Biomarker identification for Alzheimer’s disease through integration of comprehensive Mendelian randomization and proteomics data by Hui Zhan, Davis Cammann, Jeffrey L. Cummings, Xianjun Dong, Jingchun Chen

“…We aimed to identify potential plasma biomarkers or drug targets for AD by investigating the causal association between plasma proteins and AD by integrating comprehensive Mendelian randomization (MR) and multi-omics data. Methods Using two-sample MR, cis protein quantitative trait loci (cis-pQTLs) for 1,916 plasma proteins were used as an exposure to infer their causal effect on AD liability in individuals of European ancestry, with two large-scale AD genome-wide association study (GWAS) datasets as the outcome for discovery and replication. …”
Get full text

Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study by Zhenzhen Chen, Qingqing Lv, Shiteng Lin, Wanlong Lin, Wei Zhuang

“…Objective We aimed to assess the causal relationship between antidepressants, depression, and PPH using a two-sample Mendelian randomization method. Methods Single nucleotide polymorphisms were identified from publicly available genetics summary databases (FinnGen database, access date: 28 December, 2023, version R9, phenocode: ANTIDEPRESSANTS, 195,321 participants; the genome-wide association studies [GWAS] catalog, access date: 3 April, 2024, GWAS ID: ebi-a-GCST90016607; Integrative Epidemiological Unit database, access date: 3 April, 2024, GWAS ID: ieu-a-1187) as alternative exposure factors for antidepressants and depression. …”
Get full text

Leukocyte Telomere Length and Polycystic Ovary Syndrome: A Transethnic Mendelian Randomization Study by Lan Cao, Jie Chen

“…Two-sample MR analysis was performed in a PCOS cohort of European ancestry (4,138 cases and 20,129 controls), with replication analyses in a Northern European PCOS cohort (3,609 cases and 229,788 controls) and in a Chinese PCOS cohort (4,386 cases and 8,017 controls). …”
Get full text

Introduction of clinical guidelines for the diagnosis and treatment of osteoarthrosis: results of a cluster randomized trial by Dmitri Mikhailovich Maksimov, O M Lesnyak

“…This was an open pragmatic cluster randomized controlled trial covering 16 general practitioners who completed the trial and 92 patients clinically diagnosed as having knee and/or hip OA (63 in the intervention group and 29 in the control group). …”
Get full text

Causal role of immune cells in IgA nephropathy: a mendelian randomization study by Jinlian Shu, Yating Ge, Yonggui Wu

“…However, the specific causal relationship between the two is inconsistent.Methods We used a two-sample mendelian randomization(MR) analysis to investigate the causal association between 731 immune cell signatures and IgA nephropathy in this study. …”
Get full text

Effect of Intradermal Sterile Water Injection on Labor Experiences: A Randomized Controlled Study by Rojjin Mamuk, Nevin Hotun Şahin

“…Methods: The sample group of the study was 120 pregnant women with severe low-back pain during labor (30-sterile water, 30-saline solution, 60-control). …”
Get full text

Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study by Zhengrui Li, Xufeng Huang, Qi Wang, Divya Gopinath

“…The data were obtained from the CNGBdb database and the UK Biobank, and analytical procedures were performed using the R package ‘TwoSampleMR’. To ensure the robustness of our findings, we conducted sensitivity studies, which included the MR-Egger intercept test, to establish strong correlations and eliminate the phenomenon of horizontal pleiotropy. …”
Get full text

Insomnia remission and improvement of bodily pain in older adults: a randomized clinical trial by Martin F. Bjurstrom, Richard Olmstead, Michael R. Irwin

“…Methods:. A community-based sample of 291 adults ages 60 years and older (mean age, 70.1 years; 57.7% female) with insomnia disorder, but no chronic pain condition, were randomized to 2 months of intervention with either CBT-I (n = 156) or SET (n = 135). …”
Get full text

Association between adjustable dietary factors and periodontitis: NHANES 2009–2014 and Mendelian randomization by Li Chen, Rui Zhao, Yarong Zhang

“…To explore the causal effect between dietary data and periodontitis by Mendelian randomization (MR) analyses. Methods A total of 11,704 participants and 21 dietary variables from the NHANES were in random forest to rank the importance in predicting periodontitis. …”
Get full text

Strategy for Calculating Magnesium Sulfate Dose in Obese Patients: A Randomized Blinded Trial by Sebastião E. Silva Filho, Omar S. Klinsky, Miguel A. M. C. Gonzalez, Sandro Dainez, Flavio Angelis, Joaquim E. Vieira

“…Strategies to calculate the dose based on the actual or corrected ideal body weight had similar outcomes related to analgesia and the resulting blood magnesium concentration. However, as the sample in this trial presented body mass indices ranging from 30.11 kg·m−2 to 47.11 kg/m−2, further studies are needed to confirm these findings in more obese patients, easily found in centers specialized.…”
Get full text

The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study by Pin Huang, Ying Xiao, Ye He

“…Methods The causative links between VTE and 211 gut microbiota at phylum, class, order, family and genus level were separately investigated using two-sample Mendelian Randomization (MR) analysis. Firstly, single nucleotide polymorphisms (SNPs) locus-wide significantly (P < 1.0 × 10− 5) related with gut microbiome abundance were extracted from large genome-wide analysis (GWAS) meta-analysis summary data. …”
Get full text

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for hyperemesis gravidarum by Fengyang Wang, Wenpeng Ruan, Qiuyuan Yin, Lei Zhu

“…Our study aims to identify novel therapeutic targets that could lead to the development of additional, more effective treatment options. Methods A two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of blood-druggable genes on HG. …”
Get full text

Identification of biomarkers and potential drug targets for esophageal cancer: a Mendelian randomization study by Chengjun Li, Xiaomeng Cui, Mudan Ren, Yan Yin, Shuixiang He

“…A total of 734 plasma proteins and 4,479 druggable genes were obtained from recent studies, and two-sample MR analyses were conducted to investigate causal relationships between these proteins and EC. …”
Get full text

A causal association between osteoporosis and postural instability: a Mendelian randomization study by Kun Zhu, ZiJie An, YaWei Li, Qiaoyu Zhang, Feng Zhang, Rui Zhao, Haiyang Yu, Qingqiang Yao

“…In this study, we conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between osteoporosis and postural instability, with osteoporosis represented by bone mineral density (BMD). …”
Get full text

The causal association between COVID-19 and ischemic stroke: a mendelian randomization study by Zhaojie Zhang, Jie Hua, Liang Chen

“…The current study sought to evaluate the causal relationship between COVID-19 and IS. Methods A two-sample Mendelian randomization (2 S-MR) approach was used to probe the relationship between genetic determinants of three COVID-19 parameters (SARS-CoV‐2 infection, COVID-19 hospitalization, and severe COVID-19) and the incidence of IS based on genome-wide association studies (GWAS) data. …”
Get full text

Blood metabolites, mitochondrial biofunction, and cervical cancer: a bidirectional Mendelian randomization study by Chongze Yang, Lan-hui Qin, Liwei Li, Meng-na Lan, Qiu-ying Wei, Yi Li, Jin-yuan Liao

“…This bidirectional two-sample Mendelian randomization study aims to investigate the potential causal relationship between blood metabolites, mitochondrial biofunction and cervical cancer. …”
Get full text

Causality Between Irritable Bowel Syndrome and Suicide Attempt: A Mendelian Randomization Study by Zhen Deng, Kai Wang, Tianshu Hou

“…We used the MRlap method to eliminate the effect of sample overlap. We also used a multivariable MR approach to control for the influence of potential confounders. …”
Get full text

Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis by Nan Li, Chuan He

“…We employed a two-sample MR approach to explore the causal links between 731 immunophenotypes and HIV-1 acquisition, using genetic variants from publicly available GWAS summary statistics as instrumental variables. …”
Get full text

Assessing the causal association of sleep abnormalities with preeclampsia and eclampsia: a Mendelian randomization analysis by Juan Li, Yuling Kong, Guosu Shi, Shuxiao Dong, Xueying Wang, Li Feng, Quanzhou Guo, Caihong Lu

“…GWAS summary data on preeclampsia/eclampsia and genetic markers for sleep abnormality were sourced from the FinnGen Consortium and IEU genetic databases. The Mendelian randomization analysis was conducted with TwoSampleMR (v0.6.2), and the inverse variance weighted (IVW) approach was employed as the principal method.Results GSEA analysis revealed that the orexin receptor pathway showed heightened expression in the preeclampsia group versus controls. …”
Get full text

Association Between Educational Attainment and Chronic Pain: A Mediation Mendelian Randomization Study by Wang H, Liu M, Li H, Xu S

“…Keywords: educational attainment, chronic pain, Mendelian randomization, risk factors…”
Get full text