A randomized phase I trial of intranasal SARS-CoV-2 vaccine dNS1-RBD in children aged 3–17 years by Kai Chu, Jiali Quan, Xiaohui Liu, Qi Chen, Xia Zang, Hanmin Jiang, Donglin Liu, Xiafei Chu, Chunlan Zhuang, Jinle Han, Xiangzhong Ye, Hongxing Pan, Shoujie Huang, Ting Wu, Jun Zhang, Ningshao Xia

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Effect of the Oral Probiotics on Salivary Alpha-amylase, Buffering Capacity, pH, and Plaque Level among Dental Students – A Pilot Randomized Controlled Trial by S. Savitha Priyadarsini, Kamlesh Manohar Palandurkar, P. G. Naveen Kumar, Mahesh R. Khairnar, Zainab Akram, Ridhi Ghodela, Sachin Kumar Jadhav, Neha Shukla

“…Materials and Methods: This parallel-arm, double-blinded randomized controlled trial was conducted for a period of 5 days on 20 randomly selected dental students allocated into two groups – enKor D and ProGG probiotics, ten in each group. …”
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Pharmacokinetics and bioequivalence assessment of two prucalopride formulations in healthy Chinese women: a randomized, open-label, two-period, two-sequence, self-crossover study by Xiangxin Huang, Ying Wang, Bei Li, Xiaoqun Shen, Xuexia Tao, Wenwen Zheng, Qi Luo, Lei Xiong, Lin Wang, Shufan Cai

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Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial by Hemalatha Rajkumar, Naseha Mahmood, Manoj Kumar, Sudarshan Reddy Varikuti, Hanumanth Reddy Challa, Shiva Prakash Myakala

“…Blood and fecal samples were collected at baseline and after 6 weeks. …”
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Effectiveness and safety of traditional Chinese medical bath therapy combined with ultraviolet irradiation in the treatment of psoriasis: A systematic review and meta-analysis of r... by Jingzhi Guan, Shaofei Yuan, Hanqimuge Wu, Risu Na, Xueqin Wu, Xin Wang, Shan Bao

“…It is necessary to conduct a scientific, normalized and high-quality RCT with multiple large samples and centers.…”
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Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial. by Wiebe M C Top, Philippe Lehert, Casper G Schalkwijk, Coen D A Stehouwer, Adriaan Kooy

“…Plasma samples were drawn at baseline, 4, 17, 30, 43 and 52 months. …”
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Cardiopulmonary bypass and internal thoracic artery: Can roller or centrifugal pumps change vascular reactivity of the graft? The IPITA study: A randomized controlled clinical tria... by Olivier Fouquet, Simon Dang Van, Anna Baudry, Philippe Meisnerowski, Pauline Robert, Frédéric Pinaud, Patrice Binuani, Jean-Marie Chrétien, Daniel Henrion, Christophe Baufreton, Laurent Loufrani

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Evaluation of maxillary miniscrew-anchored molar distalization appliance versus clear aligners in adult with Class II malocclusion: study protocol for a randomized controlled trial by Hao Liu, Ziyan Tang, Zhicheng Gong, Cui Ye, Haimiao Wu

“…Cone-beam CT and digital dental models will be collected before orthodontic intervention and after molar distalization for all samples. This study will register pre- and post-treatment images using maxillary bone structures and then analyze three-dimensional tooth movement. …”
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Sun-dried tomato powder reduces blood sugar levels and improves the lipid profile among people with type-2 diabetes: A randomized controlled trial by Dr Altaf Ahmed, Prashanth Shetty, Geetha B Shetty

“…One cohort provided blood samples daily for 10 consecutive days for laboratory analysis. …”
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Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized c... by Christian N Lotz, Emmanuel C Mrimi, Pierre H H Schneeberger, Said M Ali, Jan Hattendorf, Jennifer Keiser

“…Spearman's rank correlation coefficient examined the correlation between STH eggs per gram in stool samples and qPCR Ct values. Diagnostic sensitivity of qPCR was calculated using a Bayesian latent class modelling approach with data from Ascaris lumbricoides infections. …”
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Action observation treatment may improve daily living activities and verb recovery in Parkinson’s disease-dementia: findings from a preliminary randomized controlled trial by Lucia Paciaroni, Elena Mastrosanti, Leonardo Biscetti, Susy Paolini, Sara Mauri, Paolo Fabbietti, Giovanni Renato Riccardi, Marco Bruno Luigi Rocchi, Giuseppe Pelliccioni

“…The aim of the present randomized controlled study was to assess the benefits of AOT treatment in the activities of daily living (ADLs) and in the linguistic abilities of the patients with Parkinson’s disease dementia (PDD) at mild–moderate stage (Hoehn & Yahr’s stage scale: 2–3).MethodsTwenty patients were enrolled and randomly assigned to an experimental group (submitted to AOT) or to a control group. …”
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Effect of Daily <i>Lactococcus cremoris</i> spp. Consumption Immobilized on Oat Flakes on Blood and Urine Biomarkers: A Randomized Placebo-Controlled Clinical Trial by Panoraia Bousdouni, Aikaterini Kandyliari, Anastasia Kargadouri, Panagiota Potsaki, Olga I. Papagianni, Maria-Eleni Stylianou, Nikoletta Stathopoulou, Panagiota Andrianopoulou, Maria Kapsokefalou, Vasiliki Bountziouka, Anastasia Kolomvotsou, Ioanna Prapa, Gregoria Mitropoulou, Chrysoula Pavlatou, Andreas G. Tzakos, Panayiotis Panas, Yiannis Kourkoutas, Antonios E. Koutelidakis

“…Blood and urine samples were collected at the baseline, 6 weeks, and 12 weeks to assess the glycemic, lipemic, inflammatory, immunological, and antioxidant biomarkers, as well as the vitamin levels. …”
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Efficacy of three different doses of esmolol to attenuate the response of hemodynamic stress to laryngoscopy and endotracheal intubation in general anaesthesia surgeries - a contro... by Pooja Singla, Lalita Chaudhary, Rupesh Yadav

“…Additionally, venous blood samples were collected to assess serum cortisol and blood glucose levels at baseline and 5 minutes post-intubation. …”
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral allosteric TYK2 inhibitor ESK‐001 using a randomized, double‐blind, placebo‐controlled study design by Sibel Ucpinar, Joyce K. Kwan, Joshua D. Hoffman, Mera K. Tilley, Jeffrey A. Douglas, Roman G. Rubio, Ruixiao Lu, Philip A. Nunn, Claire L. Langrish

“…Transcriptomic analysis of unstimulated whole blood samples confirmed dose‐dependent inhibition of Type I IFN‐induced genes and SIGLEC1, a novel TYK2‐responsive biomarker. …”
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Vitamin D probiotics fortification improve vitamin D and total antioxidant capacity levels among pregnant women: a single-blinded randomized controlled trial by Vivian Ayamah, Charles Apprey, Eric Owusu Mensah, Reginald Adjetey Annan, Ebenezer Senu

“…Sociodemographic and clinical data were collected. Venous blood samples were also collected at baseline and end line for serum 25(OH)D and TAC quantification using ELISA (Thermo scientific). …”
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Effect of weight loss and liraglutide on neutrophil gelatinase-associated lipocalin levels among individuals with overweight and knee osteoarthritis: Exploratory analyses of a rand... by Asbjørn Seenithamby Poulsen, Zara Rebecca Stisen, Marie Skougaard, Robin Christensen, Anders Overgaard, Henrik Gudbergsen, Stine Jacobsen, Andreas Peter Balslev-Clausen, Marius Henriksen, Lars Erik Kristensen, Henning Bliddal

“…Results: 168 participants were enrolled to the initial intensive diet intervention; 127 participants, with NGAL samples, were randomized. Following the 8-week diet intervention, NGAL concentrations rose by 93.0 ​ng/mL (95 ​% CI: 18.9 to 167.1, P ​= ​0.015), with no correlation to weight loss magnitude. 52 weeks of treatment with either liraglutide or placebo, liraglutide did not cause a greater decrease in serum NGAL (14.9 ​ng/ml, 95%CI: −92.1 to 121.7 ​ng/mL, P ​= ​0.78). …”
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Virtual reality as a potential therapy in a rehabilitation sanatorium for patients after ischemic stroke: impact on quality of life and social participation—a randomized trial by Marcela Dabrowská, Lucie Honzíková, Dalibor Pastucha, Dalibor Pastucha, Miroslav Janura, Miroslav Janura, Hana Tomášková, Iva Fiedorová, Iva Fiedorová, Šárka A. Čechová, Šárka A. Čechová, Jana Trdá, Milan Elfmark

“…Based on the results of normality test were used: t-test for two samples (age, time since stroke), the chi-square test (gender), nonparametric paired Wilcoxon test and Mann–Whitney U test. …”
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Study protocol for a randomized double-blinded placebo-controlled trial on mepolizumab for patients with chronic rhinosinusitis with nasal polyps, NSAID exacerbated respiratory dis... by Annina Lyly, Annina Lyly, Johanna Sahlman, Johanna Sahlman, Karoliina Pajala, Karoliina Pajala, Maija Salminen, Maija Salminen, Saara Sillanpää, Saara Sillanpää, Jura Numminen, Jura Numminen, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Anu Laulajainen-Hongisto, Mika Mäkelä, Paula Kauppi, Iiris Kangasniemi, Markus Lilja, Markus Lilja, Sari Hammaren-Malmi, Paula Virkkula, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi

“…The study lasts for 6 months, including recruitment visit 2–4 weeks before randomization. Participants will attend 6 visits, during four of which they will receive a subcutaneous injection of the study product. …”
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Effect of a Six-Month Dance Intervention on Postural Control and Fall-Related Outcomes in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial by Ulrich Thiel, Nicole Halfpaap, Berit K. Labott, Fabian Herold, Corinna Langhans, Kristinn Heinrichs, Patrick Müller, Notger G. Müller, Anita Hökelmann

“…Scores on the Falls Efficacy Scale improved significantly in the intervention group, reflecting reduced fear of falling, although only shown by a paired-samples <i>t</i>-test (t(23)= 2.276, <i>p</i> = 0.032, d = 0.465). …”
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The Safety and Immunogenicity of a 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/TT) in Infants: A Double-Blind, Randomized, Phase III Trial by Zhiqiang Xie, Jiangjiao Li, Xue Wang, Lili Huang, Jinbo Gou, Wei Zhang, Haitao Huang, Wangyang You, Feiyu Wang, Xiaolong Li, Jinming Zhang, Qiang Han, Xiaomin Ma, Yanxia Wang

“…Methods: A total of 1200 infants were randomly assigned to either the experimental PCV13i group or the control PCV13 group in a 1:1 ratio. …”
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