Tegoprazan and low- or high-dose amoxicillin dual therapy versus bismuth-containing quadruple therapy for eradication (TREAT): protocol for a multicenter, open-label, non-inferior... by Yi Hu, Xin Xu, Cong He, Nian-Shuang Li, Yong Xie, Xu Shu, Nong-Hua Lu, Yin Zhu

“…Stool samples will be collected at baseline to detect antibiotic resistance and at baseline, week 2, and weeks 8–10 to evaluate the alteration of gut microbiota. …”
Get full text

Evaluation of the Effect of Lactobacillus paracasei (HF.A00232) in Children (6–13 years old) with Perennial Allergic Rhinitis: A 12-week, Double-blind, Randomized, Placebo-controll... by Wen-Ya Lin, Lin-Shien Fu, Heng-Kuei Lin, Chian-Yin Shen, Yee-Jun Chen

“…Methods: This study was a 12-week, double-blind, randomized, placebo-controlled trial. Sixty children with AR aged 6–13 years with nasal total symptoms score (NTSS) ≥5 who fulfilled the inclusion criteria were enrolled. …”
Get full text

Double-Blind, Randomized, Three-Armed, Placebo-Controlled, Clinical Investigation to Evaluate the Benefit and Tolerability of Two Dosages of IQP-AE-103 in Reducing Body Weight in O... by Ralf Uebelhack, Udo Bongartz, Stephanie Seibt, Gordana Bothe, Pee Win Chong, Patricia De Costa, Natalia Wszelaki

“…Methods. A double-blind, randomized, placebo-controlled trial involved one hundred and eight subjects (BMI between 25 and 35 kg/m2) that were randomly assigned to either the low-dose or the high-dose IQP-AE-103 group, or the placebo group. …”
Get full text

Magnitude and durability of ProC6C-AlOH/Matrix-Mtm vaccine-induced malaria transmission-blocking antibodies in Burkinabe adults from a Phase 1 randomized trial by Mohammad Naghizadeh, Kazutoyo Miura, Ebenezer Addo Ofori, Carole Long, Issaka Sagara, Alfred B. Tiono, Jordan Plieskatt, Michael Theisen

Get full text

Patient-Centered Risk Prediction, Prevention, and Intervention Platform (TIMELY) to Support the Continuum of Care in Coronary Artery Disease Using eHealth and Artificial Intelligen... by Mirela Habibovic, Emma Douma, Hendrik Schäfer, Manuela Sestayo-Fernandez, Tom Roovers, Xin Sun, Henrik Schmidt, Mona Kotewitsch, Jos Widdershoven, David Cantarero-Prieto, Frank Mooren, Carlos Pena-Gil, José Rámon González Juanatey, Martin Schmidt, Hagen Malberg, Vassilis Tsakanikas, Dimitrios Fotiadis, Dimitris Gatsios, Jos Bosch, Willem Johan Kop, Boris Schmitz

“…MethodsAn international, multicenter, randomized controlled trial will be conducted to evaluate the effectiveness of the TIMELY integrated platform and app. …”
Get full text

Combination of Compound Kushen injection with first-line treatment versus first-line treatment alone for advanced colorectal cancer: a study protocol for a multicenter, openlabel,... by Jingyuan Wu, Yuansha Ge, Guanghui Zhu, Ruike Gao, Xiaoyu Zhu, Ying Zhang, Jie Li

“…Methods This is a multicenter, randomized, open-label controlled clinical trial in which 320 patients with advanced CRC will be randomly assigned to the treatment group or the control group in a 1:1 ratio. …”
Get full text

The food effect on the pharmacokinetics of TQB3616 capsule in Chinse healthy subjects: a randomized, open-label, single-center, two-period, two-sequence crossover phase I clinical... by Jun Dai, Yanan Zhou, Lei Zhang, Qing Ren, Zhengzhi Liu, Yanli Wang, Yang Cheng, Qiaohuan Deng, Haimiao Yang, Hong Zhang

“…PurposeThe purpose of this study was to evaluate the food effect on the pharmacokinetics of TQB3616 capsule in Chinse healthy subjects.MethodsThe subjects were randomly allocated to two distinct sequences in a 1:1 ratio. …”
Get full text

Effect of fasting-induced headache on calcitonin gene related peptide (CGRP) and other clinical biomarkers on the first day of Ramadan: Sub-analysis from a randomized open label cl... by Abdulrahman Alwhaibi, Fawaz Alasmari, Faris Almutairi, Mohammed A. Assiri, Feras S. Aldawsari, Saud T. Aloyayd, Abdullah A. Alhejji, Jawaher A. Alotaibi, Abdulrazaq Albilali, Omar A. Almohammed, Sary Alsanea

“…Methods As part of a randomized, open-label clinical trial that evaluated the effect of paracetamol as a prophylactic therapy for FIH, blood samples from stratified subjects in the prophylaxis and control groups were withdrawn while fasting after the 1st dose of paracetamol (in the prophylaxis group) and prior to reporting headache occurrence. …”
Get full text

Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standa... by Mehmet Nevzat Pisak, Edibe Bereket, Aydin Erenmemisoglu

“…Methods A single-dose, open-label, randomized, three-period, three-sequence crossover trial was conducted in 12 healthy male volunteers (18–50 years). …”
Get full text

Evaluation of the effectiveness of combined treatment of coronary heart disease – coronary artery bypass grafting, transplantation of autologous bone marrow mononuclear cells: a ra... by V. V. Komok, N. S. Bunenkov, S. A. Beliy, V. M. Pizin, V. M. Kondratev, A. V. Dulaev, A. E. Kobak, T. S. Maksimova, I. P. Sergienko, E. V. Parusova, L. A. Smirnova, E. V. Babenko, B. V. Afanasev, A. S. Nemkov, G. G. Khubulava

“…For analysis of variance, taking into account various factors, the model of variance analysis for dependent samples – Repeated Measures ANOVA – was used. Results. …”
Get full text

Unravelling NK cell subset dynamics and specific gene signatures post-ibrutinib therapy in chronic lymphocytic leukaemia via single-cell transcriptomics by Chunlan Liu, Tianjian Ding, Rong Zou, Aili Zhang, Zhengzhuo Zhi, Sili Wang

“…Methods Peripheral blood samples from patients clinically and pathologically diagnosed with monoclonal B-cell lymphocytosis (MBL), newly diagnosed with CLL (ND-CLL), postibrutinib-treated patients who achieved a complete response (CR) or partial response (PR), and those with Richter's syndrome (RS) were collected. …”
Get full text

CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process by Mikel Tainta, Mikel Tainta, Mikel Tainta, Mikel Tainta, Mirian Ecay-Torres, Myriam Barandiaran, Myriam Barandiaran, Myriam Barandiaran, Ainara Estanga, Carolina López, Miren Altuna, Miren Altuna, Ane Iriondo, Jon Saldias, Maite Garcia-Sebastian, Marta Cañada, Maria de Arriba, Imanol Reparaz-Escudero, Mikel L. Sáez de Asteasu, Mikel L. Sáez de Asteasu, Mikel Izquierdo, Mikel Izquierdo, Nekane Balluerka, Arantxa Gorostiaga, Naia Ros, Goretti Soroa, Jara Domper, Jara Domper, Lucia Gayoso, Lucia Gayoso, Maria Arrizabalaga-Lopez, Usune Etxeberria, Usune Etxeberria, Maria Ines Torres, Elena Alberdi, Elena Alberdi, Estibaliz Capetillo-Zarate, Estibaliz Capetillo-Zarate, Estibaliz Capetillo-Zarate, Maider Mateo-Abad, Itziar Vergara, Javier Mar, Pablo Martinez-Lage

“…The secondary outcomes measure cost-effectiveness, quality of life, and functional abilities. Blood samples and brain imaging will also be collected to evaluate the effects of the intervention on brain structure and plasma biomarkers.ResultsRecruitment has been completed with 1051 participants selected (mean age (standard deviation, SD) of 69.65 (6.36), 58,50 % female, and mean CAIDE (SD) of 7.62 (1.427). …”
Get full text

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis by Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning

“…Methods This study identified differentially expressed genes (DEGs) by comparing gene expression levels between normal and KOA samples from the GEO database. Subsequently, we intersected the DEGs with aging‐related circadian rhythm genes to obtain a set of aging‐associated circadian rhythm genes differentially expressed in KOA. …”
Get full text

Remote Sensing of Alpine Peatlands: Challenges of Mapping Thousands of Sparse Small Sites Scattered Across Extensive Mountainous Territories by Qiqi Li, Manudeo Singh, Sonia Silvestri

“…The results show that the data set of single‐year time series multi‐source imagery, binary samples (peatland or non‐peatland), and 30 m DEM is the most effective for mapping alpine peatlands. …”
Get full text

Efficacy of two brands of Mebendazole (500 mg) in the treatment of Ascaris lumbricoides and hookworm infection among school-aged children in South Gondar zone, Northwest Ethiopia:... by Birhanu Malede, Ayalew Jejaw Zeleke, Yenesew Mihret Wondmagegn, Abebaw Setegn, Hailegebriel Wondimu, Ayenew Berhan, Tadesse Misganaw, Gashaw Azanaw Amare, Tegegne Eshetu

“…Convenient sampling technique was used to select schools and study participants. …”
Get full text

Effect of behavioural change communication through women development army on optimal complementary feeding practice among children aged 6–23 months in Southwest Ethiopia: a cluster... by Meseret Tamrat Gebretsadik, Dessalegn Tamiru, Assefa Legesse Sisay, Tefera Belachew

“…The study used two-stage cluster sampling to allocate villages into control and intervention groups and systematic random sampling methods to select participants. …”
Get full text

A Comparative Study between Conventional Diaphragmatic Breathing Exercise and Virtual Reality-based Diaphragmatic Breathing Exercise on Quality of Life in Chronic Obstructive Pulmo... by Sridhar Shirodkar, Medha Deo

“…Conclusion: Future studies need to address the long-term effects and stability of the results with a larger sample size, compare the approach with the existing treatments, and make the required smaller changes to the program for better outcomes.…”
Get full text

Clinical and microbiological evaluation of dental plaque on topical application of olive oil, olive oil with 35% Curcuma zedoaria, and olive oil with 30% Azadirachta indica in hosp... by Anshula Deshpande, Simron Baishya, Sneha Dori, Medha Wadhwa, Khushali Shah

“…Settings and Design: This was a randomized control trial. Materials and Methods: 84 hospitalized children of age group 3–14 years were randomly divided by computer-generated random allocation into Group A-EVOO, Group B-EVOO + 35% CZ, Group C-EVOO + 30% AI, and Group D-normal saline with 21 participants in each group and applied with sterile gauze. …”
Get full text

Effects of Nutrition Education on Improving Knowledge and Practice of Complementary Feeding of Mothers with 6- to 23-Month-Old Children in Daycare Centers in Hawassa Town, Southern... by Selam Deksiyous Muluye, Tefera Belachew Lemma, Tona Zema Diddana

“…Among the total daycare centers in the town, five were assigned to receive nutrition education and the rest five for the control group (CG). The simple random sampling technique used to select individual participants from each daycare center. …”
Get full text

Social-demographic and behavioral predictors of core indicators of complementary feeding practices among mothers of children aged 6–23 months: baseline results from a cluster-rando... by Tadele Amente, Yohannes Kebede, Tefera Belachew

Get full text