Exploring the Causal Relationship Between Osteoporosis and Rheumatoid Arthritis: A Bidirectional Mendelian Randomization Study by Li J, Bao L, Dai C, He M

“…This study used a two-sample Mendelian randomization (MR) approach to investigate this causal relationship.Methods: Genetic instruments for osteoporosis and RA were obtained from published genome-wide association studies (GWAS). …”
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Mendelian randomization reveals plasminogen as a common therapeutic target for myocardial infarction and atrial fibrillation by Hadi Charati, Ahmad Hamta

“…Methods: The present study utilizes cis-protein quantitative trait loci (cis-pQTLs) for 4,719 plasma proteins to assess their causality on MI and AF. Results: Two-sample Mendelian randomization (MR) identifies 21 and 9 plasma proteins for MI and AF, respectively (FDR P<0.05), with plasminogen (PLG) being a commonly protective factor against both diseases. …”
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Comparative Evaluation of Phacoemulsification with Goniosynechialysis and Phacoemulsification with Viscogonioplasty in Angle-Closure: A Randomized Clinical Trial by เดชาทร อาสนทอง

“…Longer-term studies with larger sample sizes are needed to confirm these results. …”
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Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis by Lei Wu, Hengheng Zhang, Yongwen Li, Jinxin Tang, Dengwen wang, Linrong Zhu

“…This study aimed to investigate the causal association between insomnia and osteoporosis, while also analyzing whether thyroid dysfunction mediates this relationship. Method: A two-sample Mendelian randomization approach was applied to examine the genetic association between insomnia and osteoporosis. …”
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Tissue adhesive to repair first-degree perineal tear: a pilot randomized controlled trial by T. Trevisan Teixeira, A. de S. Caroci, W. Sousa Brunelli, M. L. Riesco

“…Materials and Methods: A pilot RCT was conducted in a birth center in São Paulo, Brazil. The sample consisted of 20 women with first-degree tear. …”
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The effect of oral curcumin capsules on symptoms of premenstrual syndrome and dysmenorrhea: a randomized controlled trial by Fatemeh Shabani, Sepideh Mashayekh-Amiri, Fatemeh Teihoomaneshfard, Mahsa Hesami, Elnaz Shaseb, Mojgan Mirghafourvand

“…The participants were randomly assigned to the intervention (n = 31) and control (n = 31) groups. …”
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Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis by Biqing Luan, Yang Yang, Qizhi Yang, Zhiqiang Li, Zhihui Xu, Yaqin Chen, Meiting Wang, Wenlin Chen, Fei Ge

“…Results were validated through bidirectional two-sample Mendelian Randomization (MR), heterogeneity tests, and pathway enrichment, leading to a mediation pathway model. …”
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Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization by Liu Qian, Meng Ling-bing, Qi Tian-qi, Ma Ya-Qing, Liang Guo-wei

“…To elucidate the causal relationships between CSF metabolites and the neurological outcomes, we conducted a two-sample Mendelian randomization analysis. Genome-wide association data from 689 individuals of European descent provided exposure levels for metabolites, analyzed alongside gene associations for cognitive performance (N  =  257,841), brain atrophy measures (cortical surface area and thickness; N  =  51,665), and hippocampal volume (N  =  33,536). …”
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Mendelian randomization analysis of CpG methylation and immune phenotypes in epithelial ovarian cancer outcomes by Jiawei Li, Wanjun Luo, Daohong Nie, Zidan Lin, Chenfei Zhou

“…In this study, genome-wide association studies (GWAS) data from the Ovarian Cancer Association Consortium (OCAC) and Methylation quantitative trait loci (mQTL) data from the Genetics of DNA Methylation Consortium (GoDMC) were analysed using two-sample Mendelian randomization (MR). We investigated the genetic effects of CpG methylation on the risk and prognosis of five major EOC histotypes. …”
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Causal association between diabetes mellitus and rheumatoid arthritis: A bidirectional Mendelian randomization study by Zhirong Gu, Jinxing Li, Liu Wu, Silin Zheng, Min Huang

“…We sought to assess the causal association between rheumatoid arthritis and Diabetes mellitus risk using a two-way two-sample Mendelian randomization (MR) analysis. Methods: Data on Diabetes mellitus and rheumatoid arthritis were obtained from the GWAS genome-wide database, and the MR method was used to explore the bidirectional causal association, the inverse variance weighted (IVW) method was used as the primary analysis method, and sensitivity analysis was performed. …”
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Network Meta-analysis of Randomized Controlled Trials Assessing Neuromodulation Therapies for Painful Diabetic Neuropathy by Li Li, Xueqin Luo, Yong Liu, Yongjie Jiang, Yankun Chen, Yangmei Chen, Jinping Wang

“…Results The data from an aggregate of 12 separate studies, comprising a total sample size of 922 participants, was subject to analysis. …”
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A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes. by Joyce P Samuel, Susan H Wootton, Travis Holder, Donald Molony

“…Only one reached the pre-specified sample size target. Secondary outcomes showed modest benefits, including decreasing medication use, fewer atrial fibrillation episodes, and improved patient satisfaction.…”
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Association between coffee consumption and metabolic syndrome: A cross‐sectional and Mendelian randomization study by Tommy Hon Ting Wong, Shan Luo, Shiu Lun Au Yeung, Jimmy Chun Yu Louie

“…Odds ratios were calculated using multivariable logistic regression, and results were verified with two‐sample Mendelian randomization. Results Consuming up to two cups of coffee per day was inversely associated with metabolic syndrome (1 cup/day: odds ratio [OR]: 0.88, 95% confidence interval [CI]: 0.85–0.92; 2 cups/day: OR: 0.90, 95% CI: 0.86–0.93). …”
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Mixed evidence for the relationship between periodontitis and Alzheimer's disease: A bidirectional Mendelian randomization study. by Yi-Qian Sun, Rebecca C Richmond, Yue Chen, Xiao-Mei Mai

“…Recent experimental studies indicated that a periodontitis-causing bacterium might be a causal factor for Alzheimer's disease (AD). We applied a two-sample Mendelian randomization (MR) approach to examine the potential causal relationship between chronic periodontitis and AD bidirectionally in the population of European ancestry. …”
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Mendelian randomization analysis revealed that albuminuria is the key factor affecting socioeconomic status in CKD patients by Jianbo Qing, Lijuan Zhang, Changqun Li, Yafeng Li

“…We employed the R packages ‘TwoSampleMR’ and ‘Mendelianrandomization’ to conduct both univariable and multivariable Mendelian randomization (MR) analyses, assessing for potential pleiotropy and heterogeneity. …”
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Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms by Lu X, Ji L, Chen D, Lian X, Yuan M

“…This review summarizes the development of MR methodologies, from single-sample to multivariable, mediation, and time-series models, and highlights key findings from the past decade. …”
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Incorporating external controls in the design of randomized clinical trials: a case study in solid tumors by Emily M. Damone, Jiawen Zhu, Herbert Pang, Xiao Li, Yinqi Zhao, Evan Kwiatkowski, Lisa A. Carey, Joseph G. Ibrahim

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VIRTUS: virtual reality exposure training for adolescents with social anxiety – a randomized controlled trial by Elizabeth S. Uduwa Vidanalage, Jella De Lee, Dirk Hermans, Iris M. Engelhard, Sara Scheveneels, Katharina Meyerbröker

“…Using a randomized controlled trial (RCT), 120 adolescents (ages 12–16) with subclinical to moderate social anxiety will be assigned to one of three conditions: VRE, IVE, or a waitlist control (WL). …”
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Assessing the quality of reports about randomized controlled trials of acupuncture treatment on Diabetic Peripheral Neuropathy. by Chen Bo, Zhao Xue, Guo Yi, Chen Zelin, Bai Yang, Wang Zixu, Wang Yajun

“…<h4>Background</h4>To evaluate the reports' qualities which are about randomized controlled trials (RCTs) of acupuncture treatment on Diabetic Peripheral Neuropathy (DPN).…”
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Causal links between plasma lipidome and ovarian cancer risk: evidence from Mendelian randomization by Huke Dong, Chen Zhang, Hua Wang, Ying Dai

“…This study utilized a two-sample Mendelian randomization method to examine the causal link between changes in 179 plasma lipid groups and ovarian cancer (OC) to gain deeper insights into this association. …”
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