Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer by Junzuo Lin, Qian Xu, Zhengfei Zhao

“…MR analysis was conducted via the R package TwoSampleMR. Bayesian colocalization analysis was applied to identify shared genetic effects between CRC risk factors and potential therapeutic targets. …”
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A Mendelian randomization study of the gut microbiota and risk of knee osteoarthritis and the mediating role of immune cells by Jiayu Zhang, Xiuyue Qiu

“…This study aimed to investigate the causal effect of GM on KOA and to identify immune cell mechanisms that may play a mediating role. A bidirectional two-sample univariable Mendelian randomization (UVMR) analysis was conducted to assess the association between GM and KOA. …”
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The Effect of Exercise on Inflammatory Markers in PCOS Women: A Systematic Review and Meta-Analysis of Randomized Trials by Mozhgan Hafizi Moori, Saeed Nosratabadi, Naghmeh Yazdi, Razieh Kasraei, Zeinab Abbasi Senjedary, Razieh Hatami

“…A weighted mean difference (WMD) using a random-effect model was applied for reporting results. …”
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The Role of Telehealth Applications in Chronic Kidney Disease Management: A Systematic Review of Randomized Controlled Trials by Duygu Akbaş Uysal, Fisun Şenuzun Aykar

“…This systematic review incorporated all full-text randomized controlled trials (RCTs) published in English that met the inclusion criteria. …”
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Adverse Effects and Safety of Antidepressants and Psychedelics for Depression in Cancer: A Systematic Review of Randomized Controlled Trials by Renan Massanobu Maekawa, Lorena Terene Lopes Guerra, José Carlos Bouso, Jaime Eduardo Cecilio Hallak, Rafael Guimarães dos Santos

“…A total of 1764 articles were identified, with 21 randomized controlled trials meeting the inclusion criteria. …”
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The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis by Dandan Han, Shaohua Zhao

“…Methods In this study, we employed a two‐sample Mendelian randomization (MR) analysis, utilizing large‐scale genome‐wide association study (GWAS) data to systematically investigate the potential causal relationship between asthma and hippocampal volume. …”
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Intramuscular Ketamine Effect on Postnasal Surgery Agitation: A Prospective Double-Blinded Randomized Controlled Trial by Husam A. Almajali, Ali M. Abu Dalo, Nidal M. Al-Soud, Ali Almajali, Abdelrazzaq Alrfooh, Thani Alawamreh, Hamza Al-Wreikat

“…This study investigates the effect of intramuscular ketamine on emergence agitation (EA) following septoplasty and open septorhinoplasty (OSRP) when administered at subanesthetic doses at the end of surgery. A random sample of 160 ASA I-II adult patients who underwent septoplasty or OSRP between May and October, 2022, was divided into two groups of eighty patients each: ketamine (Group K) and saline (Group S) with the latter serving as the control group. …”
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A Pilot Randomized Controlled Trial of a Single-Session Digital Acceptance and Commitment Therapy Intervention by Michael E. Levin, Miriam N. Mukasa, Emily M. Bowers, Korena S. Klimczak, Ty B. Aller

“…Single-session DMHIs may help by providing a low-intensity intervention that takes less time to complete. This pilot randomized controlled trial sought to evaluate the acceptability and preliminary efficacy of a single-session DMHI based on acceptance and commitment therapy (ACT) in a non-clinical sample of college students. …”
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Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization. by Gbenga A Kayode, Loukas Zagkos, Godspower Oboli, Sonya Abraham, Gregory Kato, Quazi Ataher, Evangelia Farmakioti, Lothar Tremmel, Stephen Burgess

“…<h4>Results</h4>Higher levels of genetically predicted CSF haptoglobin was associated with lower risk of catastrophic aSAH in multi-ancestry (OR: 0.79, 95% CI: 0.65 to 0.96, p = 0.019) and White British sample analyses (OR: 0.78, 95% CI: 0.63 to 0.95, p = 0.013), while the lack of association with related traits supported effects specific to outcomes after aSAH. …”
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Clinical efficacy on acupuncture for perennial allergic rhinitis: a study protocol for a randomized clinical trial by Jia-xin Yang, Jia-xin Yang, Shu-ren Ming, Hui Chen, Yue-lai Chen

“…This trial investigates the comparative effectiveness and tolerability of acupuncture vs. placebo needling for allergic rhinitis patients.MethodsThis clinical trial features a stratified randomization scheme with 1:1 allocation, single-blind assessment, and a total sample size of 84 participants. …”
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Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials by Mahmoud Kandeel, Mohamed A. Morsy, Khalid M. Al Khodair, Sameer Alhojaily

“…Future studies should focus on rigorous RCTs and larger sample sizes to substantiate these preliminary findings. …”
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Exploring Conscious Sedation in Pediatric Oral Surgery: A Non-Randomized Clinical Trial on Safety and Efficacy by Niccolò Cenzato, Lorenzo Pasquali, Gregorio Menozzi, Cinzia Maspero

“…However, the absence of randomization may have influenced group allocation and outcome interpretation. …”
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Promoting HPV Vaccination in College Students Through Educational Video: Results from a Randomized Trial by Angela Chia-Chen Chen, Kimberly Arcoleo, Alli Walsh

“…Results: At baseline, approximately 56% of the sample (<i>n</i> = 215; mean age = 23.5, 71.2% male) have learned about HPV in the past. …”
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Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial by Vincenzo Piccolo, Adua Marzocchi, Maria Maisto, Vincenzo Summa, Gian Carlo Tenore, Angela Amoresano, Angela Amoresano

“…However, given the relatively small sample size, further large-scale and multicenter trials are needed to confirm its clinical applicability in broader migraine population.…”
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Causal Effects of Smoking, Alcohol, Coffee, and Tea Intake on Gynecologic Cancers: A Mendelian Randomization Study by Miao J, Xu Y

“…Jiayan Miao, Yuexin Xu Department of Obstetrics and Gynecology, Nanjing Maternal and Child Health Hospital, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Yuexin Xu, Email 2513510533@qq.comObjective: The two-sample Mendelian randomization (MR) approach was used to evaluate the causal association between modifiable lifestyle and gynecological tumors.Methods: Based on publicly accessible summary level genome-wide association study (GWAS), the exposures were age of smoking initiation, cigarettes per day, smoking cessation, smoking initiation, alcohol intake, tea intake, coffee intake, and the outcomes were cervical, ovarian and endometrial cancer. …”
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Effect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study by Hang Li, Guangjiao Yin, Guangjiao Yin, Yanfang Zhang, Ziwei Wang, Fang Lv, Rui Li, Juanjuan Qin, Juanjuan Qin, Xujun Ye, Xujun Ye

“…Two-sample Mendelian randomization (MR) analysis was employed to explore causal relationships.ResultsAfter adjusting for BMI, WHR shows a positive causal relationship with LV hypertrophy and a significant negative causal relationship with LV volume and diastolic function. …”
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Anemia and testosterone deficiency risk: insights from NHANES data analysis and a Mendelian randomization analysis by Zhenming Zheng, Jiashan Pan, Ming Liu, Zhimin Chen, Lvwen Zhang, Jingjing Gao, Pan Gao, Xiansheng Zhang

“…This study investigated the influence of anemia on testosterone levels.Methods Utilizing data from six NHANES cycles, including demographic, testosterone levels, and hemoglobin concentrations, we employed multivariable-adjusted logistic regression to investigate the relationship between anemia and testosterone levels. Moreover, a two-sample Mendelian randomization (MR) study employing genome-wide association study (GWAS) data examined the causal relationship. …”
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Causal relationship between circulating immune cells and the risk of esophageal cancer: a Mendelian randomization study by Shangren Wang, Ruizhen Wang, Aiqiao Zhang, Xiaofeng Duan, Xiaobin Shang, Hongjing Jiang

“…Methods We employed bidirectional two-sample Mendelian Randomization (MR) analysis to explore the causal relationship between immune cell phenotypes and EC. …”
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Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study by Dongliang Chen, Shengchen Liu, Jian Li, Yueyun Zhou, Tong Jing, Aizeretiaili Maimaiti, Fuhua Huang

“…This study aimed to investigate the potential causal relationships between autoimmune and aortic diseases from a genetic perspective. Methods: A two-sample Mendelian randomization (MR) study was implemented to investigate the relationships between 17 common autoimmune diseases and aortic diseases. …”
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Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study by Linyi Zheng, Yuqiang Li, Cenap Güngör, Heming Ge

“…Methods We conducted a two-sample, bidirectional Mendelian randomization analysis. …”
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