doaa Nadhim, Mutaz Banjar, Khalid Metwalli, Mohsen Aljabri, Marta Tanasiewicz

“…Materials and Methods: A randomized, observational study enrolled 441 participants residing in Southern Sweden, aged 20 and 89 years and diagnosed with PDS. …”
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Effectiveness of transcranial direct electrical stimulation in management of patellofemoral pain syndrome: A randomized controlled trial by Mahesh Sharma, Ramesh C. Patra, Shashikumar C. Govindappa

“…MATERIALS AND METHODS: Patients with patellofemoral pain were randomly put into two groups for a 6-week protocol. …”
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Randomized pharmacokinetic study comparing subcutaneous and intravenous palonosetron in cancer patients treated with platinum based chemotherapy. by Belen Sadaba, Anabel del Barrio, Miguel Angel Campanero, Jose Ramon Azanza, Almudena Gomez-Guiu, Jose Maria Lopez-Picazo, Salvador Martin Algarra, Francisco Guillén Grimá, Maria Blanco Prieto, Jose Luis Perez-Gracia, Alfonso Gurpide

“…Blood samples were collected at baseline and 10, 15, 30, 45, 60, 90 minutes and 2, 3, 4, 6, 8, 12 and 24 h after palonosetron administration. …”
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Effects of Tibetan Music on Neuroendocrine and Autonomic Functions in Patients Waiting for Surgery: A Randomized, Controlled Study by Antonella Cotoia, Floriana Dibello, Fiorenzo Moscatelli, Alberto Sciusco, Pietro Polito, Alberto Modolo, Crescenzio Gallo, Giuseppe Cibelli, Gilda Cinnella

“…The salivary α-amylase (sAA) samples were collected at T0, T35, and T45. Results. …”
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Exploring the Potential Association Between Inhaled Corticosteroid and Face Aging Risk: A Mendelian Randomization Study by Junpeng Li, Yaqiong Liu, Gujie Wu, Shanye Yin, Lin Cheng, Wenjun Deng

“…<b>Methods</b>: We identified ICS target genes using DrugBank and DGIdb databases and derived genetic instruments from cis-eQTL data in whole-blood samples (n = 31,684). GWAS data for facial aging traits (n = 423,999) and plasma metabolites (1400 metabolites, n = 8000) were analyzed. …”
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Integrated multiomics and Mendelian randomization identify CHIT1 as a novel sepsis biomarker and therapeutic target by Guorui Li, Yunlong Mao, Jiaxiang Liao, Yuquan Zhou

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The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial by Kala Kumar Bharani, Ashok Kumar Devarasetti, Rajendar Bobbili, Amit Khurana, Donga Durga Veera Hanuman, Roupesh Gudepu, Swapna Guda

“…We hypothesized that ARE might promote a healthy gut by its adaptogenic and anti-inflammatory effects and improve vital parameters for healthy ageing.MethodsA randomized, double-blind, placebo-controlled trial was conducted in Telangana, India. …”
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Mendelian randomization analysis of inflammatory biomarkers and hepatocellular carcinoma risk: genetic causality and single-cell transcriptomics by GuangXin Shao, Xiao Yun, Hongyue Xie, Beicheng Sun

“…Single-cell RNA sequencing data from four HCC samples (BT1306, BT1307, scrSOL004, scrSOL006) were analyzed to validate findings through cellular heterogeneity analysis, cell-cell communication networks, and pathway enrichment analysis. …”
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Cognitive behavioral therapy for ADHD predominantly inattentive presentation: randomized controlled trial of two psychological treatments by Elinor Eskilsson Strålin, Lisa B. Thorell, Tobias Lundgren, Sven Bölte, Sven Bölte, Sven Bölte, Benjamin Bohman

“…Future research with larger samples and long-term follow-ups is recommended to validate and expand upon these results.…”
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Promoting healthy aging through intergenerational exchange and digital empowerment: a pilot randomized controlled trial by Giulia Cossu, Stefano Lorrai, Alessia Galetti, Alessandra Perra, Massimo Tusconi, Giuseppe Carrà, Antonio Preti, Anita Holzinger, Mauro Giovanni Carta

“…Future studies with larger samples and extended follow-up periods are needed to corroborate this preliminary evidence.Clinical trial registrationClinicalTrials.gov, identifier NCT06162871.…”
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Efficacy of a Mixed Wavelength Laser for Vaginal Health in Postmenopausal Women: A Randomized Controlled Trial by Salinas Pena J, Tameish S, Guilarte Calzada C, Cavallé Busquets P

“…The aim of the study is to evaluate the efficacy and safety of a mixed-wavelength laser in alleviating GSM symptoms compared to sham.Patients and Methods: A randomized single-blind sham-controlled trial was conducted. 31 postmenopausal women with Vaginal Maturation Value (VMV < 50%) were randomized into laser or sham intervention groups, receiving three monthly treatments. …”
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The effects of dexmedetomidine on thiol/disulphide homeostasis in coronary artery bypass surgery: a randomized controlled trial by Yusuf Ozguner, Savaş Altınsoy, Gökçen Kültüroğlu, Dilek Unal, Julide Ergil, Salim Neşelioğlu, Özcan Erel

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Sphingolipid metabolism-related genes for the diagnosis of metabolic syndrome by integrated bioinformatics analysis and Mendelian randomization identification by Weidong Li, Qixing Zhong, Naisheng Deng, Xinhao Zhou, Haitao Wang, Jun Ouyang, Zhifen Guan, Bohao Cheng, Lijun Xiang, Yueming Huang, Yao Wang

“…The levels of five immune cell types, including plasmacytoid dendritic cells, exhibited notable differences between the MetS and normal samples. TAX1BP3 exhibited a markedly negative correlation with activated CD8 T cell (r = -0.584), whereas it showed a markedly positive correlation with plasmacytoid dendritic cells (r = 0.744). …”
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Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer by John Wright, Stephanie Lheureux, Ilaria Colombo, Ramy Gadalla, Pamela S Ohashi, Xuan Li, Lisa Wang, Matthew S Block, David G Brooks, Andrea Jewell, Carolyn McCourt, Eugenia Girda, Sarah Temkin, Gini F Fleming, Linda Duska, Daniela E Matei, Panagiotis A Konstantinopoulos, Ben X Wang, Stephanie L Gaillard, Michael McHale, Floor J Backes, Theresa L Werner, Siobhan Kehoe, Rachel Wildman, Shirin Soleimani, Scott Lien, Trevor Pugh

“…Baseline biopsy and serial peripheral blood mononuclear cell (PBMC) samples were analyzed and associations between patient outcome and immune data from cytometry by time of flight (CyTOF) and PBMCs were explored.Results Median PFS was 5.3 (90% CI 3.5 to 9.2) months in Arm A (n=36) and 1.9 (90% CI 1.6 to 3.4) months in Arm B (n=18) (HR=0.59, 90% CI 0.35 to 0.98; log-rank p=0.09, meeting the prespecified statistical significance criteria). …”
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A household randomized-control trial of insecticide-treated screening for malaria control in unimproved houses in Tanzania by Olukayode G. Odufuwa, Sarah Jane Moore, Zawadi Mageni Mboma, Rehema Mwanga, Fatuma Matwewe, Lorenz Martin Hofer, Isaya Matanila, Said Abbasi, Mohammed Ally Rashid, Rose Philipo, Fadhila Kihwele, Jason Moore, Hien Nguyen, Rune Bosselmann, Ole Skovmand, Jennifer C. Stevenson, Joseph B. Muganga, John Bradley

“…Secondary outcomes included indoor total mosquito per trap/night (June–July 2022), adverse effects after one month of ITS installation (August 2021), and chemical bioavailability and retention of ITS samples after one year of field use (June/July 2022). …”
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