The influence of pH and temperature on benthic chlorophyll-a: Insights from SHAP-XGBoost and random forest models by Sangar Khan, Noël P.D. Juvigny-Khenafou, Tatenda Dalu, Paul J. Milham, Yasir Hamid, Kamel Mohamed Eltohamy, Habib Ullah, Bahman Jabbarian Amiri, Hao Chen, Naicheng Wu

“…There is little information on machine learning predictive models of benthic chl–a and input parameters in lotic ecosystems, and to fill this gap, we predict benthic chl–a levels in China's Thousand Islands Lake (TIL) watershed using machine learning algorithms. Water samples for nutrient and metal analysis were collected across 147 sites in the TIL catchment. …”
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Susceptibility assessment of freeze-thaw erosion induced debris flow using random forest, Eastern Tibetan Plateau by Yongjie Yang, Yongjie Yang, Yongjie Yang, Yuqi Zhang, Yuqi Zhang, Yuqi Zhang, Hai Huang, Hai Huang, Jinsong Zhu, Jinsong Zhu, Jinsong Zhu, Qiwei Lv, Qiwei Lv, Qiwei Lv, Jiang Peng, Jiang Peng

“…Nevertheless, when comparing watershed samples, both models demonstrated limited predictive power. …”
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Sleep Promotion Program for Improving Sleep Behaviors in Adolescents: A Randomized Controlled Pilot Study by Bindu John, Sumanth Shetty Bellipady, Shrinivasa Undaru Bhat

“…Methods. A randomized controlled trial design with stratified random sampling method was used. …”
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Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization. by Zhengze Zhang, Yanan Lian, Yuewen He, Hao Liu, Kai Meng, Yong Wang, Wuhua Ma

“…This study aims to further elucidate the causal relationship between the two, employing Two-Sample and Multivariable Mendelian randomization methods.…”
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Health Implications Associated with Fat-Free Mass: A Phenome-Wide Mendelian Randomization Study by Yuchen Ying, Chunxia Zhang, Shanshan Wu, Shudan Wang, Jiangfang Lian, Yupin Lin, Haiwang Guan, Dihui Cai

“…Methods: We conducted a comprehensive analysis integrating a phenome-wide association study (PheWAS), a two-sample Mendelian randomization (MR) analysis, and a systematic review to investigate the associations between FFM and health outcomes. …”
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The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis by Lin S, Wu C, Pan Y

“…This study aims to analyze the potential causal relationship between circulating inflammatory proteins and OA using Mendelian randomization (MR) analysis.Methods: This study used bidirectional two-sample MR analysis, employing the inverse variance-weighted as the primary MR method. …”
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Efficacy of metronidazole in reducing pain after hemorrhoidectomy: a meta-analysis of randomized controlled trials by Hui Dong, Wen-Xing Chen, Yue-Juan Li, Deng-Chao Wang

“…However, due to the limitations of this study, further verification is needed from future large-sample, multi-center, well-designed high-quality RCTs. …”
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Metabolic Insights into Urinary Stone Formation: Evidence from Mendelian Randomization, Clinical, and in vivo Studies by Lintao Miao, Jiacheng Xiang, Yuanyuan Yang, Senyuan Hong, Jianxuan Sun, Sihan Zhang, Yuan Gong, Qidong Xia, Shaogang Wang

“…Using genome-wide association study (GWAS) data for 1,091 blood and 1,172 urine metabolites, we conducted a two-sample Mendelian randomization (MR) analysis, validated by meta-analysis, to explore metabolic influences on stone formation. …”
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Deciphering the gut microbiota’s role in diverticular disease: insights from a Mendelian randomization study by Biaohui Zheng, Dongbo Chen, Hao Zeng, Shuangming Lin

“…In light of this, we decided to use a bidirectional two-sample Mendelian randomization (MR) study to investigate the causal relationship between gut microbiota and intestinal diverticular disease in greater depth.MethodsTo investigate the potential causal relationship between gut microbiota and intestinal diverticular disease, we conducted a two-sample MR study in a European ancestry. …”
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Association between fruit intake and abdominal adiposity in 1,707 randomly selected U.S. children by Larry A. Tucker

“…BackgroundThis investigation was conducted to determine the relationship between fruit intake and abdominal adiposity in 1,707 U.S. children.MethodsThe children were randomly selected as part of the National Health and Nutrition Examination Survey (NHANES), so the sample represented U.S. children 8–11 years old. …”
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Causal effects of retinol and vitamin D on tongue cancer risk: a mendelian randomization study by Jiawei Zhang, Yake Lou, Hong Chen, Xiaofeng Huang

“…Therefore, we aimed to assess the causal relationships of retinol and vitamin D with the risk of tongue cancer using the two-sample Mendelian randomization (MR) method. Methods Single nucleotide polymorphisms (SNPs) related to retinol, vitamin D and tongue cancer were obtained from the up-to-date genome-wide association study (GWAS) catalogue, which was screened for instrumental variables (IVs). …”
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Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study by Kai Feng, Jiang Yuan, Yanhui Wei, Min Li

“…Firstly, we conducted a two-sample Mendelian randomization (MR) study of these two diseases. …”
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Brain Connectivity Yields Insights into the Pathogenesis of Epilepsy and Subtypes: Evidence from Mendelian Randomization Analysis by Zhipeng He, Shishi Tang, Yurong Hu, Yuxuan Li, Junhao Liang, Li Fang, Miaoxin Li, Ziyi Chen, Yi Zhou

“…We conducted a bidirectional two-sample Mendelian randomization (MR) to explore the causal relationship between epilepsy subtypes and brain connectivity properties within RSNs. …”
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Unravelling the association between metformin and pan-cancers: Mendelian randomization combined with NHANES database analysis by Jia-Cheng Xiang, Ye An, Jian-Xuan Sun, Jin-Zhou Xu, Yi-Fan Xiong, Shao-Gang Wang, Qi-Dong Xia

“…Methods A bidirectional two-sample Mendelian randomization (MR) design was used to assess causal relationships between metformin and 18 cancer types. …”
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Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis by Chuchun Fang, Xuewei Liu, Chen Yu, Songlin Li, Xueying Liu, Shifeng Qiu, Hongbin Liang, Caiwen Ou, Jiancheng Xiu

“…We aimed to investigate the causal relationship between different types of cancer-targeted therapies and cardiovascular disease (CVD) outcomes through a two-sample Mendelian randomization (MR) study. Methods This genome-wide association study was conducted using a two-sample Mendelian randomization framework. …”
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Impact of Milk Consumption and Dietary Patterns on Pelvic Organ Prolapse: A Mendelian Randomization Study by Xia X, Hu Y, Xu J, Fan S, Zhang Y

“…Xinglu Xia,1 Yiqin Hu,1 Jingui Xu,1 Suhong Fan,1 Yunfeng Zhang2 1Department of Gynaecology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, 324000, People’s Republic of China; 2Department of Anaesthesiology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, 324000, People’s Republic of ChinaCorrespondence: Yunfeng Zhang, Department of Anaesthesiolog, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, No. 100, Minjiang Avenue, Kecheng District, Quzhou, Zhejiang, 324000, People’s Republic of China, Tel +86-13157001161, Email yfz1161@163.comBackground: Pelvic organ prolapse (POP) severely impacts women’s quality of life and disrupts their daily routines. This study uses two-sample Mendelian randomization (MR) to explore the causal link between dietary habits and POP, providing useful insights for its treatment.Materials and Methods: We used genome-wide association (GWAS) data from Europeans for our study. …”
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Unveiling the interplay among skin microbiota, cytokines, and T2DM: an insightful Mendelian randomization study by Zhe Zhang, Chunyu Jiang, Yi-qi Xing, Tianke Yang, Linxuan Zou, Zhuqiang Jia, Lin Zhao, Xin Han, Xueling Qu, Zhen Zhang, Junwei Zong, Shouyu Wang

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Causal Relationship Between Air Pollutants and Blood Pressure Phenotypes: A Mendelian Randomization Study by Xianshang Zhu, Huabo Mao, Hongyu Zeng, Fengli Lv, Jiancheng Wang

“…Our study aimed to investigate potential causal relationships between five air pollutants and four blood pressure phenotypes through two-sample Mendelian randomization. Methods: Two-sample Mendelian randomization (MR) analyses were performed using genome-wide association studies (GWAS) data from the IEU OpenGWAS project. …”
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Ottawa nutritional guide intervention for nausea and vomiting in pregnancy: a randomized controlled trial protocol by Sana Nazmi, Fereshteh Behmanesh, Hossein-Ali Nikbakht, Seddigheh Esmaeilzadeh

“…This study will assess the impact of an educational program based on the Ottawa Nutritional Guide on symptoms in pregnant women and explore sexual satisfaction as a secondary outcome. Methods In this randomized controlled clinical trial, a total of 60 pregnant women aged between 15 and 45 years, who scored 3–16 on the Rhodes Index of Nausea, Vomiting and Retching (RINVR), will be selected via convenience sampling. …”
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Study on the anti-penetration randomness of metal protective structures based on optimized artificial neural network by Lan Liu, Weidong Chen, Shengzhuo Lu, Yanchun Yu, Mingwu Sun

“…And by adopting the Back Propagation Neural Network optimized by Dynamic Lifecycle Genetic Algorithm (DLGABPNN) as the surrogate model of APRMPS, this paper presents the technical route of DLGABPNN-MCS, the Monte Carlo Simulation with DLGABPNN calculation as repeated sampling tests, to addressing APRMPS. Finally, with two applied examples of the anti-penetration randomness of metal targets, this paper demonstrates the application procedures for this method, proves the higher efficiency of Dynamic Lifecycle Genetic Algorithm than Genetic Algorithm in optimizing Back Propagation Neural Network and verifies the effectiveness of DLGABPNN-MCS in studying APRMPS. …”
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