Causal Association of Primary Biliary Cholangitis with Adverse Pregnancy and Neonatal Outcomes: A Two-Sample Mendelian Randomization Study by Li R, Tan J, Yang X, Ning Z

“…However, the available observational study evidence results are inconsistent, and causality is unclear.Methods: We used a two-sample Mendelian randomization (MR) analysis to assess the association between PBC and multiple adverse pregnancy events and neonatal outcomes in a European population. …”
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Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study by Song X, Wang Y, Li P, Wang Y, Wen X, Nie Q, An W, Wang H, He F

“…Xuwen Song,1 Yikang Wang,2 Pengsheng Li,3 Yafei Wang,4 Xinghui Wen,4 Qingwen Nie,1 Wanlu An,1 Huan Wang,1 Fang He1 1Department of Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China; 3Department of Obstetrics, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, Guangdong Province, People’s Republic of China; 4Department of Obstetrics and Gynecology, The Second People’s Hospital of Guiyang, Guiyang, Guizhou Province, People’s Republic of ChinaCorrespondence: Fang He, Department of Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Tel +8618922182396, Email hefangjnu@126.comBackground: Observational epidemiologic investigations into the link between diabetes mellitus and preeclampsia (PE) have been conducted, but genetic evidence is still lacking. We utilized a two-sample Mendelian randomization (MR) analysis to shed light on the potential influence of type 2 diabetes mellitus (T2DM) on PE at the genetic prediction level.Methods: We carried out a two-sample bidirectional MR analysis, utilizing genetic variants associated with T2DM (N=461,920) and PE (N=219,817) from the largest available genome-wide association studies. …”
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Complex Role of Circulating Triglycerides in Breast Cancer Onset and Survival: Insights From Two‐Sample Mendelian Randomization Study by Wu Zhang, Zhiru Li, Yuquan Huang, Jing Zhao, Shaowei Guo, Qian Wang, Sihan Guo, Qingxia Li

“…We performed a two‐sample causality inference analysis using the inverse‐variance weighted method. …”
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Causal association between EBV and gastritis, gastric cancer, and gastric ulcer: a two-sample Mendelian randomization study by Xiaoyuan Qiao, Jun Ma, Chunyan Wang, Xing Gou, Lijuan Huo

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Causal effect between circulating metabolic markers and glioma: a bidirectional, two-sample, Bayesian weighted Mendelian randomization by Jiachen Wang, Chengzhuo Wang, Shenglan Li, Mengqian Huang, Rong Zhang, Yuxiao Chen, Zhuang Kang, Wenbin Li

“…Based on publicly available genome-wide association study data, this study employed a bidirectional, two-sample Mendelian randomization (MR) analysis, combined with Bayesian weighted MR, to investigate the causal effect of 233 circulating metabolic traits on glioma and its subtypes, with the expectation of discovering new diagnostic and therapeutic targets. …”
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Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study by Yao Yiming, Zhou Shiqiang, Fang Yumin, Zeng Wenxing, Zhan Shaofeng

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Causal impacts of 731 immunocyte phenotypes on colorectal cancer-evidence from a bidirectional two-sample Mendelian randomization by Xinyue Gu, Shihui Zhao, Mingyu Xia, Songtao Du, Liqiang Song, Tianyi Xia, Bomiao Zhang

“…The bidirectional two-sample Mendelian randomization analysis was performed to explore the association between 731 types of immune cell phenotypes-specific changes and colorectal cancer. …”
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Enhancing the robustness of Mendelian randomization studies: lessons from a two-sample analysis of viral infections and colorectal cancer by Tianfei Yu, Jinyong Xia, Haichang Yin, Nana Yi, Lanlan Zhang, Ming Li

“…Abstract This Matters Arising article critically examines the study “Genetic susceptibility association between viral infection and colorectal cancer risk: a two-sample Mendelian randomization analysis” by Li et al., highlighting both its contributions and methodological limitations. …”
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Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study by DU Yuhan*，LIANG Jiahao，SONG Mingze，WANG Hai

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Exploring the causal role of plasma metabolites and metabolite ratios in prostate cancer: a two-sample Mendelian randomization study by Changzhou Feng, Haining Li, Chu Zhang, Ying Zhou, Huanhuan Zhang, Ping Zheng, Shaolin Zhao, Lei Wang, Jin Yang

“…By employing a novel two-sample Mendelian randomization (MR) approach, this study aims to elucidate the causal relationships between the circulating metabolome and PCa risk, utilizing comprehensive data on genetically determined plasma metabolites and metabolite ratios.MethodsFor the MR analysis, we utilized data from the GWAS Catalog database to analyze 1,091 plasma metabolites and 309 ratios in relation to PCa outcomes within two independent GWAS datasets. …”
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A two-sample Mendelian randomization study reveals the causal effects of statin medication on gut microbiota abundance in the European population by Peng Zhou, Peng Zhou, Chen Qiu, Zequn Zhuang, Kaihang Shi, Zhihui Yang, Yuyan Ding, Huiheng Qu, Jiazeng Xia, Jiazeng Xia

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NONPARAMETRIC METHOD OF RECONSTRUCTING PROBABILITY DENSITY ACCORDING TO THE OBSERVATIONS OF A RANDOM VARIABLE by A. D. Kryzhanovsky, A. A. Pastushkov

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The impact of fractional cover distribution in training samples on the accuracy of fractional cover estimation: a model-based evaluation by Rujia Wang, Chen Shi

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Digital model of a pseudo-random number generator based on a continuous chaotic system by Y. A. Drybin, S. V. Sadau, V. S. Sadau

Subjects: “…time sampling, deterministic chaos, lorentz system, random sequences, digital model…”
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FRRT*-Connect: A Bidirectional Sampling-Based Path Planner with Potential Field Guidance for Complex Obstacle Environments by Wenshan Yan, Xiangrong Xu, Aleksandar Rodić, Petar B. Petrovich

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Pre-modulated multi-coset sampling system by Huang Zhen, Bai Zhengyao

“…At present, the compressed sampling system mainly includes three sampling system: random demodulator，modulated wideband converter and multi-coset sampling, among them, the system framework of multi-coset sampling is simple and has a high reconstruction success rate. …”
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Sampling method for IDS in high bandwidth network by NING Zhuo1, GONG Jian1, GU Wen-jie1

“…A novel sampling method,IDSampling,was developed to solve the performance unbalance problem that IDS could not scale well in G+bit/s link,which was adaptive with the consumption of the memory bottleneck.With the help of the heuristic messages,such as the entropy of the single-packet flow and the flow length,IDSampling applied the simple sampling strategy based on the entropy of the single-packet flow when the large-scale anomaly occurred,or another complicated one instructed by the feedback of the rear detection results by default.In both cases IDSampling tried to guaran-tee the equal security with detection cost as low as it could.The results of experiment show that ①IDSampling keeps IDS effective by cutting off its load significantly when it is overloaded,at the same time it can guarantee the detection accuracy of the large-scale attack;②Comparing with the other two overwhelming sampling methods,the random packet sampling and the random flow sampling,the number of attack packets sampled by IDSampling is higher than that of the former two,the number outweighs the former two one order of magnitude especially in the large-scale anomaly case.…”
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Unconstrained Metropolis–Hastings Sampling of Covariance Matrices by Daniel Turek

“…Markov chain Monte Carlo (MCMC), the predominant algorithm for fitting hierarchal models to data in a Bayesian setting, relies on the ability to sample from the full conditional distributions of unobserved parameters. …”
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An effective imputation method to minimize the effect of random non-response in estimation of population variance on successive occasions by Anup K. Sharma

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Efficacy and Safety of a Novel Tapered-Tip Sheath System for Biliary-Lesion Tissue Sampling: A Randomized Controlled Trial by Hirokazu Okada, Norimitsu Uza, Tomoaki Matsumori, Hajime Yamazaki, Muneji Yasuda, Takeshi Kuwada, Yoshihiro Nishikawa, Takahisa Maruno, Masahiro Shiokawa, Atsushi Takai, Ken Takahashi, Akihisa Fukuda, Etsuro Hatano, Sachiko Minamiguchi, Hiroshi Seno

“…In this study, we aimed to assess the efficacy and safety of a novel tapered-tip sheath system for tissue sampling from biliary strictures. Methods: This single-center, randomized, parallel-group clinical trial included patients aged 20 to 85 years admitted to Kyoto University Hospital for biliary strictures. …”
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