Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis by Yuxin Lin, Xiaoping Zhong, Zhengyuan Chi, Hui Li, Rui Han, Hao Li, Shukai Zheng, Shijie Tang, Jiasheng Chen

“…Although the mechanisms underlying TS-induced CP remain incompletely understood, this study provides novel insights by integrating multi-omics with Mendelian Randomization (MR) analyses. By utilizing two-sample MR and sensitivity analyses, we identified protective metabolites associated with CP, including glycerate, glycochenodeoxycholate, and isobutyrylcarnitine. …”
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Circulating 25‐Hydroxyvitamin D Levels During Pregnancy and Risk of Congenital Heart Diseases: Multivariable and Mendelian Randomization Analyses Using 3 Birth Cohorts by Karen Christina Walker, Ina O. Specht, Vibeke Hjortdal, Henrik T. Christesen, Berit L. Heitmann, Gillian Santorelli, Jane West, Per Magnus, Pål R. Njølstad, Elizabeth C. Corfield, Alexandra Havdahl, Maria Magnus, Kurt Taylor, Deborah A Lawlor

“…Results were pooled across the 3 cohorts in a meta‐analysis with random effects and consistency between results from the MVR and MR was examined. …”
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Intravenous vs. Oral Dose Comparison of Ibuprofen and Tramadol Combinations—Enantiomers, Metabolite, Linearity, and Sex-Related Effects: A Pharmacokinetics Randomized Clinical Tria... by Carmen Portolés-Díez, María Rosario Salas-Butrón, Ana Ascaso-del-Rio, Ana B. Rivas-Paterna, Leonor Laredo-Velasco, Carlos Calandria, Nuria Sanz, Annik Bergeron, Luis Santé, Emilio Vargas-Castrillón, Antonio Portolés-Pérez

“…Given the exploratory nature of the study, the sample size was small to provide sufficient power for comparisons of differences across all subgroups. …”
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Safety and efficacy of different rotational speed during rotational atherectomy in coronary heart disease patients (RACE): study protocol for a randomized controlled trial by Jie Xu, Yu-wei Wang, Li-Kun Ma, Hao Hu, Hong-Wu Chen, Jing-Sheng Hua, Xiang-Yong Kong, Dan Li, Long-Wei Li, Jia-Wei Wu

“…An estimated 210 patients will be enrolled based on sample size calculation, randomly assigned in a 1:1:1 ratio to different rotational speed protocols using a random number table. …”
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Associations Between Obstructive Sleep Apnea and Metabolic Dysfunction-Associated Fatty Liver Disease: Insights from Comprehensive Mendelian Randomization and Gene Expression Analy... by Ma T, Liao C, Chen W, Feng J

“…We aimed to investigate their causal associations and shared biomarkers using Mendelian randomization (MR) and bioinformatics approaches.Methods: We used OSA-related and MAFLD-related GWAS data to explore their causal relationship and the role of body mass index (BMI) through two-sample and network MR analysis. …”
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SUNLAND: a randomized, double-blinded phase II GERCOR trial of sunitinib versus placebo and lanreotide in patients with advanced progressive midgut neuroendocrine tumors by Pascal Hammel, Denis Smith, Pauline Afchain, Sophie Dominguez-Tinajero, Jean-François Seitz, Astrid Lievre, Eric Van Cutsem, Eric Assenat, Frédéric Di Fiore, Marc Peeters, Iradj Sobhani, Eric Raymond, Emilie Charton, Dewi Vernerey, Louis De Mestier, Catherine Lombard-Bohas

“…The planned sample size was 104 patients. The primary outcome was investigator-assessed progression-free survival (PFS). …”
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Scaling up interpersonal psychotherapy training: A pilot randomized controlled trial of digital asynchronous self-directed vs. synchronous group workshop training by Paula Ravitz, Natalie Heeney, Andrea Lawson, Edward McAnanama, Clare Pain, Alex Kiss, Priya Watson, Jan Malat, Sophie Grigoriadis, Simone Vigod, Daisy R. Singla

“…Methods: We developed digital IPT training and evaluated it in a pilot parallel randomized controlled trial. Psychiatry residents (N=25) in Toronto, Canada, were randomly assigned, 1:1, to an asynchronous self-directed digital course (intervention; n=13) or synchronous group training-as-usual workshop (control; n=12) and then delivered ∼12 clinically-supervised individual IPT sessions to depressed patients (N=26; 10≥PHQ9<20). …”
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Understanding the risk of diabetic retinopathy from glucagon-like peptide-1 receptor agonists: a Mendelian randomization study and systematic review of European populations by Baixuan Shen, Wanying Wang, Yuanhui Guo, Zilong Chen, Chuanxin Liu, Jiarui Huang, Ying Li

“…Therefore, clinical trials with larger sample sizes and longer follow-up times are warranted to determine this.…”
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The impact of the SKILLZ intervention on sexual and reproductive health empowerment among Zambian adolescent girls and young women: results of a cluster randomized controlled trial by Lila A. Sheira, Chama Mulubwa, Calvin Chiu, Jenala Chipungu, Chelsea Coakley, Helene Smith, Ushma D. Upadhyay, Chansa Chilambe, Besa Chibwe, Jake M. Pry, Boyd Mkandawire, Maggie Musonda, Carolyn Bolton Moore, Jenny Liu

“…Methods Data come from the ‘SKILLZ’ study, a cluster randomized controlled trial evaluating the impact of a peer-led, sports-based health education program. …”
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Impacts of multisectoral cash plus programs after four years in an urban informal settlement: Adolescent Girls Initiative-Kenya (AGI-K) randomized trial. by Beth Kangwana, Karen Austrian, Erica Soler-Hampejsek, Nicole Maddox, Rachel J Sapire, Yohannes Dibaba Wado, Benta Abuya, Eva Muluve, Faith Mbushi, Joy Koech, John A Maluccio

“…<h4>Methods</h4>The study used a randomized trial design, longitudinally following 2,075 girls 11-14 years old in 2015 until 2019. …”
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Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative con... by Judith S Brand, Romy Gaillard, Jane West, Rosemary R C McEachan, John Wright, Ellis Voerman, Janine F Felix, Kate Tilling, Deborah A Lawlor

“…Study limitations include measurement error due to maternal self-report of smoking and the modest sample size for MR analyses resulting in unconfounded estimates being less precise. …”
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Effects of Mental Imagery on Quality of Life, Cognitive, and Emotional Status in Older Adults with Early-Stage Alzheimer’s Disease Dementia: A Randomized Controlled Trial by Anna Christakou, Christina Bouzineki, Marousa Pavlou, George Stranjalis, Vasiliki Sakellari

“…The sample from an Athens Day Care Center of the Alzheimer Association was randomized to (a) the MI and exercise group (intervention group, n = 55), (b) the only exercise group (1st control group, n = 52), and (c) the neither MI nor exercise group (2nd control group, n = 53). …”
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Protocol for a parallel-group, superiority randomized controlled trial of the PulsePoint mobile application to increase bystander resuscitation in out-of-hospital cardiac arrest by Steven C. Brooks, John M. Tallon, Sandra Jenneson, Ashish R. Panchal, Robert Grierson, Laurie J. Morrison, Damon C. Scales, Andrew Day, Lindsay O’Donnell, Randy S. Wax, Helen Connolly, Jennie Helmer, Heidi Corneil, Jim Christenson

“…Eligible 9-1-1 calls for suspected non-traumatic OHCA occurring in a public (non-residential) location are randomized in real time to activation or suppression of the PulsePoint system. …”
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Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study by Mengyuan Wang, Zhouyi Yin, Hengmin Xu, Zongchao Liu, Sha Huang, Wenhui Wu, Yang Zhang, Tong Zhou, Weicheng You, Kaifeng Pan, Wenqing Li

“…Methods: Plasma metabolites associated with GC risk were identified through a case-control study. Bi-directional two-sample Mendelian randomization analyses were performed to determine potential causal relationships utilizing the Shandong Intervention Trial (SIT), a nested case-control study of the Mass Intervention Trial in Linqu, Shandong province (MITS), China, the UK Biobank, and the FinnGen project. …”
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Genetic influence of the brain imaging phenotypes, brain and cerebrospinal fluid metabolites and brain genes on migraine subtypes: a Mendelian randomization and multi-omics study by Ping-An Zhang, Jie-Lin Wang, Mei-Hua Dong, Xiang-Chun Huang, Nai-Jian Li, Run-Dong Qin, Jing Li

“…Traits showing significant correlations were analyzed using bidirectional two-sample MR (TSMR), followed by two-step TSMR to identify cross-omics mediation effects. …”
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From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis by Yifan Zhou, Jialong Dong, Zhenyu Wang, Chen Huang, Xiaotong Yu, Xinjun Wang, Bo Yang, Yuechen Wu, Qing Peng

“…Methods GWAS data of 207 GM taxa (from phylum to species) were acquired from the Dutch Microbiome Project (N = 7,824), and DR from FinnGen (over 300,000 individuals). A bidirectional two-sample Mendelian Randomization (TSMR) analysis was conducted to elucidate directional causality between GM and DR. …”
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Effectiveness of Group Problem Management Plus, a brief psychological intervention for adults affected by humanitarian disasters in Nepal: A cluster randomized controlled trial. by Mark J D Jordans, Brandon A Kohrt, Manaswi Sangraula, Elizabeth L Turner, Xueqi Wang, Pragya Shrestha, Renasha Ghimire, Edith Van't Hof, Richard A Bryant, Katie S Dawson, Kedar Marahatta, Nagendra P Luitel, Mark van Ommeren

“…<h4>Methods and findings</h4>We conducted a cluster randomized controlled trial (cRCT) from November 25, 2018 through September 30, 2019. …”
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Genetic evidence reveals phosphatidylcholine as a mediator in the causal relationship between omega-3 and multiple myeloma risk by Jian Li, Youxuan Li, Jun Wang, Yilang Zhou, Zhenzhen Wu, Yu Song, Guoqing Zhu, Jie Tian

“…First, we conducted a two-sample MR study with MM using the omega-3 GWAS data from Richardson TG. …”
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Unveiling Potential Blood Markers for Endometriosis Through the Integration and Experimental Validation of Immune Cell Traits Genome and Genome-Wide Associated Data by Mei J, Jiang XY, Zhang B, Wang L, Zhang AX, Li JJ, Chen SX, Xu X, Hu JJ, Zhou SG

“…The flow cytometry results indicated that the expression level of CD28 on CD28+ DN (CD4-CD-8) was significantly increased in the ectopic intima of EM patients.Conclusion: Our study demonstrated a causal relationship between immune traits and EM, and the results were verified by clinical samples. The study may provide new biomarkers for the early diagnosis and immunotherapy of EM.Keywords: endometriosis, Mendelian randomization, immune cell traits, flow cytometry…”
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A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain by Cheng DK, Simpson R, Moineddin R, Katz J, Mulsant BH, Vasudev A, Greiver M, Hosseiny F, Inzitari M, Newman RI, Rivlin​ L, Foat KD, Furlan AD, Flannery JF, Telner D, Bosma R, Naimer M, Chung C, Pinto AD, Nelson MLA, Upshur R, Sud A

“…Future trials should include larger sample sizes in non-pandemic conditions to better evaluate the effectiveness of SSM. …”
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