Evaluating causal associations of chronotype with pregnancy and perinatal outcomes and its interactions with insomnia and sleep duration: a mendelian randomization study by Qian Yang, Maria C. Magnus, Fanny Kilpi, Gillian Santorelli, Ana Goncalves Soares, Jane West, Per Magnus, Siri E. Håberg, Kate Tilling, Deborah A Lawlor, M Carolina Borges, Eleanor Sanderson

“…Methods We conducted two-sample MR using 105 genetic variants reported in a genome-wide association study (N = 248,100) to instrument for lifelong predisposition to evening- versus morning-preference. …”
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The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis by Siwen Zhong, Wei Li, Xingliang Yang, Jun Qiao, Quliang Zhong, Yuan Tian, Peng Chen, Yuewei Tao, Fa Sun, Tao Li

“…Methods First, we performed two-sample Mendelian randomization (MR) to confirm the causal relationship between SLE and PCa risk, followed by a two-step MR analysis to evaluate the mediation effects of immune cell characteristics and sex hormone levels. …”
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Use of Wearable Transdermal Alcohol Sensors for Monitoring Alcohol Consumption After Detoxification With Contingency Management: Pilot Randomized Feasibility Trial by Eileen Brobbin, Colin Drummond, Stephen Parkin, Paolo Deluca

“…MethodsA feasibility study was conducted of a convenience sample of 29 current service users from 3 South London alcohol services. …”
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Acupuncture for systemic therapy-associated insomnia in patients with breast cancer: a systematic review and meta-analysis of randomized controlled trials by Lingling Gao, Ying Sun, Tianyu Luo, Huiying Chen, Shan Huang, Ling Zhu, Meixia Ye

“…More studies with rigorous designs and larger sample sizes are warranted to verify the efficacy and safety of acupuncture for insomnia among patients with breast cancer.…”
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The Effect of Digital Addiction Training on University Students’ Digital Addiction, Sleep Quality, and Orexin-A Levels: Randomized Controlled Trial by Zehra İncedal Sonkaya, Burak Yazgan

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Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization by Wu Qianhao, Wu Qianhao, Zhang Jinwen, Zhang Jinwen, Miao Jingjie, Miao Jingjie, Chen Xiaoyu, Zhao Yangfei, Yao Wenxiu, Jiang Xu, Wang Xiaojun, Han Peipei, Guo Qi, Guo Qi

“…However, the causal metabolites and their mechanistic networks remain elusive.MethodsWe combined untargeted LC/GC-MS metabolomics (N=98 Chinese elderly), weighted gene co-expression network analysis (WGCNA), and two-sample Mendelian randomization (MR) using GWAS data (59,333 depression cases with 434,831 controls) to identify depression-associated metabolites and pathways.ResultsLC/GC-MS analysis identified 1,458 metabolites, with 84 differentially expressed in depression (VIP>1.5, p<0.05). …”
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User accommodation to an active microprocessor-controlled knee in individuals with unilateral transfemoral amputation: a 5-week non-randomized trial by Elke Lathouwers, Alexandre Maricot, Bruno Tassignon, Sybille Geers, Louis Flynn, Tom Verstraten, Kevin De Pauw

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Causality effect of 21 metals in plasma and serum, 731 immunocytes, and schizophrenia: an intermediary Mendelian randomization study in East Asian populations by Yunchang Yang, Yaofeng Wang, Yunqin Sun

“…This study utilized two-sample Mendelian randomization (MR) analysis to establish causal relationships, which was achieved by employing various statistical methods, including inverse variance-weighted, simple mode, MR–Egger, weighted median, and weighted mode. …”
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Differential effects of left DLPFC anodal and cathodal tDCS interventions on the brain in children with autism: A randomized controlled trial by Jiannan Kang, Juanmei Wu, Xinping Huang, Wenqin Mao, Xiaoli Li

“…Methods: This study recruited a total of 24 children with ASD (20 males and 4 females; mean age ± SD: 5.5 ± 1.2 years), who were randomly divided into two groups receiving either anodal or cathodal tDCS targeting the DLPFC. …”
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Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis by Xinping Huang, Hailong Shu, Man Xu, Weixiao Ke, Wanting Chen, Wenbin Huang, Hai Wang, Yifan Zhu, Yongxia Yang

“…Methods This study systematically investigated the relationship between taurine level changes and breast cancer development through cell experiments, animal models, and clinical sample analysis. 1H NMR and HPLC techniques were used to measure taurine levels in different breast cancer cell lines, MMTV-PyMT transgenic mouse models, and clinical patient serum. …”
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Chinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trials by Xiao-wen Zhang, Jing Li, Wen-bin Hou, Yue Jiang, Ruo-xiang Zheng, De-hao Xu, Chen Shen, Nicola Robinson, Jian-ping Liu

“…Conclusions: CHM may improve the liver function indices and effective rate for HIV/AIDS patients with DILI. However, the sample size was small and quality was low. Larger-samples of high-quality trials are needed.…”
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VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation by Wu W, Cai H, Nan Y, Tang J, Wang Y

“…In this paper, we identified new susceptibility genes in RA and investigated their underlying mechanisms using integrated Mendelian randomization (MR) analysis.Methods: Two-sample MR analyses were used to determine the causative links among eQTLs, metabolites, and RA risk. …”
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Supera cognitive stimulation study with cognitively-unimpaired older adults: methodology and initial results of a randomized controlled clinical trial by Thais Bento Lima da Silva, Tiago Nascimento Ordonez, Gabriela dos Santos, Laydiane Alves Costa, Ana Paula Bagli Moreira, Diana dos Santos Bacelar, Maria Antonia Antunes de Souza, Sabrina Aparecida da Silva, Sonia Maria Dozzi Brucki, Monica Sanches Yassuda

“…The aim of the present study was to describe the methods and the initial characteristics of the participants in a randomized controlled trial on cognitive stimulation. …”
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The California Resuscitation Outcomes Consortium (CAL-ROC): A novel collaboration to facilitate the implementation of randomized clinical trials in the prehospital setting by Juliana Tolles, Jake Toy, Nichole Bosson, David G. Dillon, J. Joelle Donofrio-Odmann, James J. Menegazzi, Juan Carlos C. Montoy, John M. VanBuren, Marianne Gausche-Hill

“…Background: Few large randomized clinical trials (RCTs) have been conducted to inform the prehospital phase of care for out-of-hospital cardiac arrest (OHCA). …”
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Iron Homeostasis as a Mediator Linking Central Obesity with MASLD and Primary Liver Cancer: A Two-Step Mendelian Randomization Study by Yuping Zeng, Xia Wang, Shenlin Liao, Chuan Li, Jie Chen, He He

“…<b>Objectives</b>: This study aimed to explore the mediating effects of iron homeostasis biomarkers linking central obesity with metabolic dysfunction-associated steatotic liver disease (MASLD) and primary liver cancer (PLC) via Mendelian randomization (MR) analysis. <b>Methods</b>: Two-sample bidirectional MR, multivariable MR, and mediation analyses were used to investigate the causal associations among obesity-related traits, iron homeostasis biomarkers, MASLD, and PLC. …”
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Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…However, few effective treatment options are available. Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets. …”
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Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study by Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan, Lin Wang, Haiyan Yang, Yan Li, Kai Chen, Jun Liu, Xi Dong, Yue Zhao, Liangshan Mu

“…Methods We applied two‐sample Mendelian randomization (MR) and colocalization analysis using summary‐level data from genome‐wide association studies of GCKR and GDM. …”
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Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study by Chaozhong Li, Zhengqing Liu, Siqian Yang, Wanrong Li, Bo Liang, Haoyu Chen, Yujia Ye, Fang Wang, Xiaoqing Liu, Yongliang Jiang, Haiying Wu, Yunzhu Peng, Zhaohui Meng

“…The primary objective of this study was to elucidate the potential causal relationships involving gut microbiota-mediated plasma metabolites, inflammatory cytokines, and AAA.Methods We utilized data from genome-wide association studies predominantly comprising individuals of European ancestry, encompassing four major gut microbiota signatures, 233 plasma metabolite signatures (N = 136,016), 91 inflammatory cytokine signatures (N = 14,824), and AAA signatures (N = 1,458,875). Mendelian randomization (MR), employed in a two-sample format, was utilized as a tool to investigate the potential causal pathways from gut microbiota to the development of AAA. …”
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Study protocol of short versus long-term levetiracetam in brain tumors (LIBRA): a phase 3 randomized controlled trial by Archya Dasgupta, Shakthivel Mani, Abhishek Chatterjee, Sadhana Kannan, Aliasgar Moiyadi, Prakash Shetty, Vikas Singh, Nandini Menon, Arpita Sahu, Amitkumar Choudhary, Kajari Bhattacharya, Ameya Puranik, Indraja Dev, Sridhar Epari, Ayushi Sahay, Aekta Shah, Nazia Bano, Farnaz Shaikh, Tejpal Gupta

“…To address this knowledge gap, the current randomized controlled non-inferiority trial will be conducted comparing a shorter regimen of levetiracetam with the standard long-term schedule. …”
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Potential Harms of Feedback After Web-Based Depression Screening: Secondary Analysis of Negative Effects in the Randomized Controlled DISCOVER Trial by Franziska Sikorski, Bernd Löwe, Anne Daubmann, Sebastian Kohlmann

“…MethodsThis is a secondary analysis of the German-wide, web-based, randomized controlled DISCOVER trial. Affected but undiagnosed individuals screening positive for depression (9-item Patient Health Questionnaire [PHQ-9] ≥10 points) were randomized 1:1:1 to receive nontailored feedback, tailored feedback, or no feedback on their screening result. …”
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