Noninvasive markers for warning premature ovarian insufficiency: a Mendelian randomisation study by Hangjing Tan, Jing Zhao, Baisheng Wang, Yanping Li

“…The metabolome, circulating plasma proteins, gut microbiota, immunophenotypes, circulating microRNAs (miRNAs), and two proteomes were obtained for two-sample Mendelian randomization (MR). Specifically, we employed inverse variance weighted (IVW) as the main method to calculate the MR effect estimates. eQTL data (from the eQTLGen Consortium) were employed for SMR. …”
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Lipidomics Reveals Common Mechanisms in Polycystic Ovarian Syndrome, Recurrent Spontaneous Abortion, and Infertility: A Genetic-Based Analysis by Tao A, Wu T, Han X, Niu D, Feng X

“…Targeting lipids may offer a promising therapeutic strategy for these diseases.Keywords: polycystic ovarian syndrome, recurrent spontaneous abortion, infertility, lipidomics, Mendelian randomization, causal relationship…”
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Effects of types of toothpastes (whitening versus regular) and brands of silicone aesthetic ligatures on discoloration of elastomeric ligatures applied to mandibular central and la... by Majid Aryannejad, Hooman Ghazi Oskouei, Marzieh Mazhari, Mehrnaz Moradinezhad

“…Methods In this hierarchical 6-arm split-mouth double-blind randomized clinical trial, 264 ligatures were applied to orthodontic brackets bonded to bilateral mandibular central and lateral incisors in 66 patients: The sample was randomized twice: Once it was randomly divided into three groups of toothpastes (n = 66 patients): Regular Crest, Advance White Arm & Hammer Whitening, and Extra Whitening Crest. …”
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Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome by Junming Wang, Pengfei Wang, Jiang Lv, Ran Chen, Wei Yan, Daikun He

“…Methods This study employed genetic data from large-scale genome-wide association studies (GWAS) on GERD (129,080 cases, 473,524 controls) and SAS (25,008 cases, 391,473 controls) for two-sample Mendelian randomization (MR) analysis to estimate the causal effects of GERD on the risk of SAS. …”
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Genetic correlation between chronic sinusitis and autoimmune diseases by Enze Wang, Yingxuan Sun, He Zhao, Meng Wang, Zhiwei Cao

“…The CRS GWAS (genome-wide association study) data and other autoimmune diseases were retrieved from ieuOpenGWAS (https://gwas.mrcieu.ac.uk/), the FinnGen alliance (https://r8.finngen.fi/), the UK Biobank (https://www.ukbiobank.ac.uk/), and the EBI database (https://www.ebi.ac.uk/).ResultsUtilizing a bivariate two-sample Mendelian randomization approach, our findings suggest a significant association of chronic rhinosinusitis with various autoimmune diseases, including allergic rhinitis (p = 9.55E-10, Odds Ratio [OR] = 2,711.019, 95% confidence interval [CI] = 261.83391–28,069.8), asthma (p = 1.81E-23, OR = 33.99643, 95%CI = 17.52439–65.95137), rheumatoid arthritis (p = 9.55E-10, OR = 1.115526, 95%CI = 1.0799484–1.1522758), hypothyroidism (p = 2.08828E-2, OR = 4.849254, 95%CI = 1.7154455–13.707962), and type 1 diabetes (p = 2.08828E-2, OR = 01.04849, 95%CI = 1.0162932–1.0817062). …”
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Association and mediation between circulating inflammatory proteins and skin fibrosis by Zirui Zhao, Dongming Lv, Ruixi Zeng, Yanchao Rong, Zhongye Xu, Rong Yin, Zhicheng Hu, Xiaoling Cao, Bing Tang

“…Two-sample MR and reverse MR were conducted to determine the effect of CIPs on skin fibrosis. …”
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Estimation of equivalent stresses and equivalents of the fatigue test programs of airframe composite elements by V. E. Strizhius

“…An example of calculating the equivalent stresses and equivalents of various modifications of the quasi-random program for CFRP T300/5208 [45/0/-45/90] 2s samples of fiber-carbon composite with the open hole is presented. …”
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Far Transfer Effects of Manualized and Computerized Cognitive Interventions on Parents’ Rated Behavioral Problems of Children aged 6–11 years with Attention-Deficit Hyperactivity D... by Sujata Satapathy, Rachna Maurya, Renu Sharma, Rajesh Sagar, Vijay Prasad Barre

“…Conclusions: The study suggests that the far transfer effects of MCTT and PSSCogRehab on behavioral improvement, particularly at the follow-up assessment, show promise and warrant further exploration with robust methodology and larger sample sizes.…”
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Effects of M-DEPTH model of depression care on maternal depression, functioning, and HIV care adherence, and infant developmental over eighteen months post-partum: results from a c... by Glenn J. Wagner, Bonnie Ghosh-Dastidar, Violet Gwokyalya, Laura J. Faherty, Jolly Beyeza-Kashesya, Juliet Nakku, Linda Kisaakye Nabitaka, Dickens Akena, Janet Nakigudde, Victoria Ngo, Ryan McBain, Hafsa Lukwata, Leticia Kyohangirwe, Barbara Mukasa, Rhoda K. Wanyenze

“…We examined whether the M-DEPTH (Maternal Depression Treatment in HIV) depression care model—including antidepressant therapy and individual problem-solving therapy—and depression alleviation would affect improvement in each of these outcome domains. Methods A sample of 354 pregnant women living with HIV (WLH) with at least mild depressive symptoms (177 in each of intervention and usual care control arms) enrolled in a cluster randomized controlled trial across eight antenatal care clinics in Uganda and had a live birth delivery. …”
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Mobile-Based Platform With a Low-Calorie Dietary Intervention Involving Prepackaged Food for Weight Loss for People With Overweight and Obesity in China: Half-Year Follow-Up Result... by Xi Wang, Suyuan Wang, Lingyu Zhong, Chenghui Zhang, Yanhong Guo, Mingxia Li, Li Zhao, Shuming Ji, Junjie Pan, Yunhong Wu

“…ResultsIn total, 220 patients were randomly assigned to intervention (n=110) and control (n=110) groups. …”
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Effect of the MyDéfi Smartphone Application on Binge Drinking Among University Students: Protocol of a Double‐Blind Multicenter Prospective National Randomized Controlled Trial Usi... by Camille André, Pierre Sauton, Méléna Dreinaza, Momar Diouf, Sandra Bodeau, Margaret Martinetti, Raphaël Trouillet, Clara deGroote, Jean‐Louis Nandrino, Adèle Alexandre, Farid Benzerouk, Fabien Gierski, Pascal Perney, Laure Grellet, Judith André, Mickael Naassila

“…Monthly dried blood spot sample for measuring phosphatidylethanol concentration and online questionnaires will be collected. …”
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Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve... by Annia F. Schreiber, Carles Subirà, Michael Sklar, Marlene Santos, Matthew Ko, Alessandro Panelli, Stefan J. Schaller, Danny Theodore, Daniel D. Rowley, David Watson, Pramod Bonde, Elias N. Baedorf Kassis, Daniel S. Talmor, Marco Ranieri, Ewan C. Goligher, Arthur Slutsky, Laurent J. Brochard

“…Safety objectives include the proportion of device- or procedure-related adverse events (SAE). The estimated sample size will be 40 patients (20 per group). Discussion The STIMIT ACTIVATOR trial is a randomized multi-center study powered to elucidate whether non-invasive phrenic nerve stimulation is feasible, safe, and preserves diaphragm thickness. …”
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Integrative causal and single-cell analyses reveal genes responsive to endocrine disruptors driving human male infertility by Yanggang Hong, Yirong Wang, Jiajun Li, Wanyi Shu, Haolin Chen, Congde Chen

“…In this study, we systematically identified EDC-related genes using curated chemical-gene interaction databases and assessed their causal roles in male infertility through Mendelian randomization (MR) and colocalization analyses, utilizing large-scale cis-eQTL and GWAS datasets. …”
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Early initiation of fast‐track care for persons living with HIV initiating dolutegravir‐based regimens during a period of severe civil unrest in Port‐au‐Prince, Haiti: a pilot rand... by Jean Bernard Marc, Samuel Pierre, Othnia Ducatel, Fabienne Homeus, Abigail Zion, Vanessa R. Rivera, Nancy Dorvil, Patrice Severe, Colette Guiteau, Vanessa Rouzier, Ingrid T. Katz, Carl Frederic Duchatelier, Guyrlaine Pierre Louis Forestal, Josette Jean, Guirlaine Bernadin, Emelyne Droit Dumont, Rose Cardelle B. Riche, Jean William Pape, Serena P. Koenig

“…Results From December 2020 to August 2022, 245 participants were randomized to standard (n = 116) and early fast‐track (n = 129) groups. …”
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The effects of 12 weeks of high-intensity interval rope skipping training on speed and power indexes in male soccer players by Bo Wei, Bo Wei, Wenhu Cheng, Jiangang Qiu

“…Data were analyzed via paired samples T-tests.Research ResultsResearch Results. …”
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Comparison of different puncture needles used for endoscopic ultrasound-guided fine-needle biopsy of Gastrointestinal subepithelial lesions (≤ 2 cm) with respect to the adequacy of... by Yasunobu Yamashita, Reiko Ashida, Toshio Shimokawa, Tetsuya Ikeda, Osama Inatomi, Takashi Ogura, Yuzo Kodama, Kotaro Takeshita, Mamoru Takenaka, Akiko Tsujimoto, Yoshiki Nakai, Yukihisa Fujinaga, Masayuki Kitano

“…This multicenter comparative open-label superiority study is designed to verify whether a 22G Fork-tip needle is superior to a 22G Franseen needle with respect to sample acquisition. Methods/design Present study will randomly assign for 110 patients (55 in the Fork-tip needle group and 55 in the Franseen needle group) with SELs measuring ≤ 2 cm, all of whom are managed at one of the 10 participating endoscopic centers. …”
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Bankruptcy Risk Factors of Russian Companies by A. A. Zhukov, E. D. Nikulin, D. A. Shchuchkin

“…For the study, one of the machine learning methods was used – the random forest method. The sample consists of companies from seven industries, including manufacturing, retail, construction, electric power, mining, agricultural production, and water supply, as well as other industries, which include companies in education, healthcare, agriculture, and hospitality. …”
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The efficacy of Lacticaseibacillus paracasei MSMC39-1 and Bifidobacterium animalis TA-1 probiotics in modulating gut microbiota and reducing the risk of the characteristics of meta... by Wongsakorn Luangphiphat, Pinidphon Prombutara, Praewpannarai Jamjuree, Chantanapa Chantarangkul, Porntipha Vitheejongjaroen, Chantaluck Muennarong, Krittapat Fukfon, Manasvin Onwan, Malai Taweechotipatr

“…This investigation involved a randomized controlled trial, double-blind, parallel study. …”
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Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-la... by David Wullimann, John Tyler Sandberg, Mira Akber, Marie Löfling, Sara Gredmark-Russ, Jakob Michaëlsson, Marcus Buggert, Kim Blom, Hans-Gustaf Ljunggren

“…Peripheral blood samples were collected before vaccination and at multiple time points afterward. …”
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Impact of the aldehyde dehydrogenase 2 (ALDH2) gene testing on alcohol drinking behaviors among the Chinese Han population: study protocol of a single-center, open-label, randomize... by Dongli Lu, Yingneng Wen, Kaijun Liao, Qiulian Lu, Shiqin Wu, Lin Fang, Zhenghua Jiang, Zhaochun Wu

“…In addition, blood samples are collected from participants in the interventional group for ALDH2 gene testing, with testing reports issued, while ALDH2 gene testing is not performed in the control group. …”
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