Osteoarthritis is a risk factor for renal function injury based on the National Health and Nutrition Examination Survey and Mendelian Randomized study by Liang Pang, Kai Wu, Yibo Zhu, Qianwei Wang, Zhihui Zheng, Cunxian Lv, Zhancheng Bao

“…CKD was calculated using the CKD-EPI equation, and logistic regression assessed by the OA-CKD association. A two-sample MR analysis was conducted using Genome-wide association studies (GWAS) data for OA, hip OA (HOA), knee OA (KOA), acute renal failure (ARF), chronic renal failure (CRF), cystatin C, serum creatinine (eGFRcrea), and microalbuminuria. …”
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Oxidative balance is associated with diabetic kidney disease and mortality in adults with diabetes mellitus: Insights from NHANES database and Mendelian randomization by Li Jiang, Jie Jian, Xulin Sai, Hongda Yu, Wanxian Liang, Xiai Wu

“…Study design A large and representative sample from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 was analyzed to study the potential association between Oxidative Balance Score (OBS) and prognosis of DKD in adult diabetic patients. …”
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Web-Based Human Papillomavirus Education and Professional Skills Intervention for Health Care Providers: Protocol for a Randomized Controlled Trial by Jacob Martinez, Jacquelin I Cordero, Meagan Whitney, Katie L LaRoche, Gabriel Frietze, Eva M Moya, Kristin Gosselink

“…Participants were recruited using a purposive sampling technique, both internet-based and in-person outreach events. …”
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The Impact of a Vitamin C + D Cream Combination on Striae Distensae in Primipara: A Randomized Controlled Clinical Trial Investigation by Hadis Taheri, Masoomeh Kheirkhah, Ali Ghobadi, Nooshin Eshraghi, Shima Haghani

“…Methods: The current research was a clinical study with a control group, which was carried out in parallel with 60 primipara at 18–20 weeks gestational age, who presented at Shahid Akbarabadi Hospital in Tehran between 20/07/2022 to 20/01/2023. Sampling was done using a continuous method, and then allocated into two groups using a random block of 4 and 8 with the Sealed Envelope online software. …”
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Optimizing a community-based intervention to improve help-seeking for depression care: study protocol for a randomized factorial trial by Nagendra P. Luitel, Brandon A. Kohrt, Bishnu Lamichhane, Anvita Bhardwaj, Kamal Gautam, Mark JD Jordans

“…The study will target the adult population, with eligibility criteria including being 18 years or older, residing in specific municipalities, meeting the CIDT threshold for depression, providing consent, and having proficiency in Nepali. The sample size will be 288, with the primary outcome being help-seeking behaviour. …”
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Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects by Wen‐Hui Liu, Hui‐Min Hu, Chen Li, Qing Shi, Yi‐Fan Li, Peng Mao, Bi‐Fa Fan

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Assessing Causality Between Plasma Brain‐Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study by Ming Chen, Hao‐Zhang Huang, Yi‐Hui Liu, Qiang Li, Lin‐Yan Fu, Cai‐Lan Hou

“…ABSTRACT Purpose This study employed a two‐sample Mendelian randomization (MR) approach to investigate the bidirectional relationship between brain‐derived neurotrophic factor (BDNF) and major depressive disorder (MDD), addressing gaps left by prior observational studies. …”
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Investigation into the impact of technology-based motivation program applied to children following cancer diagnosis and their families: a randomized controlled study by Zeynep Kisecik Sengul, Ebru Kilicarslan

“…Chi-square test, Fisher-Exact test, Independent Sample-t test, Mann–Whitney U test, Wilcoxon test, Pearson and Spearman correlation coefficients were used to evaluate the data. …”
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Mediating Role of Blood Metabolites in the Relationship Between Immune Cell Traits and Heart Failure: A Mendelian Randomization and Mediation Analysis by Yi Liu, Chenfu Shen, Yu Cao

“…Methods To investigate the causative relationships and underlying mechanisms between immune cell traits and adult HF, 3 main methods of Mendelian randomization were used: 2‐sample Mendelian randomization, multivariable Mendelian randomization with controlling for several factors affecting HF, and mediation analysis. …”
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Short-Term Spinal Cord Stimulation or Pulsed Radiofrequency for Elderly Patients with Postherpetic Neuralgia: A Prospective Randomized Controlled Trial by Lei Sheng, Zihao Liu, Wang Zhou, Xiaojun Li, Xin Wang, Qingjuan Gong

“…A single-center study with a relatively small sample size. Conclusions. Both PRF and stSCS are effective and safe neuromodulation techniques for elderly patients with PHN. …”
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Resilience in Stroke survivor-care-partner Dyads (ReStoreD): a study protocol for a randomized-control trial by Alexandra L. Terrill, Sasha Gordon, Catharine Sparks, Brian B. Baucom, Beth Cardell, Justin J. MacKenzie, Jennifer J. Majersik, Maija Reblin, Lorie G. Richards

“…Methods Using a fully powered, randomized waitlist-control design, the efficacy of ReStoreD to reduce emotional distress in both dyad members will be determined (Aim 1). …”
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A Causal Inference Study of Circulating Metabolites Mediating the Effect of Obesity‐Related Indicators on the Incidence of Anxiety Disorders by Cheng Qin, Wenbin Gai

“…Methods Employing data from the UK Biobank and FinnGen Consortium, this study conducted genome‐wide association studies (GWAS) and employed a two‐sample Mendelian Randomization (MR) approach to investigate the association between genetic predictors of obesity and anxiety disorders (AD). …”
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Assessment of causality association between serum adiponectin levels and the risk of Alzheimer’s disease and Parkinson’s disease: a Mendelian randomization study by Jiali Lin, Langhuan Lei, Qiuyu Liang, Xiaozhi Huang, Yanping Ding, Liuxian Pan, Jianrong Yang, Wei Li, Wei Li

“…BackgroundUntil recently, the association between circulating adiponectin (ADPN) levels and the risk of Alzheimer’s disease (AD) and Parkinson’s disease (PD) remained unclear.MethodsWe utilized public data from the IEU GWAS database to conduct a two-sample bidirectional Mendelian randomization (MR) analysis and multiple sensitivity analyses. …”
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Cultural Humility: A Collaborative Approach to Recruiting Patients with Deliberate Self-Harm into a Multi-Hospital Randomized Controlled Trial by Suzanne H. Brownhill, Garry J. Stevens, Trent E. Hammond, Richard Baldacchino, Rose Maposa, Bonyface Makoni, Aviva Sheb'a, Jagadeesh Andepalli, Anita Kotak, Olav D'Souza, Azadeh Atashnama, Anish Thayil, Alison Jones

“…Methods: A descriptive study was conducted with a convenience sample of team members who represented different cultures in the study. …”
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Effectiveness of a distance-learning vs standard training in the integrated management of childhood illnesses: a cluster randomized controlled trial by Saidul Abrar, Assad Hafeez, Sana Rahim, Suhail A. R. Doi, Muhammad Naseem Khan

“…Healthcare workers in BHUs (n = 13) randomized to the intervention arm were trained as per the dIMCI protocols while those (n = 13) randomized to the control arm were trained as per the standard protocol. …”
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Effects of Fluid Gelatin for Lumbar Spinal Stenosis Undergoing Lumbar Endoscopic Bilateral Decompression: A Prospective, Randomized Controlled Trial by Hao Yan, Mingdong Yu, Huaibin Wang, Rongsheng Dou, Xiaoyan Xia, Ruzhan Yao, Weiqiang Liu, Jesse Li‐Ling

“…Secondary outcomes encompassed surgical time, intraoperative blood loss, perioperative blood loss, length of stay, and complications. Independent sample t tests were used to compare continuous data. …”
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The ARMADILLO text message intervention to improve the sexual and reproductive health knowledge of adolescents in Peru: Results of a randomized controlled trial. by Jose E Perez-Lu, Fiorella Guerrero, César P Cárcamo, Mónica Alburqueque, Marina Chiappe, Michelle J Hindin, Ndema Habib, Lale Say, Lianne Gonsalves, Angela M Bayer

“…<h4>Results</h4>In total, 712 participants were randomized to the three arms: 659 completed an endline assessment and were included in the primary analysis. …”
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Effect of Antibiotics on Clinical and Laboratory Outcomes After Mandibular Third Molar Surgery: A Double-Blind Randomized Clinical Trial by Fatemeh Soleymani, José Eduardo Maté Sánchez de Val, Artiom Lijnev, Mehrdad Makiabadi, Carlos Pérez-Albacete Martínez

“…<b>Methods</b>: Eighteen healthy adult patients requiring impacted mandibular third molar extraction were randomly assigned to two groups: an experimental group (EG) receiving 2 g of amoxicillin and a placebo group (PG) receiving empty capsules, one hour before the surgery and before taking the first saliva sample. …”
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Causal Pathways Between Breast Cancer and Cardiovascular Disease Through Mediator Factors: A Two-Step Mendelian Randomization Analysis by Lu W, Li K, Wu H, Li J, Ding Y, Li X, Liu Z, Xu H, Zhu Y

“…Our study endeavors to investigate the causal association between BC and CVD, with a focus on identifying potential metabolic mediators and elucidating their mediation effects in this causality.Methods: In this study, we conducted two-sample Mendelian randomization (MR) to estimate the causal effect of BC (overall BC, ER+ BC, ER- BC) from the Breast Cancer Association Consortium (BCAC) on CVD including coronary heart disease (CHD), hypertensive heart disease (HHD), ischaemic heart disease (IHD), and heart failure (HF) from the FinnGen consortium. …”
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Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study by Ming-Jie Jia, Li Zhou, Xing-Ning Liu, Hui-Lin Li

“…ObjectiveTo investigate the association between polycystic ovary syndrome (PCOS) and inflammatory proteins, and to identify and quantify the role of serum metabolites as potential mediators.MethodsUtilizing summary-level data from a genome-wide association study (GWAS), we conducted a two-sample Mendelian Randomization (MR) analysis, a genetic approach that uses genetic variants as instrumental variables to assess the causal relationships between risk factors and outcomes. …”
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