Effects of fructo-oligosaccharides on genitourinary tract infections and birth outcomes in pregnant women: a randomized controlled trial in Bangladesh by Shamima Sultana, Yukiko Wagatsuma, Rumana Sharmin, Dilruba Ahmed, Arif Hasan Chowdhury, Ahshanul Haque, Tahmeed Ahmed, Harald Brüssow, Shafiqul Alam Sarker

“…A higher rate of Lactobacillus in the stool samples of infants whose mothers received FOS was observed. …”
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Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study by Yong Shen⁺, Siqi Xie⁺, Yu Lin⁺, Yifan Fang, Bing Zhang, Jinna Zhang

“…Methods Genome-wide association study (GWAS) data for maternal smoking around birth and offspring constipation were obtained from the Mendelian randomization (MR) Base platform. Single nucleotide polymorphisms (SNPs) significantly associated with maternal smoking around birth were utilized as instrumental variables in two-sample MR analyses to explore the relationship between maternal smoking and offspring constipation. …”
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Metabolic biomarkers mediate allergic rhinitis via circulating inflammatory proteins: Evidence from a Mendelian randomization study by Xiang Cao, Boyang Zhang, Wei Wang, Zijiao Xu, Zhixin Jiang

“…Data were extracted from comprehensive Genome-Wide Association Studies (GWAS). A two-sample MR approach was employed to assess both the direct and mediated effects of CIPs on AR through MBs. …”
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Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial by Ramona Schiumerini, Paola Baccarini, Adele Fornelli, Davide Allegri, Francesca Lodato, Alessia Gazzola, Pasquale Apolito, Nunzio P. Longo, Anna M. Polifemo, Franca Patrizi, Federica Buonfiglioli, Stefania Ghersi, Marco Bassi, Liza Ceroni, Antonella Ghetti, Giulio Fonti, Vincenzo Cennamo

“…Conclusions: PL+CSP of small polyps did not improve endoscopic and histological complete resection rates and polyp sample retrieval. PL+CSP had higher rates of intraprocedural bleeding and was “time-consuming”.…”
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Multi‐Omics Mendelian Randomization Identifies a DNA Methylation‐ZDHHC20‐Immune Axis Associated With Schizophrenia Risk by Qinghua Guo, Chao Chen, Yong Wang, Libo Guo, Shaomei Shang

“…Methods We utilized Mendelian randomization (MR), integrating expression, protein, and methylation quantitative trait loci (eQTL, pQTL, mQTL) to explore causal pathways in schizophrenia. …”
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Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial by Hao Yan, Mei Gao, Yu Zhang, Huaibin Wang, Yushan Zhu, Tiangang Zhou, Ruzhan Yao, Weiqiang Liu, Jesse Li‐Ling

“…These 96 patients were randomly divided into two groups: the SHM group (48 patients, using flowable gelatin) and the non‐SHM group (48 patients, not using flowable gelatin). …”
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Pilot Randomized Controlled Trial of iCanWork: Theory-Guided Return-to-Work Intervention for Individuals Touched by Cancer by Christine Maheu, Maureen Parkinson, Kyla Johnson, Wing Lam Tock, Naomi Dolgoy, Simon-Pierre Dupuis, Mina Singh

“…In response, iCanWork—a theoretically informed, multidisciplinary RTW intervention integrating vocational rehabilitation (VR) and occupational therapy (OT)—was conceptualized and developed to address the gap identified in recent reviews for robust, work-health-focused RTW interventions. Methods: A pilot randomized controlled trial was conducted to explore the feasibility, acceptability, and preliminary work-related outcomes of the iCanWork intervention among 23 ITBC participants randomized to either the intervention or control group. …”
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Russian Randomized Trial to Select Optimal Antibiotic Prophylaxis in Radical Cystectomy: Initial Results of MACS-TRIAL (NCT05392634) by A. K. Nosov, M. V. Berkut, E. M. Mamizhev, T. Yu. Galunova, D. I. Rumyantseva, D. P. Semeyko, S. A. Reva, S. Yu. Konyashkina

“…Statistical data processing was performed with StatPlus:Mac LE.Results and discussion. 36 patients were included in the study (39% of the expected sample). For the period from May 30, 2022 to February 01, 2023. …”
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PROJECT PREVENT: a randomized controlled trial of preoperative vaginal metronidazole to decrease patient issues and infections after hysterectomy by Tana Pradhan, Helen Zhang, Amanda Kadesh, Ama Buskwofie, Sonali Patankar, Sharifa Menon, Timothy Ryntz, Cara L. Grimes

“…Sample size calculation was based on a 20% difference in issues and infection (30% incidence and 10% in the intervention arm) with 80% power and an alpha error of 0.05 and indicated 62 subjects needed in each arm.Setting Outpatient gynecology clinics at a single academic institution.Participants 154 subjects were screened for eligibility between July 2020 and September 2022. 133 underwent hysterectomy including 68 subjects (51.1%) randomized to the metronidazole and 65 (48.9%) controls. …”
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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease by Zhihao Qi, Quan Li, Shuhua Yang, Chun Fu, Burong Hu

“…Herein, we employed a multi-omics summary data-based Mendelian randomization (SMR) approach to ascertain the potential causal effects of DDR-related genes in IBD. …”
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Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT) by Manuel Hecht, Anette Blümle, Harald Binder, Martin Schumacher, Nadine Binder

“…First, all eligible IITs were sampled. Then, ISTs were randomly selected while ensuring balance across certain trial characteristics. …”
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Clinical and microbial evaluation of mouthwash containing Achyranthes aspera and Trachyspermum ammi: A randomized controlled non-inferiority trial by Ram Surath Kumar, Anil V. Ankola, Roopali M. Sankeshwari, Vinuta Hampiholi, Sagar Jalihal, Atrey J. Pai Khot, Varkey Nadakkavukaran Santhosh, Kavitha Ragu

“…Methods: This was a randomized controlled non-inferiority trial involving 108 children with plaque-induced gingivitis who were randomly assigned to three groups of 36 children each: Group A, AA + TA mouthwash; Group B, CHX mouthwash; and Group C, placebo mouthwash. …”
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Head-mounted camera as a debriefing tool for surgical simulation-based training: a randomized controlled study in Senegal by Abdourahmane Ndong, Adja C. Diallo, Armaun D. Rouhi, Diago A. Dia, Sebastian Leon, Cheikhou Dieng, Mohamed L. Diao, Jacques N. Tendeng, Noel N. Williams, Mamadou Cissé, Kristoffel R. Dumon, Ibrahima Konaté

“…Further research with larger sample sizes is recommended to validate these findings and explore long-term impacts on surgical proficiency.…”
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Feasibility and Preliminary Effects of Acupuncture for Cognitive Dysfunction in Diverse Cancer Survivors: A Pilot, Randomized, Placebo-Controlled Trial by Xiaotong Li, Kaitlin Lampson, Tim A. Ahles, James C. Root, Q. Susan Li, Yuelin Li, Anam Ahsan, Jun J. Mao, Kevin T. Liou

“…The improvements from RA persisted through week 16 in both the total sample and the sub-group. Eleven mild adverse events were reported, with pain and bleeding at the needling sites being the most common. (4) Conclusions: The findings support the feasibility and safety of conducting a randomized, placebo-controlled trial to evaluate acupuncture for cognitive dysfunction in cancer survivors.…”
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Effects of lifestyle intervention by a nurse-led app on the prevention of symptoms in postpartum women: a randomized controlled trial by Yulian Liang, Shiying Wang, Jie Tao, Zheng Yao, Yongzi Yao, Jinguo Zhai

“…A total of 150 participants were randomly allocated (1:1) to either an intervention group (n = 75) or a control group (n = 75). …”
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Effects of tongue tamers and customized bonded spurs as an early treatment of anterior open bite: a randomized clinical study by Safa B. Alawy, Shaimaa S. EL-Desouky, Ibrahim A. Kabbash, Shimaa M. Hadwa

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Exergame-Based Behavior Change Interventions for Promoting Physical Activity: Systematic Review and Meta-Analysis of Randomized Controlled Studies by Si-Jia Li, Hao-Ming Ma, Lin-Qing Zhu, Hong-Yu Yu, Ao-Qi Wang, Xing-Yi Tang, Run-Yuan Pei, Mei-Hua Piao

“…ObjectiveA systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to examine the overall effects of exergame-based interventions for promoting PA and their influencing factors. …”
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Efficacy of different treatment strategies in patients with mucopolysaccharidosis: a systematic review and network meta-analysis of randomized controlled trials by Lingling Huang, Jianru Wu, Biyu Tang, Jingying Wu, Fenfang Wei, Hong Qiao Li, Limin Li, Xinru Wang, Bei Wang, Wenyu Wu, Xiang Hong

“…Hence, further evidence from large-sample RCT is needed.…”
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Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial. by Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

“…The clinical study's main limitations were the relatively small sample size and stable, well-compensated population.…”
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Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study by Haoqi Zhu, Jingyi Pan

“…To elucidate potential causal relationships between these clinical entities, we conducted a comprehensive investigation employing bidirectional two-sample Mendelian randomization (MR) analysis complemented by multivariable Mendelian randomization (MVMR) methodology. …”
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