The relative data hungriness of unpenalized and penalized logistic regression and ensemble-based machine learning methods: the case of calibration by Peter C. Austin, Douglas S. Lee, Bo Wang

“…Optimism is the difference in model performance between derivation and validation samples. The term “data hungriness” refers to the sample size needed for a modelling technique to generate a prediction model with minimal optimism. …”
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Multi-omics analysis reveals that low cathepsin S expression aggravates sepsis progression and worse prognosis via inducing monocyte polarization by Xiao-Ting Luo, Hui-Rong Hu, Zhen-Dong Sun, Li-Hong Zhang, Yan Li

“…Nonetheless, the prognostic role and precise function of monocytes in sepsis are still inadequately understood.MethodsSingle-cell transcriptomic sequencing and bioinformatics analysis were performed on peripheral blood samples from septic patients to identify key molecules in cell subsets. …”
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Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning by Bing Ma, Xiaoru Wang, Chengfei Xu, Zelin Xu, Fei Zhang, Wendan Cheng

“…This study aimed to uncover the genes with a causal relationship to KOA using Mendelian randomization (MR), transcriptomic profiling, and machine learning methods. …”
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Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and serum thyroid function measures: Recent Findings from NHANES 2007–201... by Mo-Yao Tan, Ping Zhang, Shan Wu, Si-Xuan Zhu, Ming Gao

“…Thus, the present article aims to explore whether there is an association between non-high-density to high-density lipoprotein cholesterol ratio (NHHR) and thyroid hormones.MethodsWe analyzed samples from 3,881 adults aged 20 years and above who took part in the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2012. …”
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Effects of Plant Extract and Dietary Supplements on Tinnitus Perception in Adults: A Systematic Review and Meta-Analysis by Yordanis Enriquez Canto, Giovani Díaz Gervasi, Luis Menacho Alvirio, Rafael Pizarro Mena

“…Study quality was assessed using the Revised Cochrane risk-of-bias tool for randomized trials. Protocol registered on PROSPERO (CRD42023446824). …”
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Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics by Chaonan Wang, Yuyao Feng, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Keqiang Shu, Deqiang Kong, Jiaxian Wang, Yiran Li, Xiangling Lei, Chen Li, Bao Liu, Wei Sun, Zhichao Lai

“…These proteins were then mapped to specific regions within the plaques, such as the fibrous cap and lipid core, and further validated in independent samples and single-cell datasets. Furthermore, Mendelian randomization techniques were employed to assess causal relationships between identified proteins levels and ischemic stroke. …”
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Statin Therapy in Early Breast Cancer: The MASTER Trial; A Randomized Phase III, Placebo-Controlled Comparison of Standard (Neo)Adjuvant Therapy Plus Atorvastatin versus Standard (... by Borgquist S, Jensen MB, Bendorff CL, Christiansen P, Offersen BV, Kodahl AR, Ewertz M, Jensen AB, Ahern TP, Cronin-Fenton D, Ejlertsen B

“…Translational endpoints are evaluated in collected blood- and tumor samples.Discussion: If a protective effect of statins on breast cancer recurrence is supported by evidence from the MASTER trial, then the indications for a safe, well-tolerated, and inexpensive treatment can be expanded towards improved clinical outcomes for breast cancer patients.Keywords: statin, breast cancer, recurrence, cholesterol, endocrine therapy, randomized trial…”
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Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis by Hesong Wang, Chenguang Wang, Ruihao Qin, Jia He, Xuan Zhang, Chenjing Ma, Shi Li, Lijun Fan, Liuying Wang, Lei Cao

“…<b>Methods:</b> We performed a proteome-wide Mendelian randomization (MR) to explore potential therapeutic targets for PsO. …”
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Seakeeping of Hydrofoil-Equipped Unmanned Surface VehicleBased on LQR and ZOA by Xinhua SHUI, Fuhai DUAN

“…To minimize the motion amplitude of hydrofoil-equipped USV during navigation, the LQR parameters were optimized using ZOA and particle swarm optimization(PSO) algorithms， respectively under different sampling frequencies and population sizes for comparison. …”
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Clinical and radiographic evaluation of Ga-Al-As diode in immature permanent mandibular first molars direct pulp capping: A 12-month randomized controlled clinical trial by Laila Shbat, Fadi Makhoul, Joul Kassis

“…The study was planned to cap half of the samples with MTA, while the other halves were subjected to laser therapy, followed by standard MTA capping. …”
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Association Between Plasma Amyloid‐Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Tr... by Qianqian Fan, Yonghui Wang, Zhihong Lu, Lini Wang, Xue Yang, Ziyu Zheng, Hailong Dong, Lize Xiong, Chong Lei

“…Participants with blood samples collected were included in this cohort study. …”
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RETRACTED: Comparison of the effect of dydrogesterone and natural micronized progesterone for luteal‐phase support in assisted reproductive technology cycles: A single‐blind random... by Masoomeh Atarieh, Maryam Javadian, Zahra Basirat, Mehdi Kashifard, Shahla Yazdani, Hajar Adib‐Rad, Maryam Abdollahzade‐Delavar, Hemmat Gholinia

“…Samples were randomly divided into two groups. The first group received a natural micronized vaginal progesterone (MVP) of 400 mg once daily and the second group received dydrogesterone (Duphestone) 20 mg twice daily. …”
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Kinematic Constrained RRT Algorithm with Post Waypoint Shift for the Shortest Path Planning of Wheeled Mobile Robots by Sisi Liu, Zhan Zhao, Jun Wei, Qianqian Zhou

“…The optimized path has good convergence and almost does not depend on the state of the initial random path. The comparative test results show that the proposed method has significant advantages over traditional RRT-based methods in terms of the sampling point number, the tree node number, and the path node number. …”
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Efficacy and safety of albendazole alone versus albendazole in combination with ivermectin for the treatment of Trichuris trichiura infections: An open-label, randomized controlled... by Marta Sólveig Palmeirim, Eveline Hürlimann, Prudence Beinamaryo, Hilda Kyarisiima, Betty Nabatte, Jan Hattendorf, Peter Steinmann, Jennifer Keiser

“…Adverse events were monitored at three and 24h post-treatment. Follow-up samples were collected 14 to 21 days post-treatment for efficacy assessment. …”
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Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning,... by Jiyuan Li, Kankan Shui, Longkai Peng, Helong Dai, Fenghua Peng

“…In transplanted kidneys, IL-2RB is predominantly expressed elevated in T cells from rejection samples and is associated with decreased renal function. 10 hub genes were identified based on T cells with high and low expression of IL-2RB, of which NGboost reached AUC 0.77. …”
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Effect of tirzepatide-induced weight loss on adipose tissue in obesity: rationale and design of the randomized placebo-controlled Tirzepatide Brown and Beige Adipose Tissue Activat... by Rok Herman, Mojca Jensterle, Simon Horvat, Luka Lezaic, Ziga Snoj, Igor Pusnik, Katja Goricar, Andrej Cör, Luka Pusnik, Vid Mlacnik, Lara Hanzelic, Andrej Janez

“…Thirty-four participants will be randomized 1:1 to receive either tirzepatide or a placebo for 24 weeks. …”
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Impact of short-term proton pump inhibitors vs. histamine-2 receptor antagonists on gut microbiota in patients with acute coronary syndrome: A multicenter randomized trial by Chen Chen, Huizhu Liang, Meibo He, Ruqiao Duan, Yu Guan, Fangfang Wang, Liping Duan, Sihan Zhou, Xiuyuan Hao

“…The primary outcomes were the alterations in gut microbiota after 7 days of acid suppressant therapy. Stool samples were collected at baseline and 7 days and analyzed by 16S ribosomal RNA (rRNA) gene sequencing. …”
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Effects and mechanisms of acupuncture for PIGD-subtype Parkinson’s disease via integration of fMRI and gut microbiota-metabolomics analysis: protocol for a prospective randomized c... by Jili Sheng, Jili Sheng, Yingqi Xu, Tao Liu, Jianfang Zhu, Caiyun Mu, Lihao Zhai, Shanhu Xu, Hanyi Wang, Xiangzhi Liu, Tao Liu, Xiaoqing Jin

“…Additionally, serum and stool samples will be collected for 16S ribosomal RNA sequencing, and liquid chromatography coupled with tandem mass spectrometry analysis (LC–MS/MS) will be employed to elucidate theunderlying mechanisms. …”
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Maternal and umbilical cord plasma purine concentrations after oral carbohydrate loading prior to elective Cesarean delivery under spinal anesthesia: a randomized controlled trial by Katarzyna Kotfis, Dominika Jamioł-Milc, Arleta Wojciechowska, Aleksandra Szylińska, Arleta Drozd, Małgorzata Zimny, Barbara Dołęgowska, Sebastian Kwiatkowski, Violetta Dziedziejko, Krzysztof Safranow

“…Blood samples were collected at 2 h after carbohydrate consumption (maternal) and at umbilical cord clamping (umbilical cord). …”
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Effect of acarbose and vildagliptin on plasma trimethylamine N-oxide levels in patients with type 2 diabetes mellitus: a 6-month, two-arm randomized controlled trial by Xinhui Yang, Xiuying Zhang, Chen Sun, Cuiling Zhao, Xiangshuang Kong, Mingming Zhao, Linong Ji, Yufeng Li

“…Using the sealed envelope method, participants were randomly allocated (1:1) to either the acarbose group (n = 50) or the vildagliptin group (n = 50). …”
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