Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study by Dima L Chaar, Aliya Yakubova, Chen Jiang, Thomas J Hoffmann, Alice Pressman, Denis Plotnikov, Hélène Choquet

“…To assess potential causal effects of migraine on POAG risk, we conducted two-sample Mendelian randomization (MR) analyses using data from European ancestry individuals. …”
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Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study by Xiaogen Kuang, Bingquan Wu, Dan Hu, Juliet Matsika, Chunliang Cheng, Jiatong Xiao, Zhiyong Cai, Mingyong Li, Jinbo Chen, Weimin Zhou, Bolong Liu

“…Methods Single nucleotide polymorphisms (SNPs) significantly associated with circulating FAs were selected from 500,000 UK Biobank blood samples and 114,999 plasma samples from a large GWAS. …”
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The causal effects of systemic antioxidant capacity on male infertility: A two-sample mendelian randomization analysis by Xiaolong Zhang, Zhirong Zhu, Chaodong Shen, Guiliang Tang

“…Abstract The present research aimed to assess the potential causal relationship between systemic antioxidant capacity and male infertility using a two-sample Mendelian randomization approach. The primary MR analysis utilized the inverse variance weighted (IVW)method, supplemented by complementary analyses including MR-Egger, weighted mode, simple mode, and weighted median methods. …”
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Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study by Renyang Tong, Ziting Liang, Chengui Zhuo, Xueyang Bai, Ling Dao, Lu Yu, Ling Li, Zhaohui Tong, Youyou Du, Longwei Xu

“…To investigate the causality between IBD and sepsis, we employed a two-sample Mendelian randomization (MR) approach. Methods A genome-wide significant threshold (P < 5 × 10–8) was achieved in order to identify single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for two types of IBD, such as Crohn's disease (CD) and ulcerative colitis (UC). …”
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Causal effects of lipid-lowering drugs on skin diseases: a two-sample Mendelian randomization study by Yong Liu, Hui Liu, Queqiao Bian

“…This study aimed to assess the causal relationship between genetically proxied lipid-lowering drugs and skin cancers and psoriasis.MethodsTwo-sample Mendelian randomization (MR) analysis was performed using single-nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS). …”
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Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study by Jiali Chen, Jianghao Xiong, Fenfen Zhang, Wanyu Pan, Shaomin Cheng

“…Abstract Objectives To assess the association between thyroid dysfunction and diabetic retinopathy (DR), a two-sample bidirectional Mendelian randomization (MR) study utilizing the Genome-wide Association Study (GWAS) database was conducted to investigate the causal relationship between these two variables. …”
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Causal Relationship Between Depression and Traumatic Brain Injury: A Two‐Sample Mendelian Randomization Analysis by Shiping Wang, Lei Pan, Binyang Wang, Qianwen Ruan, Ying Shi, Tong Sun, Xu Yang, Lei Zhang, Xiaohua Ke, Geng Li, Meihua Qiu, Chuanxiong Li

“…Methods This bidirectional two‐sample Mendelian randomization (MR) analysis investigated causal relationships between depression (n = 170,756) and TBI (n = 3193) using genome‐wide association study (GWAS) summary statistics. …”
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Causal effect between breast cancer and ovarian cancer: a two-sample mendelian randomization study by Cheng Qian, Yan Xing, Wenjun Cheng

“…Methods This study aimed to assess the connection between BC and OC using a two sample Mendelian randomization (MR) approach, exclusively employing aggregate level data from publicly available genome wide association studies (GWASs). …”
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Causal relationship between hyperthyroidism and cataracts: a two-sample bi-directional mendelian randomization study by Helin Ding, Taige Chen, Hao Peng, Lu Wang, Jun Gu

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The causal association between ankylosing spondylitis and endometrial cancer: a two-sample mendelian randomization study by Yanpin Gu, Yupei Shao

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Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study by Ziqi Zhang, Jieyu Niu, Wenhao Sun, Yuqing Sun, Ying Tan, Jiangyi Yu

“…Objective We explored the causal relationship between certain dietary habits and the risk of developing diabetic kidney disease (DKD) using two-sample Mendelian randomization and multivariate Mendelian randomization.Research design and methods This study is based on pooled data from a genome-wide association study (GWAS) of 83 dietary habits in a European population. …”
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Association between metabolic syndrome and low back pain: a two-sample Mendelian randomization study by Wei Yan, Lingjun Kong, Tianxiang He, Guangxin Guo, Qingguang Zhu, Xiaobing Xi, Min Fang

Subjects: “…Two-sample Mendelian randomization…”
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Exploring the causal relationship between iron status and subarachnoid hemorrhage based on two sample mendelian randomization by Qian Chen, Weiling Shou, Li Zhang, Jiaying Fang, Ye Guo

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Association between gestational diabetes mellitus and offspring health: a two-sample mendelian randomization study by Mi Yan, Zhengdong Chen, Jia Tang, Xinyu Duan, Wenjie Peng, Rui Liu, Wanwei Li, Zhangxue Hu, Yanfei Liu

Subjects: “…Two-sample mendelian randomization study…”
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Evaluating the impact of smoking on the risk of dry eye disease: a two-sample Mendelian randomization study by Kuiliang Yang, Han Zhang, Yujin Wang, Yulin Yan, Zixian Yang, Shanshan Wan, Wanju Yang, Yanning Yang

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Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study by Yue Yang, Zheng Zhang, Hai-tao Lu, Qian-qian Xu, Li Zhuo, Wen-ge Li

“…This study applied bivariate causal analysis and two-sample Mendelian randomization (MR) methods to examine the association between various smoking behaviors – initiation, cessation, age at initiation, cigarettes smoked per day, and lifetime smoking – and CKD, using genome-wide data. …”
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Metabolomic Understanding of variable risk factors for kidney cancer: a two-sample Mendelian randomization study by Yihao Zhu, Ke Wang, Yuan Yu, Xuwen Li, Yabo Zhai, Can Chen, Yajian Li, Mingshuai Wang, Dong Chen, Nianzeng Xing, Feiya Yang, Xiongjun Ye

“…Method We explored the role of plasma metabolites and urinary metabolites in kidney cancer using two-sample mendelian randomization (MR) separately and validated it using multiple databases; in addition, we performed rigorous tests of pleiotropy and heterogeneity to ensure that the results were robust. …”
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Causal Relationship Between Migraine and Postpartum Depression: A Two-Sample Bidirectional Mendelian Randomization Study by Zhou XJ, Chen R, Niu YM

“…Prior research has shown a strong correlation between the two conditions, but the exact cause is unknown.Methods: A bidirectional Mendelian randomization (MR) approach was employed to assess causality, utilizing discovery and replication samples from publicly available genome-wide association study (GWAS) datasets. …”
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Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study by Liang H, Wu Q, Yang S, Zhang S, Miao J, Jin H, Wang X

“…This study aimed to investigate whether potential risk factors have a causal effect on NP at the genetic level using a two-sample Mendelian randomization (MR) analysis.Methods: Summary-level data for potential risk factors, including distress, anxiety disorder, depression, mood, sleep disorder, loneliness, education, alcohol consumption, smoking, time spent using the computer, and physical activity, as well as NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). …”
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Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis by Li-Hui Fang, Jia-Qi Zhang, Jin-Ke Huang, Xu-Dong Tang

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