Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis by Xiaorui Zhou, Juan Liao, Li Liu, Yajing Meng, Dailan Yang, Xuehong Zhang, Lu Long

“…We conducted a longitudinal cohort study and a two-sample Mendelian randomization (MR) analysis to assess the association of depression with severe NAFLD risk. …”
Get full text

The efficacy of a novel tomato extracts formulation on skin aging and pigmentation: A randomized, double-blind, parallel-controlled trial by Silu Zhang, Shan Lu, Yun Wang, Jiayi Ni, Guoxun Xiao

“…After eight weeks of intervention with the sample, blood levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) increased, while malondialdehyde (MDA) levels decreased. …”
Get full text

Investigating the Mediating Role of Cardiometabolic Traits in the Causal Link Between SHBG Levels and Stroke Risk via Network Mendelian Randomization by Peijiang Pan, Hao Liang, Mingli Li

“…We explored whether SHBG levels are causally associated with stroke via cardiometabolic traits. A network two-sample Mendelian randomization (MR) study was conducted to determine the mediating roles of cardiometabolic traits in the causal effects of SHBG levels on stroke subtypes. …”
Get full text

NOURISH-US: a mixed-methods, randomized crossover study of a program designed to reduce the financial burden of food allergy by Michael A. Golding, Sarah Baldwin, Brandon Kim, Zoe Harbottle, Manvir Bhamra, Dylan S. Mackay, Moshe Ben-Shoshan, Jennifer D. Gerdts, Elissa M. Abrams, Sara J. Penner, Jo-Anne St-Vincent, Jennifer L. P. Protudjer

“…Results A total of 14 participants were randomized to a sequence using Stata. However, 5 participants were dropped from the final quantitative sample due to a failure to complete one or more set of quantitative measures. …”
Get full text

Longitudinal Associations Between Adolescents’ mHealth App Use, Body Dissatisfaction, and Physical Self-Worth: Random Intercept Cross-Lagged Panel Study by Hayriye Gulec, Michal Muzik, David Smahel, Lenka Dedkova

“…MethodsThe data were gathered from a nationally representative sample of Czech adolescents aged between 11 and 16 years (N=2500; n=1250, 50% girls; mean age 13.43, SD 1.69 years) in 3 waves with 6-month intervals. …”
Get full text

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study. by Mark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard M Martin, Steven Thomas, Jessica Tyrrell, Paul Brennan, Miranda Pring, Stefania Boccia, Andrew F Olshan, Brenda Diergaarde, Rayjean J Hung, Geoffrey Liu, Danny Legge, Eloiza H Tajara, Patricia Severino, Martin Lacko, Andrew R Ness, George Davey Smith, Emma E Vincent, Rebecca C Richmond

“…We appraised the relationship of genetically-proxied cholesterol-lowering drug targets and other circulating lipid traits with oral (OC) and oropharyngeal (OPC) cancer risk using two-sample Mendelian randomization (MR). For the primary analysis, germline genetic variants in HMGCR, NPC1L1, CETP, PCSK9 and LDLR were used to proxy the effect of low-density lipoprotein cholesterol (LDL-C) lowering therapies. …”
Get full text

The participation in cervical cancer screening is not altered by the Hawthorne effect among patients of doctors participating in the randomized clinical trial PaCUDAHL by Gabrielle Lisembard, Michaël Rochoy, François Quersin, Valérie Deken, Alain Duhamel, Axel Descamps, Christophe Berkhout, Fanny Serman

“…Abstract Objective The PaCUDAHL randomized clinical trial evaluated an HPV self-sampling device provided by the family doctor to female patients not participating in the usual opportunistic cervical screening program from 2016 to 2019. …”
Get full text

ST waveform analysis vs cardiotocography alone for intrapartum fetal monitoring: An updated systematic review and meta‐analysis of randomized trials by Ellen Blix, Kjetil Gundro Brurberg, Eirik Reierth, Liv Merete Reinar, Pål Øian

“…Material and methods We performed systematic literature searches to identify randomized controlled trials and assessed included studies for risk of bias. …”
Get full text

Results of a double-blind, randomized, comparative, cross-sectional study of the pharmacokinetics and pharmacodynamics of genetically engineered human insulin preparations by Alexander Mayorov, Olga Avdeeva, Ekaterina Koksharova, Tatyana Belikova, Ekaterina Mishina, Roman Dray

“…The duration of blood sampling to determine the pharmacokinetic parameters was 10 hours: the concentration of insulin in the blood was determined by enzyme-linked immunosorbent assay. …”
Get full text

An introduction to MyBFF@school, a school-based childhood obesity intervention program: a cluster randomized controlled trial by Abdul Halim Mokhtar, Zahari Ishak, Fuziah Md. Zain, Rusidah Selamat, Abqariyah Yahya, Muhammad Yazid Jalaludin

“…The main MyBFF@school in 2016 addressed the challenges and improvised the design which were elaborated in subsequent articles in this supplement. This cluster randomized controlled trial was conducted in three states; Federal Territory of Kuala Lumpur, Selangor and Negeri Sembilan in 23 primary and 15 secondary schools were selected through proportionate random sampling. …”
Get full text

Sliding window constrained fault-tolerant filtering of compressor vibration data by Shaolin Hu, Xianxi Chen, Guoxi Sun

“…This difference series is then subjected to an additional smoothing estimation process, and the resulting smoothed estimates are employed to compensate for the smoothed estimates of the original sampled series. The experimental results indicate that, compared with sliding mean filtering, sliding median filtering and Savitzky–Golay filtering, the method proposed in this paper can more effectively filter out random errors and reduce the impact of outliers when dealing with sampling data contaminated by noise and outliers. …”
Get full text

Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis by Mingrui Zou, Mingmei Lin, Kai-Lun Hu, Rong Li

“…This study aims to integrate transcriptome-wide association study (TWAS), Mendelian randomization (MR), and bioinformatics analyses to reveal novel putatively causal genes and potential mechanisms. …”
Get full text

A randomized controlled trial of a therapist-guided online intervention for depressed adults and its utility as an adjunctive to antidepressants and psychotherapy by Manuel Heinrich, Pavle Zagorscak, Christina Kampisiou, Johannes Bohn, Lars Schulze, Carmen Schaeuffele, Annette Brose, Christine Knaevelsrud

“…Method This parallel, two-arm RCT (1:1 allocation ratio, simple randomization) examines the effectiveness of a therapist-guided cognitive-behavioral IBI compared to unstandardized CAU in a self-selected sample of adults (≥ 18 years). …”
Get full text

Efficacy and safety of medroxyprogesterone acetate on noninvasive ventilation -treated exacerbated COPD patients: a double-blind randomized clinical trial by Mohsen Gholinataj Jelodar, Mohammadreza Malek-Ahmadi, Adeleh Sahebnasagh, Farhad Mohammadi, Fatemeh Saghafi

“…Materials and methods This double-blind clinical trial was conducted on consecutive exacerbated COD patients referred to Shahid Rahnemoun Hospital, Yazd, Iran, from February 2022 to August 2022. Through a block randomized sampling method with a 1:1 allocation ratio, 58 eligible patients with hypercapnic exacerbated COPD on NIV were divided into two study groups: the intervention (treated with MPA 10 mg every 8 h) and the control (treated with placebo). …”
Get full text

The effect of lavender inhalation aromatherapy on pain, anxiety and sleep quality in patients following orthopedic surgery: A randomized clinical trial by Tahere Momeni-Ghale Ghasemi, Amir Musarezaie, Shahnaz Alikhah, Amir Hossein Saeidi

“…Eligible patients were recruited through consecutive sampling and were randomly assigned to either the intervention group (n=40) or the control group (n=40). …”
Get full text

The effect of tuinatherapy with chamomile oil extract on the severity of back pain in female operating room technologists: A randomized clinical trial by Seyedeh Maryam Seyedi, Soheila Bakhtiari, Mahboubeh Valiani

“…Methods & Materials: This double-blind, randomized controlled clinical trial included 105 female operating room technologists selected via convenience sampling from several hospitals in Isfahan. …”
Get full text

Dual-functional probe for sensitive detection of MCF-7 cells and mendelian randomization analysis of MUC1 association with multiple cancers by Zhuzheng Wu, Qingquan Chen, Zhifeng Lin, Yating Chen, Xiaohao Gan, Ye He

“…Additionally, through two-sample Mendelian randomization (MR) analysis, we verified a potential correlation between breast cancer and MUC1 (PIVW<0.05), while also proving no potential correlation between liver cancer and MUC1 (PIVW>0.05). …”
Get full text

Robot-assisted laparoscopic surgery versus conventional laparoscopic surgery in randomized controlled trials: A systematic review and meta-analysis. by Hyunsuk Frank Roh, Seung Hyuk Nam, Jung Mogg Kim

“…Among a total of 1,517 articles, 27 clinical reports with a mean sample size of 65 patients per report (32.7 patients who underwent RLS and 32.5 who underwent CLS), met the inclusion criteria.…”
Get full text

Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: A phase II, randomized study by Kjersti Skipar, Tord Hompland, Kjersti V. Lund, Christina S. Fjeldbo, Kristina Lindemann, Taran P. Hellebust, Heidi Lyng, Kjersti Bruheim

“…Patients and methods: Patients were included in a 1:1 randomized, open-label design, comparing standard chemoradiotherapy ± metformin. …”
Get full text

A randomized cross-over study of the acute effects of running 5 km on glucose, insulin, metabolic rate, cortisol and Troponin T. by Boris Keselman, Marta Vergara, Sofia Nyberg, Fredrik H Nystrom

“…The participants were randomized regarding the order of the two trial-days in this cross-over study.…”
Get full text