A Bayesian network meta-analysis of non-pharmacological interventions for neonatal pain management: a clinical effectiveness comparison by Lingxue Xu, Lali Xiang, Lihui Pan, Peipei Xue, Juan Li, Yurong He, Hongyan Liu, Yuwei Hu, Bo Zheng

“…A Bayesian model was employed for the analysis, and heterogeneity was quantified using random-effects standard deviation (RESD), τ², and I² statistics. …”
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Adapting Sensory Analysis to the Pandemic Era: Exploring “Remote Home Tasting” of Sous-Vide Chicken Breast for Research Continuity by Francesca Masino, Giuseppe Montevecchi, Andrea Antonelli, Domenico Pietro Lo Fiego, Patrizia Fava, Roberta Foligni, Andrea Pulvirenti

“…Judges tasted 6 out of 13 randomized samples, recording intensities on a cloud-based sensory card. …”
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Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins by Min Luo, Min Luo, Ying Tang, Jing Qiu, Jing Qiu, Kai Yang, Kai Yang, WenJing Dai, WenJing Dai, EnRong Fang, EnRong Fang

“…Using an integrated approach combining proteome-wide Mendelian randomization and Bayesian colocalization analysis, this study identifies novel therapeutic targets for COPD. …”
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Gene prediction of the relationship between iron deficiency anemia and immune cells by Xuanxuan Xu, Zhixia Li, Huimin Liu, Zhiping Huang, Tao Xiong, Yuanyan Tang

“…Herein, we used Mendelian randomization (MR) to assess whether this association is causal.Methods We selected IDA genetic variants, including 8376 samples and 9810691 single nucleotide polymorphisms, and immune cells from a large open genome-wide association study (GWAS) for a bidirectional MR study. …”
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Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study by Howard Trachtman, Jai Radhakrishnan, Michelle N. Rheault, Charles E. Alpers, Jonathan Barratt, Hiddo J.L. Heerspink, Irene L. Noronha, Vlado Perkovic, Brad Rovin, Hernán Trimarchi, Muh Geot Wong, Alex Mercer, Jula Inrig, William Rote, Ed Murphy, Patricia W. Bedard, Sandra Roth, Stewart Bieler, Radko Komers

“…Results: The primary analysis population includes 371 patients (336 adult, 35 pediatric [<18 years]) who were randomized and received study drug (median age, 42 years). …”
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Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and... by Michael E. Herce, Caitlin Cassidy, Alexandra Munson, Jessie K. Edwards, Sarah E. Rutstein, Mitch Matoga, Chimwemwe Kumwenda, Katherine R. Simon, Joep J. van Oosterhout, Carrie M. Cox, Funny Kamanga, Wiza Kumwenda, Sam Phiri, Ethel Rambiki, Agness Thawani, Jacqueline Huwa, Bridget Malewezi, Tisu Mvalo, Agatha Bula, Lameck Chinula, Irving Hoffman, Madeleine A. Squibb, Rose K. Nyirenda, Friday Saidi, Mina C. Hosseinipour, Maganizo B. Chagomerana

“…These outcomes will be assessed using routinely collected clinic data augmented with field surveys enrolling a sample of MIPs randomly selected from each clinic. …”
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Minimax rates and adaptivity in combining experimental and observational data by Chen Shuxiao, Li Sai, Zhang Bo, Ye Ting

“…Randomized controlled trials (RCTs) are the gold standard for evaluating the causal effect of a treatment; however, they often have limited sample sizes and sometimes poor generalizability. …”
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Low dose baclofen and standard dose acamprosate had comparable changes in brain glutamate, brain Gamma amino butyric acid (GABA) and craving among patients with alcohol dependence... by Akhil Kesan, Pranjal Dey, Sourav Khanra, Samiksha Singhai, Monalisa Boro

“…Material and Methods: Forty patients with ADS were recruited with purposive sampling and were randomized into two groups using computer-generated randomization. …”
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Calculating the true level of predictors significance when carrying out the procedure of regression equation specification by Nikita A. Moiseev

“…The paper is devoted to a new randomization method that yields unbiased adjustments of p-values for linear regression models predictors by incorporating the number of potential explanatory variables, their variance-covariance matrix and its uncertainty, based on the number of observations. …”
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Nighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1–2 Carbohydrate Exchanges (15–30 grams) over 12 Weeks in Ad... by Terrence M Riley, Justin Wright, Regina Lamendella, Jordan E Bisanz, Jeremy Chen See, Khushi Kanani, Penny M Kris-Etherton, Kristina S Petersen

“…Results: The analytical sample included 51 participants (37% female, 49 ± 10 y, 31.5 ± 4 kg/m2, FPG 102 ± 10 mg/dL) who completed the trial (of 66 randomly assigned). β-diversity analysis showed community dissimilarity between the pistachio and usual care conditions postcondition (P = 0.001). …”
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Molecular insights into ulcerative colitis and orbital inflammation by Kang Tan, Pei Liu, Zixuan Wu, Xi Long, Yunfeng Yu, Pengfei Jiang, Qinghua Peng

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Improving type 2 diabetes detection among at-risk individuals – comparing the effectiveness of active opportunistic screening using spot capillary-HbA1c testing and venous HbA1c te... by Linda Chan, Esther Yee Tak Yu, Eric Yuk Fai Wan, Samuel Yeung Shan Wong, David Vai Kiong Chao, Welchie Wai Kit Ko, Catherine Xiao Rui Chen, Paul Po Ling Chan, Emma Victoria Marianne Bilney, Eng Sing Lee, Wei Leik Ng, Cindy Lo Kuen Lam

“…If preliminary HbA1c was ≥ 5.6%, a confirmatory oral glucose tolerance test was offered. Randomization occurred at the clinic level using a random allocation sequence generated by statistical software. …”
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Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis by Xiao-cui Wang, Xiao-cui Wang, Li Song, Xin-han Wang, Xin-han Wang

“…Future studies should incorporate more RCTs to further validate the efficacy of dietary polyphenols (like DHM and quercetin), which are limited in sample sizes, in treating NAFLD. On the other hand, it is essential to investigate improvements in the bioavailability of these dietary polyphenols and to clarify their safety profiles.…”
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Describing the initial results of a pragmatic, cluster randomized clinical trial to examine the impact of a multifaceted digital intervention for the prevention of type 2 diabetes... by Sofía Mira-Martínez, Sofía Mira-Martínez, Sofía Mira-Martínez, Rocío Zamanillo-Campos, Rocío Zamanillo-Campos, Rocío Zamanillo-Campos, Narges Malih, Narges Malih, Narges Malih, Maria Antonia Fiol-deRoque, Maria Antonia Fiol-deRoque, Maria Antonia Fiol-deRoque, Maria Antonia Fiol-deRoque, Escarlata Angullo-Martínez, Rafael Jimenez, Rafael Jimenez, Maria Jesús Serrano-Ripoll, Maria Jesús Serrano-Ripoll, Maria Jesús Serrano-Ripoll, Maria Jesús Serrano-Ripoll, José Iván Oña, Aina M Galmes-Panades, Aina M Galmes-Panades, Aina M Galmes-Panades, Rocío Gómez-Juanes, Rocío Gómez-Juanes, Rocío Gómez-Juanes, Rocío Gómez-Juanes, Jadwiga Konieczna, Jadwiga Konieczna, Jerónima Miralles, Jerónima Miralles, Dora Romaguera, Dora Romaguera, María Clara Vidal-Thomasa, María Clara Vidal-Thomasa, María Clara Vidal-Thomasa, Joan Llobera-Canaves, Joan Llobera-Canaves, Joan Llobera-Canaves, Joan Llobera-Canaves, Mauro García-Toro, Mauro García-Toro, Mauro García-Toro, Mauro García-Toro, Elena Gervilla-García, Elena Gervilla-García, Catalina Vicens, Catalina Vicens, Catalina Vicens, Oana Bulilete, Oana Bulilete, Oana Bulilete, Oana Bulilete, Juan José Montaño, Juan José Montaño, Margalida Gili, Margalida Gili, Margalida Gili, Margalida Gili, Miquel Roca, Miquel Roca, Miquel Roca, Antoni Colom, Antoni Colom, Ignacio Ricci-Cabello, Ignacio Ricci-Cabello, Ignacio Ricci-Cabello, Ignacio Ricci-Cabello

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SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper by João Pedro Ferreira, Francisco Vasques‐Nóvoa, Francisca Saraiva, Ana C. Oliveira, Jorge Almeida, Ana Beatriz Batista, Arsénio Barbosa, Ana Filipa Ferreira, Cátia Costa, Diogo Santos‐Ferreira, Fernando Friões, Cândida Goncalves, João Tiago Guimarães, Marta Leite, Pedro Marques, Joana Mascarenhas, Maria Inês Matos, Catarina Pereira, Pedro Rodrigues, Abhinav Sharma, Gualter Silva, Inês Pereira‐Sousa, Carla Sousa, Faiez Zannad, Joana Pimenta, Ricardo Fontes‐Carvalho, Adelino Leite‐Moreira

“…Abstract Background Sodium glucose co‐transporter 2 inhibitors (SGLT2i) and mineralocorticoid receptor antagonists (MRA) reduce heart failure (HF) events in patients with heart failure and mildly reduced or preserved ejection fraction (HFmr/pEF). The randomized comparison of SGLT2i/MRA combination versus SGLT2i or MRA alone requires further testing in HFmr/pEF. …”
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Performance evaluation of photovoltaic scenario generation by Siyu Ren, Tongxin Yang, Jun Luo, Gang Wu, Gang Wu, Kai Mao, Bowen Liu

“…Subsequently, an autoregressive model is employed to quantify the influence of environmental randomness on photovoltaic scenarios. The proposed evaluation model not only comprehensively validates the reliability of various photovoltaic scenario generation techniques but also identifies the corresponding month or season of generated samples through scenario feature analysis. …”
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Multidimensional bioinformatics perspective on smoking-linked driver genes and immune regulatory mechanisms in non-small cell lung cancer by Can Ouyang, Xiaopeng Yu, Huazhong Wang, Puhua Zeng

“…First, smoking-linked lung cancer driver genes (SLDCGs) were identified, followed by Mendelian Randomization (MR) and Summary-based Mendelian Randomization (SMR) analyses to further validate their causal relationships. …”
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The future of critical care: AI-powered mortality prediction for acute variceal gastrointestinal bleeding and acute non-variceal gastrointestinal bleeding patients by Zhou Liu, Guijun Jiang, Liang Zhang, Palpasa Shrestha, Yugang Hu, Yi Zhu, Guang Li, Yuanguo Xiong, Liying Zhan

“…The Synthetic Minority Over-sampling Technique-Edited Nearest Neighbors (SMOTE-ENN) and Adaptive Synthetic Sampling (ADASYN) were adopted to address the imbalance of the dataset. …”
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Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized co... by Sivaprakasam T Selvavinayagam, Sathish Sankar, Yean K Yong, Abdul R Anshad, Samudi Chandramathi, Anavarathan Somasundaram, Sampath Palani, Parthipan Kumarasamy, Roshini Azhaguvel, Ajith B Kumar, Sudharshini Subramaniam, Manickam Malathi, Venkatachalam Vijayalakshmi, Manivannan Rajeshkumar, Anandhazhvar Kumaresan, Ramendra P Pandey, Nagarajan Muruganandam, Natarajan Gopalan, Meganathan Kannan, Amudhan Murugesan, Pachamuthu Balakrishnan, Siddappa N Byrareddy, Aditya P Dash, Vijayakumar Velu, Marie Larsson, Esaki M Shankar, Sivadoss Raju

“…A total of 13464 mosquito pools and 5577 human serum samples from 186 clusters were collected. Of these, 3.76% of the mosquito pools were positive for DENV. …”
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Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized dou... by Urban Alehagen, Peter Johansson, Jan Aaseth, Jan Alexander, Kerstin Brismar

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