Recombinant human growth hormone and brain neoplasm association: a pharmacovigilance and Mendelian randomization analysis based on US FAERS, Japanese JADER, and Canadian CVARD by Li Huang, Mei Zhang, Fang Li, Yinpeng Xu

“…Disproportionality analysis methods, including the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), and Information Component (IC), were used to detect pharmacovigilance signals. Subsequently, a two-sample Mendelian randomization analysis was conducted, treating rhGH as the exposure and brain neoplasm as the outcome, to evaluate the causal relationship.ResultsA total of 323 reports of rhGH-associated brain neoplasms AEs were identified (FAERS: n = 282; JADER: n = 14; CVARD: n = 27). …”
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CD28+ CD45RA− CD8br AC mediated the effects of Interleukin- 6 on Alzheimer's disease: A Mendelian Randomization Study by Rui Xu, YongJun Gao

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Mixing a Grounded Theory Approach with a Randomized Controlled Trial Related to Intimate Partner Violence: What Challenges Arise for Mixed Methods Research? by Cristina Catallo, Susan M. Jack, Donna Ciliska, Harriet L. MacMillan

“…Little is known about how to systematically integrate complex qualitative studies within the context of randomized controlled trials. A two-phase sequential explanatory mixed methods study was conducted in Canada to understand how women decide to disclose intimate partner violence in emergency department settings. …”
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Comparing supervised classification algorithm–feature combinations for Spartina alterniflora extraction: a case study in Zhanjiang, China by Qiujie Chen, Qiujie Chen, Chunyan Shen, Hong Du, Danling Tang

“…The sample dataset was divided into training and validation sets at a ratio of 7:3, yielding a sub-dataset with Jeffries–Matusita distances of 1.893–2.000, which satisfied classification requirements. …”
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Context-Tailored Food-Based Nutrition Education and Counseling for Pregnant Women to Improve Birth Outcomes: A Cluster-Randomized Controlled Trial in Rural Malawi by Penjani Rhoda Kamudoni, Lillian Kaunda, Marion Tharrey, Maggie Mphande, Shyreen Chithambo, Elaine Ferguson, Zumin Shi, Ibrahimu Mdala, Kenneth Maleta, Alister Munthali, Gerd Holmboe-Ottesen, Per Ole Iversen

“…Twenty villages (clusters) were randomly assigned to an intervention or a control group. …”
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Enhancing Engagement, Practice Integration, and Skill Learning in Mobile Technology–Delivered Interventions Using Human Support: Randomized Controlled Trial With Depressed College... by Colleen S Conley, Brynn M DeLorenzo, Carol H Gonzales, Ian J Kahrilas, Jennifer Duffecy, Rebecca L Silton

“…ObjectiveThis randomized controlled trial evaluated the impact of two human support enhancements—(1) a one-time face-to-face orientation with or without (2) placement in a peer supportive accountability group—on self-reported and objectively captured mTDI engagement, practice integration, and skill learning among a sample of college students with depression. …”
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VORTEX (Variscite origin recognition technology X-ray based) Data. A European geoarchaeological green phosphate compositional datasetZenodo by Daniel Sánchez-Gómez, José Ángel Garrido-Cordero, José María Martínez-Blanes, Rodrigo Villalobos García, Manuel Edo i Benaiges, Ana Catarina Sousa, María Dolores Zambrana Vega, Ferran Borrell, Rosa Barroso Bermejo, Primitiva Bueno Ramírez, Carlos P. Odriozola

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Causal association between ceramide and salt sensitive hypertension based on plasma metabolomics by YANG Xiaojun, Zhang Bower, LI Boya, WEN Fuyuan, QU Aibin, YAO Xinyue, ZHANG Ling

“…Multivariable Logistic regression analysis was conducted to explore the association between plasma metabolites and SSH. One-sample and two-sample MR analyses and sensitivity analysis were performed to assess the causal relationship between metabolites and SSH. …”
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Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets by Lin Xiao, Tianen Wu

“…Method We conducted a two-sample bidirectional MR analysis using IVW, MR-Egger, weighted median, and other models, leveraging public genetic datasets. …”
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An Integrative Machine Learning Model for Predicting Early Safety Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation by Abilkhair Kurmanaliyev, Kristina Sutiene, Rima Braukylienė, Ali Aldujeli, Martynas Jurenas, Rugile Kregzdyte, Laurynas Braukyla, Rassul Zhumagaliyev, Serik Aitaliyev, Nurlan Zhanabayev, Rauan Botabayeva, Yerlan Orazymbetov, Ramunas Unikas

“…To handle unbalanced classification problems, an adaptive synthetic (ADASYN) sampling approach was used. A fined-tuned random forest (RF) machine learning model was developed to predict early safety outcomes, defined as all-cause mortality, stroke, life-threatening bleeding, acute kidney injury (stage 2 or 3), coronary artery obstruction requiring intervention, major vascular complications, and valve-related dysfunction requiring repeat procedures. …”
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Testing a Machine Learning–Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial by Ariana Kamberi, Benjamin Weitz, Julie Flahive, Julianna Eve, Reem Najjar, Tara Liaghat, Daniel Ford, Peter Lindenauer, Sharina Person, Thomas K Houston, Megan E Gauvey-Kern, Jackie Lobien, Rajani S Sadasivam

“…ConclusionsWe have recruited a diverse sample of individuals who are socioeconomically disadvantaged and designed a rigorous protocol to evaluate the Adapt2Quit recommender system. …”
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Evaluating the performance of pixel-based and object-based multidimensional clustering algorithms for automated surface water mapping by Bohao Li, Kai Liu, Ming Wang, Yanfang Wang, Linmei Zhuang, Weihua Zhu, Chenxia Li, Linhao Zhang, Yanan Chen

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Artificial intelligence-driven near-infrared spectrophotometry model for rapid quantification of anti-nutritional factors in soybean (Glycine max.) by Norberto Jose Palange, Tonny Obua, Julius Pyton Sserumaga, Enoch Wembabazi, Mildred Ochwo-Ssemakula, Ephraim Nuwamanya, Isaac Onziga Dramadri, Moses Matovu, Richard Edema, Phinehas Tukamuhabwa

“…Predictive models were developed through partial least squares (PLS) and random forest (RF) regressions. The random forest models outperformed partial least squares regression with the best predictive performance of R2 test = 0.97; RPD = 5.95 and R2 test = 0.96; RPD = 3.62 for phytate and TTI, respectively. …”
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Randomized community trial to assess nutritional, socioeconomic, and health outcomes of a food forest initiative in Santa Elena Province, Ecuador: a study protocol by Marco Faytong-Haro, Marco Faytong-Haro, Alonso Quijano-Ruiz, Daniel Sanchez, Daniel Sanchez, Patricio Alvarez-Munoz, Patricio Alvarez-Munoz, Stephanie Gallegos-Caamaño, Victor Yambay-Delgado, Karina Checa, María José Delgado-Rendón, Andrea Angulo-Prado

“…In contrast, another similarly characterized commune, also randomly selected through cluster-based sampling, will serve as a control group, receiving no intervention. …”
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The Impact of a Nurse-Led Physical Activity Program on Reducing Obesity and Enhancing Quality of Life Among Obese Adolescents: A Randomized Controlled Trial by Baby Ilavarasi Chakkaravarthi, Theranirajan Ethiraj, Shankar Shanmugam Rajendran, Kannan Kasinathan, Johnson Chinnadurai, Thillainayaki Chandran, Rathiswari Posan

“…Methods and Materials: A quantitative randomized control study was conducted at Choolaimedu Higher Secondary School, Chennai, involving 100 adolescents aged 12–14 years. …”
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Using motivational interviewing to improve sleep quality among patients with hypertension attending a tertiary hospital in southern Nigeria: a randomized controlled trial by Tijani Idris Ahmad Oseni, Ndifreke Ekpo Udonwa, Moyosore Taiwo Makinde, Sekinat Odunaye-Badmus, Aisha Sokunbi, Neba Francis Fuh, Bolanle Oluwatosin Adewuyi, Ofure Ileso, Afiong Oboko Oku

“…Patients were selected through systematic random sampling and randomised into intervention and control group with the intervention group having monthly sessions of motivational interviewing in addition to standard care for hypertension and the control group having standard care only. …”
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Impact of eHealth education to reduce anemia among school-going adolescent girls in rural Bangladesh: Study protocol of a randomized controlled trial by Md Jiaur Rahman, Md Moshiur Rahman, Masayuki Kakehashi, Ryota Matsuyama, Mohammad Habibur Rahman Sarker, Mohammad Ali, Sumaita Kabir Promitee, Junaidi Budi Prihanto, Ashir Ahmed, Yoko Shimpuku

“…A total of 138 anemic (mild and moderate) participants were enrolled. We randomized schools to reduce the health education bias through a simple coin toss technique, then allocated participants to the intervention group (n = 69) and control group (n = 69) by stratified random sampling technique. …”
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The Effect of Benson Relaxation Technique and Lavender Aromatherapy on Anxiety and Hemodynamic Indices of Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical... by Nilufar Mousavi, Behzad Imani, Salman Khazaei, Amir Shams

“…Materials and Methods: In this randomized, nonblinded, parallel-group controlled trial, 105 candidates for CABG were randomly selected by convenience sampling and then allocated to relaxation (n=35), aromatherapy (n=35), and control (n=35) groups by a six-block random assignment. …”
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Dietary patterns and their associations with the occurrence and severity of early childhood caries among 1-5-year-olds in Iran: A multicenter cluster randomized survey. by Ehsan Javadzadeh, Samaneh Razeghi, Ahmadreza Shamshiri, Simin Z Mohebbi

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The added value of an internet-based intervention for treatment of aggression in forensic psychiatric outpatients—study protocol for a multicentre, mixed-methods randomized control... by Hanneke Kip, Lisa Klein Haneveld, Saskia M Kelders

“…Methods This study uses a multicentre mixed-methods randomized controlled trial (RCT) design, with four Dutch forensic outpatient organizations. …”
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