Immune cell phenotypes as causal factors in liver disease progression revealed by Mendelian randomization by Jingtao Huang, Wenlu Zou, Zhihua Lv, Huan Han, Jiapeng Huang, Hanwen Su

“…In this study, we employed a two-sample Mendelian randomization (MR) approach to explore potential causal relationships between peripheral immune cell phenotypes and liver diseases, using genetic instrumental variables from large-scale genome-wide association studies (GWAS). …”
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Type 2 diabetes and colorectal cancer: genetic causality explored via Mendelian randomization by Qiuhong Ke, Yongbing Huang, Libin Cheng, Chaolin Lin, Linhua Zhao, Wulong Huang, Zhisheng Chen, Yimin Xu, Yipiao Huang, Lanlan Cai, Bin Lin, Rui Tang

“…Genetic instruments for T2D were derived from two large genome-wide association studies (GWAS) with a total sample size of X individuals, and CRC genetic instruments were obtained from a GWAS with Y individuals. …”
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The Impact of SGLT1 Inhibition on Frailty and Sarcopenia: A Mediation Mendelian Randomization Study by Bang‐Bang Huang, Yu‐Jie Zhang, Guang‐Feng Ruan, Xing Yu, Qin Liu, Mei‐Jin Zhang, Ming‐Zhong Yu, Ai Chen, Ye‐Bei Liang, Liang‐Di Xie, Li Luo

“…The present study investigated the possible effect of SGLT1 inhibition on these conditions and explored potential mediators. Methods A two‐sample Mendelian randomization (MR) analysis was performed to assess the effect of SGLT1 inhibition on frailty index (FI) and low grip strength in individuals aged 60 years and older using both the FNIH and EWGSOP criteria. …”
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Causal relationship between hormone levels and lung cancer: a Mendelian randomization study by Zhiying Feng, Jingmin Fu, Kangyu Wang, Jiaxin Yang, Xuelian Jiang, Qiong Wu

“…Different hormone levels have different potential roles in the occurrence, development, and metastasis of lung cancer, but the association between hormone levels and lung cancer is not clear.ObjectiveThis study aims to explore the causal relationship between hormone levels and lung cancer using Mendelian randomization. Sensitivity and heterogeneity tests were conducted to ensure the reliability of the results, offering insights into the prevention, diagnosis, and treatment of lung cancer.MethodsWe employed a two-sample Mendelian randomization (MR) analysis using large-scale publicly available genome-wide association studies (GWAS) data to assess the causal relationship between hormone levels and lung cancer. …”
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Multi-omic biomarkers associated with multiple sclerosis: from Mendelian randomization to drug prediction by Wei Yang, chenglin Liu, Zhenhua Li, Miao Cui

“…The framework commenced with a two-sample Mendelian randomization (MR) study utilizing two large plasma protein quantitative trait locus (pQTL) datasets. …”
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Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits by Ryota Toki, Sotaro Fushiki, Shun Kojima, Yoichi Sutoh, Yayoi Otsuka-Yamasaki, Sei Harada, Miho Iida, Aya Hirata, Naoko Miyagawa, Minako Matsumoto, Shun Edagawa, Atsuko Miyake, Kazuyo Kuwabara, Akiyoshi Hirayama, Masahiro Sugimoto, Asako Sato, Kaori Amano, Tomoyoshi Soga, Masaru Tomita, Kazuharu Arakawa, Kengo Kinoshita, Mika Sakurai-Yageta, Gen Tamiya, Hideki Ohmomo, Atsushi Shimizu, Tomonori Okamura, Toru Takebayashi

“…Causal effects of AAs on 11 cardiometabolic traits were examined using two-sample MR analyses. We identified 85 locus-metabolite associations across 43 genes for 18 AAs, including 44 novel loci linked to metabolic genes. …”
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Randomized clinical trial of peer integrated collaborative care intervention after physical injury by Eileen M Bulger, Peter Thomas, Jin Wang, Lauren K Whiteside, Ronald Maier, Allison Engstrom, Douglas F Zatzick, Joan Russo, Patrick Heagerty, Khadija Abu, Tanya Knutzen, Jake Shoyer, Navneet Birk, Cristina Conde, Paige Ryan, Matt Iles-Shih, Lawrence Palinkas

“…Intervention patients consistently demonstrated higher satisfaction with emotional aspects of healthcare (F(5,1652)=2.87, p=0.01).Conclusions The intervention demonstrated no significant improvements in primary outcomes in the intent-to-treat sample. The peer integrated collaborative care intervention contributed to higher patient satisfaction with the emotional aspects of healthcare.Level of evidence Level II, randomized clinical trial.Trial registration number NCT03569878.…”
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Corneal Biomechanics as a Causal Factor in Myopia and Astigmatism: Evidence from Mendelian Randomization by Pinghui Wei, PhD, Guoge Han, PhD, Qi Su, MBBS, Lanbo Jia, MBBS, Chao Xue, PhD, Yan Wang, PhD

“…This study aimed to clarify this relationship using Mendelian randomization (MR), offering new insights into the prevention and treatment of refractive errors. …”
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An efficient dynamic reliability method for maglev vehicle-bridge systems and its application in random controller parameters analysis by Lidong Wang, Qingrong Li, Xun Zhang, Xiumeng Bu, Peng Hu, Yan Han

“…Then, by treating the controller parameters as normally distributed random variables, the accuracy and efficiency of the proposed reliability method were verified through comparison with the Monte Carlo method and the one-stage sampling surrogate model. …”
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Investigation of key performance metrics in TiOX/TiN based resistive random-access memory cells by Brandon R. Zink, William A. Borders, Advait Madhavan, Brian D. Hoskins, Jabez McClelland

“…In this work, we performed a systematic study on six different TiOX/TiN RRAM samples with varying layer thicknesses. For each sample, we investigate how the layer thicknesses, presence of background oxygen, and testing parameters influence key performance metrics in each sample. …”
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Insight into the main determinants of the struggle against overweight and obesity in Chile: Use of random forest techniques and econometric models. by Francisca Romo-Muñoz, Rodrigo Romo-Muñoz, Sebastián Niklitschek-Soto, Cristhian Aguilera-Carrasco, José M Gil

“…A random forest (RF) classification model was used, and based on the results obtained, an econometric model of the censored dependent variable, specifically the Heckman sample selection model, was specified and estimated. …”
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The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study by Zong Jiang, Xiaoling Yao, Yuzheng Yang, Fang Tang, Wukai Ma, Xueming Yao, Weiya Lan

“…The UKB-B-14,486 dataset contains 462,933 samples in total, including 38,472 OA samples, 424,461 control samples, and 9,851,867 SNPs, all collected from the European population in 2018. …”
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The effects of social media restriction: Meta-analytic evidence from randomized controlled trials by Kaitlyn Burnell, Diana J. Meter, Fernanda C. Andrade, Ashley N. Slocum, Madeleine J. George

“…All studies included college student or adult samples (Mage = 23.38) and samples skewed female (70 %). …”
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Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization by Shi Li, Kaijiong Zhang, Guiji Zhang, Min Shi, Xing Yin, Bo Wang

“…Methods We combined SNP data from GTEx V8 eQTL and FinnGen databases for Mendelian randomization analysis, and performed single-cell analysis on melanoma samples. …”
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Characterizing HIV-1 Tropism and Key Positions within the V3 Loop Using Random Forest Analysis by Karenn Evangelista Miranda, Letícia Martins Raposo

“…The most prevalent subtype was B, representing 54.45% of the sample. Random forest analysis identified positions 2, 5, 8, 11, 12, 13, 18, 20, 21, 22, 24, 25, 32, and 34 as crucial for HIV-1 tropism. …”
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Direct Transport Calculation of Three-dimensional C5G7 Benchmark Based on the Random Ray Method by SONG Peitao1, 2, 3, , QIN Shuai4, ZHANG Qian4

“…Despite its advantages, TRRM suffers from slow convergence due to the statistical variance inherent in random sampling, with a convergence rate of O(N−1/2). …”

Building interprofessional identity in neurology with interactive interprofessional learning: a randomized controlled trial by P. Altmann, B. Fasching, T. Rothschedl, S. Matuschitz, N. Krajnc, J. Ebner, M. Handgraaf, K. Gottfried, P. S. Rommer, T. Berger, M. Wagner-Menghin

“…Results On a group level, The IPL intervention group (n = 27) demonstrated improvements in all domains of interprofessional identity on the EPIS-G (paired samples t-test, p < 0.001) which was not observed in the control group (n = 10). …”
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Stress and salivary cortisol in emergency medical dispatchers: A randomized shifts control trial. by Sarah Bedini, François Braun, Laurence Weibel, Michel Aussedat, Bruno Pereira, Frédéric Dutheil

“…The pattern of shifts was randomized. Saliva was sampled every 15 minutes for 2 hours, i.e. 6 consecutive times, starting 15 minutes after the first life-and-death incoming emergency call between 2 and 5 pm during three types of shift. …”
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Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial by Shiva Ganjali, Amirhossein Sahebkar, Elahe Mahdipour, Khadijeh Jamialahmadi, Sepideh Torabi, Saeed Akhlaghi, Gordon Ferns, Seyed Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan

“…Thirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks. …”
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The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) by Aigul T. Altynbekova, Elmira M. Mamytova, Yusuf Kh-M Shidakov, Aicholpon T. Israilova, Bolotbek Alymjan ulu, Rustam R. Tuhvatshin

“…Methods: The design of the study is experimental randomized. The study was conducted on sexually mature 7-8 months old lineal Wistar male rats, which were randomly divided into 2 groups – control (n=10) and experimental (n=9). …”
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