Anti-inflammatory effect of chamomile from randomized clinical trials: a systematic review and meta-analyses by Jason Valmy, Stephanie Greenfield, Satoru Shindo, Toshihisa Kawai, Jorge Cervantes, Bo-Young Hong

“…Chamomile’s widespread recognition and application in medicine highlights its significance in herbal therapeutic practices globally.Objective To explore chamomile as a low-risk antimicrobial and anti-inflammatory agent, utilizing clinical characteristics derived from the existing body of evidence from randomized clinical trials within the current literature.Methods We conducted a systematic review of randomized clinical trials using the search terms ‘chamomile anti-inflammatory antimicrobial randomized clinical trials’ and ‘chamomile anti-inflammatory antimicrobial’. …”
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Exploring the causal relationship of gut microbiota in nonunion: a Mendelian randomization analysis mediated by immune cell by Yun-fei Yu, Hai-Feng Gong, Wei-Ju Li, Mao Wu, Gang Hu

“…This study aims to elucidate the causal relationship between GM and nonunion using Mendelian Randomization (MR) and to explore the mediating role of immune cells.MethodsUsing a two-step, two-sample Mendelian randomization approach, this study explores the causal link between GM and nonunion, as well as the mediating role of immune cells in this relationship. …”
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A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors by Fangsheng Chen, Yuan Zhou, Xinwen Mao, Ronggui Lin, Heguang Huang

“…Two-sample MR analysis identified significant correlations between GM and immune cell types. …”
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Effect of mediolateral leg perturbations on walking balance in people with chronic stroke: A randomized controlled trial. by Alexa A Krause, Nicholas K Reimold, Aaron E Embry, Heather L Knight, Camden J Jacobs, Andrea D Boan, Jesse C Dean

“…The objective of this parallel, double-blinded, randomized controlled trial was to investigate whether repeated perturbations cause sustained increases in step modulation (NCT02964039; funded by the VA). 54 PwCS at the Medical University of South Carolina were randomly assigned to one of three intervention groups: Control (n = 18), with minimal forces; Assistive (n = 18), pushing the swing leg toward a mechanically appropriate location; Perturbing (n = 18), pushing the swing leg away from a mechanically appropriate location. …”
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Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

“…The secondary outcomes are GWG, the occurrence of hypertensive syndromes, macrosomia, and neonatal hypoglycemia. The sample will comprise 92 pregnant women, 46 per group. …”
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Mendelian randomization studies of gastric cancer reveal potential risk factors, promising biomarkers and therapeutic targets by Maowei He, Yanting Duan, Yuanyan Zhang, Chao Qian, Jiawei Jin

“…Abstract Objective To further understand the causal relationship between potential risk factors or biomarkers and gastric cancer, we performed an extensive Mendelian randomization (MR) analysis. Methods Genetic instruments were extracted from 486 available traits in 24 subcategories from the MR-Base platform, and ordinary two-sample MR, reverse MR, and mediating effect analyses were conducted based on 6563 gastric cancer cases and 195,745 controls from the BioBank Japan Project. …”
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Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study by Mao W, Wu L

“…Our study aimed to implement a comprehensive analytical framework incorporating bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) to investigate the causal relationship between BMD and CS.Methods: Genome-wide association summary statistics for BMDs across four skeletal sites and five age groups, and CS, were obtained from public databases. …”
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Genetically proxied inhibition of Phosphodiesterase-5 and cancer risks: A drug-target Mendelian randomization analysis by Kefu Tang, Binbin Li, Xi Wu, Meng Wang

“…To clarify whether PDE5 inhibitors medication may affect the risk of cancer, 2-sample cis-Mendelian randomisation (MR) analysis was therefore performed. …”
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Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis by Chunhong Ma, Dandan Liu, Changchun Ye, Zilu Chen, Ranran Kong, Jianzhong Li, Xuejun Sun, Zhengshui Xu

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Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis by Yu-Peng Xu, Zheng-Qi Song, Ming-Li Chen, Yang-Li Fang, Hui-Di Zhang

“…This study investigates the causal role of diverse plasma complement proteins in CKD and its clinical types to discover new biomarkers and therapeutic targets.Method Using two-sample Mendelian randomization (MR), we examined the causal relationships between 28 plasma complement proteins and CKD outcomes. …”
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Effect of intervention on screen time in preschoolers: a systematic review and meta-analysis of randomized controlled trials by Yan Wu, Xiaobin Xi, Chunkai Zhang, Jieying Jiang, Sunyue Ye

“…Subgroup analyses (e.g., sample size, child age, gender, intervention duration) were conducted, with statistical tests (e.g., the chi-square test) comparing subgroup differences. …”
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Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization by XueLian Chen, JianRong Zeng, FengYun Cao, Jun Cai, Xin Ma, ChangYu Pu

“…This study aimed to explore bidirectional causal relationships between genetically predicted oxidative stress injury biomarkers (OSIBs) and lung cancer risk using mendelian randomization (MR). Methods A two-sample bidirectional MR approach was used to assess causal effects of 16 OSIBs on lung cancer subtypes (small cell lung cancer, squamous cell carcinoma, and adenocarcinoma) and vice versa. …”
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A Hybrid Mangrove Identification Method by Combining the Time-Frequency Threshold of the Mangrove Index With a Random Forest Binary Classifier by Zhuokai Jian, Bin Ai, Jiali Zeng, Yuchao Sun

“…Specifically, the method utilized a small sample size to successfully obtain pure and accurate mangrove classification. …”
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Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study by Wei Ji, Wei Ji, Liping Sun, Liping Sun, Yue Huang, Yue Huang, Jie Bai, Jie Bai, Jijian Zheng, Jijian Zheng, Kan Zhang, Kan Zhang

“…Eighty-two pediatric patients aged 2–18 years who were scheduled for elective ERCP were randomly assigned to receive either oxycodone (0.2 mg/kg) or fentanyl (2 μg/kg). …”
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Genetically Predicted 1400 Blood Metabolites in Relation to Risk of Prostate Cancer: A Mendelian Randomization Study by Xiaojin Lu, Yongming Chen, Yuxiao Jiang, Jiaxin Ning, Shengjie Liu, Zhengtong Lv, Miao Wang, Huiming Hou, Ming Liu

“…GWAS data for PCa were obtained from the UK Biobank (UKB) database (79,148 cases, 61,106 controls) for a two‐sample Mendelian randomization (MR) preliminary analysis, where we investigated potential causal relationships between 1400 metabolites and PCa. …”
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Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin by Juhong Pan, Xingyue Huang, Yueying Chen, Nan Jiang, Yuxin Guo, Shiyuan Zhou, Yao Zhang, Bo Hu, Qing Deng, Qing Zhou

“…Abstract This study employed a trans-ethnic two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between membranous nephropathy (MN) and peripheral artery disease (PAD). …”
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Causal relationships between serum metabolites and coronary heart disease risk: a mendelian randomization study by Xiao-Yan Meng, Xiao-Yan Meng, Yong-Qing Zhu, Yong-Qing Zhu, Ying-Jie Zhang, Ying-Jie Zhang, Wei Sun, Shu-Ang Li

“…The primary analysis employed the inverse variance weighted (IVW) method, supplemented by additional analyses, including MR-Egger, weighted median, weighted mode, and sample mode. To bolster the robustness and reliability of our findings, we performed sensitivity analyses, which included evaluating, horizontal pleiotropy and leave-one-out analysis. …”
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The Effects of Cinnamon on Metabolic and Hormonal Status of Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial by Sanam Hadipour, Leila Amini, Bahare Afshar, Afsaneh Ghasemi, Hamid Haghani, Homa Sadeghi Avval Shahr, Shayesteh Jahanfar

“…Eligible women were randomly allocated into intervention (n=33) and placebo (n=33) groups. …”
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Genetic analysis the causal associations between metal elements and thyroid cancer: a bidirectional Mendelian randomization by Siyi Yan, Ting Huang, Nan Shi, Keke Hu, Junhua Guo, Zhifeng Ye, Yinyan Shao, Heran Zhou

“…Methods We performed a two-sample Mendelian randomization (MR) analysis to assess the causal relationships between 21 metal elements and thyroid cancer risk in East Asian populations. …”
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Exploring the Impact of Robotic Hand Rehabilitation on Functional Recovery in Parkinson’s Disease: A Randomized Controlled Trial by Loredana Raciti, Desiree Latella, Gianfranco Raciti, Chiara Sorbera, Mirjam Bonanno, Laura Ciatto, Giuseppe Andronaco, Angelo Quartarone, Giuseppe Di Lorenzo, Rocco Salvatore Calabrò

“…<b>Methods:</b> A single-blind, randomized controlled trial was conducted with PD patients allocated to RAT or CPT. …”
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