Evaluation of platelet derived growth factor-BB levels in injectable platelet rich fibrin coated graft using gingival pedicle split thickness tunnel technique for isolated gingival... by Leena Patil, M. Jayasheela, M.G. Triveni, G.V. Gayathri

“…Methodology: 20 patients exhibiting Miller’s class I/II isolated gingival recession were selected for this parallel arm randomized controlled trial. Recipient site was prepared using GPST technique, free gingival graft was harvested and de-epithelialized, further graft was coated with i-PRF and wound fluid samples from surgical site were collected at baseline, 3rd day and 7th day for group A. …”
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Low-dose dobutamine in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (the DOBERMANN-D trial): study protocol for a double-blinded, pla... by Sarah Louise Duus Holle, Joakim Bo Kunkel, Christian Hassager, Redi Pecini, Sebastian Wiberg, Pernille Palm, Lene Holmvang, Lia Evi Bang, Jesper Kjærgaard, Jakob Hartvig Thomsen, Thomas Engstrøm, Jacob Eifer Møller, Jacob Thomsen Lønborg, Helle Søholm, Martin Frydland

“…Blood samples are drawn at time points from study inclusion (before infusion, 12, 24, 36, and 48 h). …”
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Evaluation of the gambling habits of Spanish adolescents and young adults post-COVID-19 and implementation of a digital escape room intervention for preventing gambling: study prot... by Alberto Barceló-Soler, Alicia Monreal-Bartolomé, Adrián Pérez-Aranda, Daniel Campos, María Beltrán-Ruiz, Marta Puebla-Guedea, Itxaso Cabrera-Gil, Javier García-Campayo, Yolanda López-del-Hoyo

“…Study 2 will be a cluster-randomized controlled trial focused on testing the effectiveness of the GAMBL-OUT digital escape-room in preventing gambling among a sample of 240 youngsters. …”
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Speech-in-noise, psychosocial, and heart rate variability outcomes of group singing or audiobook club interventions for older adults with unaddressed hearing loss: A SingWell Proje... by Chi Yhun Lo, Benjamin Rich Zendel, Deniz Baskent, Christian Boyle, Emily Coffey, Nathan Gagne, Assal Habibi, Ellie Harding, Merel Keijzer, Gunter Kreutz, Bert Maat, Eva Schurig, Mridula Sharma, Carmen Dang, Sean Gilmore, Helen Henshaw, Colette M McKay, Arla Good, Frank A Russo

“…However, there is a lack of robust evidence, primarily due to the literature being based on small sample sizes, single site studies, and a lack of randomized controlled trials. …”
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Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis by Qiongbing Zheng, Qiongbing Zheng, Youmian Lan, Jiexin Chen, Ling Lin, Ling Lin

“…Clinical synovial tissue samples were used to validate CKAP2 expression via quantitative real-time polymerase chain reaction (qRT-PCR), western blot, and immunohistochemistry (IHC). …”
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Gelsolin (GSN) as a key regulator in estrogen receptor-positive breast cancer: implications for prognosis, chemotherapy sensitivity, and immune infiltration by Mian Lv, Huiling Wang, Guanqing Feng, Qingxiao Nong, Shouwen Tao, Yanfei Ma, Dalang Fang

“…Immunohistochemistry analysis demonstrated significantly lower GSN expression in ER + BC cases compared to normal samples, consistent with finding from TCGA cohorts. …”
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Exercise-changed gut mycobiome as a potential contributor to metabolic benefits in diabetes prevention: an integrative multi-omics study by Yao Wang, Jiarui Chen, Yueqiong Ni, Yan Liu, Xiang Gao, Michael Andrew Tse, Gianni Panagiotou, Aimin Xu

“…With our established randomized controlled trial of exercise intervention in Chinese males with prediabetes (n = 39, ClinicalTrials.gov:NCT03240978), we investigated the dynamics of human gut mycobiome and further interrogated their associations with exercise-elicited outcomes using multi-omics approaches.Methods Clinical variations and biological samples were collected before and after training. …”
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Evaluation of biosimilarity of RinGlar® (GEROPHARM LLC, Russia) and Lantus® (Sanofi-Aventis Deutschland GmbH, Germany) using the euglycemic hyperinsulinemic clamp technique in pati... by Alexander Y. Mayorov, Roman V. Drai, Tatiana L. Karonova, Olga I. Avdeeva, Igor E. Makarenko, Ekaterina O. Koksharova, Ekaterina Е. Mishina, Yulia А. Sevastyanova, Olena V. Afonkina

“…During the study, regular blood sampling was performed, the amount of insulin glargine in the samples was determined by ELISA. …”
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Proactive Cyber Resilience: A Unified Assessment Methodology for Incident Forecasting With Cyber Threat Intelligence Integration by Hayat Abdulla Asad Cue, Thirimachos Bourlai, Mark Lupo

“…To address some of the limitations introduced by our real-world dataset’s scarcity and unbalanced characteristics, we expanded the number of observations 15 times by generating and balancing over 200 synthetic assessment results using Random-OverSampling and SMOTE. Experimental results show that synthetic data contribute positively to identifying risk categories based on cybersecurity posture scores below 45/100 and above 61/100, predicting additional attack techniques under variable implementation conditions, such as T1027, and confirming a multifold reduction in assessment time from months to days.…”
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Early Prediction Detection of Retail and Corporate Credit Risks Using Machine Learning Algorithms by Mohamed A. Hamada, Karim Farag, Adejor E. Abiche

“…It will cover the period from 2011 to 2023 and analyze a sample of 26 banks operating in Egypt. Additionally, it classifies credit risk into retail and corporate categories to develop more robust predictive models tailored for the retail and corporate sectors of bank credit risk management, thereby underscoring the paper’s novelty. …”
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Short-term Wind Power Forecasting Based on BWO‒VMD and TCN‒BiGRU by LU Jing, ZHANG Yanru, WANG Rui

“…On this basis, a comprehensive index combining sample entropy and VMD decomposition to reconstruct the errors of each order component is used as a fitness function. …”
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A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data reveal... by Zhou An, Meichun Zeng, Xianhua Wang

“…This study aimed to investigate whether a causal relationship exists between smoking dependence and Barrett’s esophagus, using Mendelian randomization analysis. Methods: Two-sample Mendelian randomization analysis was conducted to evaluate the impact of smoking and Barrett’s esophagus. …”
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Effects of a multi-modal static and dynamic balance and hand function training program on multi-dimensional balance ability, hand function, and life-space mobility in rural older a... by Xinyu Yang, Shasha Li, Xiangdong Xu, Guojing Guo, Xiaofang Song, Yashuang Sun, Mengxue Shi, Canqi Ren

“…Methods A single-blind, four-group parallel, multicenter randomized controlled trial was used. Four rural communities in Huzhou, Zhejiang Province, were included in the study, with an estimated total sample size of 132 individuals. …”
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Intervention With WhatsApp Messaging to Compare the Effect of Self-Designed Messages and Standardized Messages in Adherence to Antiretroviral Treatment in Young People Living With... by Jeffrey Freidenson-Bejar, Dianne Espinoza, Rodrigo Calderon-Flores, Fernando Mejia, Elsa González-Lagos

“…Based on an estimated 10% difference in adherence, 78.9% power, and a 2-sided α of .05, the target sample size was set at 120, later increased to 131 to include a 2-week pilot phase. …”
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California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of AC... by Lauren Y. Kim, Sophia Miryam Schüssler-Fiorenza Rose, Summer Mengelkoch, Daniel P. Moriarity, Jeffrey Gassen, Jenna C. Alley, Lydia G. Roos, Tao Jiang, Arash Alavi, Durga Devi Thota, Xinyue Zhang, Dalia Perelman, Tamar Kodish, Janice L. Krupnick, Michelle May, Katy Bowman, Jenna Hua, Yaping Joyce Liao, Alicia F. Lieberman, Atul J. Butte, Patricia Lester, Shannon M. Thyne, Joan F. Hilton, Michael P. Snyder, George M. Slavich

“…In this protocol paper, we describe the scientific gaps motivating this study as well as the sample, study design, procedures, measures, and planned analyses. …”
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Recruitment of Young Gay, Bisexual, and Other Men Who Have Sex With Men for a Web-Based Human Papillomavirus Vaccination Intervention: Differences in Participant Characteristics an... by Daniel J Marshall, Amy L Gower, Mira L Katz, José A Bauermeister, Abigail B Shoben, Paul L Reiter

“…ConclusionsWe were able to recruit a large national sample of young gay, bisexual, and other men who have sex with men for a web-based HPV vaccination intervention via multiple methodologies. …”
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Gallium-68-labeled fibroblast activation protein inhibitor-46 PET in patients with resectable or borderline resectable pancreatic ductal adenocarcinoma: A phase 2, multicenter, sin... by Aashna Karbhari, Sherly Mosessian, Kamaxi H Trivedi, Frank Valla, Mark Jacobson, Mark J Truty, Nandakumar G Patnam, Diane M Simeone, Elcin Zan, Tracy Brennan, Hongli Chen, Phillip H Kuo, Ken Herrmann, Ajit H Goenka

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Post-exposure prophylaxis with SA58 (anti-SARS-COV-2 monoclonal antibody) nasal spray for the prevention of symptomatic COVID-19 in healthy adult workers: a randomized, single-blin... by Rui Song, Gang Zeng, Jianxing Yu, Xing Meng, Xiaoyou Chen, Jing Li, Xiaoliang Xie, Xiaojuan Lian, Zhiyun Zhang, Yunlong Cao, Weidong Yin, Ronghua Jin

“…Recruited participants were randomized in a ratio of 3:1 to receive SA58 or placebo. …”
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Chemical Diversity of UK-Grown Tea Explored Using Metabolomics and Machine Learning by Amanda J. Lloyd, Alina Warren-Walker, Jasen Finch, Jo Harper, Kathryn Bennet, Alison Watson, Laura Lyons, Pilar Martinez Martin, Thomas Wilson, Manfred Beckmann

“…The chemical diversity of fresh leaf samples from various garden locations was explored within the plantation. …”
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Identifying Common Diagnostic Biomarkers and Therapeutic Targets between COPD and Sepsis: A Bioinformatics and Machine Learning Approach by Li X, Xiao Y, Yang M, Zhang X, Yuan Z, Zhang Z, Zhang H, Liu L, Zhao M

“…This study aimed to explore shared diagnostic genes, potential mechanisms, and the role of immune cells in the COPD-sepsis relationship using Mendelian randomization (MR) and bioinformatics approaches, while also identifying potential therapeutic drugs.Methods: Two-sample MR analysis was performed using genome-wide association data to assess genetically predicted COPD and sepsis. …”
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