Causal association between modifiable risk factors and esophageal cancer: A Mendelian randomization study by Xiaoqing Wang, Weiguang Zhang, Tianxin Lin, Renyan Mao, Ye Lin, Jingchuan Yu, Limin Ruan, Jihong Lin, Lei Gao, Peipei Zhang, Zhimin Shen, Mingqiang Kang

“…Method We adopted single nucleotide polymorphisms (SNPs) as genetic instrumental variables and conducted a two-sample Mendelian randomization (MR) analysis to estimate the causal influence of 14 amendable risk factors on EC, incorporating 740 cases and 372,016 controls. …”
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Causal relationship between type 2 diabetes mellitus and cognitive impairment based on Mendelian randomization by LIN Yijia, CHENG Lizhen, HU Tingjun, MIAO Ya

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Identification of causal plasma metabolite biomarkers for ischemic stroke using Mendelian randomization and mediation analysis by Jian Lyu, Fumei Liu, Yan Chai, Xiting Wang, Yi Liu, Yanming Xie

“…We explored the causal effects of 1,400 plasma metabolites on IS outcomes using a two-sample Mendelian randomization (MR) framework. We assessed causal relationships between IS and 11 common clinical risk factors and further examined these relationships for metabolites. …”
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Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study by Kehan Long, Tengfei Zheng, Ao Gong, Zhendong Ying, Lei Zhang

“…BackgroundThis study examines the indirect causal relationships between dietary habits and osteoporosis, mediated through liposomes, utilizing a two-sample Mendelian randomization (MR) approach. The research leverages genetic variations as instrumental variables to explore the genetic influences on dietary habits, liposomes, and osteoporosis, aiming to unravel the complex interplay between diet, lipid metabolism, and bone health.MethodsThe study utilized genome-wide association studies (GWAS) data for liposomes from Finnish individuals and osteoporosis-related data, alongside dietary factors from the OpenGWAS database. …”
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Mendelian Randomization and Transcriptomics Analysis Reveal Potential Relationships Between Lipids, Immune Cells and PCOS by Xie Y, Zhang Z, Zhao Y, Zhang J, Yin Q

“…However, there is still a lack of conclusive causal evidence as to whether immune cells mediate the relationship between lipids and PCOS.Methods: This study used a two-step two-sample Mendelian randomisation (TSMR) analysis to explore the causal relationship between plasma lipid groups and PCOS, and the mediating role of immune cells in this relationship. …”
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The effectiveness of topical colloidal silver in recalcitrant chronic rhinosinusitis: a randomized crossover control trial by John R. Scott, Rohin Krishnan, Brian W. Rotenberg, Leigh J Sowerby

“…Methods A prospective cohort study was conducted using a convenience sample of 20 randomized patients with crossover methodology, comparing nasal sprays with CS versus saline. …”
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Correlation of air pollution and risk of sudden sensorineural hearing loss: a Mendelian randomization study by Xiaoli Luo, Wenqi Zuo, Quanwei Ren, Linlin Wang, Di Wu, Yilin Xiang, Shixun Zhong

“…However, the causal relationship behind this association has not yet been established. We employed a Two-Sample Mendelian Randomization (MR) approach to investigate the causal relationship between air pollution (nitrogen dioxide, nitrogen oxides, PM2.5, PM10, and PM2.5–10) and SSNHL.Independent genetic variants associated with air pollution and SSNHL were selected as instrumental variables (IVs) at a genome-wide significance level. …”
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Investigating the correlation of hip circumference to cardiovascular disease and type‐2 diabetes using Mendelian randomization by Hongtao Liu, Zhaoyu Li, Su Yan, Shaopeng Ming

“…Design MR analysis utilized genetic variation from the MR Base in a two‐sample analysis. Three methods were employed: MR‐Egger regression, weighted median estimator, and inverse variance weighting (IVW). …”
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Association Between Dietary Taste Preferences and Primary Ovarian Insufficiency: A Mendelian Randomization Study by Xu S, Zhou Y, Wang L, Zhang Y

“…Shuying Xu,1 You Zhou,1 Lina Wang,2 Yang Zhang2 1Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China; 2The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, People’s Republic of ChinaCorrespondence: Yang Zhang, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33, Beiling Road, Liaohe Street, Huanggu District, Shenyang City, Liaoning Province, People’s Republic of China, Tel +8618102457388, Email zy172888@126.comPurpose: To investigate the effects of dietary taste preferences on primary ovarian insufficiency (POI) by two-sample Mendelian randomization analysis, excluding confounding factors.Patients and Methods: Single nucleotide polymorphisms (SNPs) associated with 139 dietary taste preferences were obtained from GWAS results provided by May-Wilson S et al. …”
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Effectiveness of Cardiac Rehabilitation for Patients after Coronary Artery Bypass Graft: Randomized Controlled Trial by Ali Suleiman Harbi, Kim Lam Soh, Putri Yubbu, Kim Geok Soh

“…Materials and Methods: A total of 122 patients were randomized into two groups: The intervention group received CCRP. …”
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Association between genetically proxied PPARG activation and psoriasis vulgaris: a Mendelian randomization study by Yan Xue, Yuning Xia, Donghao Cheng, Taiyu Shi, Ping Mei, Sheng Hong

“…The DrugBank10 databases function to identify genes encoding protein products targeted by active constituents of lipid-modifying targets. A two-sample MR analysis and summary-data-based MR (SMR) analysis estimated the associations between expressions of drug target genes and symptoms of psoriasis vulgaris. …”
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Heterogeneity of the liver cancer tumor microenvironment: mitochondrial metabolism and causal inference through Mendelian randomization by Xiaping Liu, Zhang Jing, Jian Chen, Linhong Su, Jun Lin, Xiaoqu Zhu, Xiaodan Ye

“…Methods Utilizing two-sample Mendelian randomization (TSMR) with data from large-scale GWAS studies, including immune cell profiles from the UK Biobank (n = 1629) and HCC cases from a multi-ethnic meta-analysis (775 cases, 1332 controls), we identified significant causal associations between specific immune cell populations, serum metabolites, and HCC risk. …”
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The causal effects of inflammatory bowel disease on its ocular manifestations: A Mendelian randomization study. by Lian Luo, Xiaowei Tang, Jia Xu, Yuxi Bao, Xinyue Hu, Xiaolin Zhong

“…The purpose of this study was to evaluate the causality of IBD on ocular manifestations using the mendelian randomization (MR) analysis.<h4>Methods</h4>We performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. …”
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Randomized controlled trial of stress management and resiliency training for depression (SMART-D)-pilot study. by Ashok Seshadri, Matthew Fuller-Tyszkiewicz, Laura Harper, Matthew M Clark, Balwinder Singh, Sherry Chesak, Aparna S Kaur, Jane McGillivray, Mark A Frye

“…Random assignment, blinding of raters and statistician were utilized. …”
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Results of the preclinical multicenter randomized controlled paclitaxel-induced neuropathy prevention replication study (PINPRICS) by Wolfgang Boehmerle, Tim Hagenacker, Markus Leo, Linda-Isabell Schmitt, Helmar C. Lehmann, Ines Klein, Regina Stegherr, Frank Konietschke, Matthias Endres, Petra Huehnchen

“…Major challenges for successful clinical translation of preclinical data include a lack of reproducibility and randomization, small sample sizes and insufficient statistical tests. …”
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The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study by Qifan Zheng, Tong Xu, Shiyin Luo, Jiahui Zhao, Yue Ying, Nan Liu, Aijia Jiang, Yaping Pan, Dongmei Zhang

“…The meta-analysis incorporating cross-sectional studies was carried out. Additionally, two-sample Mendelian randomization (MR) analysis was performed to explore the associations between genetically predicted oral infectious diseases (including dental caries, periodontitis, and pulp and periapical diseases) and lacunar stroke, utilizing summary-level data from genome-wide association studies (GWAS). …”
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Lipid Profiles, Telomere Length, and the Risk of Malignant Tumors: A Mendelian Randomization and Mediation Analysis by Shupeng Liu, Zhengzheng Fu, Hui Liu, Yinghui Wang, Meijuan Zhou, Zhenhua Ding, Zhijun Feng

“…<b>Methods:</b> This study employed two-sample Mendelian randomization (MR) with mediation analysis to investigate their causal relationships, examining lipid profiles as exposure, TL as mediator, and nine cancer types as outcomes. …”
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Genetically proxied gut microbiota and cancer risk: a scoping review of Mendelian randomization studies by Yating Cui, Jianguo Xu, Qingyong Zheng, Junfei Wang, Caihua Xu, Mingyue Zhang, Jiang Li, Jinhui Tian

“…Data extraction encompassed study design, study population, definition of microbial exposure, details of genetic instrument variables, sample size, effect estimates, and statistical significance. …”
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The causal relationship between the human gut microbiota and pyogenic arthritis: a Mendelian randomization study by Boliang Bai, Longfei Luo, Feng Yao, Qian Sun, Xingguang Chen, Wen Zheng, Lang Jiang, Xiaodong Wang, Guanghao Su

“…There is also a lack of theoretical basis for the application of the gut microbiota in the treatment of pyogenic arthritis.MethodsIn our study, we utilized the largest genome-wide association study (GWAS) data from the MiBioGen Consortium involving 13,400 participants and extracted summary statistical data of the microbiota metabolic pathways of 7,738 participants of European descent from the Dutch Microbiome Project (DMP) The data of pyogenic arthritis were derived from the FinnGen R10 database, including 1,086 patients and 147,221 controls. We employed the two-sample Mendelian randomization approach to investigate the causal association between the gut microbiota and pyogenic arthritis. …”
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No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies by Jinhua Chen, Qiuhan Xu, Yiling Wang, Sisi Jiang, Baorong Zhang, Jun Tian

“…Methods: We conducted a two-way Mendelian randomization (MR) analysis using genome-wide association study data. …”
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